The mitochondrial matrix also contains the mitochondria's DNA and ribosomes. The word "matrix" stems from the fact that this space is viscous, compared to the relatively aqueous cytoplasm. The cytosolic compartment has a water content of 3.8μl/mg protein, while the mitochondrial matrix 0.8μl/mg protein. It is not known how mitochondria maintain osmotic balance across the inner mitochondrial membrane, although the membrane contains aquaporins that are believed to be conduits for regulated water transport. Mitochondrial matrix has a pH of about 7.8. Mitochondrial DNA was discovered by Nash and Margit in 1963.
One to many double stranded mainly circular DNA is present in mitochondrial matrix.
Mitochondrial DNA is 1% of total DNA of a cell. It is rich in Guanine and Cytosine content.
Mitochondria of mammals have 55s ribosomes.
Mitochondria structure and function | Cell Physiology medical animation
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash
Introduction
--------------------
Mitochondria are often described as the powerhouses of the cell because of their central role in the synthesis of ATP, a vital source of energy for the body. They are composed of a double membrane, intramembranous space, and matrix. Various mitochondrial types can be differentiated based on the inner membrane structure.
Structure
---------------
The structure and DNA of mitochondria resemble the structure and DNA of prokaryotes. Mitochondria are believed to have been prokaryotes originally that evolved into endosymbionts living inside eukaryotes
Mitochondrial me...
published: 21 Oct 2017
Mitochondria Structure & Function
Official Ninja Nerd Website: https://ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
https://www.ninjanerd.org/lecture/mitochondria-structure-function
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on the Mitochondria Structure & Function. During this lecture we will be continuing our discussion of the cell and the organelles that make up the cell. For this lesson, we will be talking about the mitochondria or the powerhouse of the cell and the functions this important organelle is responsible for. We will also be including a mitochondria animation from our talented friends @nucleusmedicalmedia. This video is a collaboration between @NinjaNerdOfficial + @nucleusmedicalmedia. If you want to see more scientifically accurate a...
published: 03 Mar 2023
Protein Transport into Mitochondria
In this Video we have discussed the Protein transport from Cytosol to Mitochondrial matrix.
The Proteins in Cytosol are transported into matrix in unfolded state.
What does mitochondrial matrix mean?
A spoken definition of mitochondrial matrix.
Intro Sound:
Typewriter - Tamskp
Licensed under CC:BA 3.0
Outro Music:
Groove Groove - Kevin MacLeod (incompetech.com)
Licensed under CC:BA 3.0
Intro/Outro Photo:
The best days are not planned - Marcus Hansson
Licensed under CC-BY-2.0
Book Image:
Open Book template PSD - DougitDesign
Licensed under CC:BA 3.0
Text derived from:
http://en.wiktionary.org/wiki/mitochondrial_matrix
Text to Speech powered by TTS-API.COM
published: 23 Feb 2015
Protein import into mitochondrial matrix
In this video we have discussed about protein import into mitochondrial matrix .
published: 28 Apr 2022
How Mitochondria Produce Energy
Subscribe to the Cortical Studios channel and hit the notification bell for new scientific animations: www.youtube.com/corticalstudios
Let's illuminate your science together. We are specialized in Mode of Action / Mechanism of Action / MoA animations: https://www.corticalstudios.com/mechanism-of-action-moa-animations. Please feel free to contact us with any questions regarding the possibilities for your unique project: [email protected]. We are an award-winning visual science agency that combines 3D animation, multimedia and scientific knowledge to meet your communication needs.Please feel free to contact us with any questions regarding the possibilities for your unique project: [email protected]. We are an award-winning visual science agency that combines 3D animation, mult...
published: 29 Jan 2016
Protein Transport into Mitochondrial Matrix|Targeting|Sorting|post Translational Translocation|Cell
Protein Targeting into Mitochondrial Matrix
I will upload regular video regarding CSIR net and GATE Life science.
