Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.
Structure
LRP6 is a transmembrane low-density lipoproteinreceptor that shares a similar structure with LRP5. In each protein, about 85% of its 1600-amino-acid length is extracellular. Each has four β-propeller motifs at the amino terminal end that alternate with four epidermal growth factor (EGF)-like repeats. Most extracellular ligands bind to LRP5 and LRP6 at the β-propellers. Each protein has a single-pass, 22-amino-acid segment that crosses the cell membrane and a 207-amino-acid segment that is internal to the cell.
Function
LRP6 acts as a co-receptor with LRP5 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway.
Interactions
Canonical WNT signals are transduced through Frizzled receptor and LRP5/LRP6 coreceptor to downregulate GSK3beta (GSK3B) activity not depending on Ser-9 phosphorylation. Reduction of canonical Wnt signals upon depletion of LRP5 and LRP6 results in p120-catenin degradation.
The LRP1 gene encodes a 600 kDa precursor protein that is processed by furin in the trans-Golgi complex, resulting in a 515 kDa alpha-chain and an 85 kDa beta-chain associated noncovalently. As a member of the LDLR family, LRP1 contains cysteine-rich complement-type repeats, EGF (gene) repeats, β-propeller domains, a transmembrane domain, and a cytoplasmic domain. The cytoplasmic domain of LRP1 is the alpha-chain, which comprises four ligand-binding domains (numbered I-IV) containing two, eight, ten, and eleven cysteine-rich complement-type repeats, respectively. These repeats bind extracellular matrix proteins, growth factors, proteases, protease inhibitorcomplexes, and other proteins involved in lipoproteinmetabolism. Of the four domains, II and IV bind the majority of the protein’s ligands. The EGF repeats and β-propeller domains serve to release ligands in low pH conditions, such as inside endosomes, with the β-propeller postulated to displace the ligand at the ligand binding repeats. The transmembrane domain is the β-chain, which contains a 100-residuecytoplasmic tail. This tail contains two NPxY motifs that are responsible for the protein’s function in endocytosis and signal transduction.
Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5gene. LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.
Structure
LRP5 is a transmembrane low-density lipoproteinreceptor that shares a similar structure with LRP6. In each protein, about 85% of its 1600-amino-acid length is extracellular. Each has four β-propeller motifs at the amino terminal end that alternate with four epidermal growth factor (EGF)-like repeats. Most extracellular ligands bind to LRP5 and LRP6 at the β-propellers. Each protein has a single-pass, 22-amino-acid segment that crosses the cell membrane and a 207-amino-acid segment that is internal to the cell.
Function
LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis.
(NANA HANGNGA) LRP.SZ X YOUNG EMI X OFFICIAL MUSIC VIDEO (prod.@glbbeats5157 )
Recording kakami raihing
https://youtube.com/@kakami.raihing
YOUNG EMI X:https://youtube.com/@youngemixpng
Lyrics 👇
LRP.SZ.
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada(*3)
Changlahor makashok thada ini la mashok
Kha ina nali shuiroi awon thada chansai
Kha nava eli wuklung eina notha haisai
Ewui wuklung hiva nawui mang sasai
YOUNG EMI X
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada
Okathuili wonyur kachungkha lei
Khanawui thada wonyur ina mathei(*2)
Nimshimri hai nawui khon
Thangkachida ina hon
Ewui ningli nawui khon
Nali i ngarai shon
Kazing nala roshon
Kazing nala thang shon
Leikashi ngathor ngayunli
Inali leishi
Ngaya salala mapi ngai
kali vahao ewui ngalem eina
Nali phakazak ipahao
Nana ewui changlahor
Nali theikha ewui ning kahor
Ina hang nga ini l...
