Hereditary breast–ovarian cancer syndromes (HBOC) are cancer syndromes that produce higher than normal levels of breast cancer and ovarian cancer in genetically related families (either one individual had both, or several individuals in the pedigree had one or the other disease). The hereditary factors may be proven or suspected to cause the pattern of breast and ovarian cancer occurrences in the family.
Hereditary causes
Approximate proportion of hereditary breast cancer cases caused by each gene
A number of genes are associated with HBOC. The most common of the known causes of HBOC are:
BRCA mutations: Harmful mutations in the BRCA1 and BRCA2 genes can produce very high rates of breast and ovarian cancer, as well as increased rates of other cancers.
Other identified genes include:
TP53: Mutations cause Li-Fraumeni syndrome. It produces particularly high rates of breast cancer among younger women with mutated genes, and despite being rare, 4% of women with breast cancer under age 30 have a mutation in this gene.
A cancer syndrome or family cancer syndrome is a genetic disorder in which inherited genetic mutations in one or more genes predispose the affected individuals to the development of cancers and may also cause the early onset of these cancers. Cancer syndromes often show not only a high lifetime risk of developing cancer, but also the development of multiple independent primary tumors. Many of these syndromes are caused by mutations in tumor suppressor genes, genes that are involved in protecting the cell from turning cancerous. Other genes that may be affected are DNA repair genes, oncogenes and genes involved in the production of blood vessels (angiogenesis). Common examples of inherited cancer syndromes are hereditary breast-ovarian cancer syndrome and hereditary non-polyposis colon cancer (Lynch syndrome).
Background
Hereditary cancer syndromes underlie 5 to 10% of all cancers. Scientific understanding of cancer susceptibility syndromes is actively expanding: additional syndromes are being found, the underlying biology is becoming clearer, and commercialization of diagnostic genetics methodology is improving clinical access. Given the prevalence of breast and colon cancer, the most widely recognized syndromes include hereditary breast-ovarian cancer syndrome (HBOC) and hereditary non-polyposis colon cancer (HNPCC, Lynch syndrome).
Hereditary Breast-Ovarian Syndromes (BRCA, Lynch syndrome, Li Fraumeni, Cowden, Peutz-Jeghers) | ♋️ Oncology | Pathology Series of Lectures | Hereditary Cancer Syndromes | Clinical Biochemistry.
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published: 21 Mar 2023
Hereditary Breast and Ovarian Cancers: Should I Seek Genetic Testing?
BRCA testing is not something every woman needs. Cancer genetic specialist Cecelia Bellcross, Ph.D., M.S., C.G.C., explains the basic criteria that would warrant a genetic test.
published: 08 Oct 2014
1. Basics of Hereditary Breast and Ovarian Cancer
published: 26 May 2020
Hereditary Breast and Ovarian Cancer Treatment Program
Led by June Hou, MD, a gynecologic oncologist in the Department of Obstetrics and Gynecology, and Meghna Trivedi, MD, a breast oncologist in the Department of Medicine, the Hereditary Breast and Ovarian Cancer Program aims to empower women with knowledge about their individualized risk and to provide seamless integration of diagnostic testing, risk-reducing strategies, and clinical research trials to achieve a personalized strategy for cancer prevention and treatment.
published: 15 Nov 2018
BRCA1 and BRCA2 Mutations & Cancer (Types of Cancer, and Who’s Most At Risk)
REUPLOADING TO FIX VIDEO ISSUE
BRCA1 and BRCA2 Mutations & Cancer (Types of Cancer, and Who’s Most At Risk)
BRCA1 and BRCA2 are genes involved in DNA repair and other important functions. However, mutations in BRCA1 and BRCA2 increase the risk of different types of cancer, including breast and ovarian cancer. In this lesson, we discuss the roles of normal functioning BRCA, different patient populations most at risk, different mutations, and different types of associated cancer.
I hope you find this lesson helpful. If you do, please like and subscribe for more lessons like this one!
