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Drug delivery

Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. It may involve scientific site-targeting within the body, or it might involve facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of drug presence. Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.

Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Drug release is from: diffusion, degradation, swelling, and affinity-based mechanisms. Most common routes of administration include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection or a nanoneedle array. For example, many immunizations are based on the delivery of protein drugs and are often done by injection.

Drug Delivery (journal)

Drug Delivery is an academic journal that publishes research on all aspects of drug delivery – a core aspect of drug development. It is owned by Informa plc (LSE: INF) which is a United Kingdom-based publisher and conference company.

Editors

Alfred Stracher and Vladimir Torchilin are co-editors of Drug Delivery.

Alfred Stracher is Distinguished Professor at SUNY Downstate Medical Center, Brooklyn, New York, USA

Vladimir Torchilin was appointed co-editor in 2009 and is currently Distinguished Professor of Pharmaceutical Sciences at The Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA.

Publication Format

Drug Delivery publishes 8 issues per year in simultaneous print and online editions and is available on a subscription basis. Individual articles can be purchased on a pay-per-view basis. The full text of all articles is offered in PDF and PDF Plus formats. All back-issues of the journal are available online and are hosted on the publisher's website.

Podcasts:

  • Precision Drug Delivery Systems | Steven Rosenzweig | TEDxCharleston

    A happy accident in the lab leads to incredible advances in cancer and dementia treatment. This MUSC and Hollings Cancer Center researcher, Steven, a PhD from the University of Toronto and former faculty at Yale Medical School, provides more. Steve lost both his parents to cancer; his mother when he was nine and his father ten years later. Consequently, when he began his career as a researcher, cancer became a focus of his work. Steve’s first exposure to research occurred when he was a senior in college, which was his entryway to scientific research leading to a Master’s degree in Physiology from Wayne State University School of Medicine and a Ph.D. in Physiology/Molecular Endocrinology from the University of Toronto. Steve was appointed Assistant Professor of Ophthalmology and Cell Biolog...

    published: 06 Apr 2022
  • Nanoparticle-based drug delivery in the fight against cancer

    This animation describes the latest research developments in nanoparticle-based cancer therapies. It explores how the technology can be used to specifically target cancer cells over healthy cells and how scientists can exploit the natural processes of cells to deliver the drug inside the cell where it is needed for its cancer-killing effect. CREDITS This animation was created by UNSW's 3D Visualisation Aesthetics Lab and was informed by the scientific imaging and cancer research of UQ IMB's Professor Rob Parton and his team. Their combined efforts are part of the research activities of the ARC Centre of Excellence in Bio-Nano Science and Technology. For more information please visit http://www.bionano.org.au. Visit our website: https://bit.ly/3ZRkcqC

    published: 30 Aug 2017
  • Nanoscience and drug delivery -- small particles for big problems | Taylor Mabe | TEDxGreensboro

    Getting sufficient therapeutic drugs to the precise disease cell would reduce the amount of medication required; reduce side effects; and enhance treatment. Mabe explores the use of nano-particles for this purpose. Taylor is a doctoral student in the NC A&T/UNC Greensboro Joint School of Nanoscience and Nanoengineering in Greensboro NC. His interests are in the delivery of medicines through nano-particles to increase medication effectiveness and reduce side effects. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx

    published: 01 Jul 2015
  • Robert S. Langer (MIT) Part 1: Advances in Controlled Drug Release Technology: An Overview

    http://www.ibiology.org/ibioseminars/robert-langer-part-1.html Talk Overview: The traditional way of taking a drug, such as a pill or injection, often results in plasma drug levels that cycle between too high and too low. To better maintain drug levels in the effective range, scientists have developed a variety of systems that release drugs at a steady rate for days or even years. In his first talk, Bob Langer gives an overview of many of these controlled release technologies, including polymer and pump systems. Langer begins Part 2 with the story of how he became interested in drug release technologies, which is also a story of the power of perseverance. As a post-doc with Judah Folkman, and after much trial and error, Langer developed a polymer system that provided a slow and con...

    published: 17 Feb 2015
  • Smart Drug Delivery System

    New "smart" material could automatically deliver your medication inside your body without a reminder. More information on this story at http://www.insidescience.org/content/smart-drug-delivery-system/1618. Additional content at http://www.insidescience.org/.

