- published: 26 Apr 2020
- views: 75260
NMDA receptor antagonist
NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-Methyl-D-aspartate receptor (NMDAR). They are used as anesthetics for animals and for humans; the state of anesthesia they induce is referred to as dissociative anesthesia. There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in adult primates like humans. Recent research conducted on primates suggests that, while very consistent and long-term ketamine use may be neurotoxic, acute use is not.
Several synthetic opioids function additionally as NMDAR-antagonists, such as pethidine, methadone, dextropropoxyphene, tramadol and ketobemidone.
Some NMDA receptor antagonists, such as ketamine, dextromethorphan (DXM), phencyclidine (PCP), methoxetamine (MXE), and nitrous oxide (N2O), are popular recreational drugs used for their dissociative, hallucinogenic, and euphoriant properties. When used recreationally, they are classified as dissociative drugs.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/NMDA_receptor_antagonist
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens agonist-mediated responses rather than provoking a biological response itself upon binding to a receptor. They are sometimes called blockers; examples include alpha blockers, beta blockers, and calcium channel blockers. In pharmacology, antagonists have affinity but no efficacy for their cognate receptors, and binding will disrupt the interaction and inhibit the function of an agonist or inverse agonist at receptors. Antagonists mediate their effects by binding to the active (orthosteric = right place) site or to allosteric (= other place) sites on receptors, or they may interact at unique binding sites not normally involved in the biological regulation of the receptor's activity. Antagonist activity may be reversible or irreversible depending on the longevity of the antagonist–receptor complex, which, in turn, depends on the nature of antagonist–receptor binding. The majority of drug antagonists achieve their potency by competing with endogenous ligands or substrates at structurally defined binding sites on receptors.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Receptor_antagonist
Adrenergic agonist
An adrenergic agonist is a drug that stimulates a response from the adrenergic receptors. The five main categories of adrenergic receptors are: α1, α2, β1, β2, and β3, although there are more subtypes, and agonists vary in specificity between these receptors, and may be classified respectively. However, there are also other mechanisms of adrenergic agonism. Epinephrine and norepinephrine are endogenous and broad-spectrum. More selective agonists are more useful in pharmacology.
An adrenergic agent is a drug, or other substance, which has effects similar to, or the same as, epinephrine (adrenaline). Thus, it is a kind of sympathomimetic agent. Alternatively, it may refer to something which is susceptible to epinephrine, or similar substances, such as a biological receptor (specifically, the adrenergic receptors).
Receptors
Directly acting adrenergic agonists act on adrenergic receptors. All adrenergic receptors are G-protein coupled, activating signal transduction pathways. The G-protein receptor can affect the function of adenylate cyclase or phospholipase C, an agonist of the receptor will upregulate the effects on the downstream pathway (it will not necessarily upregulate the pathway itself).
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Adrenergic_agonist
NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.
The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is named this because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations with a reversal potential near 0 mV. A property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg2+ & Zn2+ ions. This allows the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell to be voltage-dependent.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/NMDA_receptor
Podcasts:
-
2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation
Drugs can interact with receptors in a number of different ways, which are typically categorized as various types of agonism, antagonism, or allosteric modulation. In this video, I describe these drug-receptor interactions. TRANSCRIPT: Agonism occurs when a drug binds to a receptor and causes a biological response. Agonist drugs typically bind to the same place on the receptor as the substance that naturally activates the receptor, or the endogenous agonist. Agonists that can generate a maximal response at a receptor are called full agonists. Partial agonists are only able to generate a fraction of the possible response at a receptor. In some cases, an agonist may bind to a receptor and cause a decrease in signaling at that receptor. These substances are called inverse agonists, and they...
published: 26 Apr 2020 -
Agonist, Partial Agonist, Antagonist and Inverse Agonist for Receptors
📝 Find notes here: https://www.nonstopneuron.com/post/agonist-partial-agonist-antagonist-and-inverse-agonist-difference-explained Explore our entire animation video library at: https://www.nonstopneuron.com/ Video Summary: When you open a tap to its maximum you are agonist. When you open it partially, you are a partial agonist. If some bug is there on the tap preventing you from doing anything with the tap, that bug is the antagonist. And when you close a leaky tap, you are an inverse agonist. 📽 More Videos on Pharmacokinetics: • Rate of drug elimination in first-order vs zero-order kinetic: https://youtu.be/Brpy8zybCAI • First Order Elimination Kinetic: https://youtu.be/Y5gcU0RGkFY • Zero Order Elimination Kinetic: https://youtu.be/DYq1hxtkhJY • Mixed Order Kinetic: https://youtu.be/RV7...
published: 19 Apr 2021 -
Agonist vs. Antagonist
Examples and analogies are used to describe the difference between agonists and antagonist drugs.
published: 07 Jun 2023 -
Receptor antagonist #receptor #antagonist #pharmacology
An antagonist can be competitive or noncompetitive. If there is competition between agonist and antagonist for the same receptor site then it is called competitive antagonism. If there is no competition between agonist and antagonist for the same receptor site and they act on two different sites of the receptor then it is called noncompetitive antagonism. Competitive antagonism can be reversible or irreversible. In competitive reversible antagonism, the action of an agonist can be reversed by increasing the concentration of antagonist and vice-versa. For details, you can refer my book: Cellular and Molecular Pharmacology. P K Sahu and P Tiwari. 1st Edition, 2021. ISBN: 978-93-5451-186-8. Nirali Prakashan. #pharmacy, #pharmacology, #clinicalpharmacology , #cellularandmolecularpharmacology...
