-
MDMA - Respect Your Brain
See how MDMA affects the brain. MDMA (ecstasy) boosts the feel-good chemicals in your brain but any amount is risky and the more you take, the more often, the more damage you can do.
For more information on the developing brain and alcohol, cannabis and MDMA visit https://yourroom.health.nsw.gov.au/respectyourbrain
published: 07 Jul 2020
-
2-Minute Neuroscience: MDMA
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug with unique prosocial effects. In this video, I discuss the current understanding of how MDMA acts on the brain to produce its effects.
TRANSCRIPT:
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug that is chemically related to amphetamine. Like other stimulants, MDMA causes increased alertness and a positive mood. But MDMA’s effects are also distinct from the effects of other stimulants, as the drug causes unique prosocial effects such as strong feelings of trust, openness, and closeness with others.
Although we don’t have a full understanding of the effects of MDMA on the brain, MDMA’s mechanism is similar in many ways to the mechanism o...
published: 28 Sep 2021
-
What's In An Ecstasy Tablet? - How Drugs Work, Ecstasy, Preview - BBC Three
Subscribe and 🔔 to the BBC 👉 https://bit.ly/BBCYouTubeSub
Watch the BBC first on iPlayer 👉 https://bbc.in/iPlayer-Home More about this programme: http://www.bbc.co.uk/programmes/b00xckv8
Drugs expert Jon Ramsey explains the huge variation in the content of commonly available ecstasy tablets. Tests he conducted on pills confiscated at the 2009 Glastonbury Festival showed that just 8% of all tablets studied contained any of the substance MDMA - the drug most users would expect to find in an 'ecstasy' tablet.
#bbc
All our TV channels and S4C are available to watch live through BBC iPlayer, although some programmes may not be available to stream online due to rights. If you would like to read more on what types of programmes are available to watch live, check the 'Are all programmes that a...
published: 12 Jan 2011
-
MDMA (Molly, Ecstasy): Tips For Staying Safe
MDMA has the potential to cause severe health issues and even fatalities. However, it's possible to use the drug in a way that's very low-risk.
MDMA overview page: https://thedrugclassroom.com/video/34-methylenedioxymethamphetamine-mdma/
MDMA overview video: https://www.youtube.com/watch?v=LdTSKZ8-0Mg
MDMA neurotoxicity video: https://www.youtube.com/watch?v=OOa5n-DsnDw
Drug checking video: https://www.youtube.com/watch?v=NneFXOj1n_U
Reddit discussion: DrugClassroom/comments/679lhp/mdma_molly_ecstasy_tips_for_staying_safe/
------------
Donate to The Drug Classroom:
https://www.patreon.com/TheDrugClassroom
https://www.paypal.me/TheDrugClassroom
Bitcoin: 1HsjCYpBHKcVCaW4uKBraCGkc1LK8xoj1B
------------
Thank you to my Patreon supporters: Glen Marshall, RollSafe.org, Jonathon Dunn,...
published: 24 Apr 2017
-
MDMA: Epic party drug or lethal toxin? (XTC, Ecstasy, Molly) - Doctor Explains
We have all heard of XTC, X, Molly or in medical terms MDMA. All names for the same drug. It is often praised for creating a warm, fussy experience filled with love, enjoyment and distortion of time and perception. This is the pitch, which might have convinced you to try it at some point in your life. Or maybe you have always been curious to do so.
That is where this video comes in. I will be covering the origin of MDMA, it’s effects, long term risks, symptoms of an overdose.
This video is part of a videoseries on the Dangers of Illicit Drugs. Find the playlists here:
https://www.youtube.com/playlist?list=PLaG3Bo3L0gX5LqgWoZVqRxEDa1hYcEYzl
The origin of MDMA:
It was developed by a German pharmaceutical company in 1912. It was intended as a compound which could be used to synthesize ...
published: 15 Feb 2023
-
Exposing the dangers of the "Molly" drug
Exposing the dangers of the "Molly" drug
published: 12 Nov 2013
-
The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast
In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the ex...
published: 12 Jun 2023
-
How to Use MDMA Safely
MDMA itself is a pretty safe substance if you know how to use it correctly. Sadly, a lot of people are unaware of the simple steps they can take to make their usage safer.
In this video I discuss reagent testing (to make sure you're likely taking MDMA), the drug's acute harm potential, how often it should be used, and "neurotoxicity."
