-
Your Brain On MDMA
What does MDMA actually do to your brain?
Watch our Science Taste Challenge: http://youtu.be/SXtg-9Q6Iew
SUBSCRIBE! http://bit.ly/10kWnZ7
--- Links to follow us below ---
Instagram and Twitter: @whalewatchmeplz and @mitchellmoffit
Clickable: http://bit.ly/16F1jeC and http://bit.ly/15J7ube
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Written and created by Mitchell Moffit (twitter @mitchellmoffit) and Gregory Brown (twitter @whalewatchmeplz).
Send us stuff!
ASAPSCIENCE INC.
P.O. Box 93, Toronto P
Toronto, ON, M5S2S6
Further Reading--
No Evidence that MDMA-Induced Enhancement of Emotional Empathy Is Related to Peripheral Oxytocin Levels or 5-HT1a Receptor Activation
http://www.ncbi.nlm.nih.gov/pmc/ar...
published: 16 Oct 2014
-
2-Minute Neuroscience: MDMA
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug with unique prosocial effects. In this video, I discuss the current understanding of how MDMA acts on the brain to produce its effects.
TRANSCRIPT:
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug that is chemically related to amphetamine. Like other stimulants, MDMA causes increased alertness and a positive mood. But MDMA’s effects are also distinct from the effects of other stimulants, as the drug causes unique prosocial effects such as strong feelings of trust, openness, and closeness with others.
Although we don’t have a full understanding of the effects of MDMA on the brain, MDMA’s mechanism is similar in many ways to the mechanism o...
published: 28 Sep 2021
-
The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast
In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the ex...
published: 12 Jun 2023
-
MDMA - Respect Your Brain
See how MDMA affects the brain. MDMA (ecstasy) boosts the feel-good chemicals in your brain but any amount is risky and the more you take, the more often, the more damage you can do.
For more information on the developing brain and alcohol, cannabis and MDMA visit https://yourroom.health.nsw.gov.au/respectyourbrain
published: 07 Jul 2020
-
This is your brain on ecstasy
Go to https://brilliant.org/NeuroTransmissions to get a 30-day free trial + the first 200 people will get 20% off their annual subscription.
Believe it or not, MDMA was legal less than 50 years ago and frequently used in therapy. The DEA changed that. But what if I told you that MDMA is making a comeback...in therapy? We're going to take an eye-opening (pun intended) delve into what ecstacy does to your brain, how molly came to be what it is today, and what possibilities lie ahead as a possible treatment for mental illness.
From its accidental inception in a pharmaceutical lab to the underground scenes of the 1970s, we uncover MDMA's evolution - from therapeutic wonder to recreational sensation to outlawed danger to...therapeutic wonder again? Anyway, I'll help you understand the neurosc...
published: 20 Sep 2023
-
Your Body On Ecstasy (MDMA)
Ecstasy or MDMA is known as the party drug in the club scene, but what chemical reactions is the drug causing your body to undergo? Check out today's epic new video that takes a deeper look at the mind-altering drug to find out what it's really doing to you.
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All videos are based on publicly available information unless otherwise noted.
Our Secret Weapon fo...
published: 28 Feb 2024
-
MDMA Therapy | Drugs, Inc.
MDMA, though illegal, can be extremely helpful in psychotherapy sessions, especially for people suffering from PTSD.
➡ Subscribe: http://bit.ly/NatGeoSubscribe
About National Geographic:
National Geographic is the world's premium destination for science, exploration, and adventure. Through their world-class scientists, photographers, journalists, and filmmakers, Nat Geo gets you closer to the stories that matter and past the edge of what's possible.
Get More National Geographic:
Official Site: http://bit.ly/NatGeoOfficialSite
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Twitter: http://bit.ly/NatGeoTwitter
Instagram: http://bit.ly/NatGeoInsta
MDMA Therapy | Drugs, Inc.
https://youtu.be/Dm9c9XiRl1A
National Geographic
https://www.youtube.com/natgeo
published: 29 Dec 2011
-
L'ecstasy : risques, consommation et conseils - AlloDocteurs
Geneviève Lafaye, psychiatre addictologue répond à vos questions sur les dangers de l'ecstasy.
Ecstasy et MDMA : c'est quoi exactement ? Pourquoi l'appelle-t-on "la drogue de l'amour" ? Existe-il des risques de problèmes psy après une prise ?
Retrouvez plus de vidéos sur votre santé sur https://www.allodocteurs.fr/videos/
👇 Abonnez-vous : https://www.youtube.com/channel/UCv6qHPwghGsyOfzEYZXcfKg
published: 15 Jan 2022
-
MDMA - ken carson ft destroy lonely
ts tuff lowk
published: 29 Sep 2024
-
MDMA: Epic party drug or lethal toxin? (XTC, Ecstasy, Molly) - Doctor Explains
We have all heard of XTC, X, Molly or in medical terms MDMA. All names for the same drug. It is often praised for creating a warm, fussy experience filled with love, enjoyment and distortion of time and perception. This is the pitch, which might have convinced you to try it at some point in your life. Or maybe you have always been curious to do so.