JJ
**MEDICAL LEGAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in...
published: 27 Jul 2022
What is Hereditary Breast and Ovarian Cancer Syndrome?
According to InformedDNA Vice President of Cancer Genetics Services Jana Pruski-Clark, only 10% of breast cancer is hereditary.
The most common form of hereditary breast cancer is simply called Hereditary Breast and Ovarian Cancer Syndrome or HBOC for short.
But what is HBOC?
Having HBOC can increase a patient’s risk of developing breast cancer. But unfortunately, this isn’t the only type of cancer a patient might have an increased risk for. They have a significantly increased risk of developing ovarian cancer too.
Find out more about Hereditary Breast and Ovarian Cancer Syndrome in the video below.
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published: 26 Jan 2015
Hereditary Breast And Ovarian Cancer Syndrome (HBOC)
Recurrent breast cancer caused by a BRCA2 gene mutation.
Health Nucleus helped a female patient with recurrent breast cancer to identify a BRCA2 variant. The identification of the BRCA2 variant assist the clinical diagnosis of hereditary breast and ovarian cancer syndrome (HBOC) in this patient. Risks for people with BRCA2 variants include breast, ovarian, pancreatic, prostate, and melanoma cancer.
HN's Chief Medical Officer, C. Thomas Caskey, MD, FACP, FACMG, FRSC, explains how to extend a single diagnosis to identify six family member who are at risk. HLI was able to reach out to the patient and patient’s family members and have these patients under care for disease prevention. Targeted therapies such as Olaparib (Lynparza) and talazoparib (Talzenna) are available for patients with ...
published: 09 Apr 2020
E15.2 Variant interpretation in Hereditary Breast and Ovarian Cancer Syndrome Patients Lessons Learn
published: 20 Jul 2020
Hereditary Breast and Ovarian Cancer in the Jewish Community
Did you know that people of Ashkenazi Jewish ancestry have a 1 in 40 chance of carrying a BRCA gene mutation, putting them increased risk for breast and ovarian cancer? Basser Research Center patients discuss their BRCA journeys.
published: 05 Dec 2013
Hereditary Breast and Ovarian Cancer in Public Health
Background: It is estimated that 1 in 300-500 people in the United States are affected by hereditary breast and ovarian cancer syndrome (HBOC), a genetic condition that predisposes individuals to developing cancer in various tissues. From Angelina Jolie’s diagnosis as a BRCA mutation carrier to the Supreme Court ruling on gene patents, HBOC has received a great deal of attention in the media recently. However, the condition continues to be underdiagnosed and genetic services that can reduce risk and identify cancers earlier are often overlooked. Using the numerous screening tools, guidelines and recommendations currently available for HBOC would save lives.
Appropriate management of individuals with HBOC can significantly reduce morbidity and mortality in this population. Therefore, an i...
Hereditary Breast-Ovarian Syndromes (BRCA, Lynch syndrome, Li Fraumeni, Cowden, Peutz-Jeghers) | ♋️ Oncology | Pathology Series of Lectures | Hereditary Cancer ...
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BRCA testing is not something every woman needs. Cancer genetic specialist Cecelia Bellcross, Ph.D., M.S., C.G.C., explains the basic criteria that would warran...
BRCA testing is not something every woman needs. Cancer genetic specialist Cecelia Bellcross, Ph.D., M.S., C.G.C., explains the basic criteria that would warrant a genetic test.
BRCA testing is not something every woman needs. Cancer genetic specialist Cecelia Bellcross, Ph.D., M.S., C.G.C., explains the basic criteria that would warrant a genetic test.
Led by June Hou, MD, a gynecologic oncologist in the Department of Obstetrics and Gynecology, and Meghna Trivedi, MD, a breast oncologist in the Department of M...
Led by June Hou, MD, a gynecologic oncologist in the Department of Obstetrics and Gynecology, and Meghna Trivedi, MD, a breast oncologist in the Department of Medicine, the Hereditary Breast and Ovarian Cancer Program aims to empower women with knowledge about their individualized risk and to provide seamless integration of diagnostic testing, risk-reducing strategies, and clinical research trials to achieve a personalized strategy for cancer prevention and treatment.