LRP 1977 Beef Hash Long Range Patrol Ration MRE Review Military Eaten Oldest Food
http://www.mremarketplace.com/
www.mreinfo.com
https://www.patreon.com/user?u=2821334&ty=h
Howdy, folks! Steve 1989 back again with a nice vintage April 1977 Date of Production LRP Menu # 1 Beef Hash, sent to me by Ruleryak. We delve into this one with brave taste tests of food made the same year as Star Wars episode 4 - A New Hope. This was made 2 years after the Vietnam war and is pretty much the same thing that special forces and recon etc. had to chow down on back in the day.
Hope you guys like the video and this one teaches us that freeze-dried vacuum sealed entrees can last for over 35 years! In this case, it was 38 years old.. and my dinner!
Check out the other awesome MRE Reviewers below:
https://www.youtube.com/channel/UChEqR37txqYozXbbitVDd7A
https://www.youtube.com/user/gsch...
published: 30 Dec 2015
All things hyperpigmentation with Keke Palmer and LRP
Dermatologist Dr Alexis Stephens Talks All things hyperpigmentation with Keke Palmer and La Roche Posay. Learn how to treat and prevent hyperpigmentation with skincare tips from the pros! Updated Hyperpigmentation Series Coming Soon!
published: 02 May 2024
NEW RELEASE! Zeiss LRP S3
This is a full review of the new Zeiss LRP S3 636-56 FFP.
published: 07 Sep 2022
Towards Best Practice in Explaining Neural Network Decisions with LRP (IJCNN 2020)
Within the last decade, neural network based predictors have demonstrated impressive - and at times superhuman - capabilities. This performance is often paid for with an intransparent prediction process and thus has sparked numerous contributions in the novel field of explainable artificial intelligence (XAI). In this paper, we focus on a popular and widely used method of XAI, the Layer-wise Relevance Propagation (LRP). Since its initial proposition LRP has evolved as a method, and a best practice for applying the method has tacitly emerged, based however on humanly observed evidence alone. In this paper we investigate - and for the first time quantify - the effect of this current best practice on feedforward neural networks in a visual object detection setting. The results verify that the...
published: 25 May 2023
Long Range Patrol LRP | Sri Lanka British Soldier Reacts
#SriLanka #LRP #Reaction
Original Video - https://www.youtube.com/watch?v=jZ8wfWmv-90&t=1110s
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published: 17 Oct 2021
LA ROCHE POSAY EFFACLAR DUO+ emptied over three tubes of this moisturiser!! #larocheposay #skincare
published: 02 Nov 2024
Product We LOVE and HATE from La Roche-Posay | Doctorly Reviews
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Disclaimer: This video is not intended to provide diagnosis, treatment, or medical advice. Content provided in this video is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.
00:00 Intro
00:37 Love/Hate Relationship?
01:46 Moisturizers
04:39 Cleansers
06:50 Sunscreens
08:25 Active Ingredients
10:10 The "Worst"
13:20 Wrapping Up
Recording kakami raihing
https://youtube.com/@kakami.raihing
YOUNG EMI X:https://youtube.com/@youngemixpng
Lyrics 👇
LRP.SZ.
Ina hang nga ini leishi sada
Nana ha...
Recording kakami raihing
https://youtube.com/@kakami.raihing
YOUNG EMI X:https://youtube.com/@youngemixpng
Lyrics 👇
LRP.SZ.
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada(*3)
Changlahor makashok thada ini la mashok
Kha ina nali shuiroi awon thada chansai
Kha nava eli wuklung eina notha haisai
Ewui wuklung hiva nawui mang sasai
YOUNG EMI X
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada
Okathuili wonyur kachungkha lei
Khanawui thada wonyur ina mathei(*2)
Nimshimri hai nawui khon
Thangkachida ina hon
Ewui ningli nawui khon
Nali i ngarai shon
Kazing nala roshon
Kazing nala thang shon
Leikashi ngathor ngayunli
Inali leishi
Ngaya salala mapi ngai
kali vahao ewui ngalem eina
Nali phakazak ipahao
Nana ewui changlahor
Nali theikha ewui ning kahor
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada
Recording kakami raihing
https://youtube.com/@kakami.raihing
YOUNG EMI X:https://youtube.com/@youngemixpng
Lyrics 👇
LRP.SZ.