MDMA neurotoxicity page: https://thedrugclassroom.com/video/mdmas-neurotoxicity-research-shows-reduce-risk-detailed/
MDMA neurotoxicity video: https://www.youtube.com/watch?v=OOa5n-DsnDw
MDMA overview page: https://thedrugclassroom.com/video/34-methylenedioxymethamphetamine-mdma/
MDMA overview video: https://www.youtube.com/watch?v=LdTSKZ8-0Mg
MDMA for PTSD video: https://www.youtube.com/watch?v=fX1MXz7BcHs
Reddit discussion: https://www.reddit.com/r/T...
published: 02 Oct 2017
-
Your Brain On MDMA
Your Brain On MDMA
In this video, we explore the effects of MDMA, also known as ecstasy or molly, on the brain. MDMA is a popular party drug that has gained notoriety for its ability to produce feelings of euphoria, empathy, and heightened sensory perception. However, the use of MDMA also carries risks, including potentially serious side effects and long-term damage to the brain. By examining the scientific research on MDMA, we hope to provide viewers with a better understanding of the drug and its potential impact on mental and physical health.
published: 27 Feb 2023
-
MDMA: What No One Told Me
This has been created strictly for education and harm reduction; to help people remain safe by properly educating them about the dangers & truths in a non-bias way. Thank you.
****************************
~Get a Test Kit: http://tinyurl.com/GetTestKit
~Support us on Patreon: https://goo.gl/EufkcZ
~Instagram: https://bit.ly/3V2Q60l
published: 12 Oct 2020
0:50
MDMA - Respect Your Brain
See how MDMA affects the brain. MDMA (ecstasy) boosts the feel-good chemicals in your brain but any amount is risky and the more you take, the more often, the m...
See how MDMA affects the brain. MDMA (ecstasy) boosts the feel-good chemicals in your brain but any amount is risky and the more you take, the more often, the more damage you can do.
For more information on the developing brain and alcohol, cannabis and MDMA visit https://yourroom.health.nsw.gov.au/respectyourbrain
https://wn.com/Mdma_Respect_Your_Brain
See how MDMA affects the brain. MDMA (ecstasy) boosts the feel-good chemicals in your brain but any amount is risky and the more you take, the more often, the more damage you can do.
For more information on the developing brain and alcohol, cannabis and MDMA visit https://yourroom.health.nsw.gov.au/respectyourbrain
- published: 07 Jul 2020
- views: 136353
2:01
2-Minute Neuroscience: MDMA
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug with unique prosocial effects. In this video, I discuss the ...
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug with unique prosocial effects. In this video, I discuss the current understanding of how MDMA acts on the brain to produce its effects.
TRANSCRIPT:
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug that is chemically related to amphetamine. Like other stimulants, MDMA causes increased alertness and a positive mood. But MDMA’s effects are also distinct from the effects of other stimulants, as the drug causes unique prosocial effects such as strong feelings of trust, openness, and closeness with others.
Although we don’t have a full understanding of the effects of MDMA on the brain, MDMA’s mechanism is similar in many ways to the mechanism of other amphetamines. MDMA inhibits the function of proteins called transporter proteins, which typically remove neurotransmitters like serotonin, dopamine, and norepinephrine from the space between neurons known as the synaptic cleft. By inhibiting transporter proteins, MDMA causes serotonin, dopamine, and norepinephrine to accumulate in the synaptic cleft, increasing neurotransmitter activity there. In contrast to other amphetamines, MDMA inhibits the serotonin transporter more potently than the dopamine or norepinephrine transporter. MDMA also uses transporter proteins to enter neurons; once inside, MDMA disrupts the storage of neurotransmitters in synaptic vesicles, causing the buildup of serotonin, dopamine, and norepinephrine inside neurons; then, MDMA facilitates the release of these neurotransmitters into the synaptic cleft, leading to increased neurotransmitter levels and activity. In addition to these mechanisms, MDMA also binds to a number of receptors directly, including specific subtypes of the serotonin receptor; these interactions may contribute to the effects of MDMA.
It’s not clear what mechanism accounts for the unique prosocial effects of MDMA. A number of studies have found that MDMA promotes the release of the hormone oxytocin, which itself has been linked to prosocial effects. At the same time, most studies have failed to find a link between increasing oxytocin levels and the prosocial effects of MDMA, leaving these effects still unexplained.
REFERENCES:
Dunlap LE, Andrews AM, Olson DE. Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine. ACS Chem Neurosci. 2018 Oct 17;9(10):2408-2427. doi: 10.1021/acschemneuro.8b00155. Epub 2018 Jul 12. PMID: 30001118; PMCID: PMC6197894.
Oeri HE. Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy. J Psychopharmacol. 2021 May;35(5):512-536. doi: 10.1177/0269881120920420. Epub 2020 Sep 10. PMID: 32909493; PMCID: PMC8155739.
Schenk S, Highgate Q. Methylenedioxymethamphetamine (MDMA): Serotonergic and dopaminergic mechanisms related to its use and misuse. J Neurochem. 2021 Jun;157(5):1714-1724. doi: 10.1111/jnc.15348. Epub 2021 Mar 25. PMID: 33711169.
https://wn.com/2_Minute_Neuroscience_Mdma
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug with unique prosocial effects. In this video, I discuss the current understanding of how MDMA acts on the brain to produce its effects.
