In biochemistry, allosteric regulation (or allosteric control) is the regulation of a protein by binding an effector molecule at a site other than the enzyme's active site.
The site to which the effector binds is termed the allosteric site. Allosteric sites allow effectors to bind to the protein, often resulting in a conformational change involving protein dynamics. Effectors that enhance the protein's activity are referred to as allosteric activators, whereas those that decrease the protein's activity are called allosteric inhibitors.
Allosteric regulations are a natural example of control loops, such as feedback from downstream products or feedforward from upstream substrates. Long-range allostery is especially important in cell signaling. Allosteric regulation is also particularly important in the cell's ability to adjust enzyme activity.
The term allostery comes from the Greekallos (ἄλλος), "other," and stereos (στερεὀς), "solid (object)." This is in reference to the fact that the regulatory site of an allosteric protein is physically distinct from its active site.
Enzymes, Feedback Inhibition, and Allosteric Regulation
published: 23 Feb 2017
Allosteric regulation of enzymes (Introduction)
this is an introductory video describing the concept behind allosteric regulator
published: 05 Apr 2020
Allosteric Regulation of Enzymes
published: 22 Mar 2014
Allosteric enzyme
This lecture explains about the allosteric regulation and alloteric enzyme inhibition. http://shomusbiology.com/
Download the study materials here-
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Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
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published: 19 Nov 2012
Allosteric regulation and feedback loops | Biomolecules | MCAT | Khan Academy
Created by Ross Firestone.
Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/biomolecules/enzyme-kinetics/v/non-enzymatic-protein-function?utm_source=YT&utm_medium=Desc&utm_campaign=mcat
Missed the previous lesson? https://www.khanacademy.org/test-prep/mcat/biomolecules/enzyme-kinetics/v/cooperativity?utm_source=YT&utm_medium=Desc&utm_campaign=mcat
MCAT on Khan Academy: Go ahead and practice some passage-based questions!
About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus ...
published: 12 Feb 2014
Regulation of Glycolysis : allosteric and transcriptional control
this video describes the allosteric and transcriptional control over the glycolysis pathway.It also tells you how glycolytic flux is regulated depending on the energy demand
published: 22 Feb 2020
Allosteric enzymes
These are the type of enzymes which have site other than the active site. This site where the regulator binds. The binding of regulator may stimulate or inhibit the enzyme activity.
published: 19 May 2020
Allosteric Regulation and Mechanism // Enzyme Regulation Biochemistry Enzymology
Hello Dear students! Welcome to my channel 'Medical Globe by Dr. Hadi
I am Dr Hadi Gold medalist , M.phl with PhD Continue and serving as Lecturer in Pharmacy Department University of Baluchistan Quetta Pakistan
---------------------------------------------------------------------------
About This Video
-------------------------------------------------------------------------
In this Video lecture You will learn Basic concept of Allosteric Regulation and Mechanism Enzyme Regulation
------------------------------------
About This Channel
-----------------------------------
This Channel Provides lectures of all subjects of medical field, specially of Biochemistry, Pharmacology for MBBS and Pharm-D covering all over Pakistan Universities and colleges and other countries where Urdu or Englis...
published: 20 Aug 2022
051-Allosteric Regulation; Summary of Enzyme Regulation
Discussion of allosteric regulation of enzymes and comparison to allosteric enzymes; example of phosphofructokinase; general overview of methods of regulation
published: 10 Jun 2014
Allosteric Control – Metabolic Control of Enzyme Activity | Biochemistry
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This video “Allosteric Control – Metabolic Control of Enzyme Activity” is part of the Lecturio course “Biochemistry"
► WATCH the complete course on http://lectur.io/biochemistrycourse
► LEARN ABOUT:
- The concept of allosteric control
- How ATCase demonstrates allosteric control
- The significance of aspartate, ATP, and CTP
- The roles of ATP versus aspartate in the activation of enzymes
- The terms C-unit and R-unit
► THE PROF:
Kevin Ahern received his B.S. and M.S. degrees from Oklahoma State University, and a Ph.D. in Biochemistry from Oregon State University. He is currently working as a professor of biochemistry and biophysics...
This lecture explains about the allosteric regulation and alloteric enzyme inhibition. http://shomusbiology.com/
Download the study materials here-
http://shomu...
This lecture explains about the allosteric regulation and alloteric enzyme inhibition. http://shomusbiology.com/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
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Thank you for watching
This video will demonstrates the mechanism of allosteric enzymes and their functions.
This lecture explains about the allosteric regulation and alloteric enzyme inhibition. http://shomusbiology.com/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
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SlideShare- www.slideshare.net/shomusbiology
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Thank you for watching
This video will demonstrates the mechanism of allosteric enzymes and their functions.