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada(*3)
Changlahor makashok thada ini la mashok
Kha ina nali shuiroi awon thada chansai
Kha nava eli wuklung eina notha haisai
Ewui wuklung hiva nawui mang sasai
YOUNG EMI X
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada
Okathuili wonyur kachungkha lei
Khanawui thada wonyur ina mathei(*2)
Nimshimri hai nawui khon
Thangkachida ina hon
Ewui ningli nawui khon
Nali i ngarai shon
Kazing nala roshon
Kazing nala thang shon
Leikashi ngathor ngayunli
Inali leishi
Ngaya salala mapi ngai
kali vahao ewui ngalem eina
Nali phakazak ipahao
Nana ewui changlahor
Nali theikha ewui ning kahor
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada
http://www.mremarketplace.com/
www.mreinfo.com
https://www.patreon.com/user?u=2821334&ty=h
Howdy, folks! Steve 1989 back again with a nice vintage April 1977 Da...
http://www.mremarketplace.com/
www.mreinfo.com
https://www.patreon.com/user?u=2821334&ty=h
Howdy, folks! Steve 1989 back again with a nice vintage April 1977 Date of Production LRP Menu # 1 Beef Hash, sent to me by Ruleryak. We delve into this one with brave taste tests of food made the same year as Star Wars episode 4 - A New Hope. This was made 2 years after the Vietnam war and is pretty much the same thing that special forces and recon etc. had to chow down on back in the day.
Hope you guys like the video and this one teaches us that freeze-dried vacuum sealed entrees can last for over 35 years! In this case, it was 38 years old.. and my dinner!
Check out the other awesome MRE Reviewers below:
https://www.youtube.com/channel/UChEqR37txqYozXbbitVDd7A
https://www.youtube.com/user/gschultz9
https://www.youtube.com/user/gundog4314
https://www.youtube.com/user/KiwiDudeMRE
https://www.youtube.com/channel/UCspVo4xdz9JPpPV6d6jp9wQ
https://www.youtube.com/channel/UCu0HgxXKhszjd3L_Y8wkt3g
LET'S GET THIS OUT ONTO A TRAY, NICE™
NICE HISS™
I'LL BE COMING BACK AT YOU WITH SOMETHING NEW OR OLD, ALRIGHT COOL SEE YA™
http://www.mremarketplace.com/
www.mreinfo.com
https://www.patreon.com/user?u=2821334&ty=h
Howdy, folks! Steve 1989 back again with a nice vintage April 1977 Date of Production LRP Menu # 1 Beef Hash, sent to me by Ruleryak. We delve into this one with brave taste tests of food made the same year as Star Wars episode 4 - A New Hope. This was made 2 years after the Vietnam war and is pretty much the same thing that special forces and recon etc. had to chow down on back in the day.
Hope you guys like the video and this one teaches us that freeze-dried vacuum sealed entrees can last for over 35 years! In this case, it was 38 years old.. and my dinner!
Check out the other awesome MRE Reviewers below:
https://www.youtube.com/channel/UChEqR37txqYozXbbitVDd7A
https://www.youtube.com/user/gschultz9
https://www.youtube.com/user/gundog4314
https://www.youtube.com/user/KiwiDudeMRE
https://www.youtube.com/channel/UCspVo4xdz9JPpPV6d6jp9wQ
https://www.youtube.com/channel/UCu0HgxXKhszjd3L_Y8wkt3g
LET'S GET THIS OUT ONTO A TRAY, NICE™
NICE HISS™
I'LL BE COMING BACK AT YOU WITH SOMETHING NEW OR OLD, ALRIGHT COOL SEE YA™
Dermatologist Dr Alexis Stephens Talks All things hyperpigmentation with Keke Palmer and La Roche Posay. Learn how to treat and prevent hyperpigmentation with s...