Led by June Hou, MD, a gynecologic oncologist in the Department of Obstetrics and Gynecology, and Meghna Trivedi, MD, a breast oncologist in the Department of Medicine, the Hereditary Breast and Ovarian Cancer Program aims to empower women with knowledge about their individualized risk and to provide seamless integration of diagnostic testing, risk-reducing strategies, and clinical research trials to achieve a personalized strategy for cancer prevention and treatment.
REUPLOADING TO FIX VIDEO ISSUE
BRCA1 and BRCA2 Mutations & Cancer (Types of Cancer, and Who’s Most At Risk)
BRCA1 and BRCA2 are genes involved in DNA repair a...
REUPLOADING TO FIX VIDEO ISSUE
BRCA1 and BRCA2 Mutations & Cancer (Types of Cancer, and Who’s Most At Risk)
BRCA1 and BRCA2 are genes involved in DNA repair and other important functions. However, mutations in BRCA1 and BRCA2 increase the risk of different types of cancer, including breast and ovarian cancer. In this lesson, we discuss the roles of normal functioning BRCA, different patient populations most at risk, different mutations, and different types of associated cancer.
I hope you find this lesson helpful. If you do, please like and subscribe for more lessons like this one!
JJ
**MEDICAL LEGAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
*AFFILIATE DISCLAIMER: This YouTube Channel uses affiliate links and may earn a commission from associated sales.
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REUPLOADING TO FIX VIDEO ISSUE
BRCA1 and BRCA2 Mutations & Cancer (Types of Cancer, and Who’s Most At Risk)
BRCA1 and BRCA2 are genes involved in DNA repair and other important functions. However, mutations in BRCA1 and BRCA2 increase the risk of different types of cancer, including breast and ovarian cancer. In this lesson, we discuss the roles of normal functioning BRCA, different patient populations most at risk, different mutations, and different types of associated cancer.
I hope you find this lesson helpful. If you do, please like and subscribe for more lessons like this one!
JJ
**MEDICAL LEGAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
*AFFILIATE DISCLAIMER: This YouTube Channel uses affiliate links and may earn a commission from associated sales.
*IMAGE DISCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and are intended for educational/teaching purposes only*
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https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
According to InformedDNA Vice President of Cancer Genetics Services Jana Pruski-Clark, only 10% of breast cancer is hereditary.
The most common form of heredi...
According to InformedDNA Vice President of Cancer Genetics Services Jana Pruski-Clark, only 10% of breast cancer is hereditary.
The most common form of hereditary breast cancer is simply called Hereditary Breast and Ovarian Cancer Syndrome or HBOC for short.
But what is HBOC?
Having HBOC can increase a patient’s risk of developing breast cancer. But unfortunately, this isn’t the only type of cancer a patient might have an increased risk for. They have a significantly increased risk of developing ovarian cancer too.
Find out more about Hereditary Breast and Ovarian Cancer Syndrome in the video below.
SUBSCRIBE FOR MORE EXPERT INFORMATION AND BREAKING BREAST CANCER NEWS
http://www.youtube.com/user/drjayharness
VISIT BREASTCANCERANSWERS.com FOR THE LATEST IN BREAKING BREAST CANCER NEWS
http://www.breastcanceranswers.com/news
SUBMIT A QUESTION
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Facebook: https://www.facebook.com/BreastCancerAnswers
Twitter: https://twitter.com/BreastCancerDr
According to InformedDNA Vice President of Cancer Genetics Services Jana Pruski-Clark, only 10% of breast cancer is hereditary.
The most common form of hereditary breast cancer is simply called Hereditary Breast and Ovarian Cancer Syndrome or HBOC for short.
But what is HBOC?