Created by Ross Firestone.
Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/biomolecules/enzyme-kinetics/v/non-enzymatic-protein-function?utm_...
Created by Ross Firestone.
Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/biomolecules/enzyme-kinetics/v/non-enzymatic-protein-function?utm_source=YT&utm_medium=Desc&utm_campaign=mcat
Missed the previous lesson? https://www.khanacademy.org/test-prep/mcat/biomolecules/enzyme-kinetics/v/cooperativity?utm_source=YT&utm_medium=Desc&utm_campaign=mcat
MCAT on Khan Academy: Go ahead and practice some passage-based questions!
About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content.
For free. For everyone. Forever. #YouCanLearnAnything
Subscribe to Khan Academy’s MCAT channel: https://www.youtube.com/channel/UCDkK5wqSuwDlJ3_nl3rgdiQ?sub_confirmation=1
Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Created by Ross Firestone.
Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/biomolecules/enzyme-kinetics/v/non-enzymatic-protein-function?utm_source=YT&utm_medium=Desc&utm_campaign=mcat
Missed the previous lesson? https://www.khanacademy.org/test-prep/mcat/biomolecules/enzyme-kinetics/v/cooperativity?utm_source=YT&utm_medium=Desc&utm_campaign=mcat
MCAT on Khan Academy: Go ahead and practice some passage-based questions!
About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content.
For free. For everyone. Forever. #YouCanLearnAnything
Subscribe to Khan Academy’s MCAT channel: https://www.youtube.com/channel/UCDkK5wqSuwDlJ3_nl3rgdiQ?sub_confirmation=1
Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
this video describes the allosteric and transcriptional control over the glycolysis pathway.It also tells you how glycolytic flux is regulated depending on the ...
this video describes the allosteric and transcriptional control over the glycolysis pathway.It also tells you how glycolytic flux is regulated depending on the energy demand
this video describes the allosteric and transcriptional control over the glycolysis pathway.It also tells you how glycolytic flux is regulated depending on the energy demand
These are the type of enzymes which have site other than the active site. This site where the regulator binds. The binding of regulator may stimulate or inhibit...
These are the type of enzymes which have site other than the active site. This site where the regulator binds. The binding of regulator may stimulate or inhibit the enzyme activity.
These are the type of enzymes which have site other than the active site. This site where the regulator binds. The binding of regulator may stimulate or inhibit the enzyme activity.
Hello Dear students! Welcome to my channel 'Medical Globe by Dr. Hadi
I am Dr Hadi Gold medalist , M.phl with PhD Continue and serving as Lecturer in Pharmacy ...
Hello Dear students! Welcome to my channel 'Medical Globe by Dr. Hadi
I am Dr Hadi Gold medalist , M.phl with PhD Continue and serving as Lecturer in Pharmacy Department University of Baluchistan Quetta Pakistan
---------------------------------------------------------------------------
About This Video
-------------------------------------------------------------------------
In this Video lecture You will learn Basic concept of Allosteric Regulation and Mechanism Enzyme Regulation
------------------------------------
About This Channel
-----------------------------------
This Channel Provides lectures of all subjects of medical field, specially of Biochemistry, Pharmacology for MBBS and Pharm-D covering all over Pakistan Universities and colleges and other countries where Urdu or English is common language
The Lectures are delivered in highly simple and conceptual level so that every student from low grade to sharp grade can take help from.