Dermatologist Dr Alexis Stephens Talks All things hyperpigmentation with Keke Palmer and La Roche Posay. Learn how to treat and prevent hyperpigmentation with skincare tips from the pros! Updated Hyperpigmentation Series Coming Soon!
Dermatologist Dr Alexis Stephens Talks All things hyperpigmentation with Keke Palmer and La Roche Posay. Learn how to treat and prevent hyperpigmentation with skincare tips from the pros! Updated Hyperpigmentation Series Coming Soon!
Within the last decade, neural network based predictors have demonstrated impressive - and at times superhuman - capabilities. This performance is often paid fo...
Within the last decade, neural network based predictors have demonstrated impressive - and at times superhuman - capabilities. This performance is often paid for with an intransparent prediction process and thus has sparked numerous contributions in the novel field of explainable artificial intelligence (XAI). In this paper, we focus on a popular and widely used method of XAI, the Layer-wise Relevance Propagation (LRP). Since its initial proposition LRP has evolved as a method, and a best practice for applying the method has tacitly emerged, based however on humanly observed evidence alone. In this paper we investigate - and for the first time quantify - the effect of this current best practice on feedforward neural networks in a visual object detection setting. The results verify that the layer-dependent approach to LRP applied in recent literature better represents the model's reasoning, and at the same time increases the object localization and class discriminativity of LRP.
Find more information here: https://ieeexplore.ieee.org/abstract/document/9206975
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Within the last decade, neural network based predictors have demonstrated impressive - and at times superhuman - capabilities. This performance is often paid for with an intransparent prediction process and thus has sparked numerous contributions in the novel field of explainable artificial intelligence (XAI). In this paper, we focus on a popular and widely used method of XAI, the Layer-wise Relevance Propagation (LRP). Since its initial proposition LRP has evolved as a method, and a best practice for applying the method has tacitly emerged, based however on humanly observed evidence alone. In this paper we investigate - and for the first time quantify - the effect of this current best practice on feedforward neural networks in a visual object detection setting. The results verify that the layer-dependent approach to LRP applied in recent literature better represents the model's reasoning, and at the same time increases the object localization and class discriminativity of LRP.
Find more information here: https://ieeexplore.ieee.org/abstract/document/9206975
Subscribe for more content like this!
Follow us on social media:
LinkedIn: https://de.linkedin.com/company/fraunhofer-hhi
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#SriLanka #LRP #Reaction
Original Video - https://www.youtube.com/watch?v=jZ8wfWmv-90&t=1110s
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#SriLanka #LRP #Reaction
Original Video - https://www.youtube.com/watch?v=jZ8wfWmv-90&t=1110s
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----------------------------------------------------------------------
Disclaimer - Everything you see and I say is all my own personal opinion and I work alone and not with any military organisations.
Copyright Disclaimer: Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.
#SriLanka #LRP #Reaction
Original Video - https://www.youtube.com/watch?v=jZ8wfWmv-90&t=1110s
Join this channel to get access to perks:
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Tactical Warrior Apparel
https://www.tacticalwarriorapparel.com/
Reflex Nutrition Supplements
https://www.reflexnutrition.com
Use Code PTHOLLMAN610
https://healthclasses.com/
Use Code CH40 for 40% Discount
Email me at - [email protected]
Online training and fitness coaching - [email protected]
Instagram
https://www.instagram.com/coachcraighollman/
Tactical Warrior Apparel Instagram https://www.instagram.com/tacticalwarriorapparel/
British Army
https://www.army.mod.uk
Household Cavalry For the Household Cavalry
https://www.army.mod.uk/who-we-are/corps-regiments-and-units/royal-armoured-corps/household-cavalry/
----------------------------------------------------------------------
Disclaimer - Everything you see and I say is all my own personal opinion and I work alone and not with any military organisations.
Copyright Disclaimer: Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.
*Shop Favorite Skincare Products*
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20% Off Paula's ...