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#proteintrageting #proteinsorting #cellbiology #mitochondria #posttranslational #matrix #innermembrane #outermembrane #intermembranespace #signalpeptide #mts #mpp #csirnet #gate #jrf #iitjam #dbt #cuceet #icar #icmr #du #bhu #phdentrance #mscentrance
published: 31 Jan 2021
Free Daily Test 9- 19th July 2024 - Live Discussion - PreMed.PK
PreMed.PK Proudly Presents Free Daily Tests by which You will Get to Cover all Topics from Physics, Chemistry, Biology, English & Logical Reasoning as per PM&DC MDCAT Curriculum (2024), before MDCAT 2024 🥳
Benefits of Free Daily Tests:
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- Detailed Explanation📜 - To clear your Doubts.
Chapter(s) Included in the Test:
1. Bioenergetics
Test Format: 50 MCQs
Total Time: 50 minutes
Test Link:
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After the Test, you can also join Live Discuss...
published: 20 Jul 2024
Mitochondrial Matrix
#CELLBIOLOGY MSc zoology Lecture, Cell and molecular biology lecture no 5
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash
Introduction
--------------------
Mitochondria are often described as the powerhouses of the cell because of their central role in the synthesis of ATP, a vital source of energy for the body. They are composed of a double membrane, intramembranous space, and matrix. Various mitochondrial types can be differentiated based on the inner membrane structure.
Structure
---------------
The structure and DNA of mitochondria resemble the structure and DNA of prokaryotes. Mitochondria are believed to have been prokaryotes originally that evolved into endosymbionts living inside eukaryotes
Mitochondrial membrane
-----------------------------------------
There are two, highly specialized mitochondrial membranes that surround the mitochondrion. They provide the framework for the electron transport chain and ATP production.
Outer membrane
---------------------------
Structure: smooth
Permeability: interspersed with pores, highly permeable for various molecules
Inner membrane
---------------------------
Structure: convoluted
Permeability: impermeable, especially to ions; however the inner membrane contains many different highly specific transport proteins
Characteristic component: cardiolipin (stabilizes the enzymes of oxidative phosphorylation)
Mitochondrial matrix
----------------------------------
Contains mitochondrial DNA (mtDNA) and ribosomes responsible for the synthesis of ∼ 15% of the mitochondrial proteins
The remaining mitochondrial proteins are encoded in the nucleus and are transported into the mitochondria in an unfolded state, where they take on their final folded structure.
Functions
-----------------
Energy production: The inner mitochondrial membrane contains the enzymes of the respiratory chain and the ATP synthase that together produce ATP (oxidative phosphorylation).
Other metabolic pathways in the matrix
Citric acid cycle
Beta-oxidation
Ketogenesis
Urea cycle
Pyruvate decarboxylation
Heme synthesis
Initiation of apoptosis
#mitochondria #bichemvideos #usmlevideos #structureofmitochondria #usmlestep1videos #animatedmedicalvideos #biochemanimatedvideos #drgbhanuprakash #mbbs #neetpg #fmge
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash
Introduction
--------------------
Mitochondria are often described as the powerhouses of the cell because of their central role in the synthesis of ATP, a vital source of energy for the body. They are composed of a double membrane, intramembranous space, and matrix. Various mitochondrial types can be differentiated based on the inner membrane structure.
Structure
---------------
The structure and DNA of mitochondria resemble the structure and DNA of prokaryotes. Mitochondria are believed to have been prokaryotes originally that evolved into endosymbionts living inside eukaryotes
Mitochondrial membrane
-----------------------------------------
There are two, highly specialized mitochondrial membranes that surround the mitochondrion. They provide the framework for the electron transport chain and ATP production.
Outer membrane
---------------------------
Structure: smooth
Permeability: interspersed with pores, highly permeable for various molecules
Inner membrane
---------------------------
Structure: convoluted
Permeability: impermeable, especially to ions; however the inner membrane contains many different highly specific transport proteins
Characteristic component: cardiolipin (stabilizes the enzymes of oxidative phosphorylation)
Mitochondrial matrix
----------------------------------
Contains mitochondrial DNA (mtDNA) and ribosomes responsible for the synthesis of ∼ 15% of the mitochondrial proteins
The remaining mitochondrial proteins are encoded in the nucleus and are transported into the mitochondria in an unfolded state, where they take on their final folded structure.
