-
2-Minute Neuroscience: GABA
In this video I discuss the neurotransmitter gamma-aminobutyric acid, or GABA. GABA is the primary inhibitory neurotransmitter in the human nervous system; its effects generally involve making neurons less likely to fire action potentials or release neurotransmitters. GABA acts at both ionotropic (GABAa) and metabotropic (GABAb) receptors, and its action is terminated by a transporter called the GABA transporter. Several drugs like alcohol and benzodiazepines cause increased GABA activity, which is associated with sedative effects.
TRANSCRIPT:
Welcome to 2 minute neuroscience, where I simplistically explain neuroscience topics in 2 minutes or less. In this installment I will discuss gamma-aminobutyric acid, or GABA.
Although GABA’s primary functions are as a neurotransmitter, it has the...
published: 18 Feb 2018
-
Neuroscience Basics: GABA and Glutamate, Animation
Basics of inhibitory and excitatory networks of the brain.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Sue Stern
©Alila Medical Media. All rights reserved.
The brain is a complex network of billions of neurons. Neurons can be excitatory or inhibitory. Excitatory neurons stimulate others to respond and transmit electrical messages, while inhibitory neurons SUPPRESS responsiveness, preventing excessive firing. Responsiveness or excitability of a neuron is determined by the value of electrical voltage across its membrane. Basically, a neuron is MORE responsive when it has more POSITIVE charges inside...
published: 24 Apr 2017
-
Neuroscience Basics: GABA Receptors and GABA Drugs, Animation
Mechanism of action of GABA-A, GABA-B and GABA-C. Allosteric modulators. Action of Benzodiazepines (benzos) and Flumazenil.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Sue Stern
©Alila Medical Media. All rights reserved.
Gamma-aminobutyric acid, or GABA, is the primary INHIBITORY neurotransmitter in the mature brain. It REDUCES neuronal activity of target cells through its binding to GABA receptors present on the cell surface. Nearly half of all synapses of the brain express some kind of GABA receptor and are thus responsive to GABA. There are at least 3 types of GABA receptors: GABA-A, GABA-B and...
published: 24 Apr 2017
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5.1 GABAergic inhibition
published: 05 Feb 2016
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Schneid Guide to GABAergic Transmission
published: 24 Jun 2020
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Inhibitory Role of GABA Neurotransmitter in Neuronal Communication (3 Minutes Microlearning)
Inhibitory Role of GABA Neurotransmitter in Neuronal Communication (3 Minutes Microlearning)
Dr BioTech Whisperer introduces the concept in 3 minutes within this video. Thank you for your support.
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published: 21 Jun 2023
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5.4 GABAergic projections
published: 05 Feb 2016
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Day 7 Prayer and Fasting | BP. Micheal Kyazze
published: 22 Jan 2024
-
GABA Receptor( BZD) - Structure and Mechanism of Action
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published: 21 Jun 2015
-
I Took GABA For 30 Days, Here's What Happened
🖐️ If you are looking for other supplements Like GABA and strategies to help with your Focus then download my FREE Focus Guide Here: 👉 https://drlegrand.com/focusguide-061923 👈
✅ Book A 1-on-1 Consultation To Learn How To Thrive With Your ADHD:
https://drlegrand.com/consultation-061923
✅ Get 10% OFF All Professional-Grade Supplements And Products When You Create A FREE Fullscript Account Using My Link Here: http://drlegrand.com/dispensary 🌿💊
#drlegrand #optimalmindperformance
******
DISCLAIMER: This content is strictly the opinion of Dr. LeGrand and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doc...
published: 19 Jun 2023
1:59
2-Minute Neuroscience: GABA
In this video I discuss the neurotransmitter gamma-aminobutyric acid, or GABA. GABA is the primary inhibitory neurotransmitter in the human nervous system; its ...
In this video I discuss the neurotransmitter gamma-aminobutyric acid, or GABA. GABA is the primary inhibitory neurotransmitter in the human nervous system; its effects generally involve making neurons less likely to fire action potentials or release neurotransmitters. GABA acts at both ionotropic (GABAa) and metabotropic (GABAb) receptors, and its action is terminated by a transporter called the GABA transporter. Several drugs like alcohol and benzodiazepines cause increased GABA activity, which is associated with sedative effects.
TRANSCRIPT:
Welcome to 2 minute neuroscience, where I simplistically explain neuroscience topics in 2 minutes or less. In this installment I will discuss gamma-aminobutyric acid, or GABA.
Although GABA’s primary functions are as a neurotransmitter, it has the structure of an amino acid and thus is referred to as an amino acid neurotransmitter. It is synthesized from another amino acid neurotransmitter, glutamate, in a reaction catalyzed by the enzyme glutamic acid decarboxylase.