*Shop Favorite Skincare Products*
Shop My Shelf: https://shopmyshelf.us/shops/dermdoctor
Amazon Favorites: https://www.amazon.com/shop/doctorly
20% Off Paula's Choice: https://www.tkqlhce.com/click-100667849-15267262
Shop SkinBetter Science: https://skinbetter.pro/doctorly
*Affiliate Links Generate Revenue for the Channel*
Disclaimer: This video is not intended to provide diagnosis, treatment, or medical advice. Content provided in this video is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.
00:00 Intro
00:37 Love/Hate Relationship?
01:46 Moisturizers
04:39 Cleansers
06:50 Sunscreens
08:25 Active Ingredients
10:10 The "Worst"
13:20 Wrapping Up
*Shop Favorite Skincare Products*
Shop My Shelf: https://shopmyshelf.us/shops/dermdoctor
Amazon Favorites: https://www.amazon.com/shop/doctorly
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Shop SkinBetter Science: https://skinbetter.pro/doctorly
*Affiliate Links Generate Revenue for the Channel*
Disclaimer: This video is not intended to provide diagnosis, treatment, or medical advice. Content provided in this video is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.
00:00 Intro
00:37 Love/Hate Relationship?
01:46 Moisturizers
04:39 Cleansers
06:50 Sunscreens
08:25 Active Ingredients
10:10 The "Worst"
13:20 Wrapping Up
Recording kakami raihing
https://youtube.com/@kakami.raihing
YOUNG EMI X:https://youtube.com/@youngemixpng
Lyrics 👇
LRP.SZ.
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada(*3)
Changlahor makashok thada ini la mashok
Kha ina nali shuiroi awon thada chansai
Kha nava eli wuklung eina notha haisai
Ewui wuklung hiva nawui mang sasai
YOUNG EMI X
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada
Okathuili wonyur kachungkha lei
Khanawui thada wonyur ina mathei(*2)
Nimshimri hai nawui khon
Thangkachida ina hon
Ewui ningli nawui khon
Nali i ngarai shon
Kazing nala roshon
Kazing nala thang shon
Leikashi ngathor ngayunli
Inali leishi
Ngaya salala mapi ngai
kali vahao ewui ngalem eina
Nali phakazak ipahao
Nana ewui changlahor
Nali theikha ewui ning kahor
Ina hang nga ini leishi sada
Nana hang nga ini kaihao sada
http://www.mremarketplace.com/
www.mreinfo.com
https://www.patreon.com/user?u=2821334&ty=h
Howdy, folks! Steve 1989 back again with a nice vintage April 1977 Date of Production LRP Menu # 1 Beef Hash, sent to me by Ruleryak. We delve into this one with brave taste tests of food made the same year as Star Wars episode 4 - A New Hope. This was made 2 years after the Vietnam war and is pretty much the same thing that special forces and recon etc. had to chow down on back in the day.
Hope you guys like the video and this one teaches us that freeze-dried vacuum sealed entrees can last for over 35 years! In this case, it was 38 years old.. and my dinner!
Check out the other awesome MRE Reviewers below:
https://www.youtube.com/channel/UChEqR37txqYozXbbitVDd7A
https://www.youtube.com/user/gschultz9
https://www.youtube.com/user/gundog4314
https://www.youtube.com/user/KiwiDudeMRE
https://www.youtube.com/channel/UCspVo4xdz9JPpPV6d6jp9wQ
https://www.youtube.com/channel/UCu0HgxXKhszjd3L_Y8wkt3g
LET'S GET THIS OUT ONTO A TRAY, NICE™
NICE HISS™
I'LL BE COMING BACK AT YOU WITH SOMETHING NEW OR OLD, ALRIGHT COOL SEE YA™
Dermatologist Dr Alexis Stephens Talks All things hyperpigmentation with Keke Palmer and La Roche Posay. Learn how to treat and prevent hyperpigmentation with skincare tips from the pros! Updated Hyperpigmentation Series Coming Soon!