Functions
-----------------
Energy production: The inner mitochondrial membrane contains the enzymes of the respiratory chain and the ATP synthase that together produce ATP (oxidative phosphorylation).
Other metabolic pathways in the matrix
Citric acid cycle
Beta-oxidation
Ketogenesis
Urea cycle
Pyruvate decarboxylation
Heme synthesis
Initiation of apoptosis
#mitochondria #bichemvideos #usmlevideos #structureofmitochondria #usmlestep1videos #animatedmedicalvideos #biochemanimatedvideos #drgbhanuprakash #mbbs #neetpg #fmge
Official Ninja Nerd Website: https://ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
https://www.ninjanerd.org/lectu...
Official Ninja Nerd Website: https://ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
https://www.ninjanerd.org/lecture/mitochondria-structure-function
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on the Mitochondria Structure & Function. During this lecture we will be continuing our discussion of the cell and the organelles that make up the cell. For this lesson, we will be talking about the mitochondria or the powerhouse of the cell and the functions this important organelle is responsible for. We will also be including a mitochondria animation from our talented friends @nucleusmedicalmedia. This video is a collaboration between @NinjaNerdOfficial + @nucleusmedicalmedia. If you want to see more scientifically accurate animations on anatomy, physiology, diseases, and conditions - Check out @nucleusmedicalmedia for more amazing scientific and medical content! We hope you enjoy this lecture and be sure to support us below! We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Mitochondria Structure & Function Introduction
0:33 Mitochondria Structure
5:52 Nucleus Medical: Overview of the Mitochondria Animation
6:18 Functions of the Mitochondria
11:12 Miscellaneous Transport
13:03 Electron Transport Chain
19:03 Mitochondria Metabolic Functions
33:57 Comment, Like, SUBSCRIBE!
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#ninjanerd #mitochondria #cellbiology
Official Ninja Nerd Website: https://ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
https://www.ninjanerd.org/lecture/mitochondria-structure-function
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on the Mitochondria Structure & Function. During this lecture we will be continuing our discussion of the cell and the organelles that make up the cell. For this lesson, we will be talking about the mitochondria or the powerhouse of the cell and the functions this important organelle is responsible for. We will also be including a mitochondria animation from our talented friends @nucleusmedicalmedia. This video is a collaboration between @NinjaNerdOfficial + @nucleusmedicalmedia. If you want to see more scientifically accurate animations on anatomy, physiology, diseases, and conditions - Check out @nucleusmedicalmedia for more amazing scientific and medical content! We hope you enjoy this lecture and be sure to support us below! We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Mitochondria Structure & Function Introduction
0:33 Mitochondria Structure
5:52 Nucleus Medical: Overview of the Mitochondria Animation
6:18 Functions of the Mitochondria
11:12 Miscellaneous Transport
13:03 Electron Transport Chain
19:03 Mitochondria Metabolic Functions
33:57 Comment, Like, SUBSCRIBE!
Join this channel to get access to perks:
https://www.youtube.com/channel/UC6QYFutt9cluQ3uSM963_KQ/join
APPAREL |
https://shop.ninjanerd.org
https://www.amazon.com/s?k=ninja+nerd&ref=nb_sb_noss_2
PODCAST |
Apple Podcast: https://podcasts.apple.com/us/podcast/ninja-nerd/id1611469997
Spotify: https://open.spotify.com/show/2ZDXoakATwCgkRH3EpCZYu?si=922326f893f4437e
Google Podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xOTQ1NjU1LnJzcw==
DONATE
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@NinjaNerdSci
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#ninjanerd #mitochondria #cellbiology
In this Video we have discussed the Protein transport from Cytosol to Mitochondrial matrix.
The Proteins in Cytosol are transported into matrix in unfolded sta...
In this Video we have discussed the Protein transport from Cytosol to Mitochondrial matrix.
The Proteins in Cytosol are transported into matrix in unfolded state.
In this Video we have discussed the Protein transport from Cytosol to Mitochondrial matrix.
The Proteins in Cytosol are transported into matrix in unfolded state.