    published: 22 Apr 2014
  • Ultrasound drug delivery

    Using ultrasound waves, researchers have found a way to enable rapid delivery of drugs to the gastrointestinal (GI) tract. This approach could make it easier to deliver drugs to patients suffering from GI disorders. (Learn more: http://mitsha.re/TGzKW) Video produced and edited by Melanie Gonick/MIT Animation courtesy of the researchers Music sampled from "Water & Spirit" by James Joshua Otto http://freemusicarchive.org/music/James_Joshua_Otto/And_then_the_mountains_moved/Water__Spirit http://creativecommons.org/licenses/by-nc/4.0/

    published: 21 Oct 2015
  • Nanoparticles for Drug Delivery

    Animation showing how nanoparticles can be used to delivery drugs

    published: 26 Apr 2016
  • Nanomedicines for oral drug delivery

    Our laboratory is active in patient-centred, pharmaceutical research. Specific interests centre around the understanding of the mucosal barrier in health and disease and overcoming this barrier to improve drug delivery. Through understanding of biology and expertise in formulation of new drug delivery systems, we seek to improve the safety of medicines and enable their administration in a patient-friendly manner. ━━━━━━━━━━━━━━━━━━━━ Additional Information ──────────────────────────── https://www.vllasaliulab.com/ https://www.linkedin.com/in/driton-vllasaliu-7a011360/?originalSubdomain=uk ━━━━━━━━━━━━━━━━━━━━ Science Animated ──────────────────────────── http://www.sciani.com/ https://twitter.com/Sci_Ani https://www.facebook.com/scianimation/ ━━━━━━━━━━━━━━━━━━━━ #OralDrugDelivery #N...

    published: 20 May 2019
  • Innovations and Breakthroughs in Epinephrine Delivery: Optimizing Outcomes With Early Interventio...

    Learn about innovative methods for epinephrine administration and improve patient outcomes. Credit available for this activity expires: 12/05/25 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/innovations-and-breakthroughs-epinephrine-delivery-2024a1000loh?ecd=bdc_podcast_libsyn_mscpedu

    published: 06 Dec 2024
  • Forms of Drug delivery

    What are examples of drug delivery? By understanding the different forms of drug delivery and their advantages and disadvantages, patients and healthcare professionals can choose the best way to administer a drug. There are non-invasive and invasive routes of administration. The most common routes are non-invasive, including oral, transdermal, mucosal, and nasal. Intravenous routes are invasive through surgical injections. This video provides a comprehensive overview of some common drug delivery forms.

    published: 30 Nov 2023
developed with YouTube
Precision Drug Delivery Systems | Steven Rosenzweig | TEDxCharleston
10:38

Precision Drug Delivery Systems | Steven Rosenzweig | TEDxCharleston

  • Order:
  • Duration: 10:38
  • Uploaded Date: 06 Apr 2022
  • views: 7983
A happy accident in the lab leads to incredible advances in cancer and dementia treatment. This MUSC and Hollings Cancer Center researcher, Steven, a PhD from the University of Toronto and former faculty at Yale Medical School, provides more. Steve lost both his parents to cancer; his mother when he was nine and his father ten years later. Consequently, when he began his career as a researcher, cancer became a focus of his work. Steve’s first exposure to research occurred when he was a senior in college, which was his entryway to scientific research leading to a Master’s degree in Physiology from Wayne State University School of Medicine and a Ph.D. in Physiology/Molecular Endocrinology from the University of Toronto. Steve was appointed Assistant Professor of Ophthalmology and Cell Biology at Yale University School of Medicine after completing three years of postdoctoral training in the Department of Cell Biology. In 1991 he was recruited to the Department of Cell and Molecular Pharmacology and Experimental Therapeutics at the Medical University of South Carolina, where he is currently a Professor and the Associate Director of Shared Resources at Hollings Cancer Center. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx
https://wn.com/Precision_Drug_Delivery_Systems_|_Steven_Rosenzweig_|_Tedxcharleston
Nanoparticle-based drug delivery in the fight against cancer
2:32

Nanoparticle-based drug delivery in the fight against cancer

  • Order:
  • Duration: 2:32
  • Uploaded Date: 30 Aug 2017
  • views: 182362
This animation describes the latest research developments in nanoparticle-based cancer therapies. It explores how the technology can be used to specifically target cancer cells over healthy cells and how scientists can exploit the natural processes of cells to deliver the drug inside the cell where it is needed for its cancer-killing effect. CREDITS This animation was created by UNSW's 3D Visualisation Aesthetics Lab and was informed by the scientific imaging and cancer research of UQ IMB's Professor Rob Parton and his team. Their combined efforts are part of the research activities of the ARC Centre of Excellence in Bio-Nano Science and Technology. For more information please visit http://www.bionano.org.au. Visit our website: https://bit.ly/3ZRkcqC
https://wn.com/Nanoparticle_Based_Drug_Delivery_In_The_Fight_Against_Cancer
Nanoscience and drug delivery -- small particles for big problems | Taylor Mabe | TEDxGreensboro
16:22