That is where this video comes in. I will be covering the origin of MDMA, it’s effects, long term risks, symptoms of an overdose.
This video is part of a videoseries on the Dangers of Illicit Drugs. Find the playlists here:
https://www.youtube.com/playlist?list=PLaG3Bo3L0gX5LqgWoZVqRxEDa1hYcEYzl
The origin of MDMA:
It was developed by a German pharmaceutical company in 1912. It was intended as a compound which could be used to synthesize ...
published: 15 Feb 2023
2:38
Your Brain On MDMA
What does MDMA actually do to your brain?
Watch our Science Taste Challenge: http://youtu.be/SXtg-9Q6Iew
SUBSCRIBE! http://bit.ly/10kWnZ7
--- Links to follow us...
What does MDMA actually do to your brain?
Watch our Science Taste Challenge: http://youtu.be/SXtg-9Q6Iew
SUBSCRIBE! http://bit.ly/10kWnZ7
--- Links to follow us below ---
Instagram and Twitter: @whalewatchmeplz and @mitchellmoffit
Clickable: http://bit.ly/16F1jeC and http://bit.ly/15J7ube
Facebook: http://on.fb.me/1fjWszw
Twitter: http://bit.ly/1d84R71
Tumblr: http://bit.ly/1amIPjF
Vine: Search "AsapSCIENCE" on vine!
Written and created by Mitchell Moffit (twitter @mitchellmoffit) and Gregory Brown (twitter @whalewatchmeplz).
Send us stuff!
ASAPSCIENCE INC.
P.O. Box 93, Toronto P
Toronto, ON, M5S2S6
Further Reading--
No Evidence that MDMA-Induced Enhancement of Emotional Empathy Is Related to Peripheral Oxytocin Levels or 5-HT1a Receptor Activation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074089/
Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy")
http://www.sciencemag.org/content/297/5590/2260.full?sid=d4561dfb-267d-41d5-a30b-34c67702fa92
New Data Intensify the Agony Over Ecstasy
http://www.sciencemag.org/content/239/4842/864.full.pdf?sid=99185c77-8afb-4637-9d61-8124ddb2593b
What are the effects of the drug Ecstasy?
http://www.scientificamerican.com/article/what-are-the-effects-of-t/
https://wn.com/Your_Brain_On_Mdma
What does MDMA actually do to your brain?
Watch our Science Taste Challenge: http://youtu.be/SXtg-9Q6Iew
SUBSCRIBE! http://bit.ly/10kWnZ7
--- Links to follow us below ---
Instagram and Twitter: @whalewatchmeplz and @mitchellmoffit
Clickable: http://bit.ly/16F1jeC and http://bit.ly/15J7ube
Facebook: http://on.fb.me/1fjWszw
Twitter: http://bit.ly/1d84R71
Tumblr: http://bit.ly/1amIPjF
Vine: Search "AsapSCIENCE" on vine!
Written and created by Mitchell Moffit (twitter @mitchellmoffit) and Gregory Brown (twitter @whalewatchmeplz).
Send us stuff!
ASAPSCIENCE INC.
P.O. Box 93, Toronto P
Toronto, ON, M5S2S6
Further Reading--
No Evidence that MDMA-Induced Enhancement of Emotional Empathy Is Related to Peripheral Oxytocin Levels or 5-HT1a Receptor Activation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074089/
Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy")
http://www.sciencemag.org/content/297/5590/2260.full?sid=d4561dfb-267d-41d5-a30b-34c67702fa92
New Data Intensify the Agony Over Ecstasy
http://www.sciencemag.org/content/239/4842/864.full.pdf?sid=99185c77-8afb-4637-9d61-8124ddb2593b
What are the effects of the drug Ecstasy?
http://www.scientificamerican.com/article/what-are-the-effects-of-t/
- published: 16 Oct 2014
- views: 11376833
2:01
2-Minute Neuroscience: MDMA
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug with unique prosocial effects. In this video, I discuss the ...
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug with unique prosocial effects. In this video, I discuss the current understanding of how MDMA acts on the brain to produce its effects.
TRANSCRIPT:
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug that is chemically related to amphetamine. Like other stimulants, MDMA causes increased alertness and a positive mood. But MDMA’s effects are also distinct from the effects of other stimulants, as the drug causes unique prosocial effects such as strong feelings of trust, openness, and closeness with others.