Having HBOC can increase a patient’s risk of developing breast cancer. But unfortunately, this isn’t the only type of cancer a patient might have an increased risk for. They have a significantly increased risk of developing ovarian cancer too.
Find out more about Hereditary Breast and Ovarian Cancer Syndrome in the video below.
SUBSCRIBE FOR MORE EXPERT INFORMATION AND BREAKING BREAST CANCER NEWS
http://www.youtube.com/user/drjayharness
VISIT BREASTCANCERANSWERS.com FOR THE LATEST IN BREAKING BREAST CANCER NEWS
http://www.breastcanceranswers.com/news
SUBMIT A QUESTION
http://www.breastcanceranswers.com/
DOWNLOAD DR. HARNESS' 15 QUESTIONS TO ASK YOUR DOCTOR
http://www.breastcanceranswers.com/
CONNECT WITH US!
Google+: http://bit.ly/16nhEnr
Facebook: https://www.facebook.com/BreastCancerAnswers
Twitter: https://twitter.com/BreastCancerDr
Recurrent breast cancer caused by a BRCA2 gene mutation.
Health Nucleus helped a female patient with recurrent breast cancer to identify a BRCA2 variant. The ...
Recurrent breast cancer caused by a BRCA2 gene mutation.
Health Nucleus helped a female patient with recurrent breast cancer to identify a BRCA2 variant. The identification of the BRCA2 variant assist the clinical diagnosis of hereditary breast and ovarian cancer syndrome (HBOC) in this patient. Risks for people with BRCA2 variants include breast, ovarian, pancreatic, prostate, and melanoma cancer.
HN's Chief Medical Officer, C. Thomas Caskey, MD, FACP, FACMG, FRSC, explains how to extend a single diagnosis to identify six family member who are at risk. HLI was able to reach out to the patient and patient’s family members and have these patients under care for disease prevention. Targeted therapies such as Olaparib (Lynparza) and talazoparib (Talzenna) are available for patients with BRCA mutations.
“Health Nucleus—where early detection and preventative care can help reduce long-term health risks to help you live a longer, healthier life.”
Subscribe to our channel: http://bit.ly/healthnucleus
Learn more about Health Nucleus:
https://www.healthnucleus.com
844-838-3322
[email protected]
Follow:
Twitter - https://twitter.com/humanlongevity and https://twitter.com/HealthNucleus
LinkedIn – https://www.linkedin.com/company/human-longevity-inc-/
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Facebook - https://www.facebook.com/humanlongevity/
Recurrent breast cancer caused by a BRCA2 gene mutation.
Health Nucleus helped a female patient with recurrent breast cancer to identify a BRCA2 variant. The identification of the BRCA2 variant assist the clinical diagnosis of hereditary breast and ovarian cancer syndrome (HBOC) in this patient. Risks for people with BRCA2 variants include breast, ovarian, pancreatic, prostate, and melanoma cancer.
HN's Chief Medical Officer, C. Thomas Caskey, MD, FACP, FACMG, FRSC, explains how to extend a single diagnosis to identify six family member who are at risk. HLI was able to reach out to the patient and patient’s family members and have these patients under care for disease prevention. Targeted therapies such as Olaparib (Lynparza) and talazoparib (Talzenna) are available for patients with BRCA mutations.
“Health Nucleus—where early detection and preventative care can help reduce long-term health risks to help you live a longer, healthier life.”
Subscribe to our channel: http://bit.ly/healthnucleus
Learn more about Health Nucleus:
https://www.healthnucleus.com
844-838-3322
[email protected]
Follow:
Twitter - https://twitter.com/humanlongevity and https://twitter.com/HealthNucleus
LinkedIn – https://www.linkedin.com/company/human-longevity-inc-/
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Did you know that people of Ashkenazi Jewish ancestry have a 1 in 40 chance of carrying a BRCA gene mutation, putting them increased risk for breast and ovarian...
Did you know that people of Ashkenazi Jewish ancestry have a 1 in 40 chance of carrying a BRCA gene mutation, putting them increased risk for breast and ovarian cancer? Basser Research Center patients discuss their BRCA journeys.