The function of GABA changes over the course of neural development, but in the mature brain it acts primarily as an inhibitory neurotransmitter; in other words when GABA interacts with the receptors of a neuron, it generally makes the neuron less likely to fire an action potential or release neurotransmitters.
There are two types of receptors GABA interacts with, GABAa and GABAb receptors. GABAa receptors are ionotropic receptors. When GABA binds to the GABAa receptor, it causes the opening of an associated ion channel that is permeable to the negatively charged ion chloride. When negative chloride ions flow into the neuron, they hyperpolarize the membrane potential of the neuron and make it less likely the neuron will fire an action potential. GABAb receptors are metabotropic (or g-protein coupled) receptors; when activated they frequently cause the opening of potassium channels. These channels allow positively charged potassium ions to flow out of the neuron, again making the neuron hyperpolarized and less likely to fire an action potential.
The actions of GABA are terminated by proteins called GABA transporters, which transport GABA from the synaptic cleft into neurons or glial cells where it is degraded primarily by mitochondrial enzymes.
Because GABA can reduce neural transmission, increased GABA activity can have sedative effects. Accordingly, a number of drugs that have such effects, like alcohol and benzodiazepines, increase activity at the GABA receptor.
REFERENCE:
Purves D, Augustine GJ, Fitzpatrick D, Hall WC, Lamantia AS, McNamara JO, White LE. Neuroscience. 4th ed. Sunderland, MA. Sinauer Associates; 2008.
https://wn.com/2_Minute_Neuroscience_Gaba
In this video I discuss the neurotransmitter gamma-aminobutyric acid, or GABA. GABA is the primary inhibitory neurotransmitter in the human nervous system; its effects generally involve making neurons less likely to fire action potentials or release neurotransmitters. GABA acts at both ionotropic (GABAa) and metabotropic (GABAb) receptors, and its action is terminated by a transporter called the GABA transporter. Several drugs like alcohol and benzodiazepines cause increased GABA activity, which is associated with sedative effects.
TRANSCRIPT:
Welcome to 2 minute neuroscience, where I simplistically explain neuroscience topics in 2 minutes or less. In this installment I will discuss gamma-aminobutyric acid, or GABA.
Although GABA’s primary functions are as a neurotransmitter, it has the structure of an amino acid and thus is referred to as an amino acid neurotransmitter. It is synthesized from another amino acid neurotransmitter, glutamate, in a reaction catalyzed by the enzyme glutamic acid decarboxylase.
The function of GABA changes over the course of neural development, but in the mature brain it acts primarily as an inhibitory neurotransmitter; in other words when GABA interacts with the receptors of a neuron, it generally makes the neuron less likely to fire an action potential or release neurotransmitters.
There are two types of receptors GABA interacts with, GABAa and GABAb receptors. GABAa receptors are ionotropic receptors. When GABA binds to the GABAa receptor, it causes the opening of an associated ion channel that is permeable to the negatively charged ion chloride. When negative chloride ions flow into the neuron, they hyperpolarize the membrane potential of the neuron and make it less likely the neuron will fire an action potential. GABAb receptors are metabotropic (or g-protein coupled) receptors; when activated they frequently cause the opening of potassium channels. These channels allow positively charged potassium ions to flow out of the neuron, again making the neuron hyperpolarized and less likely to fire an action potential.
The actions of GABA are terminated by proteins called GABA transporters, which transport GABA from the synaptic cleft into neurons or glial cells where it is degraded primarily by mitochondrial enzymes.
Because GABA can reduce neural transmission, increased GABA activity can have sedative effects. Accordingly, a number of drugs that have such effects, like alcohol and benzodiazepines, increase activity at the GABA receptor.
REFERENCE:
Purves D, Augustine GJ, Fitzpatrick D, Hall WC, Lamantia AS, McNamara JO, White LE. Neuroscience. 4th ed. Sunderland, MA. Sinauer Associates; 2008.
- published: 18 Feb 2018
- views: 573733
1:29
Neuroscience Basics: GABA and Glutamate, Animation
Basics of inhibitory and excitatory networks of the brain.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com...
Basics of inhibitory and excitatory networks of the brain.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Sue Stern
©Alila Medical Media. All rights reserved.
The brain is a complex network of billions of neurons. Neurons can be excitatory or inhibitory. Excitatory neurons stimulate others to respond and transmit electrical messages, while inhibitory neurons SUPPRESS responsiveness, preventing excessive firing. Responsiveness or excitability of a neuron is determined by the value of electrical voltage across its membrane. Basically, a neuron is MORE responsive when it has more POSITIVE charges inside; and is LESS responsive when it becomes more NEGATIVE.