TRANSCRIPT:
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug that is chemically related to amphetamine. Like other stimulants, MDMA causes increased alertness and a positive mood. But MDMA’s effects are also distinct from the effects of other stimulants, as the drug causes unique prosocial effects such as strong feelings of trust, openness, and closeness with others.
Although we don’t have a full understanding of the effects of MDMA on the brain, MDMA’s mechanism is similar in many ways to the mechanism of other amphetamines. MDMA inhibits the function of proteins called transporter proteins, which typically remove neurotransmitters like serotonin, dopamine, and norepinephrine from the space between neurons known as the synaptic cleft. By inhibiting transporter proteins, MDMA causes serotonin, dopamine, and norepinephrine to accumulate in the synaptic cleft, increasing neurotransmitter activity there. In contrast to other amphetamines, MDMA inhibits the serotonin transporter more potently than the dopamine or norepinephrine transporter. MDMA also uses transporter proteins to enter neurons; once inside, MDMA disrupts the storage of neurotransmitters in synaptic vesicles, causing the buildup of serotonin, dopamine, and norepinephrine inside neurons; then, MDMA facilitates the release of these neurotransmitters into the synaptic cleft, leading to increased neurotransmitter levels and activity. In addition to these mechanisms, MDMA also binds to a number of receptors directly, including specific subtypes of the serotonin receptor; these interactions may contribute to the effects of MDMA.
It’s not clear what mechanism accounts for the unique prosocial effects of MDMA. A number of studies have found that MDMA promotes the release of the hormone oxytocin, which itself has been linked to prosocial effects. At the same time, most studies have failed to find a link between increasing oxytocin levels and the prosocial effects of MDMA, leaving these effects still unexplained.
REFERENCES:
Dunlap LE, Andrews AM, Olson DE. Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine. ACS Chem Neurosci. 2018 Oct 17;9(10):2408-2427. doi: 10.1021/acschemneuro.8b00155. Epub 2018 Jul 12. PMID: 30001118; PMCID: PMC6197894.
Oeri HE. Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy. J Psychopharmacol. 2021 May;35(5):512-536. doi: 10.1177/0269881120920420. Epub 2020 Sep 10. PMID: 32909493; PMCID: PMC8155739.
Schenk S, Highgate Q. Methylenedioxymethamphetamine (MDMA): Serotonergic and dopaminergic mechanisms related to its use and misuse. J Neurochem. 2021 Jun;157(5):1714-1724. doi: 10.1111/jnc.15348. Epub 2021 Mar 25. PMID: 33711169.
- published: 28 Sep 2021
- views: 351762
2:10
What's In An Ecstasy Tablet? - How Drugs Work, Ecstasy, Preview - BBC Three
Subscribe and 🔔 to the BBC 👉 https://bit.ly/BBCYouTubeSub
Watch the BBC first on iPlayer 👉 https://bbc.in/iPlayer-Home More about this programme: http://www.bbc...
Subscribe and 🔔 to the BBC 👉 https://bit.ly/BBCYouTubeSub
Watch the BBC first on iPlayer 👉 https://bbc.in/iPlayer-Home More about this programme: http://www.bbc.co.uk/programmes/b00xckv8
Drugs expert Jon Ramsey explains the huge variation in the content of commonly available ecstasy tablets. Tests he conducted on pills confiscated at the 2009 Glastonbury Festival showed that just 8% of all tablets studied contained any of the substance MDMA - the drug most users would expect to find in an 'ecstasy' tablet.
#bbc
All our TV channels and S4C are available to watch live through BBC iPlayer, although some programmes may not be available to stream online due to rights. If you would like to read more on what types of programmes are available to watch live, check the 'Are all programmes that are broadcast available on BBC iPlayer?' FAQ 👉 https://bbc.in/2m8ks6v.
https://wn.com/What's_In_An_Ecstasy_Tablet_How_Drugs_Work,_Ecstasy,_Preview_BBC_Three
Subscribe and 🔔 to the BBC 👉 https://bit.ly/BBCYouTubeSub
Watch the BBC first on iPlayer 👉 https://bbc.in/iPlayer-Home More about this programme: http://www.bbc.co.uk/programmes/b00xckv8
Drugs expert Jon Ramsey explains the huge variation in the content of commonly available ecstasy tablets. Tests he conducted on pills confiscated at the 2009 Glastonbury Festival showed that just 8% of all tablets studied contained any of the substance MDMA - the drug most users would expect to find in an 'ecstasy' tablet.
#bbc
All our TV channels and S4C are available to watch live through BBC iPlayer, although some programmes may not be available to stream online due to rights. If you would like to read more on what types of programmes are available to watch live, check the 'Are all programmes that are broadcast available on BBC iPlayer?' FAQ 👉 https://bbc.in/2m8ks6v.