Although we don’t have a full understanding of the effects of MDMA on the brain, MDMA’s mechanism is similar in many ways to the mechanism of other amphetamines. MDMA inhibits the function of proteins called transporter proteins, which typically remove neurotransmitters like serotonin, dopamine, and norepinephrine from the space between neurons known as the synaptic cleft. By inhibiting transporter proteins, MDMA causes serotonin, dopamine, and norepinephrine to accumulate in the synaptic cleft, increasing neurotransmitter activity there. In contrast to other amphetamines, MDMA inhibits the serotonin transporter more potently than the dopamine or norepinephrine transporter. MDMA also uses transporter proteins to enter neurons; once inside, MDMA disrupts the storage of neurotransmitters in synaptic vesicles, causing the buildup of serotonin, dopamine, and norepinephrine inside neurons; then, MDMA facilitates the release of these neurotransmitters into the synaptic cleft, leading to increased neurotransmitter levels and activity. In addition to these mechanisms, MDMA also binds to a number of receptors directly, including specific subtypes of the serotonin receptor; these interactions may contribute to the effects of MDMA.
It’s not clear what mechanism accounts for the unique prosocial effects of MDMA. A number of studies have found that MDMA promotes the release of the hormone oxytocin, which itself has been linked to prosocial effects. At the same time, most studies have failed to find a link between increasing oxytocin levels and the prosocial effects of MDMA, leaving these effects still unexplained.
REFERENCES:
Dunlap LE, Andrews AM, Olson DE. Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine. ACS Chem Neurosci. 2018 Oct 17;9(10):2408-2427. doi: 10.1021/acschemneuro.8b00155. Epub 2018 Jul 12. PMID: 30001118; PMCID: PMC6197894.
Oeri HE. Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy. J Psychopharmacol. 2021 May;35(5):512-536. doi: 10.1177/0269881120920420. Epub 2020 Sep 10. PMID: 32909493; PMCID: PMC8155739.
Schenk S, Highgate Q. Methylenedioxymethamphetamine (MDMA): Serotonergic and dopaminergic mechanisms related to its use and misuse. J Neurochem. 2021 Jun;157(5):1714-1724. doi: 10.1111/jnc.15348. Epub 2021 Mar 25. PMID: 33711169.
https://wn.com/2_Minute_Neuroscience_Mdma
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug with unique prosocial effects. In this video, I discuss the current understanding of how MDMA acts on the brain to produce its effects.
TRANSCRIPT:
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug that is chemically related to amphetamine. Like other stimulants, MDMA causes increased alertness and a positive mood. But MDMA’s effects are also distinct from the effects of other stimulants, as the drug causes unique prosocial effects such as strong feelings of trust, openness, and closeness with others.
Although we don’t have a full understanding of the effects of MDMA on the brain, MDMA’s mechanism is similar in many ways to the mechanism of other amphetamines. MDMA inhibits the function of proteins called transporter proteins, which typically remove neurotransmitters like serotonin, dopamine, and norepinephrine from the space between neurons known as the synaptic cleft. By inhibiting transporter proteins, MDMA causes serotonin, dopamine, and norepinephrine to accumulate in the synaptic cleft, increasing neurotransmitter activity there. In contrast to other amphetamines, MDMA inhibits the serotonin transporter more potently than the dopamine or norepinephrine transporter. MDMA also uses transporter proteins to enter neurons; once inside, MDMA disrupts the storage of neurotransmitters in synaptic vesicles, causing the buildup of serotonin, dopamine, and norepinephrine inside neurons; then, MDMA facilitates the release of these neurotransmitters into the synaptic cleft, leading to increased neurotransmitter levels and activity. In addition to these mechanisms, MDMA also binds to a number of receptors directly, including specific subtypes of the serotonin receptor; these interactions may contribute to the effects of MDMA.
It’s not clear what mechanism accounts for the unique prosocial effects of MDMA. A number of studies have found that MDMA promotes the release of the hormone oxytocin, which itself has been linked to prosocial effects. At the same time, most studies have failed to find a link between increasing oxytocin levels and the prosocial effects of MDMA, leaving these effects still unexplained.
REFERENCES:
Dunlap LE, Andrews AM, Olson DE. Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine. ACS Chem Neurosci. 2018 Oct 17;9(10):2408-2427. doi: 10.1021/acschemneuro.8b00155. Epub 2018 Jul 12. PMID: 30001118; PMCID: PMC6197894.
Oeri HE. Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy. J Psychopharmacol. 2021 May;35(5):512-536. doi: 10.1177/0269881120920420. Epub 2020 Sep 10. PMID: 32909493; PMCID: PMC8155739.
Schenk S, Highgate Q. Methylenedioxymethamphetamine (MDMA): Serotonergic and dopaminergic mechanisms related to its use and misuse. J Neurochem. 2021 Jun;157(5):1714-1724. doi: 10.1111/jnc.15348. Epub 2021 Mar 25. PMID: 33711169.
- published: 28 Sep 2021
- views: 351762
2:17:35
The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast
In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to ca...
In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry.
