'+pages+''); $('.stream > div:odd').addClass('bgr_color'); updateHeight('#history'); }); window.activateTabArea = ensure(function(tab, areas){ var parsed = false; var parts = (areas || '').split('/'); window.fsonload = $.inArray('fs', parts) >= 0; if(fsonload){ parts.splice(parts.indexOf('fs'), 1); } var replayMode = false; if($.inArray('replay', parts)>=0){ replayMode = 'replay'; } var noSoundMode = false; if($.inArray('nosound', parts)>=0){ noSoundMode = 'nosound'; } if($.inArray('ns', parts)>=0){ noSoundMode = 'ns'; } var previewMode = null; if($.inArray('p', parts)>=0){ previewMode = 'p'; } if($.inArray('preview', parts)>=0){ previewMode = 'preview'; } if($.inArray('repeat', parts)>=0){ replayMode = 'repeat'; } if($.inArray('r', parts)>=0 || $.inArray('ro', parts)>=0){ replayMode = 'r'; } if(replayMode){ parts.splice(parts.indexOf(replayMode), 1); } if(noSoundMode){ parts.splice(parts.indexOf(noSoundMode), 1); } if(previewMode){ parts.splice(parts.indexOf(previewMode), 1); } if(previewMode){ if(!parts.length){ parts = ['1-14', '999:59']; } } var area = parts[0]; if(tab == 'history' && false){ var page = parseInt(area || '1') || 1; $.ajax({ url: 'https://login.wn.com/recent/json/?pp='+history_pp+'&skip='+history_pp*(page-1), dataType: 'jsonp', success: function(response){ $ensure(function(){ renderHistory(response, page); }); } }); return true; } if(tab == 'global_history' && false){ var page = parseInt(area || '1') || 1; globalHistory.fetchStream(page, '', function(){ updateHeight('#global_history'); }); return true; } if(tab == 'my_playlists' && false){ var page = parseInt(area || '1') || 1; myPlaylists.fetchStream(page, '', function(){ updateHeight('#my_playlists'); }); return true; } if(tab == 'my_videos' && false){ var page = parseInt(area || '1') || 1; myVideos.fetchStream(page, '', function(){ updateHeight('#my_videos'); }); return true; } if(tab == 'related_sites' && areas && matchPosition(areas)){ var seconds = parsePosition(areas); scrollRelated(seconds); return false; } if(matchPosition(area) || matchAction(area)){ parts.unshift('1'); area = parts[0]; } if(tab == 'expand' && area && area.match(/\d+/)) { var num = parseInt(area); if(num < 100){ //FIX ME. 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Proteolysis

Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.

Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases and is used in some venoms to damage their prey.

Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.

Podcasts:

  • Proteolysis

    Proteolysis -This lecture explains about the protein degradation process by ubiquitination. http://shomusbiology.com/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We ...

    published: 26 Nov 2012
  • Dr. Walter Schmidt shares the importance and role of proteolysis in cance research

    For additional information visit http://www.cancerquest.org/walter-schmidt-interview In this video, Dr. Walter Schmidt explains other experiments that he is working on. To learn more about cancer and watch additional interviews, please visit the CancerQuest website at http://www.cancerquest.org

    published: 29 Mar 2013
  • How it Works: Proteolysis Targeting Chimeras (PROTAC® degraders)

    Arvinas is engineering an expansive pipeline of proteolysis targeting chimeras, or PROTAC® protein degraders, designed to harness the body’s own natural protein disposal system (the ubiquitin proteasome system) to selectively and efficiently degrade and remove disease-causing proteins.

    published: 24 Sep 2020
  • Science Animation - Proteolytic cleavage

    Proteolytic cleavage, a crucial biological process, involves the hydrolysis of peptide bonds in proteins. Enzymes called proteases catalyze this reaction, leading to the breakdown of larger protein molecules into smaller peptides or amino acids. This process regulates cellular functions, activates signaling pathways, and facilitates protein maturation, essential for diverse physiological processes.