Did you know that people of Ashkenazi Jewish ancestry have a 1 in 40 chance of carrying a BRCA gene mutation, putting them increased risk for breast and ovarian cancer? Basser Research Center patients discuss their BRCA journeys.
Background: It is estimated that 1 in 300-500 people in the United States are affected by hereditary breast and ovarian cancer syndrome (HBOC), a genetic condit...
Background: It is estimated that 1 in 300-500 people in the United States are affected by hereditary breast and ovarian cancer syndrome (HBOC), a genetic condition that predisposes individuals to developing cancer in various tissues. From Angelina Jolie’s diagnosis as a BRCA mutation carrier to the Supreme Court ruling on gene patents, HBOC has received a great deal of attention in the media recently. However, the condition continues to be underdiagnosed and genetic services that can reduce risk and identify cancers earlier are often overlooked. Using the numerous screening tools, guidelines and recommendations currently available for HBOC would save lives.
Appropriate management of individuals with HBOC can significantly reduce morbidity and mortality in this population. Therefore, an integrated public health approach focused on the identification of individuals at risk for HBOC is critical to impacting health outcomes of individuals and families.
Objective: This webinar will highlight real world examples of successful programs that address HBOC, describe available screening tools and other resources related to HBOC and provide patient perspectives on the importance of identifying individuals and families with HBOC.
Audience: Public health professionals, primary care clinicians, oncologists, and other healthcare professionals involved in cancer, genetics or chronic disease prevention are encouraged to participate in this webinar.
Background: It is estimated that 1 in 300-500 people in the United States are affected by hereditary breast and ovarian cancer syndrome (HBOC), a genetic condition that predisposes individuals to developing cancer in various tissues. From Angelina Jolie’s diagnosis as a BRCA mutation carrier to the Supreme Court ruling on gene patents, HBOC has received a great deal of attention in the media recently. However, the condition continues to be underdiagnosed and genetic services that can reduce risk and identify cancers earlier are often overlooked. Using the numerous screening tools, guidelines and recommendations currently available for HBOC would save lives.
Appropriate management of individuals with HBOC can significantly reduce morbidity and mortality in this population. Therefore, an integrated public health approach focused on the identification of individuals at risk for HBOC is critical to impacting health outcomes of individuals and families.
Objective: This webinar will highlight real world examples of successful programs that address HBOC, describe available screening tools and other resources related to HBOC and provide patient perspectives on the importance of identifying individuals and families with HBOC.
Audience: Public health professionals, primary care clinicians, oncologists, and other healthcare professionals involved in cancer, genetics or chronic disease prevention are encouraged to participate in this webinar.
Hereditary Breast-Ovarian Syndromes (BRCA, Lynch syndrome, Li Fraumeni, Cowden, Peutz-Jeghers) | ♋️ Oncology | Pathology Series of Lectures | Hereditary Cancer Syndromes | Clinical Biochemistry.
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BRCA testing is not something every woman needs. Cancer genetic specialist Cecelia Bellcross, Ph.D., M.S., C.G.C., explains the basic criteria that would warrant a genetic test.
Led by June Hou, MD, a gynecologic oncologist in the Department of Obstetrics and Gynecology, and Meghna Trivedi, MD, a breast oncologist in the Department of Medicine, the Hereditary Breast and Ovarian Cancer Program aims to empower women with knowledge about their individualized risk and to provide seamless integration of diagnostic testing, risk-reducing strategies, and clinical research trials to achieve a personalized strategy for cancer prevention and treatment.
REUPLOADING TO FIX VIDEO ISSUE
BRCA1 and BRCA2 Mutations & Cancer (Types of Cancer, and Who’s Most At Risk)
BRCA1 and BRCA2 are genes involved in DNA repair and other important functions. However, mutations in BRCA1 and BRCA2 increase the risk of different types of cancer, including breast and ovarian cancer. In this lesson, we discuss the roles of normal functioning BRCA, different patient populations most at risk, different mutations, and different types of associated cancer.