#HubermanLab #Science
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Helix Sleep: https://helixsleep.com/huberman
ROKA: https://roka.com/huberman
HVMN: https://hvmn.com/huberman
LMNT: https://drinklmnt.com/huberman
Momentous: https://livemomentous.com/huberman
Social & Website
Instagram - https://www.instagram.com/hubermanlab
Twitter - https://twitter.com/hubermanlab
Facebook - https://www.facebook.com/hubermanlab
TikTok - https://www.tiktok.com/@hubermanlab
Website - https://hubermanlab.com
Newsletter - https://hubermanlab.com/neural-network
Articles
A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus: https://bit.ly/3oV8zSl
Effects of MDMA on sociability and neural response to social threat and social reward: https://bit.ly/3NlOYUC
The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity: https://bit.ly/42yMEhl
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA: https://bit.ly/3NlNERM
Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans: https://bit.ly/42AF6e0
RETRACTED: Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy"): https://bit.ly/3J9PTVU
Science forced to retract article on “ecstasy”: https://bit.ly/3oRRpVM
Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs: https://bit.ly/3P93gcM
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study: https://go.nature.com/3WqI2Zd
The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD: https://bit.ly/42wqeNP
Books
PIHKAL: A Chemical Love Story: https://amzn.to/45ZY80w
Trauma: The Invisible Epidemic: https://amzn.to/45VdgfA
The Body Keeps the Score: https://amzn.to/3XgH5Dz
Other Resources
Multidisciplinary Association for Psychedelic Studies (MAPS): https://maps.org
Participate in a MAPS trial: https://maps.org/take-action/participate-in-trial
Huberman Lab episode on psilocybin: https://bit.ly/43yP80G
Huberman Lab episode on psychedelics for mental health: https://bit.ly/3NqC3Rz
Huberman Lab episode on dopamine, mindset & drive: https://bit.ly/3IqQzVb
Huberman Lab episode on leveraging dopamine: https://bit.ly/3P3dCuD
Timestamps
00:00:00 MDMA “Ecstasy”
00:04:37 Sponsors: Helix Sleep, ROKA, HVMN
00:08:18 MDMA History & Synthesis; Legality
00:14:45 MDMA, Methamphetamine (Meth), Dopamine & Serotonin
00:23:30 MDMA vs Psychedelics vs Ketamine
00:26:54 MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma
00:33:36 Sponsor: AG1
00:34:51 Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages
00:45:48 Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD)
00:52:36 Long-Term Effects, Threat Detection & PTSD
00:56:14 MDMA, Social Connection & Empathy; Meth, SSRIs
01:06:10 Sponsor: LMNT
01:07:22 Oxytocin & MDMA
01:16:10 Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl
01:26:36 Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature
01:37:07 Post-MDMA “Crash”, Prolactin & P 5 P
01:43:07 PTSD & Trauma; Talk Therapy, SSRIs
01:54:09 PTSD Treatment: Talk Therapy + MDMA
02:02:46 MDMA & Addiction; Dissociative PTSD & Empathy
02:09:47 Side-Effects?, MDMA Efficacy & Legality
02:15:22 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com
Disclaimer: https://hubermanlab.com/disclaimer
https://wn.com/The_Science_Of_Mdma_Its_Therapeutic_Uses_Benefits_Risks_|_Huberman_Lab_Podcast
In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry.
#HubermanLab #Science
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Helix Sleep: https://helixsleep.com/huberman
ROKA: https://roka.com/huberman
HVMN: https://hvmn.com/huberman
LMNT: https://drinklmnt.com/huberman
Momentous: https://livemomentous.com/huberman
Social & Website
Instagram - https://www.instagram.com/hubermanlab
Twitter - https://twitter.com/hubermanlab
Facebook - https://www.facebook.com/hubermanlab
TikTok - https://www.tiktok.com/@hubermanlab
Website - https://hubermanlab.com
Newsletter - https://hubermanlab.com/neural-network
Articles
A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus: https://bit.ly/3oV8zSl
Effects of MDMA on sociability and neural response to social threat and social reward: https://bit.ly/3NlOYUC
The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity: https://bit.ly/42yMEhl
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA: https://bit.ly/3NlNERM
Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans: https://bit.ly/42AF6e0
RETRACTED: Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy"): https://bit.ly/3J9PTVU
Science forced to retract article on “ecstasy”: https://bit.ly/3oRRpVM
Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs: https://bit.ly/3P93gcM
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study: https://go.nature.com/3WqI2Zd
The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD: https://bit.ly/42wqeNP
Books
PIHKAL: A Chemical Love Story: https://amzn.to/45ZY80w
Trauma: The Invisible Epidemic: https://amzn.to/45VdgfA
The Body Keeps the Score: https://amzn.to/3XgH5Dz
Other Resources
Multidisciplinary Association for Psychedelic Studies (MAPS): https://maps.org
Participate in a MAPS trial: https://maps.org/take-action/participate-in-trial
Huberman Lab episode on psilocybin: https://bit.ly/43yP80G
Huberman Lab episode on psychedelics for mental health: https://bit.ly/3NqC3Rz
Huberman Lab episode on dopamine, mindset & drive: https://bit.ly/3IqQzVb
Huberman Lab episode on leveraging dopamine: https://bit.ly/3P3dCuD
Timestamps
00:00:00 MDMA “Ecstasy”
00:04:37 Sponsors: Helix Sleep, ROKA, HVMN
00:08:18 MDMA History & Synthesis; Legality
00:14:45 MDMA, Methamphetamine (Meth), Dopamine & Serotonin
00:23:30 MDMA vs Psychedelics vs Ketamine
00:26:54 MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma
00:33:36 Sponsor: AG1
00:34:51 Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages
00:45:48 Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD)
00:52:36 Long-Term Effects, Threat Detection & PTSD
00:56:14 MDMA, Social Connection & Empathy; Meth, SSRIs
01:06:10 Sponsor: LMNT
01:07:22 Oxytocin & MDMA
01:16:10 Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl
01:26:36 Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature
01:37:07 Post-MDMA “Crash”, Prolactin & P 5 P
01:43:07 PTSD & Trauma; Talk Therapy, SSRIs
01:54:09 PTSD Treatment: Talk Therapy + MDMA
02:02:46 MDMA & Addiction; Dissociative PTSD & Empathy
02:09:47 Side-Effects?, MDMA Efficacy & Legality
02:15:22 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com
Disclaimer: https://hubermanlab.com/disclaimer
- published: 12 Jun 2023
- views: 366098
0:50
MDMA - Respect Your Brain
See how MDMA affects the brain. MDMA (ecstasy) boosts the feel-good chemicals in your brain but any amount is risky and the more you take, the more often, the m...