What does mitochondrial matrix mean?
A spoken definition of mitochondrial matrix.
Intro Sound:
Typewriter - Tamskp
Licensed under CC:BA 3.0
Outro Music...
What does mitochondrial matrix mean?
A spoken definition of mitochondrial matrix.
Intro Sound:
Typewriter - Tamskp
Licensed under CC:BA 3.0
Outro Music:
Groove Groove - Kevin MacLeod (incompetech.com)
Licensed under CC:BA 3.0
Intro/Outro Photo:
The best days are not planned - Marcus Hansson
Licensed under CC-BY-2.0
Book Image:
Open Book template PSD - DougitDesign
Licensed under CC:BA 3.0
Text derived from:
http://en.wiktionary.org/wiki/mitochondrial_matrix
Text to Speech powered by TTS-API.COM
What does mitochondrial matrix mean?
A spoken definition of mitochondrial matrix.
Intro Sound:
Typewriter - Tamskp
Licensed under CC:BA 3.0
Outro Music:
Groove Groove - Kevin MacLeod (incompetech.com)
Licensed under CC:BA 3.0
Intro/Outro Photo:
The best days are not planned - Marcus Hansson
Licensed under CC-BY-2.0
Book Image:
Open Book template PSD - DougitDesign
Licensed under CC:BA 3.0
Text derived from:
http://en.wiktionary.org/wiki/mitochondrial_matrix
Text to Speech powered by TTS-API.COM
Subscribe to the Cortical Studios channel and hit the notification bell for new scientific animations: www.youtube.com/corticalstudios
Let's illuminate your sc...
Subscribe to the Cortical Studios channel and hit the notification bell for new scientific animations: www.youtube.com/corticalstudios
Let's illuminate your science together. We are specialized in Mode of Action / Mechanism of Action / MoA animations: https://www.corticalstudios.com/mechanism-of-action-moa-animations. Please feel free to contact us with any questions regarding the possibilities for your unique project: [email protected]. We are an award-winning visual science agency that combines 3D animation, multimedia and scientific knowledge to meet your communication needs.Please feel free to contact us with any questions regarding the possibilities for your unique project: [email protected]. We are an award-winning visual science agency that combines 3D animation, multimedia and scientific knowledge to meet your communication needs.
Free scientific illustrations: https://www.corticalstudios.com/stock
Explaining the complex process of oxidative phosphorylation. Excerpt from a Mode of Action MoA animation.
#mechanismofaction #moa #medicalanimation #medicalanimations #science #scientificanimation #modeofaction #mitochondria #visualization
Looking to develop a MoA animation or a MoD animation? Let's illuminate your science together: https://www.corticalstudios.com/contact
Cortical Studios - Animation Illuminates Science
https://corticalstudios.com
https://www.instagram.com/corticalstudios/
@corticalstudios
3D Artists: Pieter van Lier and Freddy Peters
Voice-over Artist: Lisa Sove
Subscribe to the Cortical Studios channel and hit the notification bell for new scientific animations: www.youtube.com/corticalstudios
Let's illuminate your science together. We are specialized in Mode of Action / Mechanism of Action / MoA animations: https://www.corticalstudios.com/mechanism-of-action-moa-animations. Please feel free to contact us with any questions regarding the possibilities for your unique project: [email protected]. We are an award-winning visual science agency that combines 3D animation, multimedia and scientific knowledge to meet your communication needs.Please feel free to contact us with any questions regarding the possibilities for your unique project: [email protected]. We are an award-winning visual science agency that combines 3D animation, multimedia and scientific knowledge to meet your communication needs.
Free scientific illustrations: https://www.corticalstudios.com/stock
Explaining the complex process of oxidative phosphorylation. Excerpt from a Mode of Action MoA animation.
#mechanismofaction #moa #medicalanimation #medicalanimations #science #scientificanimation #modeofaction #mitochondria #visualization
Looking to develop a MoA animation or a MoD animation? Let's illuminate your science together: https://www.corticalstudios.com/contact
Cortical Studios - Animation Illuminates Science
https://corticalstudios.com
https://www.instagram.com/corticalstudios/
@corticalstudios
3D Artists: Pieter van Lier and Freddy Peters
Voice-over Artist: Lisa Sove
Protein Targeting into Mitochondrial Matrix
I will upload regular video regarding CSIR net and GATE Life science.
