Plakophilin-1 is a protein that in humans is encoded by the PKP1gene.
Function
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome.
Plakophilin-3 is a protein that in humans is encoded by the PKP3gene.
Function
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.
Two splice variants of the PKP2gene have been identified. The first has a molecular weight of 97.4 kDa (881 amino acids) and the second of molecular weight of 92.7 kDa (837 amino acids). A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.
Plakophilin-2 is a member of the armadillo repeat and plakophilin protein family. Plakophilin proteins contain nine central, conserved armadillo repeat domains flanked by N-terminal and C-terminal domains. Alternately spliced transcripts encoding protein isoforms have been identified.
Plakophilin 2 localizes to cell desmosomes and nuclei and binds plakoglobin, desmoplakin, and the desmosomal cadherins via N-terminal head domain.
A stratigraphic unit is a volume of rock of identifiable origin and relative age range that is defined by the distinctive and dominant, easily mapped and recognizable petrographic, lithologic or paleontologic features (facies) that characterize it.
Units must be mappable and distinct from one another, but the contact need not be particularly distinct. For instance, a unit may be defined by terms such as "when the sandstone component exceeds 75%".
Lithostratigraphic units
Sequences of sedimentary and volcanic rocks are subdivided on the basis of their lithology. Going from smaller to larger in scale, the main units recognised are Bed, Member, Formation, Group and Supergroup.
Bed
A bed is a lithologically distinct layer within a member or formation and is the smallest recognisable stratigraphic unit. These are not normally named, but may be in the case of a marker horizon.
Member
A member is a named lithologically distinct part of a formation. Not all formations are subdivided in this way and even where they are recognized, they may only form part of the formation.
The 1994 Group was a coalition of smaller research-intensive universities in the United Kingdom, founded in 1994 to defend these universities' interests following the creation of the Russell Group by larger research-intensive universities earlier that year.
The 1994 Group originally represented seventeen universities, rising to nineteen, and then dropping to eleven. The Group started to falter in 2012, when a number of high performing members left to join the Russell Group. The 1994 Group ultimately dissolved in November 2013.
Role
The group sought "to represent the views of its members on the current state and the future of higher education through discussions with the government, funding bodies, and other higher education interest groups" and "[made] its views known through its research publications and in the media".