See how MDMA affects the brain. MDMA (ecstasy) boosts the feel-good chemicals in your brain but any amount is risky and the more you take, the more often, the more damage you can do.
For more information on the developing brain and alcohol, cannabis and MDMA visit https://yourroom.health.nsw.gov.au/respectyourbrain
https://wn.com/Mdma_Respect_Your_Brain
See how MDMA affects the brain. MDMA (ecstasy) boosts the feel-good chemicals in your brain but any amount is risky and the more you take, the more often, the more damage you can do.
For more information on the developing brain and alcohol, cannabis and MDMA visit https://yourroom.health.nsw.gov.au/respectyourbrain
- published: 07 Jul 2020
- views: 136353
23:27
This is your brain on ecstasy
Go to https://brilliant.org/NeuroTransmissions to get a 30-day free trial + the first 200 people will get 20% off their annual subscription.
Believe it or not,...
Go to https://brilliant.org/NeuroTransmissions to get a 30-day free trial + the first 200 people will get 20% off their annual subscription.
Believe it or not, MDMA was legal less than 50 years ago and frequently used in therapy. The DEA changed that. But what if I told you that MDMA is making a comeback...in therapy? We're going to take an eye-opening (pun intended) delve into what ecstacy does to your brain, how molly came to be what it is today, and what possibilities lie ahead as a possible treatment for mental illness.
From its accidental inception in a pharmaceutical lab to the underground scenes of the 1970s, we uncover MDMA's evolution - from therapeutic wonder to recreational sensation to outlawed danger to...therapeutic wonder again? Anyway, I'll help you understand the neuroscience--its mechanism and potential risks while contemplating its newfound resurgence in modern medicine, with groundbreaking trials hinting at transformative therapies for PTSD and beyond.
But the real question remains: Could MDMA be the revolutionary treatment we've been waiting for, a potential beacon of hope in the realm of mental health? Or is it just a fun way to spend an evening at a rave or in a cuddle puddle?
Share your thoughts on MDMA and its potential uses! Have you had any personal experiences with MDMA, positive or negative? Do you believe it should be used in a medical or recreational setting? Leave those all in the comments.
0:00 - Does a magic pill exist for me?
2:16 - From accidental discovery to infamy
5:05 - Shulgin and the spread of MDMA
6:09 - From therapy aid to party drug
7:52 - The DEA is no fun
10:04 - What MDMA does to the brain
12:24 - Risks of MDMA
14:51 - The MDMA comeback in therapy
16:48 - MDMA's promising future
19:14 - My own take on MDMA
20:43 - Sign up for Brilliant plz?
22:39 - Tell me your thoughts and experiences
Wanna watch this video without ads and see all of our exclusive content? Head over to https://nebula.tv/videos/neurotransmissions-this-is-your-brain-on-ecstasy
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We couldn’t do all of this without our awesome Patreon Producers, Ryan Shaver, Carrie McKenzie, and Jareth Arnold. You three are like a warm, supportive cuddle puddle.
And thanks to our other high-level Patrons, including:
Marcelo Kenji
12tone
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Susan Jones
Ilsa Jerome
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Marcel Ward
City Beautiful
https://wn.com/This_Is_Your_Brain_On_Ecstasy
Go to https://brilliant.org/NeuroTransmissions to get a 30-day free trial + the first 200 people will get 20% off their annual subscription.
Believe it or not, MDMA was legal less than 50 years ago and frequently used in therapy. The DEA changed that. But what if I told you that MDMA is making a comeback...in therapy? We're going to take an eye-opening (pun intended) delve into what ecstacy does to your brain, how molly came to be what it is today, and what possibilities lie ahead as a possible treatment for mental illness.