    published: 12 Oct 2023
  • Proteolysis

    Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. In general, this occurs by the hydrolysis of the peptide bond, and is most commonly achieved by cellular enzymes called proteases, but may also occur by intramolecular digestion, as well as by non-enzymatic methods such as the action of mineral acids and heat. Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. This video i...

    published: 23 Nov 2014
  • Limited proteolysis and drug development

    Learn about how Biognosys' Limited Proteolysis (LiP) technology is advancing techniques in mass spectrometry, proteomics, and drug development. For more information, see biognosys.com

    published: 15 Jun 2022
  • Proteolysis | Proteolytic Degradation | Zymogen Activation | Proteolytic Cleavage |

    published: 29 Nov 2021
  • Protein degradation or Proteolysis or Ubiquitination

    In this video lecture we will explain the protein degradation or Proteolysis or Ubiquitination. In this video lecture we will explain the following content related to this lecture. 1. Introduction to Ubiquitination or Proteolysis or Protein degradation 2. Digramatically explanation of Proteolysis 3. Requirements for Protein degradation A. Ubiquitine Protein. B. Ubiquitin enzymes i.e Ubiquitine activating enzymes (E1). Ubiquitine conjugate enzymes (E2). Ubiquitine ligase enzymes (E3). 4. Machinisms of protein degradation or Proteolysis or Ubiquitination. 5. What are proteosomes. etc etc etc.

    published: 23 Apr 2020
  • The ubiquitin-proteasome mediated protein degradation pathway | Ubiquitin ligase | Proteasome

    This video talks about The ubiquitin-proteasome mediated protein degradation pathway | Ubiquitin ligase | Proteasome For Notes, flashcards, daily quizzes, and practice questions follow Instagram page: https://www.instagram.com/animatedbiologywitharpan/ Facebook page: https://www.facebook.com/Animated-biology-with-Arpan-109894017509038/?ref=pages_you_manage Follow me on other social media - Facebook : https://www.facebook.com/arpan.parich... Instagram : https://www.instagram.com/arpanparichha/ Linked in : https://in.linkedin.com/in/arpan-pari... Twitter : https://twitter.com/arpan_parichha?la... Link to my other channel - Lets crack bio exams https://www.youtube.com/channel/UC4IpyopsGWSjaPACNTZLuqg The Nerd Medic YouTube channel: Youtube: https://youtube.com/c/TheNerdMedic00 Instagra...

    published: 24 Aug 2024
  • [Conférence] A. CIECHANOVER - The Ubiquitin System and Intracellular Proteolysis

    Conférence : Journée des Prix Nobels, Médailles Fields et Prix Abel à l'Académie des sciences Lien de la conférence : http://www.academie-sciences.fr 00:00:00 Introduction 00:03:56 Topological Diversity of Proteolytic Systems 00:05:32 Roles of Intracellular Protein Degradation 00:10:11 Rudolf Schoenheimer 1898-1941 00:13:38 Christian de Duve 00:14:00 The Lysosome 00:17:17 The Hierarchical Structure of the Ubiquitin-Conjugating Machinery 00:22:01 The Ubiquitin Proteasome Pathway 00:23:36 Structure of the Yeast Proteasome and CP 00:28:46 The concept of Molecular Glue © Académie des sciences - Tous droits réservés