- published: 12 Jan 2011
- views: 834236
8:13
MDMA (Molly, Ecstasy): Tips For Staying Safe
MDMA has the potential to cause severe health issues and even fatalities. However, it's possible to use the drug in a way that's very low-risk.
MDMA overview ...
MDMA has the potential to cause severe health issues and even fatalities. However, it's possible to use the drug in a way that's very low-risk.
MDMA overview page: https://thedrugclassroom.com/video/34-methylenedioxymethamphetamine-mdma/
MDMA overview video: https://www.youtube.com/watch?v=LdTSKZ8-0Mg
MDMA neurotoxicity video: https://www.youtube.com/watch?v=OOa5n-DsnDw
Drug checking video: https://www.youtube.com/watch?v=NneFXOj1n_U
Reddit discussion: DrugClassroom/comments/679lhp/mdma_molly_ecstasy_tips_for_staying_safe/
------------
Donate to The Drug Classroom:
https://www.patreon.com/TheDrugClassroom
https://www.paypal.me/TheDrugClassroom
Bitcoin: 1HsjCYpBHKcVCaW4uKBraCGkc1LK8xoj1B
------------
Thank you to my Patreon supporters: Glen Marshall, RollSafe.org, Jonathon Dunn, Thomas Anaya, Ross Martin, Star Ape, michael hoogwater, Beau Jaco, and David Kernell.
------------
Facebook - http://facebook.com/thedrugclassroom
Twitter - http://twitter.com/drugclassroom
------------
The Drug Classroom (TDC) is dedicated to providing the type of drug education everyone should have. Drugs are never going to leave our society and there has never been a society free from drugs.
Therefore, it only makes sense to provide real education free from propaganda.
TDC doesn't advocate drug use. Rather, we operate with the intention of reducing the harm some substances can bring.
Feel free to ask questions!
https://wn.com/Mdma_(Molly,_Ecstasy)_Tips_For_Staying_Safe
MDMA has the potential to cause severe health issues and even fatalities. However, it's possible to use the drug in a way that's very low-risk.
MDMA overview page: https://thedrugclassroom.com/video/34-methylenedioxymethamphetamine-mdma/
MDMA overview video: https://www.youtube.com/watch?v=LdTSKZ8-0Mg
MDMA neurotoxicity video: https://www.youtube.com/watch?v=OOa5n-DsnDw
Drug checking video: https://www.youtube.com/watch?v=NneFXOj1n_U
Reddit discussion: DrugClassroom/comments/679lhp/mdma_molly_ecstasy_tips_for_staying_safe/
------------
Donate to The Drug Classroom:
https://www.patreon.com/TheDrugClassroom
https://www.paypal.me/TheDrugClassroom
Bitcoin: 1HsjCYpBHKcVCaW4uKBraCGkc1LK8xoj1B
------------
Thank you to my Patreon supporters: Glen Marshall, RollSafe.org, Jonathon Dunn, Thomas Anaya, Ross Martin, Star Ape, michael hoogwater, Beau Jaco, and David Kernell.
------------
Facebook - http://facebook.com/thedrugclassroom
Twitter - http://twitter.com/drugclassroom
------------
The Drug Classroom (TDC) is dedicated to providing the type of drug education everyone should have. Drugs are never going to leave our society and there has never been a society free from drugs.
Therefore, it only makes sense to provide real education free from propaganda.
TDC doesn't advocate drug use. Rather, we operate with the intention of reducing the harm some substances can bring.
Feel free to ask questions!
- published: 24 Apr 2017
- views: 307115
5:17
MDMA: Epic party drug or lethal toxin? (XTC, Ecstasy, Molly) - Doctor Explains
We have all heard of XTC, X, Molly or in medical terms MDMA. All names for the same drug. It is often praised for creating a warm, fussy experience filled with ...
We have all heard of XTC, X, Molly or in medical terms MDMA. All names for the same drug. It is often praised for creating a warm, fussy experience filled with love, enjoyment and distortion of time and perception. This is the pitch, which might have convinced you to try it at some point in your life. Or maybe you have always been curious to do so.
That is where this video comes in. I will be covering the origin of MDMA, it’s effects, long term risks, symptoms of an overdose.
This video is part of a videoseries on the Dangers of Illicit Drugs. Find the playlists here:
https://www.youtube.com/playlist?list=PLaG3Bo3L0gX5LqgWoZVqRxEDa1hYcEYzl
The origin of MDMA:
It was developed by a German pharmaceutical company in 1912. It was intended as a compound which could be used to synthesize medications to control bleeding. Although soon people started experimenting with it and found out it’s stimulant and psychedelic properties.