published: 26 Nov 2018 -
CINV: The Role of NK1 Receptor Antagonists
Lee S. Schwartzberg, MD; Eric Roeland, MD; James Natale, PharmD, BCOP; and Charles L. Loprinzi, MD, describe NK1 receptor antagonists and how these drugs aid in subsiding the effects of chemotherapy-induced nausea and vomiting.
published: 17 Aug 2016 -
Angiotensin Receptor Blockers (ARBs) - Hypertension Treatment - Cardiac Pharmacology
Angiotensin Receptor Blockers (ARBs) - Losartan, Valsartan , “sartans” Hypertension Treatment - ACE inhibitors - Cardiac Pharmacology 😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/ - With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep... Disclaimer: I use affiliate links.... ►👨🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. If you like my videos, please consider leaving a tip at ht...
published: 19 Apr 2019 -
Histamine H1 Receptor Antagonist Drugs | Semester-5 | Lecture-3 | Fit Pharma
Free Lecture Notes Link- https://drive.google.com/file/d/1ah0_-mzYQ_1nfcs0zaXFKjB7mtVy33CA/view?usp=sharing Hello friends, This video is all about Histamine H1 Receptor Antagonist Drugs. The subject is Medicinal Chemistry-II. I hope you will like and understand this topic. If you love my work, please like, share, and subscribe to my channel. Thanks for Watching. Thank you. #education #fitpharma #bpharma #bpharmacy As always, we appreciate your support! If you find this video helpful, please give it a thumbs up, share it with your peers, and subscribe for more insightful content. Keep in mind that this tutorial is for educational purposes only, and it's essential to refer to your course materials and consult with your professors for accurate information. Thank you for watching! 🎓✨...
published: 18 Nov 2024 -
Orexin receptor antagonists for the treatment of insomnia
Orexin receptor antagonists (ORAs) are a new class of drugs in development for the treatment of insomnia, the first of which -suvorexant- was approved by the FDA in 2014, followed by lemborexant in 2019. Liborio Parrino, PhD, Università degli Studi di Parma, Parma, Italy, discusses the promise of ORAs as an exciting new treatment approach for patients with insomnia. Continued investigation into the orexin (also known as hypocretin) system and further drug development will not only bring clinical advantages but further our knowledge on the pathophysiology of sleep disorders. This interview took place at the European College of Neuropsychopharmacology congress 2021.
published: 08 Oct 2021 -
Pharmacology - ALPHA & BETA BLOCKERS - ADRENERGIC ANTAGONISTS ( MADE EASY)
👉📖 READY TO ACE YOUR EXAM? 📚 GET STUDY NOTES ON PATREON! https://www.patreon.com/speedpharmacology Adrenergic antagonists are a group of drugs that inhibit the function of adrenergic receptors. Alpha and beta receptor blockers allow blood to flow more easily thereby lowering blood pressure and the heart rate, which makes these drugs useful in treatment of cardiovascular diseases (e.g. hypertension, congestive heart failure, arrhythmias, and angina). This pharmacology lecture covers topics such as location and function of alpha and beta adrenergic receptors, mechanism of action of adrenergic antagonists: alpha selective blockers, alpha non-selective blockers, beta selective blockers, beta non-selective blockers, first, second and third generation beta blockers. Adrenergic antagonists ment...
published: 17 Oct 2016 -
Treating Insomnia in the Elderly: Orexin Receptor Antagonist
The use of lemborexant, a dual antagonist of the orexin receptors, is considered as a novel approach to managing elderly patients with insomnia disorder.
published: 01 Oct 2019
developed with YouTube
2:00
2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation
- Order: Reorder
- Duration: 2:00
- Uploaded Date: 26 Apr 2020
- views: 75260
Drugs can interact with receptors in a number of different ways, which are typically categorized as various types of agonism, antagonism, or allosteric modulati...
Drugs can interact with receptors in a number of different ways, which are typically categorized as various types of agonism, antagonism, or allosteric modulation. In this video, I describe these drug-receptor interactions.
TRANSCRIPT:
Agonism occurs when a drug binds to a receptor and causes a biological response. Agonist drugs typically bind to the same place on the receptor as the substance that naturally activates the receptor, or the endogenous agonist. Agonists that can generate a maximal response at a receptor are called full agonists. Partial agonists are only able to generate a fraction of the possible response at a receptor. In some cases, an agonist may bind to a receptor and cause a decrease in signaling at that receptor. These substances are called inverse agonists, and they can produce effects that are opposite to those of an agonist.
Receptor antagonism occurs when a drug binds to a receptor but does not activate the receptor; in the process, it interferes with the ability of agonists to activate the receptor. The most common type of antagonism is reversible competitive antagonism, where a drug competes with an agonist for its binding site, in the process limiting the amount of agonist that can bind to the receptor at the same time. Reversible competitive antagonists frequently unbind and rebind to receptors. An agonist can replace the antagonist while it is unbound, allowing the antagonist’s effects to be overcome with the addition of more agonist. Irreversible competitive antagonists, sometimes called non-competitive antagonists, also bind to the site where an agonist binds but unbind from the receptor very slowly, if at all. They can reduce the maximal effect an agonist has, regardless of how much agonist is present.
Some drugs may bind to a receptor at a different site from where an agonist binds and influence the function of the receptor. These drugs, often called allosteric modulators, may increase or decrease the likelihood of an agonist binding to a receptor, enhance or reduce the effects an agonist has when it does bind, or activate the receptor on their own.