GABA is a major INHIBITORY neurotransmitter. Upon binding, it triggers GABA receptors, ligand-gated chloride channels, to open and allow chloride ions to flow into the neuron, making it more NEGATIVE and LESS likely to respond to new stimuli.
Glutamate receptors, another type of ion channel, upon binding by glutamate, open to allow POSITIVELY-charged ions into the cell, making it more POSITIVE and MORE likely to generate electrical signals.
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
https://wn.com/Neuroscience_Basics_Gaba_And_Glutamate,_Animation
Basics of inhibitory and excitatory networks of the brain.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Sue Stern
©Alila Medical Media. All rights reserved.
The brain is a complex network of billions of neurons. Neurons can be excitatory or inhibitory. Excitatory neurons stimulate others to respond and transmit electrical messages, while inhibitory neurons SUPPRESS responsiveness, preventing excessive firing. Responsiveness or excitability of a neuron is determined by the value of electrical voltage across its membrane. Basically, a neuron is MORE responsive when it has more POSITIVE charges inside; and is LESS responsive when it becomes more NEGATIVE.
GABA is a major INHIBITORY neurotransmitter. Upon binding, it triggers GABA receptors, ligand-gated chloride channels, to open and allow chloride ions to flow into the neuron, making it more NEGATIVE and LESS likely to respond to new stimuli.
Glutamate receptors, another type of ion channel, upon binding by glutamate, open to allow POSITIVELY-charged ions into the cell, making it more POSITIVE and MORE likely to generate electrical signals.
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
- published: 24 Apr 2017
- views: 259072
2:20
Neuroscience Basics: GABA Receptors and GABA Drugs, Animation
Mechanism of action of GABA-A, GABA-B and GABA-C. Allosteric modulators. Action of Benzodiazepines (benzos) and Flumazenil.
Purchase a license to download a n...
Mechanism of action of GABA-A, GABA-B and GABA-C. Allosteric modulators. Action of Benzodiazepines (benzos) and Flumazenil.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Sue Stern
©Alila Medical Media. All rights reserved.
Gamma-aminobutyric acid, or GABA, is the primary INHIBITORY neurotransmitter in the mature brain. It REDUCES neuronal activity of target cells through its binding to GABA receptors present on the cell surface. Nearly half of all synapses of the brain express some kind of GABA receptor and are thus responsive to GABA. There are at least 3 types of GABA receptors: GABA-A, GABA-B and GABA-C. GABA-A and GABA-C are ligand-gated chloride channels. Upon transmitter binding, they open and allow chloride ions to flow into the neuron, making it more NEGATIVE, or HYPER-polarized, and thus LESS likely to generate action potentials. GABA-B acts through a G-protein to activate potassium channels, which allow positively-charged potassium to flow OUT of the cell, again resulting in membrane HYPER-polarization and a subsequent decrease in neuron responsiveness.
GABA is believed to play a major role in controlling neuronal hyperactivity associated with fear, anxiety and convulsions.
GABA-A receptor is composed of 5 protein subunits. In addition to binding sites for GABA, it has allosteric binding sites for other substances known as GABA modulators. These are molecules that can INCREASE or DECREASE the action of GABA, but have no effect in the absence of GABA.
For example, benzodiazepines, a class of drugs used to treat anxiety, bind to GABA-A receptor and facilitate its binding to GABA, thus potentiating GABA inhibitory effect. Other positive modulators include barbiturates, alcohol, propofol, among others.
Examples of negative modulators are convulsants, such as Flumazenil. Flumazenil reverses the effects of benzodiazepines by competing with them at the same binding site on GABA-A.
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
https://wn.com/Neuroscience_Basics_Gaba_Receptors_And_Gaba_Drugs,_Animation
Mechanism of action of GABA-A, GABA-B and GABA-C. Allosteric modulators. Action of Benzodiazepines (benzos) and Flumazenil.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Sue Stern
©Alila Medical Media. All rights reserved.
Gamma-aminobutyric acid, or GABA, is the primary INHIBITORY neurotransmitter in the mature brain. It REDUCES neuronal activity of target cells through its binding to GABA receptors present on the cell surface. Nearly half of all synapses of the brain express some kind of GABA receptor and are thus responsive to GABA. There are at least 3 types of GABA receptors: GABA-A, GABA-B and GABA-C. GABA-A and GABA-C are ligand-gated chloride channels. Upon transmitter binding, they open and allow chloride ions to flow into the neuron, making it more NEGATIVE, or HYPER-polarized, and thus LESS likely to generate action potentials. GABA-B acts through a G-protein to activate potassium channels, which allow positively-charged potassium to flow OUT of the cell, again resulting in membrane HYPER-polarization and a subsequent decrease in neuron responsiveness.