In the 80s and 90s MDMA started to becoming widely available on the street as a party drug.
Statistics:
Sinds then, the popularity of MDMA sky rocketed. A recent study found that about 20% of all Americans had used MDMA in the previous year. And about 1% of Americans aged 19-28 had used it in the last month.
How does it work?
MDMA works by increasing the release of the neurotransmitters serotonin, dopamine and noradrenaline. It also blocks their re-absorption. Together, this leads to an increased concentration of these neurotransmitters in several pathways of your brain.
The "positive" effects:
This mechanism causes the short term effects you might associate with MDMA: an enhanced sense of pleasure, euphoria, more self-confidence, increased energy, feelings of peacefulness, acceptance, and empathy.
The "negative" effects:
Unfortunately using MDMA can also cause several adverse effects, like: Jaw clenching, teeth grinding, restlessness, insomnia, irritability, anxiety, sweating, thirst, nausea, impulsiveness, increased heart rate, rising body temperature and high blood pressure.
Withdrawal symptoms:
Among others: Irritability, depression, confusion, agression, muscle cramps, problems with sleep, anxiety, memory deficits, loss of attention, nausea, decreased appetite and decreased libido.
Overdose:
The risk of overdose is quite low. However, repeated use within a short time frame can increase this risk. In addition MDMA is prone to being “cut” with other illicit and potentially deadly chemicals. This further increases your risk on serious medical problems or an overdose.
The same is true for voluntarily combining MDMA with marijana, alcohol or other drugs.
Now pay attention: common symptoms for an overdose are: excessive thirst, heavy sweating, muscle cramping, shaking chills, little to no urine output, blurred vision, fainting and seizures.
Seek immediate medical help if you recognize these symptoms, as they can lead to severe liver damage, kidney failure, brain damage, heart failure and potentially death.
- Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor. -
Literature:
1: A. Perez. J. Leonard (2022). How long does molly stay in your system? Medical News Today.
2: NIDA. (2021). Can you overdose or die if you use MDMA use (Ecstasy or Molly)? NIDA.
3: J. Halpern. A. Sherwood. J. Hudson et al. (2011). neurocognitive features of long-term ecstasy users with minimal exposure to other drugs. Addiction.106: 777-86.
4: NIDA. (2022). MDMA (Ecstasy) Abuse Research Report: Introduction. NIDA.
* The images in this video are used for educational purposes only. Most of the images and video material in this video come from https://www.canva.com/.
Follow me on Instagram: @HOWTOMEDICATE
Follow me on Facebook: @HOWTOMEDICATE
Follow me on Tiktok: @How2medicate
Support me on Patreon: https://www.patreon.com/howtomedicate
https://wn.com/Mdma_Epic_Party_Drug_Or_Lethal_Toxin_(Xtc,_Ecstasy,_Molly)_Doctor_Explains
We have all heard of XTC, X, Molly or in medical terms MDMA. All names for the same drug. It is often praised for creating a warm, fussy experience filled with love, enjoyment and distortion of time and perception. This is the pitch, which might have convinced you to try it at some point in your life. Or maybe you have always been curious to do so.
That is where this video comes in. I will be covering the origin of MDMA, it’s effects, long term risks, symptoms of an overdose.
This video is part of a videoseries on the Dangers of Illicit Drugs. Find the playlists here:
https://www.youtube.com/playlist?list=PLaG3Bo3L0gX5LqgWoZVqRxEDa1hYcEYzl
The origin of MDMA:
It was developed by a German pharmaceutical company in 1912. It was intended as a compound which could be used to synthesize medications to control bleeding. Although soon people started experimenting with it and found out it’s stimulant and psychedelic properties.
In the 80s and 90s MDMA started to becoming widely available on the street as a party drug.
Statistics:
Sinds then, the popularity of MDMA sky rocketed. A recent study found that about 20% of all Americans had used MDMA in the previous year. And about 1% of Americans aged 19-28 had used it in the last month.
How does it work?
MDMA works by increasing the release of the neurotransmitters serotonin, dopamine and noradrenaline. It also blocks their re-absorption. Together, this leads to an increased concentration of these neurotransmitters in several pathways of your brain.
The "positive" effects:
This mechanism causes the short term effects you might associate with MDMA: an enhanced sense of pleasure, euphoria, more self-confidence, increased energy, feelings of peacefulness, acceptance, and empathy.
The "negative" effects:
Unfortunately using MDMA can also cause several adverse effects, like: Jaw clenching, teeth grinding, restlessness, insomnia, irritability, anxiety, sweating, thirst, nausea, impulsiveness, increased heart rate, rising body temperature and high blood pressure.
Withdrawal symptoms:
Among others: Irritability, depression, confusion, agression, muscle cramps, problems with sleep, anxiety, memory deficits, loss of attention, nausea, decreased appetite and decreased libido.