These Lectures can cover most of the medical competitive Exams like mdcat ,Etea CSS, MBBS Entrance Test etc
------------------------------------------------------------------------------------------------------------
My Channel in Urdu for FSC classes
Dr Hafiz sultan academy
--------------------------------------------------------------------------------------------------------
Official face Book page link
https://web.facebook.com/Dr-Hadi-Medical-Lectures-105689134539022
Related videos or playlists along with their links
------------------------------------------------------------------------------------------------------
Biological oxidation and metabolism videos link
https://www.youtube.com/watch?v=1P41aBGvkaE&list=PLenLGe2cBD58vQ_59TQSCgsOLfBtl2Mll
Carbohydrate chapter complete in English
https://www.youtube.com/watch?v=yfVXFv7vFxQ&list=PLenLGe2cBD58Cb1SledBfB7a555ac3Nco
lipids chapter link
https://www.youtube.com/watch?v=DBgEBCaqZq4&list=PLenLGe2cBD5-PfduvbnjwB2o0l-YKL-A3
Protein full chapter link
https://www.youtube.com/watch?v=dv7qJbs45AI&list=PLenLGe2cBD59NAyWjiOanFOwnn4yTSgsx
Biotechnology in Urdu Hindi link
https://www.youtube.com/watch?v=qALJX78ClBs&list=PLenLGe2cBD5_1O4BlQ4Wkjqt_dJ9J6XYl
Nucleic acid link
https://www.youtube.com/watch?v=heLzFKSYaTk&
list=PLenLGe2cBD5_zmU058HpO2gu3r5nax2Ov
#AllostericRegulation #Enzymology #EnzymeRegulation
Hello Dear students! Welcome to my channel 'Medical Globe by Dr. Hadi
I am Dr Hadi Gold medalist , M.phl with PhD Continue and serving as Lecturer in Pharmacy Department University of Baluchistan Quetta Pakistan
---------------------------------------------------------------------------
About This Video
-------------------------------------------------------------------------
In this Video lecture You will learn Basic concept of Allosteric Regulation and Mechanism Enzyme Regulation
------------------------------------
About This Channel
-----------------------------------
This Channel Provides lectures of all subjects of medical field, specially of Biochemistry, Pharmacology for MBBS and Pharm-D covering all over Pakistan Universities and colleges and other countries where Urdu or English is common language
The Lectures are delivered in highly simple and conceptual level so that every student from low grade to sharp grade can take help from.
These Lectures can cover most of the medical competitive Exams like mdcat ,Etea CSS, MBBS Entrance Test etc
------------------------------------------------------------------------------------------------------------
My Channel in Urdu for FSC classes
Dr Hafiz sultan academy
--------------------------------------------------------------------------------------------------------
Official face Book page link
https://web.facebook.com/Dr-Hadi-Medical-Lectures-105689134539022
Related videos or playlists along with their links
------------------------------------------------------------------------------------------------------
Biological oxidation and metabolism videos link
https://www.youtube.com/watch?v=1P41aBGvkaE&list=PLenLGe2cBD58vQ_59TQSCgsOLfBtl2Mll
Carbohydrate chapter complete in English
https://www.youtube.com/watch?v=yfVXFv7vFxQ&list=PLenLGe2cBD58Cb1SledBfB7a555ac3Nco
lipids chapter link
https://www.youtube.com/watch?v=DBgEBCaqZq4&list=PLenLGe2cBD5-PfduvbnjwB2o0l-YKL-A3
Protein full chapter link
https://www.youtube.com/watch?v=dv7qJbs45AI&list=PLenLGe2cBD59NAyWjiOanFOwnn4yTSgsx
Biotechnology in Urdu Hindi link
https://www.youtube.com/watch?v=qALJX78ClBs&list=PLenLGe2cBD5_1O4BlQ4Wkjqt_dJ9J6XYl
Nucleic acid link
https://www.youtube.com/watch?v=heLzFKSYaTk&
list=PLenLGe2cBD5_zmU058HpO2gu3r5nax2Ov
#AllostericRegulation #Enzymology #EnzymeRegulation
Discussion of allosteric regulation of enzymes and comparison to allosteric enzymes; example of phosphofructokinase; general overview of methods of regulation
Discussion of allosteric regulation of enzymes and comparison to allosteric enzymes; example of phosphofructokinase; general overview of methods of regulation
Discussion of allosteric regulation of enzymes and comparison to allosteric enzymes; example of phosphofructokinase; general overview of methods of regulation
► Sign up here and try our FREE content: http://lectur.io/freecontentyt
► If you’re an medical educator or faculty member, visit: http://lectur.io/medytb2u
T...
► Sign up here and try our FREE content: http://lectur.io/freecontentyt
► If you’re an medical educator or faculty member, visit: http://lectur.io/medytb2u
This video “Allosteric Control – Metabolic Control of Enzyme Activity” is part of the Lecturio course “Biochemistry"
► WATCH the complete course on http://lectur.io/biochemistrycourse
► LEARN ABOUT:
- The concept of allosteric control
- How ATCase demonstrates allosteric control
- The significance of aspartate, ATP, and CTP
- The roles of ATP versus aspartate in the activation of enzymes
- The terms C-unit and R-unit
► THE PROF:
Kevin Ahern received his B.S. and M.S. degrees from Oklahoma State University, and a Ph.D. in Biochemistry from Oregon State University. He is currently working as a professor of biochemistry and biophysics at Oregon State University.
► LECTURIO is your daily study companion for med school:
Created and taught by medical experts, Lecturio combines videos, recall quizzes, an advanced clinical question bank, and study hacks delivered in a way to maximize the use of learning science-validated strategies, no matter if you are a pre-medical, medical, physician associate, or nursing practitioner student studying for USMLE® Step 1 & Step 2 CK, COMLEX Level 1 & 2, NBME® exams, MCAT, MBBS, NEET-PG, or other boards.