GABA is believed to play a major role in controlling neuronal hyperactivity associated with fear, anxiety and convulsions.
GABA-A receptor is composed of 5 protein subunits. In addition to binding sites for GABA, it has allosteric binding sites for other substances known as GABA modulators. These are molecules that can INCREASE or DECREASE the action of GABA, but have no effect in the absence of GABA.
For example, benzodiazepines, a class of drugs used to treat anxiety, bind to GABA-A receptor and facilitate its binding to GABA, thus potentiating GABA inhibitory effect. Other positive modulators include barbiturates, alcohol, propofol, among others.
Examples of negative modulators are convulsants, such as Flumazenil. Flumazenil reverses the effects of benzodiazepines by competing with them at the same binding site on GABA-A.
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
- published: 24 Apr 2017
- views: 371909
2:14
Inhibitory Role of GABA Neurotransmitter in Neuronal Communication (3 Minutes Microlearning)
Inhibitory Role of GABA Neurotransmitter in Neuronal Communication (3 Minutes Microlearning)
Dr BioTech Whisperer introduces the concept in 3 minutes within th...
Inhibitory Role of GABA Neurotransmitter in Neuronal Communication (3 Minutes Microlearning)
Dr BioTech Whisperer introduces the concept in 3 minutes within this video. Thank you for your support.
☕ BUY ME A COFFEE
Support us with a morning coffeebreak
https://www.buymeacoffee.com/biotechW
#scienceconcepts #biologyteacher #sciencestudent #neurotransmission #questionsandanswers #sciencefacts #amazingscience #neurotransmitter #brainscience #gaba #inhibitory #inhibitoryneurotransmitter
https://wn.com/Inhibitory_Role_Of_Gaba_Neurotransmitter_In_Neuronal_Communication_(3_Minutes_Microlearning)
Inhibitory Role of GABA Neurotransmitter in Neuronal Communication (3 Minutes Microlearning)
Dr BioTech Whisperer introduces the concept in 3 minutes within this video. Thank you for your support.
☕ BUY ME A COFFEE
Support us with a morning coffeebreak
https://www.buymeacoffee.com/biotechW
#scienceconcepts #biologyteacher #sciencestudent #neurotransmission #questionsandanswers #sciencefacts #amazingscience #neurotransmitter #brainscience #gaba #inhibitory #inhibitoryneurotransmitter
- published: 21 Jun 2023
- views: 7326
6:11
GABA Receptor( BZD) - Structure and Mechanism of Action
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CHECK OUT NEWEST VIDEO: "Nucleic acids - DNA and RNA structure "
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https://wn.com/Gaba_Receptor(_Bzd)_Structure_And_Mechanism_Of_Action
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- published: 21 Jun 2015
- views: 385785
4:27
I Took GABA For 30 Days, Here's What Happened
🖐️ If you are looking for other supplements Like GABA and strategies to help with your Focus then download my FREE Focus Guide Here: 👉 https://drlegrand.com/foc...
🖐️ If you are looking for other supplements Like GABA and strategies to help with your Focus then download my FREE Focus Guide Here: 👉 https://drlegrand.com/focusguide-061923 👈
✅ Book A 1-on-1 Consultation To Learn How To Thrive With Your ADHD:
https://drlegrand.com/consultation-061923
✅ Get 10% OFF All Professional-Grade Supplements And Products When You Create A FREE Fullscript Account Using My Link Here: http://drlegrand.com/dispensary 🌿💊
#drlegrand #optimalmindperformance
******
DISCLAIMER: This content is strictly the opinion of Dr. LeGrand and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. LeGrand nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
https://wn.com/I_Took_Gaba_For_30_Days,_Here's_What_Happened
🖐️ If you are looking for other supplements Like GABA and strategies to help with your Focus then download my FREE Focus Guide Here: 👉 https://drlegrand.com/focusguide-061923 👈
✅ Book A 1-on-1 Consultation To Learn How To Thrive With Your ADHD:
https://drlegrand.com/consultation-061923
✅ Get 10% OFF All Professional-Grade Supplements And Products When You Create A FREE Fullscript Account Using My Link Here: http://drlegrand.com/dispensary 🌿💊
#drlegrand #optimalmindperformance
******
DISCLAIMER: This content is strictly the opinion of Dr. LeGrand and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. LeGrand nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
- published: 19 Jun 2023
- views: 100680