Interglacial periods which occurred during the Pleistocene are investigated to better understand present and future climate. Thus, the present interglacial, the Holocene, is compared with MIS 11 or Marine Isotope Stage 5.
Characteristics
MIS 11 represents the longest and warmest interglacial interval of the last 500 kyr. In fact, it shows the highest-amplitude deglacial warming in the last 5 Myr and possibly lasted twice the other interglacial stages. MIS 11 is characterized by overall warm sea-surface temperatures in high latitudes, strong thermohaline circulation, unusual blooms of calcareous plankton in high latitudes, higher sea level than the present, coral reef expansion resulting in enlarged accumulation of neritic carbonates, and overall poor pelagic carbonate preservation and strong dissolution in certain areas. MIS 11 is considered the warmest interglacial period of the last 500,000 years.
Tous son of Nowzar (Persian توس نوذر) is a mythological Iranian prince and hero from the Pishdadian-Dynasty, which deeds and adventures were told in Ferdowsi's Shahnameh.
Tous was a wise and brave man but also proud and pugnacious. And because of these characteristics he did not possess the king's divine glory (Middle Persian: khvarrah; Persian: farr) and was not elected by the other nobles of Iran as heir to his father King Nowzar. Instead, his cousin Zav became the new king of Iran and founder of the famous Kayanian dynasty. Nevertheless, Tous was a loyal vassal to the following kings Kai Kobad and Kai Kavoos and a great warrior defending Iran against her old arch-rival Turan, the land of the Turanians. Among the first and noblest knights of Iran he accompanied the king on several campaigns, and his coat of arms shows the device of a golden elephant as well as he and his kin wore golden shoes.
PRODUCED BY ENRY-K
COMPOSED and INTERPRETED BY ENRY-K & CRUZ CAFUNÉ
MIXING BY KIKO CABALLERO
MASTER BY MARCO ROSTAGNO
ENRY-K & MONTEBELLO AGENCY
published: 28 Sep 2023
Mis12
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Mis12 · elektrabel
Missing.2
℗ 2014 elektrabel
Released on: 2014-06-01
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published: 27 Aug 2019
Gene Music Using Protein Sequence of MIS12 "MIS12 KINETOCHORE COMPLEX COMPONENT"
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Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of MIS12 'MIS12 KINETOCHORE COMPLEX COMPONENT'
published: 13 Dec 2015
Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2
Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2. Haining Zhou et al (2016), Nature Communications http://dx.doi.org/10.1038/ncomms10151
The spindle assembly checkpoint (SAC) arrests cells in mitosis by sensing unattached kinetochores, until all chromosomes are bi-oriented by spindle microtubules. Kinetochore accumulation of the SAC component Mad1–Mad2 is crucial for SAC activation. However, the mechanism by which Mad1–Mad2 accumulation at kinetochores is regulated is not clear. Here we find that Cep57 is localized to kinetochores in human cells, and binds to Mis12, a KMN (KNL1/Mis12 complex/Ndc80 complex) network component. Cep57 also interacts with Mad1, and depletion of Cep57 results in decreased kinetochore localization of Mad1–Mad2, redu...
Shop MIS12 - https://www.redbubble.com/people/genemusic/works/44797557-mis12?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of MIS12 'MIS12 KINETOCHORE COMPLEX COMPONENT'
Shop MIS12 - https://www.redbubble.com/people/genemusic/works/44797557-mis12?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of MIS12 'MIS12 KINETOCHORE COMPLEX COMPONENT'
Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2. Haining Zhou et al (2016), Nature Communications http://dx.doi....
Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2. Haining Zhou et al (2016), Nature Communications http://dx.doi.org/10.1038/ncomms10151
The spindle assembly checkpoint (SAC) arrests cells in mitosis by sensing unattached kinetochores, until all chromosomes are bi-oriented by spindle microtubules. Kinetochore accumulation of the SAC component Mad1–Mad2 is crucial for SAC activation. However, the mechanism by which Mad1–Mad2 accumulation at kinetochores is regulated is not clear. Here we find that Cep57 is localized to kinetochores in human cells, and binds to Mis12, a KMN (KNL1/Mis12 complex/Ndc80 complex) network component. Cep57 also interacts with Mad1, and depletion of Cep57 results in decreased kinetochore localization of Mad1–Mad2, reduced SAC signalling and increased chromosome segregation errors. We also show that the microtubule-binding activity of Cep57 is involved in the timely removal of Mad1 from kinetochores. Thus, these findings reveal that the KMN network-binding protein Cep57 is a mitotic kinetochore component, and demonstrate the functional connection between the KMN network and the SAC.
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Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2. Haining Zhou et al (2016), Nature Communications http://dx.doi.org/10.1038/ncomms10151
The spindle assembly checkpoint (SAC) arrests cells in mitosis by sensing unattached kinetochores, until all chromosomes are bi-oriented by spindle microtubules. Kinetochore accumulation of the SAC component Mad1–Mad2 is crucial for SAC activation. However, the mechanism by which Mad1–Mad2 accumulation at kinetochores is regulated is not clear. Here we find that Cep57 is localized to kinetochores in human cells, and binds to Mis12, a KMN (KNL1/Mis12 complex/Ndc80 complex) network component. Cep57 also interacts with Mad1, and depletion of Cep57 results in decreased kinetochore localization of Mad1–Mad2, reduced SAC signalling and increased chromosome segregation errors. We also show that the microtubule-binding activity of Cep57 is involved in the timely removal of Mad1 from kinetochores. Thus, these findings reveal that the KMN network-binding protein Cep57 is a mitotic kinetochore component, and demonstrate the functional connection between the KMN network and the SAC.
Good channel: https://www.youtube.com/Dlium
Subscribe, like and comment.
Good website: https://www.dlium.com
Bookmark, subscribe and comment.
Shop MIS12 - https://www.redbubble.com/people/genemusic/works/44797557-mis12?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of MIS12 'MIS12 KINETOCHORE COMPLEX COMPONENT'
Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2. Haining Zhou et al (2016), Nature Communications http://dx.doi.org/10.1038/ncomms10151
The spindle assembly checkpoint (SAC) arrests cells in mitosis by sensing unattached kinetochores, until all chromosomes are bi-oriented by spindle microtubules. Kinetochore accumulation of the SAC component Mad1–Mad2 is crucial for SAC activation. However, the mechanism by which Mad1–Mad2 accumulation at kinetochores is regulated is not clear. Here we find that Cep57 is localized to kinetochores in human cells, and binds to Mis12, a KMN (KNL1/Mis12 complex/Ndc80 complex) network component. Cep57 also interacts with Mad1, and depletion of Cep57 results in decreased kinetochore localization of Mad1–Mad2, reduced SAC signalling and increased chromosome segregation errors. We also show that the microtubule-binding activity of Cep57 is involved in the timely removal of Mad1 from kinetochores. Thus, these findings reveal that the KMN network-binding protein Cep57 is a mitotic kinetochore component, and demonstrate the functional connection between the KMN network and the SAC.
Good channel: https://www.youtube.com/Dlium
Subscribe, like and comment.
Good website: https://www.dlium.com
Bookmark, subscribe and comment.