Nanoscience and drug delivery -- small particles for big problems | Taylor Mabe | TEDxGreensboro

  • Order:
  • Duration: 16:22
  • Uploaded Date: 01 Jul 2015
  • views: 70167
Getting sufficient therapeutic drugs to the precise disease cell would reduce the amount of medication required; reduce side effects; and enhance treatment. Mabe explores the use of nano-particles for this purpose. Taylor is a doctoral student in the NC A&T/UNC Greensboro Joint School of Nanoscience and Nanoengineering in Greensboro NC. His interests are in the delivery of medicines through nano-particles to increase medication effectiveness and reduce side effects. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx
https://wn.com/Nanoscience_And_Drug_Delivery_Small_Particles_For_Big_Problems_|_Taylor_Mabe_|_Tedxgreensboro
Robert S. Langer (MIT) Part 1: Advances in Controlled Drug Release Technology: An Overview
37:45

Robert S. Langer (MIT) Part 1: Advances in Controlled Drug Release Technology: An Overview

  • Order:
  • Duration: 37:45
  • Uploaded Date: 17 Feb 2015
  • views: 98195
http://www.ibiology.org/ibioseminars/robert-langer-part-1.html Talk Overview: The traditional way of taking a drug, such as a pill or injection, often results in plasma drug levels that cycle between too high and too low. To better maintain drug levels in the effective range, scientists have developed a variety of systems that release drugs at a steady rate for days or even years. In his first talk, Bob Langer gives an overview of many of these controlled release technologies, including polymer and pump systems. Langer begins Part 2 with the story of how he became interested in drug release technologies, which is also a story of the power of perseverance. As a post-doc with Judah Folkman, and after much trial and error, Langer developed a polymer system that provided a slow and constant release of an anti-angiogenesis factor. Initially, his results were met with skepticism, by both scientists and the patent office. Today, many, many companies have developed peptide delivery systems based on that original work. Langer also describes ongoing research in areas such as targeted drug delivery and externally controlled microchips designed for drug delivery. In Part 3, Langer focuses on the materials used in drug delivery and medical devices. Many of the original materials used in medicine were adapted from completely unrelated uses and often generated their own problems. Langer describes work by his lab and others to make polymers designed for specific medical uses. For instance, a porous polymer can be shaped into an ear or nose and act as a scaffold onto which a patient’s cells can be seeded to grow a new structure. Different polymers have been successfully used as scaffolds to grow new blood vessels or artificial skin for burn victims. Speaker Biography: Robert Langer is the David H. Koch Institute Professor at the Massachusetts Institute of Technology. Research in Langer’s lab focuses on the development of polymers for use in drug delivery devices that will release molecules such as drugs, proteins, RNA or DNA at controlled rates and for extended periods of time. His lab also is working on methods to create new tissues such as cartilage, skin and liver for use in medicine. Langer has written over 1250 articles and has over 1000 patents; he is the most cited engineer ever. He has been honored with numerous awards including being one of only seven people to receive both the US National Medal of Science and the National Medal of Technology and Innovation. He is also one of only a few people to be elected to the US National Academy of Sciences, Institute of Medicine and National Academy of Engineering. He is the only engineer to win the Gairdner Foundation International Award. In 2014, Langer received the Breakthrough Prize in Life Sciences and the Kyoto Prize. Langer received his BS in Chemical Engineering from Cornell University and his ScD in Chemical Engineering from MIT.
https://wn.com/Robert_S._Langer_(Mit)_Part_1_Advances_In_Controlled_Drug_Release_Technology_An_Overview
Smart Drug Delivery System
1:49

Smart Drug Delivery System

  • Order:
  • Duration: 1:49
  • Uploaded Date: 22 Apr 2014
  • views: 18017
New "smart" material could automatically deliver your medication inside your body without a reminder. More information on this story at http://www.insidescience.org/content/smart-drug-delivery-system/1618. Additional content at http://www.insidescience.org/.
https://wn.com/Smart_Drug_Delivery_System
Ultrasound drug delivery
1:53