Within the last decade, neural network based predictors have demonstrated impressive - and at times superhuman - capabilities. This performance is often paid for with an intransparent prediction process and thus has sparked numerous contributions in the novel field of explainable artificial intelligence (XAI). In this paper, we focus on a popular and widely used method of XAI, the Layer-wise Relevance Propagation (LRP). Since its initial proposition LRP has evolved as a method, and a best practice for applying the method has tacitly emerged, based however on humanly observed evidence alone. In this paper we investigate - and for the first time quantify - the effect of this current best practice on feedforward neural networks in a visual object detection setting. The results verify that the layer-dependent approach to LRP applied in recent literature better represents the model's reasoning, and at the same time increases the object localization and class discriminativity of LRP.
Find more information here: https://ieeexplore.ieee.org/abstract/document/9206975
Subscribe for more content like this!
Follow us on social media:
LinkedIn: https://de.linkedin.com/company/fraunhofer-hhi
Twitter: https://twitter.com/FraunhoferHHI
Instagram: https://www.instagram.com/fraunhofer_hhi/
#SriLanka #LRP #Reaction
Original Video - https://www.youtube.com/watch?v=jZ8wfWmv-90&t=1110s
Join this channel to get access to perks:
https://www.youtube.com/channel/UCPT6dAoVB1lZXM4WuGwIxjw/join
Amazon Shop - See what items I recommend https://www.amazon.co.uk/shop/craighollman?ref=cm_sw_em_r_inf_own_craighollman_dp_eHUqFesPDaD6E
Tactical Warrior Apparel
https://www.tacticalwarriorapparel.com/
Reflex Nutrition Supplements
https://www.reflexnutrition.com
Use Code PTHOLLMAN610
https://healthclasses.com/
Use Code CH40 for 40% Discount
Email me at - [email protected]
Online training and fitness coaching - [email protected]
Instagram
https://www.instagram.com/coachcraighollman/
Tactical Warrior Apparel Instagram https://www.instagram.com/tacticalwarriorapparel/
British Army
https://www.army.mod.uk
Household Cavalry For the Household Cavalry
https://www.army.mod.uk/who-we-are/corps-regiments-and-units/royal-armoured-corps/household-cavalry/
----------------------------------------------------------------------
Disclaimer - Everything you see and I say is all my own personal opinion and I work alone and not with any military organisations.
Copyright Disclaimer: Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.
*Shop Favorite Skincare Products*
Shop My Shelf: https://shopmyshelf.us/shops/dermdoctor
Amazon Favorites: https://www.amazon.com/shop/doctorly
20% Off Paula's Choice: https://www.tkqlhce.com/click-100667849-15267262
Shop SkinBetter Science: https://skinbetter.pro/doctorly
*Affiliate Links Generate Revenue for the Channel*
Disclaimer: This video is not intended to provide diagnosis, treatment, or medical advice. Content provided in this video is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.
00:00 Intro
00:37 Love/Hate Relationship?
01:46 Moisturizers
04:39 Cleansers
06:50 Sunscreens
08:25 Active Ingredients
10:10 The "Worst"
13:20 Wrapping Up
Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.
Structure
LRP6 is a transmembrane low-density lipoproteinreceptor that shares a similar structure with LRP5. In each protein, about 85% of its 1600-amino-acid length is extracellular. Each has four β-propeller motifs at the amino terminal end that alternate with four epidermal growth factor (EGF)-like repeats. Most extracellular ligands bind to LRP5 and LRP6 at the β-propellers. Each protein has a single-pass, 22-amino-acid segment that crosses the cell membrane and a 207-amino-acid segment that is internal to the cell.
Function
LRP6 acts as a co-receptor with LRP5 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway.
Interactions
Canonical WNT signals are transduced through Frizzled receptor and LRP5/LRP6 coreceptor to downregulate GSK3beta (GSK3B) activity not depending on Ser-9 phosphorylation. Reduction of canonical Wnt signals upon depletion of LRP5 and LRP6 results in p120-catenin degradation.