I have cleared CSIR net with AIR 24 and Gate...
Protein Targeting into Mitochondrial Matrix
I will upload regular video regarding CSIR net and GATE Life science.
I have cleared CSIR net with AIR 24 and Gate Life Science.
If you want me to make an video on specific topic, please comment below.
If you like the video, do share it with your friends.
Bansal Biology Instgram handle
https://www.instagram.com/bansalbiology/?hl=en
Bansal Biology Telegram channel
@bansalbiology
#proteintrageting #proteinsorting #cellbiology #mitochondria #posttranslational #matrix #innermembrane #outermembrane #intermembranespace #signalpeptide #mts #mpp #csirnet #gate #jrf #iitjam #dbt #cuceet #icar #icmr #du #bhu #phdentrance #mscentrance
Protein Targeting into Mitochondrial Matrix
I will upload regular video regarding CSIR net and GATE Life science.
I have cleared CSIR net with AIR 24 and Gate Life Science.
If you want me to make an video on specific topic, please comment below.
If you like the video, do share it with your friends.
Bansal Biology Instgram handle
https://www.instagram.com/bansalbiology/?hl=en
Bansal Biology Telegram channel
@bansalbiology
#proteintrageting #proteinsorting #cellbiology #mitochondria #posttranslational #matrix #innermembrane #outermembrane #intermembranespace #signalpeptide #mts #mpp #csirnet #gate #jrf #iitjam #dbt #cuceet #icar #icmr #du #bhu #phdentrance #mscentrance
PreMed.PK Proudly Presents Free Daily Tests by which You will Get to Cover all Topics from Physics, Chemistry, Biology, English & Logical Reasoning as per PM&DC...
PreMed.PK Proudly Presents Free Daily Tests by which You will Get to Cover all Topics from Physics, Chemistry, Biology, English & Logical Reasoning as per PM&DC MDCAT Curriculum (2024), before MDCAT 2024 🥳
Benefits of Free Daily Tests:
- Detailed Scorecard` 🗂️ - To give you an Account of your Performance & Progress.
- Timed & Practiced Mode🕓 - To help you with Time Management.
- Leaderboard📊 - To create a Competitive Environment among the Students.
- Detailed Explanation📜 - To clear your Doubts.
Chapter(s) Included in the Test:
1. Bioenergetics
Test Format: 50 MCQs
Total Time: 50 minutes
Test Link:
https://premed.pk/attempt/test%20sessions/PreMed.PK%20Daily%20Test%202024/Free%20Daily%20Test%209%20-%20PreMed.PK%20-%2019th%20July,%202024
After the Test, you can also join Live Discussion Session by Miss. Tahreem Gardezi & Miss. Maria Islam on our YouTube Channel so don't forget to follow us there 🌝🌟
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Test Schedule:
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#MDCAT2024 #MDCATPreparation #MDCATGuide #MDCATMotivation #MDCATTips #MedicalAdmissions #MedicalEntranceExam #MedicalCollegePrep #MedicalSchoolAdmissions #PreMedicine #AKUAdmissions #AKUMCAT #AKUEntranceExam #MedicalEducation #StudyAbroadMedicine #MBBSinPakistan #MBBSAbroad #MedicalUrdu #MedicalHindi #MedicalStudents #DoctorLife #MedSchoolJourney #PreMedPk #drhamzaashraf #KingEdwardMedicalUniversity #KEMU #KingEdward #doctorscommunity#AKUEntranceExam #MedicalEducation #StudyAbroadMedicine #MBBSinPakistan #MBBSAbroad #MedicalUrdu #MedicalHindi #MedicalStudents #DoctorLife #MedSchoolJourney #PreMedPk #drhamzaashraf #KingEdwardMedicalUniversity #KEMU #KingEdward #doctorscommunity
PreMed.PK Proudly Presents Free Daily Tests by which You will Get to Cover all Topics from Physics, Chemistry, Biology, English & Logical Reasoning as per PM&DC MDCAT Curriculum (2024), before MDCAT 2024 🥳
Benefits of Free Daily Tests:
- Detailed Scorecard` 🗂️ - To give you an Account of your Performance & Progress.