From its accidental inception in a pharmaceutical lab to the underground scenes of the 1970s, we uncover MDMA's evolution - from therapeutic wonder to recreational sensation to outlawed danger to...therapeutic wonder again? Anyway, I'll help you understand the neuroscience--its mechanism and potential risks while contemplating its newfound resurgence in modern medicine, with groundbreaking trials hinting at transformative therapies for PTSD and beyond.
But the real question remains: Could MDMA be the revolutionary treatment we've been waiting for, a potential beacon of hope in the realm of mental health? Or is it just a fun way to spend an evening at a rave or in a cuddle puddle?
Share your thoughts on MDMA and its potential uses! Have you had any personal experiences with MDMA, positive or negative? Do you believe it should be used in a medical or recreational setting? Leave those all in the comments.
0:00 - Does a magic pill exist for me?
2:16 - From accidental discovery to infamy
5:05 - Shulgin and the spread of MDMA
6:09 - From therapy aid to party drug
7:52 - The DEA is no fun
10:04 - What MDMA does to the brain
12:24 - Risks of MDMA
14:51 - The MDMA comeback in therapy
16:48 - MDMA's promising future
19:14 - My own take on MDMA
20:43 - Sign up for Brilliant plz?
22:39 - Tell me your thoughts and experiences
Wanna watch this video without ads and see all of our exclusive content? Head over to https://nebula.tv/videos/neurotransmissions-this-is-your-brain-on-ecstasy
We published a book called Brains Explained. You can buy it! https://amzn.to/3hkmCdo
Join our mess of a Discord server: https://discord.gg/rD6wjQa7Vs
If you like what we do, support our work by becoming a Patron: https://www.patreon.com/neurotransmissions
Alternatively, if you wanna support the channel and get some fun emojis to use in comments and a badge next to your name in the process, consider becoming a "member" of our channel right here on YT:
https://www.youtube.com/@neurotransmissions/membership
We couldn’t do all of this without our awesome Patreon Producers, Ryan Shaver, Carrie McKenzie, and Jareth Arnold. You three are like a warm, supportive cuddle puddle.
And thanks to our other high-level Patrons, including:
Marcelo Kenji
12tone
Linda L Schubert
Susan Jones
Ilsa Jerome
k b
Marcel Ward
City Beautiful
- published: 20 Sep 2023
- views: 233279
15:33
Your Body On Ecstasy (MDMA)
Ecstasy or MDMA is known as the party drug in the club scene, but what chemical reactions is the drug causing your body to undergo? Check out today's epic new v...
Ecstasy or MDMA is known as the party drug in the club scene, but what chemical reactions is the drug causing your body to undergo? Check out today's epic new video that takes a deeper look at the mind-altering drug to find out what it's really doing to you.
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All videos are based on publicly available information unless otherwise noted.
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https://wn.com/Your_Body_On_Ecstasy_(Mdma)
Ecstasy or MDMA is known as the party drug in the club scene, but what chemical reactions is the drug causing your body to undergo? Check out today's epic new video that takes a deeper look at the mind-altering drug to find out what it's really doing to you.
🔔 SUBSCRIBE TO THE INFOGRAPHICS SHOW ► https://www.youtube.com/c/theinfographicsshowOFFICIAL?sub_confirmation=1
🔖 MY SOCIAL PAGES
TikTok ► https://www.tiktok.com/@theinfographicsshow
Discord ► https://discord.gg/theinfoshow
Facebook ► https://www.facebook.com/TheInfographicsShow
Twitter ► https://twitter.com/TheInfoShow
💭 Find more interesting stuff on:
https://www.theinfographicsshow.com
📝 SOURCES:
https://pastebin.com/YE0r9LYc
All videos are based on publicly available information unless otherwise noted.
Our Secret Weapon for growing on YouTube ➼ https://vidiq.com/theinfoshow/
- published: 28 Feb 2024
- views: 397367
2:45
MDMA Therapy | Drugs, Inc.
MDMA, though illegal, can be extremely helpful in psychotherapy sessions, especially for people suffering from PTSD.
➡ Subscribe: http://bit.ly/NatGeoSubscribe
...
MDMA, though illegal, can be extremely helpful in psychotherapy sessions, especially for people suffering from PTSD.
➡ Subscribe: http://bit.ly/NatGeoSubscribe
About National Geographic:
National Geographic is the world's premium destination for science, exploration, and adventure. Through their world-class scientists, photographers, journalists, and filmmakers, Nat Geo gets you closer to the stories that matter and past the edge of what's possible.
Get More National Geographic:
Official Site: http://bit.ly/NatGeoOfficialSite
Facebook: http://bit.ly/FBNatGeo
Twitter: http://bit.ly/NatGeoTwitter
Instagram: http://bit.ly/NatGeoInsta
MDMA Therapy | Drugs, Inc.
https://youtu.be/Dm9c9XiRl1A
National Geographic
https://www.youtube.com/natgeo
https://wn.com/Mdma_Therapy_|_Drugs,_Inc.