Create your free account now: http://lectur.io/medicalpremium
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► Sign up here and try our FREE content: http://lectur.io/freecontentyt
► If you’re an medical educator or faculty member, visit: http://lectur.io/medytb2u
This video “Allosteric Control – Metabolic Control of Enzyme Activity” is part of the Lecturio course “Biochemistry"
► WATCH the complete course on http://lectur.io/biochemistrycourse
► LEARN ABOUT:
- The concept of allosteric control
- How ATCase demonstrates allosteric control
- The significance of aspartate, ATP, and CTP
- The roles of ATP versus aspartate in the activation of enzymes
- The terms C-unit and R-unit
► THE PROF:
Kevin Ahern received his B.S. and M.S. degrees from Oklahoma State University, and a Ph.D. in Biochemistry from Oregon State University. He is currently working as a professor of biochemistry and biophysics at Oregon State University.
► LECTURIO is your daily study companion for med school:
Created and taught by medical experts, Lecturio combines videos, recall quizzes, an advanced clinical question bank, and study hacks delivered in a way to maximize the use of learning science-validated strategies, no matter if you are a pre-medical, medical, physician associate, or nursing practitioner student studying for USMLE® Step 1 & Step 2 CK, COMLEX Level 1 & 2, NBME® exams, MCAT, MBBS, NEET-PG, or other boards.
Create your free account now: http://lectur.io/medicalpremium
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This lecture explains about the allosteric regulation and alloteric enzyme inhibition. http://shomusbiology.com/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
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SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
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Thank you for watching
This video will demonstrates the mechanism of allosteric enzymes and their functions.
Created by Ross Firestone.
Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/biomolecules/enzyme-kinetics/v/non-enzymatic-protein-function?utm_source=YT&utm_medium=Desc&utm_campaign=mcat
Missed the previous lesson? https://www.khanacademy.org/test-prep/mcat/biomolecules/enzyme-kinetics/v/cooperativity?utm_source=YT&utm_medium=Desc&utm_campaign=mcat
MCAT on Khan Academy: Go ahead and practice some passage-based questions!
About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content.
For free. For everyone. Forever. #YouCanLearnAnything
Subscribe to Khan Academy’s MCAT channel: https://www.youtube.com/channel/UCDkK5wqSuwDlJ3_nl3rgdiQ?sub_confirmation=1
Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
this video describes the allosteric and transcriptional control over the glycolysis pathway.It also tells you how glycolytic flux is regulated depending on the energy demand
These are the type of enzymes which have site other than the active site. This site where the regulator binds. The binding of regulator may stimulate or inhibit the enzyme activity.
Hello Dear students! Welcome to my channel 'Medical Globe by Dr. Hadi
I am Dr Hadi Gold medalist , M.phl with PhD Continue and serving as Lecturer in Pharmacy Department University of Baluchistan Quetta Pakistan
---------------------------------------------------------------------------
About This Video
-------------------------------------------------------------------------
In this Video lecture You will learn Basic concept of Allosteric Regulation and Mechanism Enzyme Regulation
------------------------------------
About This Channel
-----------------------------------
This Channel Provides lectures of all subjects of medical field, specially of Biochemistry, Pharmacology for MBBS and Pharm-D covering all over Pakistan Universities and colleges and other countries where Urdu or English is common language
The Lectures are delivered in highly simple and conceptual level so that every student from low grade to sharp grade can take help from.