Overdose:
The risk of overdose is quite low. However, repeated use within a short time frame can increase this risk. In addition MDMA is prone to being “cut” with other illicit and potentially deadly chemicals. This further increases your risk on serious medical problems or an overdose.
The same is true for voluntarily combining MDMA with marijana, alcohol or other drugs.
Now pay attention: common symptoms for an overdose are: excessive thirst, heavy sweating, muscle cramping, shaking chills, little to no urine output, blurred vision, fainting and seizures.
Seek immediate medical help if you recognize these symptoms, as they can lead to severe liver damage, kidney failure, brain damage, heart failure and potentially death.
- Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor. -
Literature:
1: A. Perez. J. Leonard (2022). How long does molly stay in your system? Medical News Today.
2: NIDA. (2021). Can you overdose or die if you use MDMA use (Ecstasy or Molly)? NIDA.
3: J. Halpern. A. Sherwood. J. Hudson et al. (2011). neurocognitive features of long-term ecstasy users with minimal exposure to other drugs. Addiction.106: 777-86.
4: NIDA. (2022). MDMA (Ecstasy) Abuse Research Report: Introduction. NIDA.
* The images in this video are used for educational purposes only. Most of the images and video material in this video come from https://www.canva.com/.
Follow me on Instagram: @HOWTOMEDICATE
Follow me on Facebook: @HOWTOMEDICATE
Follow me on Tiktok: @How2medicate
Support me on Patreon: https://www.patreon.com/howtomedicate
- published: 15 Feb 2023
- views: 135174
2:17:35
The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast
In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to ca...
In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry.
#HubermanLab #Science
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Articles
A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus: https://bit.ly/3oV8zSl
Effects of MDMA on sociability and neural response to social threat and social reward: https://bit.ly/3NlOYUC
The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity: https://bit.ly/42yMEhl
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA: https://bit.ly/3NlNERM
Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans: https://bit.ly/42AF6e0
RETRACTED: Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy"): https://bit.ly/3J9PTVU
Science forced to retract article on “ecstasy”: https://bit.ly/3oRRpVM
Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs: https://bit.ly/3P93gcM
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study: https://go.nature.com/3WqI2Zd
The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD: https://bit.ly/42wqeNP
Books
PIHKAL: A Chemical Love Story: https://amzn.to/45ZY80w
Trauma: The Invisible Epidemic: https://amzn.to/45VdgfA
The Body Keeps the Score: https://amzn.to/3XgH5Dz
Other Resources
Multidisciplinary Association for Psychedelic Studies (MAPS): https://maps.org
Participate in a MAPS trial: https://maps.org/take-action/participate-in-trial
Huberman Lab episode on psilocybin: https://bit.ly/43yP80G
Huberman Lab episode on psychedelics for mental health: https://bit.ly/3NqC3Rz
Huberman Lab episode on dopamine, mindset & drive: https://bit.ly/3IqQzVb
Huberman Lab episode on leveraging dopamine: https://bit.ly/3P3dCuD
Timestamps
00:00:00 MDMA “Ecstasy”
00:04:37 Sponsors: Helix Sleep, ROKA, HVMN
00:08:18 MDMA History & Synthesis; Legality
00:14:45 MDMA, Methamphetamine (Meth), Dopamine & Serotonin
00:23:30 MDMA vs Psychedelics vs Ketamine
00:26:54 MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma
00:33:36 Sponsor: AG1
00:34:51 Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages
00:45:48 Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD)
00:52:36 Long-Term Effects, Threat Detection & PTSD
00:56:14 MDMA, Social Connection & Empathy; Meth, SSRIs
01:06:10 Sponsor: LMNT
01:07:22 Oxytocin & MDMA
01:16:10 Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl
01:26:36 Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature
01:37:07 Post-MDMA “Crash”, Prolactin & P 5 P
01:43:07 PTSD & Trauma; Talk Therapy, SSRIs
01:54:09 PTSD Treatment: Talk Therapy + MDMA
02:02:46 MDMA & Addiction; Dissociative PTSD & Empathy
02:09:47 Side-Effects?, MDMA Efficacy & Legality
02:15:22 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com
Disclaimer: https://hubermanlab.com/disclaimer
https://wn.com/The_Science_Of_Mdma_Its_Therapeutic_Uses_Benefits_Risks_|_Huberman_Lab_Podcast
In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry.
