Jagged is the eighteenth studio album by the musician Gary Numan, his first original album in over five years, following Pure in 2000. Stylistically Jagged was a development of its predecessor's chorus-driven, anthemic industrial sound, utilising heavier electronics and more prominent live drumming. Although reaction to the new record was predominantly positive, critical opinion was more heavily divided than had been the case with the almost universal praise enjoyed by Pure. Reaching number 59 in the UK album charts, Jagged charted no higher than the earlier release, some commentators and fans regarding the long time between albums as a missed opportunity for consolidation in the wake of Pure's reception and the number 13 UK chart position attained by Numan's 2003 single with Rico, "Crazier". Jagged was the first album issued on Numan's own Mortal Records label, licensed to Cooking Vinyl. The US release, on Metropolis Records, included an alternate mix of "Fold" as a bonus track. In April Numan embarked on a tour of the UK, Europe and North America to promote the album.
International Wrestling Syndicate (2004–2010, 2014–present)
2.0 began working for Montreal, Quebec-based International Wrestling Syndicate (IWS) in June 2004. For the first six months in the promotion, Jagged and Shane Matthews worked as faces, but on January 2005 2.0 turned heel at a Northern Championship Wrestling (NCW) co-promoted event with IWS. On March 26, 2005, 2.0 received their first shot at the IWS Tag Team Championship, but were unable to dethrone the defending champions the Flying Hurricanes (Kenny the Bastard and Takao) in a four-way match, which also included SLI (Marc Le Grizzly and Viking) and the Wrecking Crew (Chris Wells and Tomassino). 2.0 received a rematch for the titles on July 9, 2005, during IWS' first, and only, show at The Arena in Philadelphia, but managed to defeat the Flying Hurricanes only via countout, which meant that they didn't win the championship. This set up a rubber match for August 20, when 2.0 finally defeated the Flying Hurricanes to win the IWS Tag Team Championship.
Jagged1 (JAG1) is one of five cell surface proteins (ligands) that interact with 4 receptors in the mammalian Notch signaling pathway. The Notch Signaling Pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems. Once the JAG1-NOTCH (receptor-ligand) interactions take place, a cascade of proteolytic cleavages is triggered resulting in activation of the transcription for downstream target genes. Located on human chromosome 20, the JAG1 gene is expressed in multiple organ systems in the body and causes the autosomal dominant disorder Alagille syndrome (ALGS) resulting from loss of function mutations within the gene. JAG1 has also been designated as CD339 (cluster of differentiation 339).
Structure and function
JAG1 was first identified as a ligand that was able to activate notch receptors when it was cloned in the mammalian rat in 1995. It is located at cytogenetic location 20p12.2 and genomic location (GRCh37) chr20:10,618,331-10,654,693 on the human chromosome 20. The structure of the JAG1 protein includes a small intracellular component, a transmembrane motif, proceeded by an extracellular region containing a cystine-rich region, 16 EGF-like repeats, a DSL domain, and finally a signal peptide totaling 1218 amino acids in length over 26 coding exons.
Something calls me From a dark place And so I pray every night Something knows me It whispers my name And I'm losing my faith I can feel it breathing But it feels like something dead and cold I can feel it waiting But it waits for something in my soul Sometimes I call out for you, and sometimes I'm afraid So I beg God For salvation, for an angel Every night And I ask God Can He forgive me? And I want to believe I think I hear it laughing But it sounds like my voice lost and old I think it showed me Heaven And now I know why I'm scared to die Am I a fool in the dark, I don't know Am I the ghost in my dreams, I don't know Am I a shadow of life, I don't know Am I afraid of the truth, I don't know Sometimes I call out for you, and sometimes I'm afraid So I ask for One small mercy? But it whispers 'Who are you?' So I ask God If He can save me?
The Jets, Browns and Jaguars will each serve as the home team for games in London next season as part of the NFL's growing slate of international play ... .
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The Citizens
10 Jan 2025
The Citizens
10 Jan 2025