    published: 18 Jul 2018
developed with YouTube
Proteolysis
6:10

Proteolysis

  • Order:
  • Duration: 6:10
  • Uploaded Date: 26 Nov 2012
  • views: 43197
Proteolysis -This lecture explains about the protein degradation process by ubiquitination. http://shomusbiology.com/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching Proteolytic cleavage breaks down proteins in meals extracellularly into smaller peptides and amino acids so that they could also be absorbed and utilized by an organism. Proteins in cells are also constantly being broken down into amino acids. This intracellular degradation of protein serves a number of functions - it removes damaged and irregular protein and avoid their accumulation, and it additionally serves to keep watch over mobile tactics by way of removing enzymes and regulatory proteins that are not needed. The amino acids may then be reused for protein synthesis. The intracellular degradation of protein is also finished in two methods - proteolysis in lysosome, or a ubiquitin-dependent procedure which pursuits unwanted proteins to proteasome. The autophagy-lysosomal pathway is almost always a non-selective process, but it may emerge as selective upon hunger whereby proteins with peptide sequence KFERQ or equivalent are selectively broken down. The lysosome comprises a gigantic quantity of proteases equivalent to cathepsins. The ubiquitin-mediated approach is selective. Proteins marked for degradation are covalently linked to ubiquitin. Many molecules of ubiquitin is also linked in tandem to a protein destined for degradation. The polyubiquinated protein is detailed to an ATP-elegant protease problematic, the proteasome. The ubiquitin is launched and reused, while the particular protein is degraded. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia. Link- http://en.wikipedia.org/wiki/Main_Page Animation source: Discover Biology, Core 3rd Edition, W W Norton and company Link- http://www.wwnorton.com/college/biology/discoverbio3/core/content/index/animations.asp
https://wn.com/Proteolysis
Dr. Walter Schmidt shares the importance and role of proteolysis in cance research
1:24

Dr. Walter Schmidt shares the importance and role of proteolysis in cance research

  • Order:
  • Duration: 1:24
  • Uploaded Date: 29 Mar 2013
  • views: 219
For additional information visit http://www.cancerquest.org/walter-schmidt-interview In this video, Dr. Walter Schmidt explains other experiments that he is working on. To learn more about cancer and watch additional interviews, please visit the CancerQuest website at http://www.cancerquest.org
https://wn.com/Dr._Walter_Schmidt_Shares_The_Importance_And_Role_Of_Proteolysis_In_Cance_Research
How it Works: Proteolysis Targeting Chimeras (PROTAC® degraders)
2:00

How it Works: Proteolysis Targeting Chimeras (PROTAC® degraders)

  • Order:
  • Duration: 2:00
  • Uploaded Date: 24 Sep 2020
  • views: 2946
Arvinas is engineering an expansive pipeline of proteolysis targeting chimeras, or PROTAC® protein degraders, designed to harness the body’s own natural protein disposal system (the ubiquitin proteasome system) to selectively and efficiently degrade and remove disease-causing proteins.
https://wn.com/How_It_Works_Proteolysis_Targeting_Chimeras_(Protac®_Degraders)
Science Animation - Proteolytic cleavage
0:12

Science Animation - Proteolytic cleavage

  • Order:
  • Duration: 0:12
  • Uploaded Date: 12 Oct 2023
  • views: 1242
Proteolytic cleavage, a crucial biological process, involves the hydrolysis of peptide bonds in proteins. Enzymes called proteases catalyze this reaction, leading to the breakdown of larger protein molecules into smaller peptides or amino acids. This process regulates cellular functions, activates signaling pathways, and facilitates protein maturation, essential for diverse physiological processes.
https://wn.com/Science_Animation_Proteolytic_Cleavage
Proteolysis
17:47

Proteolysis

  • Order:
  • Duration: 17:47
  • Uploaded Date: 23 Nov 2014
  • views: 5138
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. In general, this occurs by the hydrolysis of the peptide bond, and is most commonly achieved by cellular enzymes called proteases, but may also occur by intramolecular digestion, as well as by non-enzymatic methods such as the action of mineral acids and heat. Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. This video is targeted to blind users. Attribution: Article text available under CC-BY-SA Creative Commons image source in video
https://wn.com/Proteolysis
Limited proteolysis and drug development
1:36

Limited proteolysis and drug development

  • Order:
  • Duration: 1:36
  • Uploaded Date: 15 Jun 2022
  • views: 1053
Learn about how Biognosys' Limited Proteolysis (LiP) technology is advancing techniques in mass spectrometry, proteomics, and drug development. For more information, see biognosys.com
https://wn.com/Limited_Proteolysis_And_Drug_Development
Proteolysis | Proteolytic Degradation | Zymogen Activation | Proteolytic Cleavage |
2:25