MDMA, though illegal, can be extremely helpful in psychotherapy sessions, especially for people suffering from PTSD.
➡ Subscribe: http://bit.ly/NatGeoSubscribe
About National Geographic:
National Geographic is the world's premium destination for science, exploration, and adventure. Through their world-class scientists, photographers, journalists, and filmmakers, Nat Geo gets you closer to the stories that matter and past the edge of what's possible.
Get More National Geographic:
Official Site: http://bit.ly/NatGeoOfficialSite
Facebook: http://bit.ly/FBNatGeo
Twitter: http://bit.ly/NatGeoTwitter
Instagram: http://bit.ly/NatGeoInsta
MDMA Therapy | Drugs, Inc.
https://youtu.be/Dm9c9XiRl1A
National Geographic
https://www.youtube.com/natgeo
- published: 29 Dec 2011
- views: 307877
2:55
L'ecstasy : risques, consommation et conseils - AlloDocteurs
Geneviève Lafaye, psychiatre addictologue répond à vos questions sur les dangers de l'ecstasy.
Ecstasy et MDMA : c'est quoi exactement ? Pourquoi l'appelle-t-...
Geneviève Lafaye, psychiatre addictologue répond à vos questions sur les dangers de l'ecstasy.
Ecstasy et MDMA : c'est quoi exactement ? Pourquoi l'appelle-t-on "la drogue de l'amour" ? Existe-il des risques de problèmes psy après une prise ?
Retrouvez plus de vidéos sur votre santé sur https://www.allodocteurs.fr/videos/
👇 Abonnez-vous : https://www.youtube.com/channel/UCv6qHPwghGsyOfzEYZXcfKg
https://wn.com/L'Ecstasy_Risques,_Consommation_Et_Conseils_Allodocteurs
Geneviève Lafaye, psychiatre addictologue répond à vos questions sur les dangers de l'ecstasy.
Ecstasy et MDMA : c'est quoi exactement ? Pourquoi l'appelle-t-on "la drogue de l'amour" ? Existe-il des risques de problèmes psy après une prise ?
Retrouvez plus de vidéos sur votre santé sur https://www.allodocteurs.fr/videos/
👇 Abonnez-vous : https://www.youtube.com/channel/UCv6qHPwghGsyOfzEYZXcfKg
- published: 15 Jan 2022
- views: 69590
5:17
MDMA: Epic party drug or lethal toxin? (XTC, Ecstasy, Molly) - Doctor Explains
We have all heard of XTC, X, Molly or in medical terms MDMA. All names for the same drug. It is often praised for creating a warm, fussy experience filled with ...
We have all heard of XTC, X, Molly or in medical terms MDMA. All names for the same drug. It is often praised for creating a warm, fussy experience filled with love, enjoyment and distortion of time and perception. This is the pitch, which might have convinced you to try it at some point in your life. Or maybe you have always been curious to do so.
That is where this video comes in. I will be covering the origin of MDMA, it’s effects, long term risks, symptoms of an overdose.
This video is part of a videoseries on the Dangers of Illicit Drugs. Find the playlists here:
https://www.youtube.com/playlist?list=PLaG3Bo3L0gX5LqgWoZVqRxEDa1hYcEYzl
The origin of MDMA:
It was developed by a German pharmaceutical company in 1912. It was intended as a compound which could be used to synthesize medications to control bleeding. Although soon people started experimenting with it and found out it’s stimulant and psychedelic properties.
In the 80s and 90s MDMA started to becoming widely available on the street as a party drug.
Statistics:
Sinds then, the popularity of MDMA sky rocketed. A recent study found that about 20% of all Americans had used MDMA in the previous year. And about 1% of Americans aged 19-28 had used it in the last month.
How does it work?
MDMA works by increasing the release of the neurotransmitters serotonin, dopamine and noradrenaline. It also blocks their re-absorption. Together, this leads to an increased concentration of these neurotransmitters in several pathways of your brain.
The "positive" effects:
This mechanism causes the short term effects you might associate with MDMA: an enhanced sense of pleasure, euphoria, more self-confidence, increased energy, feelings of peacefulness, acceptance, and empathy.
The "negative" effects:
Unfortunately using MDMA can also cause several adverse effects, like: Jaw clenching, teeth grinding, restlessness, insomnia, irritability, anxiety, sweating, thirst, nausea, impulsiveness, increased heart rate, rising body temperature and high blood pressure.
Withdrawal symptoms:
Among others: Irritability, depression, confusion, agression, muscle cramps, problems with sleep, anxiety, memory deficits, loss of attention, nausea, decreased appetite and decreased libido.
Overdose:
The risk of overdose is quite low. However, repeated use within a short time frame can increase this risk. In addition MDMA is prone to being “cut” with other illicit and potentially deadly chemicals. This further increases your risk on serious medical problems or an overdose.