#HubermanLab #Science
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Helix Sleep: https://helixsleep.com/huberman
ROKA: https://roka.com/huberman
HVMN: https://hvmn.com/huberman
LMNT: https://drinklmnt.com/huberman
Momentous: https://livemomentous.com/huberman
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Facebook - https://www.facebook.com/hubermanlab
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Website - https://hubermanlab.com
Newsletter - https://hubermanlab.com/neural-network
Articles
A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus: https://bit.ly/3oV8zSl
Effects of MDMA on sociability and neural response to social threat and social reward: https://bit.ly/3NlOYUC
The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity: https://bit.ly/42yMEhl
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA: https://bit.ly/3NlNERM
Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans: https://bit.ly/42AF6e0
RETRACTED: Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy"): https://bit.ly/3J9PTVU
Science forced to retract article on “ecstasy”: https://bit.ly/3oRRpVM
Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs: https://bit.ly/3P93gcM
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study: https://go.nature.com/3WqI2Zd
The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD: https://bit.ly/42wqeNP
Books
PIHKAL: A Chemical Love Story: https://amzn.to/45ZY80w
Trauma: The Invisible Epidemic: https://amzn.to/45VdgfA
The Body Keeps the Score: https://amzn.to/3XgH5Dz
Other Resources
Multidisciplinary Association for Psychedelic Studies (MAPS): https://maps.org
Participate in a MAPS trial: https://maps.org/take-action/participate-in-trial
Huberman Lab episode on psilocybin: https://bit.ly/43yP80G
Huberman Lab episode on psychedelics for mental health: https://bit.ly/3NqC3Rz
Huberman Lab episode on dopamine, mindset & drive: https://bit.ly/3IqQzVb
Huberman Lab episode on leveraging dopamine: https://bit.ly/3P3dCuD
Timestamps
00:00:00 MDMA “Ecstasy”
00:04:37 Sponsors: Helix Sleep, ROKA, HVMN
00:08:18 MDMA History & Synthesis; Legality
00:14:45 MDMA, Methamphetamine (Meth), Dopamine & Serotonin
00:23:30 MDMA vs Psychedelics vs Ketamine
00:26:54 MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma
00:33:36 Sponsor: AG1
00:34:51 Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages
00:45:48 Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD)
00:52:36 Long-Term Effects, Threat Detection & PTSD
00:56:14 MDMA, Social Connection & Empathy; Meth, SSRIs
01:06:10 Sponsor: LMNT
01:07:22 Oxytocin & MDMA
01:16:10 Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl
01:26:36 Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature
01:37:07 Post-MDMA “Crash”, Prolactin & P 5 P
01:43:07 PTSD & Trauma; Talk Therapy, SSRIs
01:54:09 PTSD Treatment: Talk Therapy + MDMA
02:02:46 MDMA & Addiction; Dissociative PTSD & Empathy
02:09:47 Side-Effects?, MDMA Efficacy & Legality
02:15:22 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com
Disclaimer: https://hubermanlab.com/disclaimer
- published: 12 Jun 2023
- views: 366098
17:16
How to Use MDMA Safely
MDMA itself is a pretty safe substance if you know how to use it correctly. Sadly, a lot of people are unaware of the simple steps they can take to make their u...
MDMA itself is a pretty safe substance if you know how to use it correctly. Sadly, a lot of people are unaware of the simple steps they can take to make their usage safer.
In this video I discuss reagent testing (to make sure you're likely taking MDMA), the drug's acute harm potential, how often it should be used, and "neurotoxicity."
MDMA neurotoxicity page: https://thedrugclassroom.com/video/mdmas-neurotoxicity-research-shows-reduce-risk-detailed/
MDMA neurotoxicity video: https://www.youtube.com/watch?v=OOa5n-DsnDw
MDMA overview page: https://thedrugclassroom.com/video/34-methylenedioxymethamphetamine-mdma/
MDMA overview video: https://www.youtube.com/watch?v=LdTSKZ8-0Mg
MDMA for PTSD video: https://www.youtube.com/watch?v=fX1MXz7BcHs
Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/73txsv/how_to_use_mdma_safely/
------------
Donate to The Drug Classroom:
https://www.patreon.com/TheDrugClassroom
https://www.paypal.me/TheDrugClassroom
Bitcoin: 1HsjCYpBHKcVCaW4uKBraCGkc1LK8xoj1B
------------
Thank you to my Patreon supporters: RollSafe.org, Jonathon Dunn, Thomas Anaya, michael hoogwater, Beau Jaco, Alexander Pavlenko, Lars Nilsson, Billy, Abdulaziz Al-Kuwari, Sam A., Reece hosford, Felix Wisniewski, Jarrod o'connell, Daniel X Moore, Dahmon Bicheno, Christoffer Finstad, Zachary Thomas Binkley, Sami Parsegov, Dane Overman, Squadra Dumay, Dragonhax, Case van der Burg, Alexander Norsk, John Riccardi, Matúš Zdút, Sebastian, Jacob Fournier-Paradis, and David Kernell.
------------
Facebook - http://facebook.com/thedrugclassroom
Twitter - http://twitter.com/drugclassroom
Email -
[email protected]
------------
The Drug Classroom (TDC) is dedicated to providing the type of drug education everyone should have. Drugs are never going to leave our society and there has never been a society free from drugs.