I hope you find this lesson helpful. If you do, please like and subscribe for more lessons like this one!
JJ
**MEDICAL LEGAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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*Check Out Some of My Other Lessons*
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
According to InformedDNA Vice President of Cancer Genetics Services Jana Pruski-Clark, only 10% of breast cancer is hereditary.
The most common form of hereditary breast cancer is simply called Hereditary Breast and Ovarian Cancer Syndrome or HBOC for short.
But what is HBOC?
Having HBOC can increase a patient’s risk of developing breast cancer. But unfortunately, this isn’t the only type of cancer a patient might have an increased risk for. They have a significantly increased risk of developing ovarian cancer too.
Find out more about Hereditary Breast and Ovarian Cancer Syndrome in the video below.
SUBSCRIBE FOR MORE EXPERT INFORMATION AND BREAKING BREAST CANCER NEWS
http://www.youtube.com/user/drjayharness
VISIT BREASTCANCERANSWERS.com FOR THE LATEST IN BREAKING BREAST CANCER NEWS
http://www.breastcanceranswers.com/news
SUBMIT A QUESTION
http://www.breastcanceranswers.com/
DOWNLOAD DR. HARNESS' 15 QUESTIONS TO ASK YOUR DOCTOR
http://www.breastcanceranswers.com/
CONNECT WITH US!
Google+: http://bit.ly/16nhEnr
Facebook: https://www.facebook.com/BreastCancerAnswers
Twitter: https://twitter.com/BreastCancerDr
Recurrent breast cancer caused by a BRCA2 gene mutation.
Health Nucleus helped a female patient with recurrent breast cancer to identify a BRCA2 variant. The identification of the BRCA2 variant assist the clinical diagnosis of hereditary breast and ovarian cancer syndrome (HBOC) in this patient. Risks for people with BRCA2 variants include breast, ovarian, pancreatic, prostate, and melanoma cancer.
HN's Chief Medical Officer, C. Thomas Caskey, MD, FACP, FACMG, FRSC, explains how to extend a single diagnosis to identify six family member who are at risk. HLI was able to reach out to the patient and patient’s family members and have these patients under care for disease prevention. Targeted therapies such as Olaparib (Lynparza) and talazoparib (Talzenna) are available for patients with BRCA mutations.
“Health Nucleus—where early detection and preventative care can help reduce long-term health risks to help you live a longer, healthier life.”
Subscribe to our channel: http://bit.ly/healthnucleus
Learn more about Health Nucleus:
https://www.healthnucleus.com
844-838-3322
[email protected]
Follow:
Twitter - https://twitter.com/humanlongevity and https://twitter.com/HealthNucleus
LinkedIn – https://www.linkedin.com/company/human-longevity-inc-/
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Facebook - https://www.facebook.com/humanlongevity/
Did you know that people of Ashkenazi Jewish ancestry have a 1 in 40 chance of carrying a BRCA gene mutation, putting them increased risk for breast and ovarian cancer? Basser Research Center patients discuss their BRCA journeys.
Background: It is estimated that 1 in 300-500 people in the United States are affected by hereditary breast and ovarian cancer syndrome (HBOC), a genetic condition that predisposes individuals to developing cancer in various tissues. From Angelina Jolie’s diagnosis as a BRCA mutation carrier to the Supreme Court ruling on gene patents, HBOC has received a great deal of attention in the media recently. However, the condition continues to be underdiagnosed and genetic services that can reduce risk and identify cancers earlier are often overlooked. Using the numerous screening tools, guidelines and recommendations currently available for HBOC would save lives.
Appropriate management of individuals with HBOC can significantly reduce morbidity and mortality in this population. Therefore, an integrated public health approach focused on the identification of individuals at risk for HBOC is critical to impacting health outcomes of individuals and families.