Proteolysis | Proteolytic Degradation | Zymogen Activation | Proteolytic Cleavage |

  • Order:
  • Duration: 2:25
  • Uploaded Date: 29 Nov 2021
  • views: 10709
https://wn.com/Proteolysis_|_Proteolytic_Degradation_|_Zymogen_Activation_|_Proteolytic_Cleavage_|
Protein degradation or Proteolysis or Ubiquitination
18:01

Protein degradation or Proteolysis or Ubiquitination

  • Order:
  • Duration: 18:01
  • Uploaded Date: 23 Apr 2020
  • views: 892
In this video lecture we will explain the protein degradation or Proteolysis or Ubiquitination. In this video lecture we will explain the following content related to this lecture. 1. Introduction to Ubiquitination or Proteolysis or Protein degradation 2. Digramatically explanation of Proteolysis 3. Requirements for Protein degradation A. Ubiquitine Protein. B. Ubiquitin enzymes i.e Ubiquitine activating enzymes (E1). Ubiquitine conjugate enzymes (E2). Ubiquitine ligase enzymes (E3). 4. Machinisms of protein degradation or Proteolysis or Ubiquitination. 5. What are proteosomes. etc etc etc.
https://wn.com/Protein_Degradation_Or_Proteolysis_Or_Ubiquitination
The ubiquitin-proteasome mediated protein degradation pathway | Ubiquitin ligase | Proteasome
7:02

The ubiquitin-proteasome mediated protein degradation pathway | Ubiquitin ligase | Proteasome

  • Order:
  • Duration: 7:02
  • Uploaded Date: 24 Aug 2024
  • views: 9837
This video talks about The ubiquitin-proteasome mediated protein degradation pathway | Ubiquitin ligase | Proteasome For Notes, flashcards, daily quizzes, and practice questions follow Instagram page: https://www.instagram.com/animatedbiologywitharpan/ Facebook page: https://www.facebook.com/Animated-biology-with-Arpan-109894017509038/?ref=pages_you_manage Follow me on other social media - Facebook : https://www.facebook.com/arpan.parich... Instagram : https://www.instagram.com/arpanparichha/ Linked in : https://in.linkedin.com/in/arpan-pari... Twitter : https://twitter.com/arpan_parichha?la... Link to my other channel - Lets crack bio exams https://www.youtube.com/channel/UC4IpyopsGWSjaPACNTZLuqg The Nerd Medic YouTube channel: Youtube: https://youtube.com/c/TheNerdMedic00 Instagram: https://instagram.com/ayan_parichha00... Facebook: https://www.facebook.com/poetsoflens/ For Physics part of bio exams - Physics for IIT JAM biotechnology https://www.youtube.com/channel/UCJvSHjOoL2FDN85hQbu7vfw #animated_biology #animated_biology_with_arpan #biology #bio_facts #CSIR_NET #IIT_JAM #IIT_JAM_BT #biotechnology #bioscience #biological_sciences #microbiology #genetics #zoology #molecular_biology #cell_biology #botany #immunology #ecology
https://wn.com/The_Ubiquitin_Proteasome_Mediated_Protein_Degradation_Pathway_|_Ubiquitin_Ligase_|_Proteasome
[Conférence] A. CIECHANOVER - The Ubiquitin System and Intracellular Proteolysis
33:17