- Timed & Practiced Mode🕓 - To help you with Time Management.
- Leaderboard📊 - To create a Competitive Environment among the Students.
- Detailed Explanation📜 - To clear your Doubts.
Chapter(s) Included in the Test:
1. Bioenergetics
Test Format: 50 MCQs
Total Time: 50 minutes
Test Link:
https://premed.pk/attempt/test%20sessions/PreMed.PK%20Daily%20Test%202024/Free%20Daily%20Test%209%20-%20PreMed.PK%20-%2019th%20July,%202024
After the Test, you can also join Live Discussion Session by Miss. Tahreem Gardezi & Miss. Maria Islam on our YouTube Channel so don't forget to follow us there 🌝🌟
https://www.youtube.com/@premed
Join the Whatsapp Group Now for further updates: https://chat.whatsapp.com/ENBTBrrzoNrG4rYaahN1hy
Test Schedule:
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#MDCAT2024 #MDCATPreparation #MDCATGuide #MDCATMotivation #MDCATTips #MedicalAdmissions #MedicalEntranceExam #MedicalCollegePrep #MedicalSchoolAdmissions #PreMedicine #AKUAdmissions #AKUMCAT #AKUEntranceExam #MedicalEducation #StudyAbroadMedicine #MBBSinPakistan #MBBSAbroad #MedicalUrdu #MedicalHindi #MedicalStudents #DoctorLife #MedSchoolJourney #PreMedPk #drhamzaashraf #KingEdwardMedicalUniversity #KEMU #KingEdward #doctorscommunity#AKUEntranceExam #MedicalEducation #StudyAbroadMedicine #MBBSinPakistan #MBBSAbroad #MedicalUrdu #MedicalHindi #MedicalStudents #DoctorLife #MedSchoolJourney #PreMedPk #drhamzaashraf #KingEdwardMedicalUniversity #KEMU #KingEdward #doctorscommunity
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
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Introduction
--------------------
Mitochondria are often described as the powerhouses of the cell because of their central role in the synthesis of ATP, a vital source of energy for the body. They are composed of a double membrane, intramembranous space, and matrix. Various mitochondrial types can be differentiated based on the inner membrane structure.
Structure
---------------
The structure and DNA of mitochondria resemble the structure and DNA of prokaryotes. Mitochondria are believed to have been prokaryotes originally that evolved into endosymbionts living inside eukaryotes
Mitochondrial membrane
-----------------------------------------
There are two, highly specialized mitochondrial membranes that surround the mitochondrion. They provide the framework for the electron transport chain and ATP production.
Outer membrane
---------------------------
Structure: smooth
Permeability: interspersed with pores, highly permeable for various molecules
Inner membrane
---------------------------
Structure: convoluted
Permeability: impermeable, especially to ions; however the inner membrane contains many different highly specific transport proteins
Characteristic component: cardiolipin (stabilizes the enzymes of oxidative phosphorylation)
Mitochondrial matrix
----------------------------------
Contains mitochondrial DNA (mtDNA) and ribosomes responsible for the synthesis of ∼ 15% of the mitochondrial proteins
The remaining mitochondrial proteins are encoded in the nucleus and are transported into the mitochondria in an unfolded state, where they take on their final folded structure.
Functions
-----------------
Energy production: The inner mitochondrial membrane contains the enzymes of the respiratory chain and the ATP synthase that together produce ATP (oxidative phosphorylation).