These Lectures can cover most of the medical competitive Exams like mdcat ,Etea CSS, MBBS Entrance Test etc
------------------------------------------------------------------------------------------------------------
My Channel in Urdu for FSC classes
Dr Hafiz sultan academy
--------------------------------------------------------------------------------------------------------
Official face Book page link
https://web.facebook.com/Dr-Hadi-Medical-Lectures-105689134539022
Related videos or playlists along with their links
------------------------------------------------------------------------------------------------------
Biological oxidation and metabolism videos link
https://www.youtube.com/watch?v=1P41aBGvkaE&list=PLenLGe2cBD58vQ_59TQSCgsOLfBtl2Mll
Carbohydrate chapter complete in English
https://www.youtube.com/watch?v=yfVXFv7vFxQ&list=PLenLGe2cBD58Cb1SledBfB7a555ac3Nco
lipids chapter link
https://www.youtube.com/watch?v=DBgEBCaqZq4&list=PLenLGe2cBD5-PfduvbnjwB2o0l-YKL-A3
Protein full chapter link
https://www.youtube.com/watch?v=dv7qJbs45AI&list=PLenLGe2cBD59NAyWjiOanFOwnn4yTSgsx
Biotechnology in Urdu Hindi link
https://www.youtube.com/watch?v=qALJX78ClBs&list=PLenLGe2cBD5_1O4BlQ4Wkjqt_dJ9J6XYl
Nucleic acid link
https://www.youtube.com/watch?v=heLzFKSYaTk&
list=PLenLGe2cBD5_zmU058HpO2gu3r5nax2Ov
#AllostericRegulation #Enzymology #EnzymeRegulation
Discussion of allosteric regulation of enzymes and comparison to allosteric enzymes; example of phosphofructokinase; general overview of methods of regulation
► Sign up here and try our FREE content: http://lectur.io/freecontentyt
► If you’re an medical educator or faculty member, visit: http://lectur.io/medytb2u
This video “Allosteric Control – Metabolic Control of Enzyme Activity” is part of the Lecturio course “Biochemistry"
► WATCH the complete course on http://lectur.io/biochemistrycourse
► LEARN ABOUT:
- The concept of allosteric control
- How ATCase demonstrates allosteric control
- The significance of aspartate, ATP, and CTP
- The roles of ATP versus aspartate in the activation of enzymes
- The terms C-unit and R-unit
► THE PROF:
Kevin Ahern received his B.S. and M.S. degrees from Oklahoma State University, and a Ph.D. in Biochemistry from Oregon State University. He is currently working as a professor of biochemistry and biophysics at Oregon State University.
► LECTURIO is your daily study companion for med school:
Created and taught by medical experts, Lecturio combines videos, recall quizzes, an advanced clinical question bank, and study hacks delivered in a way to maximize the use of learning science-validated strategies, no matter if you are a pre-medical, medical, physician associate, or nursing practitioner student studying for USMLE® Step 1 & Step 2 CK, COMLEX Level 1 & 2, NBME® exams, MCAT, MBBS, NEET-PG, or other boards.
Create your free account now: http://lectur.io/medicalpremium
► INSTALL our free Lecturio app
iTunes Store: https://app.adjust.com/z21zrf
Play Store: https://app.adjust.com/b01fak
► LET’S CONNECT:
• Facebook: https://www.facebook.com/lecturio.medical.education.videos
• Instagram: https://www.instagram.com/lecturio_medical_videos
• Pinterest: https://www.pinterest.de/lecturiomedical
• LinkedIn: https://www.linkedin.com/company/lecturio-medical/
In biochemistry, allosteric regulation (or allosteric control) is the regulation of a protein by binding an effector molecule at a site other than the enzyme's active site.
The site to which the effector binds is termed the allosteric site. Allosteric sites allow effectors to bind to the protein, often resulting in a conformational change involving protein dynamics. Effectors that enhance the protein's activity are referred to as allosteric activators, whereas those that decrease the protein's activity are called allosteric inhibitors.
Allosteric regulations are a natural example of control loops, such as feedback from downstream products or feedforward from upstream substrates. Long-range allostery is especially important in cell signaling. Allosteric regulation is also particularly important in the cell's ability to adjust enzyme activity.
The term allostery comes from the Greekallos (ἄλλος), "other," and stereos (στερεὀς), "solid (object)." This is in reference to the fact that the regulatory site of an allosteric protein is physically distinct from its active site.
You've got to accentuate the positive Eliminate the negative Latch on to the affirmative Don't mess with Mister In-Between You've got to spread joy up to the maximum Bring gloom down to the minimum Have faith or pandemonium Liable to walk upon the scene (To illustrate his last remark Jonah in the whale, Noah in the ark What did they do Just when everything looked so dark) Man, they said we better Accentuate the positive Eliminate the negative Latch on to the affirmative Don't mess with Mister In-Between No, do not mess with Mister In-Between Do you hear me, hmm? (Oh, listen to me children and-a you will hear About the elininatin' of the negative And the accent on the positive) And gather 'round me children if you're willin' And sit tight while I start reviewin' The attitude of doin' right (You've gotta accentuate the positive Eliminate the negative Latch on to the affirmative Don't mess with Mister In-Between) You've got to spread joy (up to the maximum) Bring gloom (down) down to the minimum Otherwise (otherwise) pandemonium Liable to walk upon the scene To illustrate (well illustrate) my last remark (you got the floor) Jonah in the whale, Noah in the ark What did they say (what did they say) Say when everything looked so dark Man, they said we better Accentuate the positive Eliminate the negative Latch on to the affirmative Don't mess with Mister In-Between