References:
Neubig RR, Spedding M, Kenakin T, Christopoulos A; International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol Rev. 2003 Dec;55(4):597-606.
Ritter JM, Flower R, Henderson G, Loke YK, MacEwan D, Rang HP. Rang & Dale's Pharmacology. 9th ed. New York, NY: Elsevier; 2020.
https://wn.com/2_Minute_Neuroscience_Agonism,_Antagonism,_Allosteric_Modulation
Drugs can interact with receptors in a number of different ways, which are typically categorized as various types of agonism, antagonism, or allosteric modulation. In this video, I describe these drug-receptor interactions.
TRANSCRIPT:
Agonism occurs when a drug binds to a receptor and causes a biological response. Agonist drugs typically bind to the same place on the receptor as the substance that naturally activates the receptor, or the endogenous agonist. Agonists that can generate a maximal response at a receptor are called full agonists. Partial agonists are only able to generate a fraction of the possible response at a receptor. In some cases, an agonist may bind to a receptor and cause a decrease in signaling at that receptor. These substances are called inverse agonists, and they can produce effects that are opposite to those of an agonist.
Receptor antagonism occurs when a drug binds to a receptor but does not activate the receptor; in the process, it interferes with the ability of agonists to activate the receptor. The most common type of antagonism is reversible competitive antagonism, where a drug competes with an agonist for its binding site, in the process limiting the amount of agonist that can bind to the receptor at the same time. Reversible competitive antagonists frequently unbind and rebind to receptors. An agonist can replace the antagonist while it is unbound, allowing the antagonist’s effects to be overcome with the addition of more agonist. Irreversible competitive antagonists, sometimes called non-competitive antagonists, also bind to the site where an agonist binds but unbind from the receptor very slowly, if at all. They can reduce the maximal effect an agonist has, regardless of how much agonist is present.
Some drugs may bind to a receptor at a different site from where an agonist binds and influence the function of the receptor. These drugs, often called allosteric modulators, may increase or decrease the likelihood of an agonist binding to a receptor, enhance or reduce the effects an agonist has when it does bind, or activate the receptor on their own.
References:
Neubig RR, Spedding M, Kenakin T, Christopoulos A; International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol Rev. 2003 Dec;55(4):597-606.
Ritter JM, Flower R, Henderson G, Loke YK, MacEwan D, Rang HP. Rang & Dale's Pharmacology. 9th ed. New York, NY: Elsevier; 2020.
5:39
Agonist, Partial Agonist, Antagonist and Inverse Agonist for Receptors
- Order: Reorder
- Duration: 5:39
- Uploaded Date: 19 Apr 2021
- views: 217209
📝 Find notes here: https://www.nonstopneuron.com/post/agonist-partial-agonist-antagonist-and-inverse-agonist-difference-explained
Explore our entire animation v...
📝 Find notes here: https://www.nonstopneuron.com/post/agonist-partial-agonist-antagonist-and-inverse-agonist-difference-explained
Explore our entire animation video library at: https://www.nonstopneuron.com/
Video Summary:
When you open a tap to its maximum you are agonist. When you open it partially, you are a partial agonist. If some bug is there on the tap preventing you from doing anything with the tap, that bug is the antagonist. And when you close a leaky tap, you are an inverse agonist.
📽 More Videos on Pharmacokinetics:
• Rate of drug elimination in first-order vs zero-order kinetic: https://youtu.be/Brpy8zybCAI
• First Order Elimination Kinetic: https://youtu.be/Y5gcU0RGkFY
• Zero Order Elimination Kinetic: https://youtu.be/DYq1hxtkhJY
• Mixed Order Kinetic: https://youtu.be/RV70vzuggDU
• Plasma Half-Life: https://youtu.be/HAaj6Lb46o4
• Terminal Half-Life: https://youtu.be/5sTFHqZN1iE
• Clearance definition explained: https://youtu.be/yvTXcx-QJ-U
• Apparent Volume of Distribution: https://youtu.be/T6kJTqT4VM8
• Redistribution: https://youtu.be/6tgVXBAoaxk
● Follow me at:
• Instagram: https://www.instagram.com/NonstopNeuron/
• Facebook: https://www.facebook.com/NonstopNeuron
Chapters
00:00 Intro
00:20 Analogy of Tap
01:21 Receptor
01:35 Agonist
01:41 Partial Agonist
01:52 Antagonist
02:03 Examples
02:35 Inverse Agonist
03:34 Example of Inverse Agonist
04:47 Summary
Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.
https://wn.com/Agonist,_Partial_Agonist,_Antagonist_And_Inverse_Agonist_For_Receptors
📝 Find notes here: https://www.nonstopneuron.com/post/agonist-partial-agonist-antagonist-and-inverse-agonist-difference-explained
Explore our entire animation video library at: https://www.nonstopneuron.com/
Video Summary:
When you open a tap to its maximum you are agonist. When you open it partially, you are a partial agonist. If some bug is there on the tap preventing you from doing anything with the tap, that bug is the antagonist. And when you close a leaky tap, you are an inverse agonist.