The same is true for voluntarily combining MDMA with marijana, alcohol or other drugs.
Now pay attention: common symptoms for an overdose are: excessive thirst, heavy sweating, muscle cramping, shaking chills, little to no urine output, blurred vision, fainting and seizures.
Seek immediate medical help if you recognize these symptoms, as they can lead to severe liver damage, kidney failure, brain damage, heart failure and potentially death.
- Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor. -
Literature:
1: A. Perez. J. Leonard (2022). How long does molly stay in your system? Medical News Today.
2: NIDA. (2021). Can you overdose or die if you use MDMA use (Ecstasy or Molly)? NIDA.
3: J. Halpern. A. Sherwood. J. Hudson et al. (2011). neurocognitive features of long-term ecstasy users with minimal exposure to other drugs. Addiction.106: 777-86.
4: NIDA. (2022). MDMA (Ecstasy) Abuse Research Report: Introduction. NIDA.
* The images in this video are used for educational purposes only. Most of the images and video material in this video come from https://www.canva.com/.
Follow me on Instagram: @HOWTOMEDICATE
Follow me on Facebook: @HOWTOMEDICATE
Follow me on Tiktok: @How2medicate
Support me on Patreon: https://www.patreon.com/howtomedicate
https://wn.com/Mdma_Epic_Party_Drug_Or_Lethal_Toxin_(Xtc,_Ecstasy,_Molly)_Doctor_Explains
We have all heard of XTC, X, Molly or in medical terms MDMA. All names for the same drug. It is often praised for creating a warm, fussy experience filled with love, enjoyment and distortion of time and perception. This is the pitch, which might have convinced you to try it at some point in your life. Or maybe you have always been curious to do so.
That is where this video comes in. I will be covering the origin of MDMA, it’s effects, long term risks, symptoms of an overdose.
This video is part of a videoseries on the Dangers of Illicit Drugs. Find the playlists here:
https://www.youtube.com/playlist?list=PLaG3Bo3L0gX5LqgWoZVqRxEDa1hYcEYzl
The origin of MDMA:
It was developed by a German pharmaceutical company in 1912. It was intended as a compound which could be used to synthesize medications to control bleeding. Although soon people started experimenting with it and found out it’s stimulant and psychedelic properties.
In the 80s and 90s MDMA started to becoming widely available on the street as a party drug.
Statistics:
Sinds then, the popularity of MDMA sky rocketed. A recent study found that about 20% of all Americans had used MDMA in the previous year. And about 1% of Americans aged 19-28 had used it in the last month.
How does it work?
MDMA works by increasing the release of the neurotransmitters serotonin, dopamine and noradrenaline. It also blocks their re-absorption. Together, this leads to an increased concentration of these neurotransmitters in several pathways of your brain.
The "positive" effects:
This mechanism causes the short term effects you might associate with MDMA: an enhanced sense of pleasure, euphoria, more self-confidence, increased energy, feelings of peacefulness, acceptance, and empathy.
The "negative" effects:
Unfortunately using MDMA can also cause several adverse effects, like: Jaw clenching, teeth grinding, restlessness, insomnia, irritability, anxiety, sweating, thirst, nausea, impulsiveness, increased heart rate, rising body temperature and high blood pressure.
Withdrawal symptoms:
Among others: Irritability, depression, confusion, agression, muscle cramps, problems with sleep, anxiety, memory deficits, loss of attention, nausea, decreased appetite and decreased libido.
Overdose:
The risk of overdose is quite low. However, repeated use within a short time frame can increase this risk. In addition MDMA is prone to being “cut” with other illicit and potentially deadly chemicals. This further increases your risk on serious medical problems or an overdose.
The same is true for voluntarily combining MDMA with marijana, alcohol or other drugs.
Now pay attention: common symptoms for an overdose are: excessive thirst, heavy sweating, muscle cramping, shaking chills, little to no urine output, blurred vision, fainting and seizures.
Seek immediate medical help if you recognize these symptoms, as they can lead to severe liver damage, kidney failure, brain damage, heart failure and potentially death.
- Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor. -
Literature:
1: A. Perez. J. Leonard (2022). How long does molly stay in your system? Medical News Today.
2: NIDA. (2021). Can you overdose or die if you use MDMA use (Ecstasy or Molly)? NIDA.
3: J. Halpern. A. Sherwood. J. Hudson et al. (2011). neurocognitive features of long-term ecstasy users with minimal exposure to other drugs. Addiction.106: 777-86.
4: NIDA. (2022). MDMA (Ecstasy) Abuse Research Report: Introduction. NIDA.
* The images in this video are used for educational purposes only. Most of the images and video material in this video come from https://www.canva.com/.
Follow me on Instagram: @HOWTOMEDICATE
Follow me on Facebook: @HOWTOMEDICATE
Follow me on Tiktok: @How2medicate
Support me on Patreon: https://www.patreon.com/howtomedicate
- published: 15 Feb 2023
- views: 135174