[Conférence] A. CIECHANOVER - The Ubiquitin System and Intracellular Proteolysis

  • Order:
  • Duration: 33:17
  • Uploaded Date: 18 Jul 2018
  • views: 123
Conférence : Journée des Prix Nobels, Médailles Fields et Prix Abel à l'Académie des sciences Lien de la conférence : http://www.academie-sciences.fr 00:00:00 Introduction 00:03:56 Topological Diversity of Proteolytic Systems 00:05:32 Roles of Intracellular Protein Degradation 00:10:11 Rudolf Schoenheimer 1898-1941 00:13:38 Christian de Duve 00:14:00 The Lysosome 00:17:17 The Hierarchical Structure of the Ubiquitin-Conjugating Machinery 00:22:01 The Ubiquitin Proteasome Pathway 00:23:36 Structure of the Yeast Proteasome and CP 00:28:46 The concept of Molecular Glue © Académie des sciences - Tous droits réservés
https://wn.com/Conférence_A._Ciechanover_The_Ubiquitin_System_And_Intracellular_Proteolysis
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Proteolysis

Proteolysis -This lecture explains about the protein degradation process by ubiquitination. http://shomusbiology.com/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching Proteolytic cleavage breaks down proteins in meals extracellularly into smaller peptides and amino acids so that they could also be absorbed and utilized by an organism. Proteins in cells are also constantly being broken down into amino acids. This intracellular degradation of protein serves a number of functions - it removes damaged and irregular protein and avoid their accumulation, and it additionally serves to keep watch over mobile tactics by way of removing enzymes and regulatory proteins that are not needed. The amino acids may then be reused for protein synthesis. The intracellular degradation of protein is also finished in two methods - proteolysis in lysosome, or a ubiquitin-dependent procedure which pursuits unwanted proteins to proteasome. The autophagy-lysosomal pathway is almost always a non-selective process, but it may emerge as selective upon hunger whereby proteins with peptide sequence KFERQ or equivalent are selectively broken down. The lysosome comprises a gigantic quantity of proteases equivalent to cathepsins. The ubiquitin-mediated approach is selective. Proteins marked for degradation are covalently linked to ubiquitin. Many molecules of ubiquitin is also linked in tandem to a protein destined for degradation. The polyubiquinated protein is detailed to an ATP-elegant protease problematic, the proteasome. The ubiquitin is launched and reused, while the particular protein is degraded. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia. Link- http://en.wikipedia.org/wiki/Main_Page Animation source: Discover Biology, Core 3rd Edition, W W Norton and company Link- http://www.wwnorton.com/college/biology/discoverbio3/core/content/index/animations.asp
6:10
Proteolysis
Proteolysis -This lecture explains about the protein degradation process by ubiquitination...
published: 26 Nov 2012
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1:24
Dr. Walter Schmidt shares the importance and role of proteolysis in cance research
For additional information visit http://www.cancerquest.org/walter-schmidt-interview In t...
published: 29 Mar 2013
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2:00
How it Works: Proteolysis Targeting Chimeras (PROTAC® degraders)
Arvinas is engineering an expansive pipeline of proteolysis targeting chimeras, or PROTAC®...
published: 24 Sep 2020
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0:12
Science Animation - Proteolytic cleavage
Proteolytic cleavage, a crucial biological process, involves the hydrolysis of peptide bon...
published: 12 Oct 2023
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17:47
Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. In gene...
published: 23 Nov 2014
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1:36
Limited proteolysis and drug development
Learn about how Biognosys' Limited Proteolysis (LiP) technology is advancing techniques in...
published: 15 Jun 2022
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2:25
Proteolysis | Proteolytic Degradation | Zymogen Activation | Proteolytic Cleavage |
published: 29 Nov 2021
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18:01
Protein degradation or Proteolysis or Ubiquitination
In this video lecture we will explain the protein degradation or Proteolysis or Ubiquitina...
published: 23 Apr 2020
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7:02
The ubiquitin-proteasome mediated protein degradation pathway | Ubiquitin ligase | Proteasome
This video talks about The ubiquitin-proteasome mediated protein degradation pathway | Ubi...
published: 24 Aug 2024
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33:17
[Conférence] A. CIECHANOVER - The Ubiquitin System and Intracellular Proteolysis
Conférence : Journée des Prix Nobels, Médailles Fields et Prix Abel à l'Académie des scien...
published: 18 Jul 2018
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Proteolysis

Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.

Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases and is used in some venoms to damage their prey.

Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.

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