📽 More Videos on Pharmacokinetics:
• Rate of drug elimination in first-order vs zero-order kinetic: https://youtu.be/Brpy8zybCAI
• First Order Elimination Kinetic: https://youtu.be/Y5gcU0RGkFY
• Zero Order Elimination Kinetic: https://youtu.be/DYq1hxtkhJY
• Mixed Order Kinetic: https://youtu.be/RV70vzuggDU
• Plasma Half-Life: https://youtu.be/HAaj6Lb46o4
• Terminal Half-Life: https://youtu.be/5sTFHqZN1iE
• Clearance definition explained: https://youtu.be/yvTXcx-QJ-U
• Apparent Volume of Distribution: https://youtu.be/T6kJTqT4VM8
• Redistribution: https://youtu.be/6tgVXBAoaxk
● Follow me at:
• Instagram: https://www.instagram.com/NonstopNeuron/
• Facebook: https://www.facebook.com/NonstopNeuron
Chapters
00:00 Intro
00:20 Analogy of Tap
01:21 Receptor
01:35 Agonist
01:41 Partial Agonist
01:52 Antagonist
02:03 Examples
02:35 Inverse Agonist
03:34 Example of Inverse Agonist
04:47 Summary
Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.
- published: 19 Apr 2021
- views: 217209
3:36
Agonist vs. Antagonist
- Order: Reorder
- Duration: 3:36
- Uploaded Date: 07 Jun 2023
- views: 54623
Examples and analogies are used to describe the difference between agonists and antagonist drugs.
Examples and analogies are used to describe the difference between agonists and antagonist drugs.
https://wn.com/Agonist_Vs._Antagonist
Examples and analogies are used to describe the difference between agonists and antagonist drugs.
- published: 07 Jun 2023
- views: 54623
6:09
Receptor antagonist #receptor #antagonist #pharmacology
- Order: Reorder
- Duration: 6:09
- Uploaded Date: 26 Nov 2018
- views: 3955
An antagonist can be competitive or noncompetitive. If there is competition between agonist and antagonist for the same receptor site then it is called competit...
An antagonist can be competitive or noncompetitive. If there is competition between agonist and antagonist for the same receptor site then it is called competitive antagonism. If there is no competition between agonist and antagonist for the same receptor site and they act on two different sites of the receptor then it is called noncompetitive antagonism. Competitive antagonism can be reversible or irreversible. In competitive reversible antagonism, the action of an agonist can be reversed by increasing the concentration of antagonist and vice-versa.
For details, you can refer my book:
Cellular and Molecular Pharmacology. P K Sahu and P Tiwari. 1st Edition, 2021. ISBN: 978-93-5451-186-8. Nirali Prakashan.
#pharmacy, #pharmacology, #clinicalpharmacology , #cellularandmolecularpharmacology, #pharmacotherapeutics, #biochemistry, #pharmacokinetics, #pharmacodynamics, #pathophysiology.
https://wn.com/Receptor_Antagonist_Receptor_Antagonist_Pharmacology
An antagonist can be competitive or noncompetitive. If there is competition between agonist and antagonist for the same receptor site then it is called competitive antagonism. If there is no competition between agonist and antagonist for the same receptor site and they act on two different sites of the receptor then it is called noncompetitive antagonism. Competitive antagonism can be reversible or irreversible. In competitive reversible antagonism, the action of an agonist can be reversed by increasing the concentration of antagonist and vice-versa.
For details, you can refer my book:
Cellular and Molecular Pharmacology. P K Sahu and P Tiwari. 1st Edition, 2021. ISBN: 978-93-5451-186-8. Nirali Prakashan.
#pharmacy, #pharmacology, #clinicalpharmacology , #cellularandmolecularpharmacology, #pharmacotherapeutics, #biochemistry, #pharmacokinetics, #pharmacodynamics, #pathophysiology.
- published: 26 Nov 2018
- views: 3955
4:55
CINV: The Role of NK1 Receptor Antagonists
- Order: Reorder
- Duration: 4:55
- Uploaded Date: 17 Aug 2016
- views: 989
Lee S. Schwartzberg, MD; Eric Roeland, MD; James Natale, PharmD, BCOP; and Charles L. Loprinzi, MD, describe NK1 receptor antagonists and how these drugs aid in...
Lee S. Schwartzberg, MD; Eric Roeland, MD; James Natale, PharmD, BCOP; and Charles L. Loprinzi, MD, describe NK1 receptor antagonists and how these drugs aid in subsiding the effects of chemotherapy-induced nausea and vomiting.
https://wn.com/Cinv_The_Role_Of_Nk1_Receptor_Antagonists
Lee S. Schwartzberg, MD; Eric Roeland, MD; James Natale, PharmD, BCOP; and Charles L. Loprinzi, MD, describe NK1 receptor antagonists and how these drugs aid in subsiding the effects of chemotherapy-induced nausea and vomiting.
- published: 17 Aug 2016
- views: 989
5:26
Angiotensin Receptor Blockers (ARBs) - Hypertension Treatment - Cardiac Pharmacology
- Order: Reorder
- Duration: 5:26
- Uploaded Date: 19 Apr 2019
- views: 81131
Angiotensin Receptor Blockers (ARBs) - Losartan, Valsartan , “sartans” Hypertension Treatment - ACE inhibitors - Cardiac Pharmacology
😍🖼Animated Mnemonics (Pi...
Angiotensin Receptor Blockers (ARBs) - Losartan, Valsartan , “sartans” Hypertension Treatment - ACE inhibitors - Cardiac Pharmacology
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Disclaimer: I use affiliate links....
►👨🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/
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https://wn.com/Angiotensin_Receptor_Blockers_(Arbs)_Hypertension_Treatment_Cardiac_Pharmacology
Angiotensin Receptor Blockers (ARBs) - Losartan, Valsartan , “sartans” Hypertension Treatment - ACE inhibitors - Cardiac Pharmacology
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Disclaimer: I use affiliate links....