Other metabolic pathways in the matrix
Citric acid cycle
Beta-oxidation
Ketogenesis
Urea cycle
Pyruvate decarboxylation
Heme synthesis
Initiation of apoptosis
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In this lecture Professor Zach Murphy will be presenting on the Mitochondria Structure & Function. During this lecture we will be continuing our discussion of the cell and the organelles that make up the cell. For this lesson, we will be talking about the mitochondria or the powerhouse of the cell and the functions this important organelle is responsible for. We will also be including a mitochondria animation from our talented friends @nucleusmedicalmedia. This video is a collaboration between @NinjaNerdOfficial + @nucleusmedicalmedia. If you want to see more scientifically accurate animations on anatomy, physiology, diseases, and conditions - Check out @nucleusmedicalmedia for more amazing scientific and medical content! We hope you enjoy this lecture and be sure to support us below! We hope you enjoy this lecture and be sure to support us below!
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In this Video we have discussed the Protein transport from Cytosol to Mitochondrial matrix.
The Proteins in Cytosol are transported into matrix in unfolded state.
What does mitochondrial matrix mean?
A spoken definition of mitochondrial matrix.
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Protein Targeting into Mitochondrial Matrix
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The mitochondrial matrix also contains the mitochondria's DNA and ribosomes. The word "matrix" stems from the fact that this space is viscous, compared to the relatively aqueous cytoplasm. The cytosolic compartment has a water content of 3.8μl/mg protein, while the mitochondrial matrix 0.8μl/mg protein. It is not known how mitochondria maintain osmotic balance across the inner mitochondrial membrane, although the membrane contains aquaporins that are believed to be conduits for regulated water transport. Mitochondrial matrix has a pH of about 7.8. Mitochondrial DNA was discovered by Nash and Margit in 1963.
One to many double stranded mainly circular DNA is present in mitochondrial matrix.
Mitochondrial DNA is 1% of total DNA of a cell. It is rich in Guanine and Cytosine content.
Mitochondria of mammals have 55s ribosomes.
By transporting long-chain fatty acids into the mitochondrial matrix for β-oxidation, it enhances energy utilization and aids weight loss, particularly when paired with a low-calorie diet and exercise.
Sponsored Content... Designed with a proprietary blend of natural herbs, JavaBurn can elevate your well-being ... Form. ... No ... By facilitating the entry of fatty acids into the mitochondrial matrix, L-Carnitine ensures a robust energy yield from fat breakdown.
... which must be ingested additionally to make possible the synthesis and renewal of collagen necessary to maintain firm extracellular matrix.” Glycine With NAC Supports Mitochondrial Health.
ALDH2 (Aldehyde Dehydrogenase 2) is a mitochondrial matrix enzyme and key regulator of mitochondrial quality control systems/health and regulator of reactive aldehydes/carbonyls, oxidative stress, inflammation, and fibrosis.
ALDH2 is a mitochondrial-matrix NAD-dependent enzyme expressed ubiquitously, particularly in organs and cells that require high mitochondrial oxidative phosphorylation under steady-state and/or specific activation states.
ALDH2 (Aldehyde Dehydrogenase 2) is a mitochondrial matrix enzyme and key regulator of mitochondrial quality control systems/health and regulator of reactive aldehydes/carbonyls, oxidative stress, inflammation, and fibrosis.
ALDH2 (Aldehyde Dehydrogenase 2) is a mitochondrial matrix enzyme and key regulator of mitochondrial quality control systems/health and regulator of reactive aldehydes/carbonyls, oxidative stress, inflammation, and fibrosis.
The vast majority of mitochondrial ... It was already known that mitochondrial proteins were imported using the signal sequence translocase of the inner membrane (TIM) into the mitochondrial matrix.
... as a regulator of mitochondrial ultrastructure ... The study provides a framework to understand calcium signaling at the mitochondrial membrane versus the internal space, or matrix, of the mitochondria.
The protein Hsp70 is involved in the import of many of these proteins into the interior of the mitochondria, the mitochondrial matrix, where it catalyzes the folding of the proteins so that they adopt the correct shape and do not clump together.
This structure aided their medicinal chemistry efforts to specifically target this compound to the mitochondrial matrix through the addition of triphenylphosphonium (TPP) to the solvent exposed region of UNC-CA157.
The Restore Your Mitochondrial MatrixSummit brings together more than 50 guest speakers, including doctors, ...Register for the Restore Your Mitochondrial Matrix Summit and reclaim your energy edge!.