Objective: This webinar will highlight real world examples of successful programs that address HBOC, describe available screening tools and other resources related to HBOC and provide patient perspectives on the importance of identifying individuals and families with HBOC.
Audience: Public health professionals, primary care clinicians, oncologists, and other healthcare professionals involved in cancer, genetics or chronic disease prevention are encouraged to participate in this webinar.
Hereditary breast–ovarian cancer syndromes (HBOC) are cancer syndromes that produce higher than normal levels of breast cancer and ovarian cancer in genetically related families (either one individual had both, or several individuals in the pedigree had one or the other disease). The hereditary factors may be proven or suspected to cause the pattern of breast and ovarian cancer occurrences in the family.
Hereditary causes
Approximate proportion of hereditary breast cancer cases caused by each gene
A number of genes are associated with HBOC. The most common of the known causes of HBOC are:
BRCA mutations: Harmful mutations in the BRCA1 and BRCA2 genes can produce very high rates of breast and ovarian cancer, as well as increased rates of other cancers.
Other identified genes include:
TP53: Mutations cause Li-Fraumeni syndrome. It produces particularly high rates of breast cancer among younger women with mutated genes, and despite being rare, 4% of women with breast cancer under age 30 have a mutation in this gene.
The two are distinct genes in that they're on different chromosomes, but they both cause a syndrome called hereditary breast and ovarian cancer syndrome ... mutations such as breast and ovarian cancer.
Most people who carry mutations that impair the gene’s function are diagnosed with hereditary breast and ovarian cancer syndrome ...Cancer syndrome should be renamed King Syndrome after Mary-Claire King.
Specifically, Act 1 of 2023 removes out-of-pocket costs associated with genetic testing for hereditary breast and ovarian cancer syndromes as well as supplemental breast screenings for women with a high lifetime risk of breast cancer.
A strong family history of breast cancer may be caused by an inherited mutation in the BRCA1 or BRCA2 genes and hereditary breast and ovarian cancer syndrome, which is linked to an increased risk of ovarian cancer.
... with known hereditary predispositions, mainly for breast, ovarian and colon cancers, plus their family members and individuals who are genetically at higher risk of developing certain cancers.
One of the conditions testing looks for is hereditary breast and ovarian cancer syndrome; another is familial hypercholesterolemia, a genetic condition that leads to high cholesterol in the blood and ...
... -- did carry a hereditary genetic mutation that upped their odds for either breast and/or ovarian cancers or Lynch syndrome, a condition that raises the odds for endometrial and colorectal cancers.
This test screens genes associated with three inherited conditions including Hereditary Breast and Ovarian Cancer (HBOC) syndrome, Lynch syndrome, and Familial Hypercholesterolemia (FH), which are all ...
I want all women to know how important it is to be regularly screened for breast cancer ... This research opportunity tested a number of hereditary risks, including but not limited to breast and ovarian cancer syndrome.
Although most breast and ... Hereditary breast and ovarian cancer syndrome is caused by mutations in either the breast cancer gene 1 or the breast cancer gene 2, commonly shortened to BRCA1 and BRCA2.
BRCA1 and BRCA2, which are genes with known associations to hereditary breast and ovarian cancer syndrome, Lynch syndrome associated genes (MLH1, MSH2, MSH6, PMS2 and EPCAM), CDH1 (mainly associated ...
ProstateCancer seems to run in some families, which suggests that in some cases, there may be an inherited or GENETIC FACTOR.Inherited gene mutations such as BRCA1 and BRCA2, which are linked to ...
BY DISEASE TYPE HEREDITARY BREAST & OVARIAN CANCER SYNDROME COWDEN SYNDROME LYNCH SYNDROME HEREDITARY LEUKEMIA AND HEMATOLOGIC MALIGNANCIES SYNDROMES FAMILIAL ADENOMATOUS POLYPOSIS (FAP) ...
“This will lead to a significant increase in early identification of individuals with hereditary cancers — breast cancer, ovarian cancer, prostate cancer and Lynch Syndrome, for example,” he says.