►👨🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/
► Visit my website: https://www.medicosisperfectionalis.com/ My Favorite Productivity App: https://airtable.com/invite/r/2zH40fus/ 📱Save on your mobile phone bill: http://fbuy.me/q6bMj 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
- published: 19 Apr 2019
- views: 81131
18:38
Histamine H1 Receptor Antagonist Drugs | Semester-5 | Lecture-3 | Fit Pharma
- Order: Reorder
- Duration: 18:38
- Uploaded Date: 18 Nov 2024
- views: 43
Free Lecture Notes Link-
https://drive.google.com/file/d/1ah0_-mzYQ_1nfcs0zaXFKjB7mtVy33CA/view?usp=sharing
Hello friends,
This video is all about Histamine H...
Free Lecture Notes Link-
https://drive.google.com/file/d/1ah0_-mzYQ_1nfcs0zaXFKjB7mtVy33CA/view?usp=sharing
Hello friends,
This video is all about Histamine H1 Receptor Antagonist Drugs. The subject is Medicinal Chemistry-II. I hope you will like and understand this topic.
If you love my work, please like, share, and subscribe to my channel.
Thanks for Watching.
Thank you.
#education #fitpharma #bpharma #bpharmacy
As always, we appreciate your support! If you find this video helpful, please give it a thumbs up, share it with your peers, and subscribe for more insightful content. Keep in mind that this tutorial is for educational purposes only, and it's essential to refer to your course materials and consult with your professors for accurate information. Thank you for watching! 🎓✨
Fit Pharma YouTube channel offers comprehensive and informative lectures on various topics related to pharmacy studies. The channel's content is designed to provide in-depth knowledge and understanding of the subject matter for pharmacy students.
Whether you're studying for exams, preparing for a career in pharmacy, or simply interested in expanding your knowledge in the field, this channel is an excellent resource for learning about the world of pharmacy.
#phenol #fitpharma #pharmacystudents #pharmacy
You can reach me here
[email protected]
Facebook-www.facebook.com/fitpharma802/
Instagram- www.instagram.com/fitpharma802/
https://wn.com/Histamine_H1_Receptor_Antagonist_Drugs_|_Semester_5_|_Lecture_3_|_Fit_Pharma
Free Lecture Notes Link-
https://drive.google.com/file/d/1ah0_-mzYQ_1nfcs0zaXFKjB7mtVy33CA/view?usp=sharing
Hello friends,
This video is all about Histamine H1 Receptor Antagonist Drugs. The subject is Medicinal Chemistry-II. I hope you will like and understand this topic.
If you love my work, please like, share, and subscribe to my channel.
Thanks for Watching.
Thank you.
#education #fitpharma #bpharma #bpharmacy
As always, we appreciate your support! If you find this video helpful, please give it a thumbs up, share it with your peers, and subscribe for more insightful content. Keep in mind that this tutorial is for educational purposes only, and it's essential to refer to your course materials and consult with your professors for accurate information. Thank you for watching! 🎓✨
Fit Pharma YouTube channel offers comprehensive and informative lectures on various topics related to pharmacy studies. The channel's content is designed to provide in-depth knowledge and understanding of the subject matter for pharmacy students.
Whether you're studying for exams, preparing for a career in pharmacy, or simply interested in expanding your knowledge in the field, this channel is an excellent resource for learning about the world of pharmacy.
#phenol #fitpharma #pharmacystudents #pharmacy
You can reach me here
[email protected]
Facebook-www.facebook.com/fitpharma802/
Instagram- www.instagram.com/fitpharma802/
- published: 18 Nov 2024
- views: 43
3:30
Orexin receptor antagonists for the treatment of insomnia
- Order: Reorder
- Duration: 3:30
- Uploaded Date: 08 Oct 2021
- views: 2112
Orexin receptor antagonists (ORAs) are a new class of drugs in development for the treatment of insomnia, the first of which -suvorexant- was approved by the FD...
Orexin receptor antagonists (ORAs) are a new class of drugs in development for the treatment of insomnia, the first of which -suvorexant- was approved by the FDA in 2014, followed by lemborexant in 2019. Liborio Parrino, PhD, Università degli Studi di Parma, Parma, Italy, discusses the promise of ORAs as an exciting new treatment approach for patients with insomnia. Continued investigation into the orexin (also known as hypocretin) system and further drug development will not only bring clinical advantages but further our knowledge on the pathophysiology of sleep disorders. This interview took place at the European College of Neuropsychopharmacology congress 2021.
https://wn.com/Orexin_Receptor_Antagonists_For_The_Treatment_Of_Insomnia
Orexin receptor antagonists (ORAs) are a new class of drugs in development for the treatment of insomnia, the first of which -suvorexant- was approved by the FDA in 2014, followed by lemborexant in 2019. Liborio Parrino, PhD, Università degli Studi di Parma, Parma, Italy, discusses the promise of ORAs as an exciting new treatment approach for patients with insomnia. Continued investigation into the orexin (also known as hypocretin) system and further drug development will not only bring clinical advantages but further our knowledge on the pathophysiology of sleep disorders. This interview took place at the European College of Neuropsychopharmacology congress 2021.
- published: 08 Oct 2021
- views: 2112
11:06
Pharmacology - ALPHA & BETA BLOCKERS - ADRENERGIC ANTAGONISTS ( MADE EASY)
- Order: Reorder
- Duration: 11:06
- Uploaded Date: 17 Oct 2016
- views: 1385857
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Adrenergic antagonists are a group of drugs that inhibit the...
