Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2gene.
Function
HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.
Heat shock factor protein 1 is a protein that in humans is encoded by the HSF1gene.
Function
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene.
Mechanism of action
HSF1 exists as an inactive monomer in a complex with Hsp40/Hsp70 and Hsp90. Upon stress, such as elevated temperature, HSF1 is released from the chaperone complex and trimerizes. HSF1 is then transported into the nucleus where it is hyperphosphorylated and binds to DNA containing heat shock elements (NGAAN). HSF1's target genes include major inducible heat shock proteins such as Hsp72, and noncoding RNA within Satellite III repeat regions. Its attenuation phase is initiated as a negative feedback loop with its gene product Hsp70 binding to its transactivation domain.
Baby, you can call on me Anytime that you feel the need And I'll be there in a hurry Givin' you the best of me And baby, you know I keep it nice and warm to satisfy Baby, you know that I am always hot for you And if there's any kinda love that will exemplify My sweetie, I have got that kinda love times two Boy, I'll do you all night long Do you anyway you want I will do you all night long I wanna please you Don't wanna tease you You can melt in my body And I will slowly melt onto you Caress your face in my valley Let me feel the sweetness of you And baby, you know I keep it special each and every time I never do nothin' once and never quite the same And baby, you know if there is anything you want from me I will supply so you can have it your way Boy, I'll do you all night long Do you anyway you want I will do you all night long I wanna please you Don't wanna tease you Here's the vibe, there's candlelight As I undress for you, baby A sip of wine, we take our time Then I undress you too I look at you, you look at me And then we both embrace And then we just let nature take it's place Boy, I'll do you all night long Do you anyway you want I will do you all night long I wanna please you Don't wanna tease you Do you anyway, any kinda way Do it anyway you want Do you anyway, any kinda way Do it with you all night long Do you anyway, any kinda way Do it anyway you want I wanna please you Don't wanna tease you Do you anyway, any kinda way Do it anyway you want Do you anyway, any kinda way Do it to you all night long Do you anyway, any kinda way Do it anyway you want I wanna please you Don't wanna tease you All night, all night long Do you anyway you want Hey, yeah yeah
The HSF was represented in court by global law firm, DLA Piper. Nicolas Patrick, pro bono and responsible business partner at DLA Piper, said they were proud to have joined the HSF in challenging the termination of the ZEP regime.
The statement did not deal with costs or timelines, but HSF said a possible location for a new Mercer-sized theater could be the site of Savannah’s Union Station... The HSF statement suggests a different path.
Business..Oluchi Chibuzor. Housing Solution Fund, a local currency real estate investment trust (REIT) has announced the successful completion its Series 1 issuance under its N100 billion Programme ... .
Housing Solution Fund (HSF), a local currency real estate investment trust (REIT), has raised hope for increased homeownership in Nigeria. read more HSF’s $100bn funding initiative raises hope for affordable homeownership ... .
Without this application, the foundation says there’s a risk of the court’s judgment being suspended as MinisterAaron Motsoaledi has filed leave to appeal, which would mean that the ZEP would expire at the end of the year ... .