[Chorus] Life, Liberty, Righteousness, and the puruist thereof It's tight, might just get, too rough to travel this road But it's good to know, that for my soul, Christ is in control Life, Liberty, Righteousness, and the puruist thereof It's tight, might just get, too tough to travel this road But it's good to know, that for my soul, Christ is in control [T.R.U-L.I.F.E.] Since the beginning of my life wit Christ its been shady Im not crazy, my light hasn't been bright but hazy Dimmed my desires within and fulfilment of my flesh And best, let's just call it sin It is what it is, so Ima deal wit this thing Put my biz in the street but be real for the king Even if it kills me, cause I've got a strange feelin Some will draw close, and others wont cause quite revealin Dont worry Im not mentionin names or situations Just makin in plain wit some internal observations Keepin it straight wit all the points that Im statin So you dont get tossed, fooled or twisted by Satan Now take it [Chorus] [2x] [T.R.U-L.I.F.E.] The wild things is, Ive been actin my childish But Im a king's kid, so there's no hints of foulness But such a loudness, that its clearly unmistakable My Lord and Savior subjected Himself to a breakable Shell that would be impaled, nailed but would rip the vale And provide a detour for those on their way to hell Not to tell, well that would not do Him any justice Like me for eternity, many have entrusted Themselves to His plan, His hand is fool proof All God and all man, stands together as pure truth I fall face in hand, His cures from the root Cleans from the heart, makes a man new I've seen what He can do [Chorus] [2x] [T.R.U-L.I.F.E.] I've had a sob story for a long time But this aint bout a kid, who trippedup, fell down or lagged behind But a story of one whose overcome, wit and by the Son Spit fire wit the tongue, lift Messiah til Im done The war's be done, but the battle jus begun Victory has I run persevere' cause Christ hung Breath left His lung, death poked fun And the King ressurected and guess what? Death got thumped! No longer wit the power to slump A man if he believes, he cant be plucked From the hand of the son Who to trust, and why do you trust this One? And when your physicals don? Have they told you what comes? Life is more then just money, sex, drugs and guns I know it dont sound fun but Ive got the right One And when I do die, my life has just begun How could I ever forget the dust is where Im from? To the face of opposition I laught It's been engrafted My righteousness is part of this total package And so is my eternal secruity That's why in all things I do now you can see me chasin purity Goodness, gratefulness, lovein-kindness To live a live of liberty and righteousness for his Highness I see Lord, thanks for removin all the blindness And pressin this coal into an H-Class diamond [Chorus]
LRP involves the use of specialised instruments including 3D camera to remove the prostate gland ... “The introduction of LRP reflects our dedication to offering state-of-the-art treatments that prioritise patient comfort with improved outcomes.”.
"The LRP tool will fit seamlessly into our members' workflows simplifying the process of obtaining loss run data," said Christian Rebello, regional manager in Iroquois' Midwest region ... LRP simplifies ...
"The LRP tool will fit seamlessly into our members' workflows simplifying the process of obtaining loss run data," said Christian Rebello, regional manager in Iroquois' Midwest region ... LRP is a simple and easy-to-use subscription software service.
WRITER, broadcast journalist and entrepreneur Quinto Jose Pastrana founded the LibraryRenewalPartnership (LRP) in 2010... The LRP libraries are found in poor areas of the country, including the ancestral domains where the IPs live.
(MENAFN - PR Newswire) NEW YORK, Oct. 13, 2022 /PRNewswire/ -- LRPMediaGroup's HR Tech and Ed Tech B2B event and digital media portfolios have been sold to Arc, backed by investment funds managed ... .
13, 2022 /PRNewswire/ -- LRPMediaGroup's HR Tech and Ed Tech B2B event and digital media portfolios have been sold to Arc, backed by investment funds managed by EagleTree Capital. LRP Media Group, ...