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https://www.patreon.com/speedpharmacology
Adrenergic antagonists are a group of drugs that inhibit the function of adrenergic receptors.
Alpha and beta receptor blockers allow blood to flow more easily thereby lowering blood pressure and the heart rate, which makes these drugs useful in treatment of cardiovascular diseases (e.g. hypertension, congestive heart failure, arrhythmias, and angina). This pharmacology lecture covers topics such as location and function of alpha and beta adrenergic receptors, mechanism of action of adrenergic antagonists: alpha selective blockers, alpha non-selective blockers, beta selective blockers, beta non-selective blockers, first, second and third generation beta blockers. Adrenergic antagonists mentioned include: Phentolamine, Phenoxybenzamine, Prazosin, Doxazosin, Terazosin, Tamsulosin, Alfuzosin, Silodosin, Yohimbine, Propranolol, Pindolol, Nadolol, Sotalol, Timolol, Atenolol, Acebutolol, Bisoprolol, Esmolol, Metoprolol, Carvedilol, Labetalol, Nebivolol, Betaxolol.
Thanks for watching and don't forget to SUBSCRIBE, hit the LIKE button👍 and click the BELL button🔔 for future notifications!!!
0:00 Intro
0:37 Alpha blockers
5:14 Beta blockers
https://wn.com/Pharmacology_Alpha_Beta_Blockers_Adrenergic_Antagonists_(_Made_Easy)
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https://www.patreon.com/speedpharmacology
Adrenergic antagonists are a group of drugs that inhibit the function of adrenergic receptors.
Alpha and beta receptor blockers allow blood to flow more easily thereby lowering blood pressure and the heart rate, which makes these drugs useful in treatment of cardiovascular diseases (e.g. hypertension, congestive heart failure, arrhythmias, and angina). This pharmacology lecture covers topics such as location and function of alpha and beta adrenergic receptors, mechanism of action of adrenergic antagonists: alpha selective blockers, alpha non-selective blockers, beta selective blockers, beta non-selective blockers, first, second and third generation beta blockers. Adrenergic antagonists mentioned include: Phentolamine, Phenoxybenzamine, Prazosin, Doxazosin, Terazosin, Tamsulosin, Alfuzosin, Silodosin, Yohimbine, Propranolol, Pindolol, Nadolol, Sotalol, Timolol, Atenolol, Acebutolol, Bisoprolol, Esmolol, Metoprolol, Carvedilol, Labetalol, Nebivolol, Betaxolol.
Thanks for watching and don't forget to SUBSCRIBE, hit the LIKE button👍 and click the BELL button🔔 for future notifications!!!
0:00 Intro
0:37 Alpha blockers
5:14 Beta blockers
- published: 17 Oct 2016
- views: 1385857
4:59
Treating Insomnia in the Elderly: Orexin Receptor Antagonist
- Order: Reorder
- Duration: 4:59
- Uploaded Date: 01 Oct 2019
- views: 3699
The use of lemborexant, a dual antagonist of the orexin receptors, is considered as a novel approach to managing elderly patients with insomnia disorder.
The use of lemborexant, a dual antagonist of the orexin receptors, is considered as a novel approach to managing elderly patients with insomnia disorder.
https://wn.com/Treating_Insomnia_In_The_Elderly_Orexin_Receptor_Antagonist
The use of lemborexant, a dual antagonist of the orexin receptors, is considered as a novel approach to managing elderly patients with insomnia disorder.
- published: 01 Oct 2019
- views: 3699
2:00
2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation
Drugs can interact with receptors in a number of different ways, which are typically categ...
published: 26 Apr 2020
2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation
2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation
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- published: 26 Apr 2020
- views: 75260
Drugs can interact with receptors in a number of different ways, which are typically categorized as various types of agonism, antagonism, or allosteric modulation. In this video, I describe these drug-receptor interactions.
TRANSCRIPT:
Agonism occurs when a drug binds to a receptor and causes a biological response. Agonist drugs typically bind to the same place on the receptor as the substance that naturally activates the receptor, or the endogenous agonist. Agonists that can generate a maximal response at a receptor are called full agonists. Partial agonists are only able to generate a fraction of the possible response at a receptor. In some cases, an agonist may bind to a receptor and cause a decrease in signaling at that receptor. These substances are called inverse agonists, and they can produce effects that are opposite to those of an agonist.
Receptor antagonism occurs when a drug binds to a receptor but does not activate the receptor; in the process, it interferes with the ability of agonists to activate the receptor. The most common type of antagonism is reversible competitive antagonism, where a drug competes with an agonist for its binding site, in the process limiting the amount of agonist that can bind to the receptor at the same time. Reversible competitive antagonists frequently unbind and rebind to receptors. An agonist can replace the antagonist while it is unbound, allowing the antagonist’s effects to be overcome with the addition of more agonist. Irreversible competitive antagonists, sometimes called non-competitive antagonists, also bind to the site where an agonist binds but unbind from the receptor very slowly, if at all. They can reduce the maximal effect an agonist has, regardless of how much agonist is present.
Some drugs may bind to a receptor at a different site from where an agonist binds and influence the function of the receptor. These drugs, often called allosteric modulators, may increase or decrease the likelihood of an agonist binding to a receptor, enhance or reduce the effects an agonist has when it does bind, or activate the receptor on their own.