Therefore, it only makes sense to provide real education free from propaganda.
TDC doesn't advocate drug use. Rather, we operate with the intention of reducing the harm some substances can bring.
Feel free to ask questions!
https://wn.com/How_To_Use_Mdma_Safely
MDMA itself is a pretty safe substance if you know how to use it correctly. Sadly, a lot of people are unaware of the simple steps they can take to make their usage safer.
In this video I discuss reagent testing (to make sure you're likely taking MDMA), the drug's acute harm potential, how often it should be used, and "neurotoxicity."
MDMA neurotoxicity page: https://thedrugclassroom.com/video/mdmas-neurotoxicity-research-shows-reduce-risk-detailed/
MDMA neurotoxicity video: https://www.youtube.com/watch?v=OOa5n-DsnDw
MDMA overview page: https://thedrugclassroom.com/video/34-methylenedioxymethamphetamine-mdma/
MDMA overview video: https://www.youtube.com/watch?v=LdTSKZ8-0Mg
MDMA for PTSD video: https://www.youtube.com/watch?v=fX1MXz7BcHs
Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/73txsv/how_to_use_mdma_safely/
------------
Donate to The Drug Classroom:
https://www.patreon.com/TheDrugClassroom
https://www.paypal.me/TheDrugClassroom
Bitcoin: 1HsjCYpBHKcVCaW4uKBraCGkc1LK8xoj1B
------------
Thank you to my Patreon supporters: RollSafe.org, Jonathon Dunn, Thomas Anaya, michael hoogwater, Beau Jaco, Alexander Pavlenko, Lars Nilsson, Billy, Abdulaziz Al-Kuwari, Sam A., Reece hosford, Felix Wisniewski, Jarrod o'connell, Daniel X Moore, Dahmon Bicheno, Christoffer Finstad, Zachary Thomas Binkley, Sami Parsegov, Dane Overman, Squadra Dumay, Dragonhax, Case van der Burg, Alexander Norsk, John Riccardi, Matúš Zdút, Sebastian, Jacob Fournier-Paradis, and David Kernell.
------------
Facebook - http://facebook.com/thedrugclassroom
Twitter - http://twitter.com/drugclassroom
Email -
[email protected]
------------
The Drug Classroom (TDC) is dedicated to providing the type of drug education everyone should have. Drugs are never going to leave our society and there has never been a society free from drugs.
Therefore, it only makes sense to provide real education free from propaganda.
TDC doesn't advocate drug use. Rather, we operate with the intention of reducing the harm some substances can bring.
Feel free to ask questions!
- published: 02 Oct 2017
- views: 386026
2:52
Your Brain On MDMA
Your Brain On MDMA
In this video, we explore the effects of MDMA, also known as ecstasy or molly, on the brain. MDMA is a popular party drug that has gained no...
Your Brain On MDMA
In this video, we explore the effects of MDMA, also known as ecstasy or molly, on the brain. MDMA is a popular party drug that has gained notoriety for its ability to produce feelings of euphoria, empathy, and heightened sensory perception. However, the use of MDMA also carries risks, including potentially serious side effects and long-term damage to the brain. By examining the scientific research on MDMA, we hope to provide viewers with a better understanding of the drug and its potential impact on mental and physical health.
https://wn.com/Your_Brain_On_Mdma
Your Brain On MDMA
In this video, we explore the effects of MDMA, also known as ecstasy or molly, on the brain. MDMA is a popular party drug that has gained notoriety for its ability to produce feelings of euphoria, empathy, and heightened sensory perception. However, the use of MDMA also carries risks, including potentially serious side effects and long-term damage to the brain. By examining the scientific research on MDMA, we hope to provide viewers with a better understanding of the drug and its potential impact on mental and physical health.
- published: 27 Feb 2023
- views: 53424
12:20
MDMA: What No One Told Me
This has been created strictly for education and harm reduction; to help people remain safe by properly educating them about the dangers & truths in a non-bias ...
This has been created strictly for education and harm reduction; to help people remain safe by properly educating them about the dangers & truths in a non-bias way. Thank you.
****************************
~Get a Test Kit: http://tinyurl.com/GetTestKit
~Support us on Patreon: https://goo.gl/EufkcZ
~Instagram: https://bit.ly/3V2Q60l
https://wn.com/Mdma_What_No_One_Told_Me
This has been created strictly for education and harm reduction; to help people remain safe by properly educating them about the dangers & truths in a non-bias way. Thank you.
****************************
~Get a Test Kit: http://tinyurl.com/GetTestKit
~Support us on Patreon: https://goo.gl/EufkcZ
~Instagram: https://bit.ly/3V2Q60l
- published: 12 Oct 2020
- views: 1089497