References:
Neubig RR, Spedding M, Kenakin T, Christopoulos A; International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol Rev. 2003 Dec;55(4):597-606.
Ritter JM, Flower R, Henderson G, Loke YK, MacEwan D, Rang HP. Rang & Dale's Pharmacology. 9th ed. New York, NY: Elsevier; 2020.
5:39
Agonist, Partial Agonist, Antagonist and Inverse Agonist for Receptors
📝 Find notes here: https://www.nonstopneuron.com/post/agonist-partial-agonist-antagonist-a...
published: 19 Apr 2021
Agonist, Partial Agonist, Antagonist and Inverse Agonist for Receptors
Agonist, Partial Agonist, Antagonist and Inverse Agonist for Receptors
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- published: 19 Apr 2021
- views: 217209
📝 Find notes here: https://www.nonstopneuron.com/post/agonist-partial-agonist-antagonist-and-inverse-agonist-difference-explained
Explore our entire animation video library at: https://www.nonstopneuron.com/
Video Summary:
When you open a tap to its maximum you are agonist. When you open it partially, you are a partial agonist. If some bug is there on the tap preventing you from doing anything with the tap, that bug is the antagonist. And when you close a leaky tap, you are an inverse agonist.
📽 More Videos on Pharmacokinetics:
• Rate of drug elimination in first-order vs zero-order kinetic: https://youtu.be/Brpy8zybCAI
• First Order Elimination Kinetic: https://youtu.be/Y5gcU0RGkFY
• Zero Order Elimination Kinetic: https://youtu.be/DYq1hxtkhJY
• Mixed Order Kinetic: https://youtu.be/RV70vzuggDU
• Plasma Half-Life: https://youtu.be/HAaj6Lb46o4
• Terminal Half-Life: https://youtu.be/5sTFHqZN1iE
• Clearance definition explained: https://youtu.be/yvTXcx-QJ-U
• Apparent Volume of Distribution: https://youtu.be/T6kJTqT4VM8
• Redistribution: https://youtu.be/6tgVXBAoaxk
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Chapters
00:00 Intro
00:20 Analogy of Tap
01:21 Receptor
01:35 Agonist
01:41 Partial Agonist
01:52 Antagonist
02:03 Examples
02:35 Inverse Agonist
03:34 Example of Inverse Agonist
04:47 Summary
Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.
3:36
Agonist vs. Antagonist
Examples and analogies are used to describe the difference between agonists and antagonist...
published: 07 Jun 2023
Agonist vs. Antagonist
Agonist vs. Antagonist
- Report rights infringement
- published: 07 Jun 2023
- views: 54623
Examples and analogies are used to describe the difference between agonists and antagonist drugs.
6:09
Receptor antagonist #receptor #antagonist #pharmacology
An antagonist can be competitive or noncompetitive. If there is competition between agonis...
published: 26 Nov 2018
Receptor antagonist #receptor #antagonist #pharmacology
Receptor antagonist #receptor #antagonist #pharmacology
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- published: 26 Nov 2018
- views: 3955
An antagonist can be competitive or noncompetitive. If there is competition between agonist and antagonist for the same receptor site then it is called competitive antagonism. If there is no competition between agonist and antagonist for the same receptor site and they act on two different sites of the receptor then it is called noncompetitive antagonism. Competitive antagonism can be reversible or irreversible. In competitive reversible antagonism, the action of an agonist can be reversed by increasing the concentration of antagonist and vice-versa.
For details, you can refer my book:
Cellular and Molecular Pharmacology. P K Sahu and P Tiwari. 1st Edition, 2021. ISBN: 978-93-5451-186-8. Nirali Prakashan.
#pharmacy, #pharmacology, #clinicalpharmacology , #cellularandmolecularpharmacology, #pharmacotherapeutics, #biochemistry, #pharmacokinetics, #pharmacodynamics, #pathophysiology.
4:55
CINV: The Role of NK1 Receptor Antagonists
Lee S. Schwartzberg, MD; Eric Roeland, MD; James Natale, PharmD, BCOP; and Charles L. Lopr...
published: 17 Aug 2016
CINV: The Role of NK1 Receptor Antagonists
CINV: The Role of NK1 Receptor Antagonists
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- published: 17 Aug 2016
- views: 989
Lee S. Schwartzberg, MD; Eric Roeland, MD; James Natale, PharmD, BCOP; and Charles L. Loprinzi, MD, describe NK1 receptor antagonists and how these drugs aid in subsiding the effects of chemotherapy-induced nausea and vomiting.
5:26
Angiotensin Receptor Blockers (ARBs) - Hypertension Treatment - Cardiac Pharmacology
Angiotensin Receptor Blockers (ARBs) - Losartan, Valsartan , “sartans” Hypertension Treatm...
published: 19 Apr 2019
Angiotensin Receptor Blockers (ARBs) - Hypertension Treatment - Cardiac Pharmacology
Angiotensin Receptor Blockers (ARBs) - Hypertension Treatment - Cardiac Pharmacology
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- published: 19 Apr 2019
- views: 81131
Angiotensin Receptor Blockers (ARBs) - Losartan, Valsartan , “sartans” Hypertension Treatment - ACE inhibitors - Cardiac Pharmacology
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18:38
Histamine H1 Receptor Antagonist Drugs | Semester-5 | Lecture-3 | Fit Pharma
Free Lecture Notes Link-
https://drive.google.com/file/d/1ah0_-mzYQ_1nfcs0zaXFKjB7mtVy33CA...
published: 18 Nov 2024
Histamine H1 Receptor Antagonist Drugs | Semester-5 | Lecture-3 | Fit Pharma
Histamine H1 Receptor Antagonist Drugs | Semester-5 | Lecture-3 | Fit Pharma
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- published: 18 Nov 2024
- views: 43
Free Lecture Notes Link-
https://drive.google.com/file/d/1ah0_-mzYQ_1nfcs0zaXFKjB7mtVy33CA/view?usp=sharing
Hello friends,
This video is all about Histamine H1 Receptor Antagonist Drugs. The subject is Medicinal Chemistry-II. I hope you will like and understand this topic.
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3:30
Orexin receptor antagonists for the treatment of insomnia
Orexin receptor antagonists (ORAs) are a new class of drugs in development for the treatme...
published: 08 Oct 2021
Orexin receptor antagonists for the treatment of insomnia
Orexin receptor antagonists for the treatment of insomnia
- Report rights infringement
- published: 08 Oct 2021
- views: 2112
Orexin receptor antagonists (ORAs) are a new class of drugs in development for the treatment of insomnia, the first of which -suvorexant- was approved by the FDA in 2014, followed by lemborexant in 2019. Liborio Parrino, PhD, Università degli Studi di Parma, Parma, Italy, discusses the promise of ORAs as an exciting new treatment approach for patients with insomnia. Continued investigation into the orexin (also known as hypocretin) system and further drug development will not only bring clinical advantages but further our knowledge on the pathophysiology of sleep disorders. This interview took place at the European College of Neuropsychopharmacology congress 2021.
11:06
Pharmacology - ALPHA & BETA BLOCKERS - ADRENERGIC ANTAGONISTS ( MADE EASY)
👉📖 READY TO ACE YOUR EXAM? 📚 GET STUDY NOTES ON PATREON!
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published: 17 Oct 2016
Pharmacology - ALPHA & BETA BLOCKERS - ADRENERGIC ANTAGONISTS ( MADE EASY)
Pharmacology - ALPHA & BETA BLOCKERS - ADRENERGIC ANTAGONISTS ( MADE EASY)
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- published: 17 Oct 2016
- views: 1385857
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https://www.patreon.com/speedpharmacology
Adrenergic antagonists are a group of drugs that inhibit the function of adrenergic receptors.
Alpha and beta receptor blockers allow blood to flow more easily thereby lowering blood pressure and the heart rate, which makes these drugs useful in treatment of cardiovascular diseases (e.g. hypertension, congestive heart failure, arrhythmias, and angina). This pharmacology lecture covers topics such as location and function of alpha and beta adrenergic receptors, mechanism of action of adrenergic antagonists: alpha selective blockers, alpha non-selective blockers, beta selective blockers, beta non-selective blockers, first, second and third generation beta blockers. Adrenergic antagonists mentioned include: Phentolamine, Phenoxybenzamine, Prazosin, Doxazosin, Terazosin, Tamsulosin, Alfuzosin, Silodosin, Yohimbine, Propranolol, Pindolol, Nadolol, Sotalol, Timolol, Atenolol, Acebutolol, Bisoprolol, Esmolol, Metoprolol, Carvedilol, Labetalol, Nebivolol, Betaxolol.
Thanks for watching and don't forget to SUBSCRIBE, hit the LIKE button👍 and click the BELL button🔔 for future notifications!!!
0:00 Intro
0:37 Alpha blockers
5:14 Beta blockers
4:59
Treating Insomnia in the Elderly: Orexin Receptor Antagonist
The use of lemborexant, a dual antagonist of the orexin receptors, is considered as a nove...
published: 01 Oct 2019
Treating Insomnia in the Elderly: Orexin Receptor Antagonist
Treating Insomnia in the Elderly: Orexin Receptor Antagonist
- Report rights infringement
- published: 01 Oct 2019
- views: 3699
The use of lemborexant, a dual antagonist of the orexin receptors, is considered as a novel approach to managing elderly patients with insomnia disorder.
NMDA receptor antagonist
NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-Methyl-D-aspartate receptor (NMDAR). They are used as anesthetics for animals and for humans; the state of anesthesia they induce is referred to as dissociative anesthesia. There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in adult primates like humans. Recent research conducted on primates suggests that, while very consistent and long-term ketamine use may be neurotoxic, acute use is not.
Several synthetic opioids function additionally as NMDAR-antagonists, such as pethidine, methadone, dextropropoxyphene, tramadol and ketobemidone.
Some NMDA receptor antagonists, such as ketamine, dextromethorphan (DXM), phencyclidine (PCP), methoxetamine (MXE), and nitrous oxide (N2O), are popular recreational drugs used for their dissociative, hallucinogenic, and euphoriant properties. When used recreationally, they are classified as dissociative drugs.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/NMDA_receptor_antagonist
2-Minute Neuroscience: Agonism, Antagonism, & Allo...
Agonist, Partial Agonist, Antagonist and Inverse A...
Agonist vs. Antagonist...
Receptor antagonist #receptor #antagonist #pharmac...
CINV: The Role of NK1 Receptor Antagonists...
Angiotensin Receptor Blockers (ARBs) - Hypertensio...
Histamine H1 Receptor Antagonist Drugs | Semester-...
Orexin receptor antagonists for the treatment of i...
Pharmacology - ALPHA & BETA BLOCKERS - ADRENERGIC ...
Treating Insomnia in the Elderly: Orexin Receptor ...
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