Ultrasound drug delivery

  • Order:
  • Duration: 1:53
  • Uploaded Date: 21 Oct 2015
  • views: 25512
Using ultrasound waves, researchers have found a way to enable rapid delivery of drugs to the gastrointestinal (GI) tract. This approach could make it easier to deliver drugs to patients suffering from GI disorders. (Learn more: http://mitsha.re/TGzKW) Video produced and edited by Melanie Gonick/MIT Animation courtesy of the researchers Music sampled from "Water & Spirit" by James Joshua Otto http://freemusicarchive.org/music/James_Joshua_Otto/And_then_the_mountains_moved/Water__Spirit http://creativecommons.org/licenses/by-nc/4.0/
https://wn.com/Ultrasound_Drug_Delivery
Nanoparticles for Drug Delivery
2:21

Nanoparticles for Drug Delivery

  • Order:
  • Duration: 2:21
  • Uploaded Date: 26 Apr 2016
  • views: 106643
Animation showing how nanoparticles can be used to delivery drugs
https://wn.com/Nanoparticles_For_Drug_Delivery
Nanomedicines for oral drug delivery
1:38

Nanomedicines for oral drug delivery

  • Order:
  • Duration: 1:38
  • Uploaded Date: 20 May 2019
  • views: 13223
Our laboratory is active in patient-centred, pharmaceutical research. Specific interests centre around the understanding of the mucosal barrier in health and disease and overcoming this barrier to improve drug delivery. Through understanding of biology and expertise in formulation of new drug delivery systems, we seek to improve the safety of medicines and enable their administration in a patient-friendly manner. ━━━━━━━━━━━━━━━━━━━━ Additional Information ──────────────────────────── https://www.vllasaliulab.com/ https://www.linkedin.com/in/driton-vllasaliu-7a011360/?originalSubdomain=uk ━━━━━━━━━━━━━━━━━━━━ Science Animated ──────────────────────────── http://www.sciani.com/ https://twitter.com/Sci_Ani https://www.facebook.com/scianimation/ ━━━━━━━━━━━━━━━━━━━━ #OralDrugDelivery #Nanomedicine #Nanoparticle ━━━━━━━━━━━━━━━━━━━━
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Innovations and Breakthroughs in Epinephrine Delivery: Optimizing Outcomes With Early Interventio...
30:37

Innovations and Breakthroughs in Epinephrine Delivery: Optimizing Outcomes With Early Interventio...

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  • Uploaded Date: 06 Dec 2024
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Learn about innovative methods for epinephrine administration and improve patient outcomes. Credit available for this activity expires: 12/05/25 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/innovations-and-breakthroughs-epinephrine-delivery-2024a1000loh?ecd=bdc_podcast_libsyn_mscpedu
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Forms of Drug delivery
1:27

Forms of Drug delivery

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  • Duration: 1:27
  • Uploaded Date: 30 Nov 2023
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What are examples of drug delivery? By understanding the different forms of drug delivery and their advantages and disadvantages, patients and healthcare professionals can choose the best way to administer a drug. There are non-invasive and invasive routes of administration. The most common routes are non-invasive, including oral, transdermal, mucosal, and nasal. Intravenous routes are invasive through surgical injections. This video provides a comprehensive overview of some common drug delivery forms.
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PLAYLIST TIME:

Precision Drug Delivery Systems | Steven Rosenzweig | TEDxCharleston

A happy accident in the lab leads to incredible advances in cancer and dementia treatment. This MUSC and Hollings Cancer Center researcher, Steven, a PhD from the University of Toronto and former faculty at Yale Medical School, provides more. Steve lost both his parents to cancer; his mother when he was nine and his father ten years later. Consequently, when he began his career as a researcher, cancer became a focus of his work. Steve’s first exposure to research occurred when he was a senior in college, which was his entryway to scientific research leading to a Master’s degree in Physiology from Wayne State University School of Medicine and a Ph.D. in Physiology/Molecular Endocrinology from the University of Toronto. Steve was appointed Assistant Professor of Ophthalmology and Cell Biology at Yale University School of Medicine after completing three years of postdoctoral training in the Department of Cell Biology. In 1991 he was recruited to the Department of Cell and Molecular Pharmacology and Experimental Therapeutics at the Medical University of South Carolina, where he is currently a Professor and the Associate Director of Shared Resources at Hollings Cancer Center. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx
10:38
Precision Drug Delivery Systems | Steven Rosenzweig | TEDxCharleston
A happy accident in the lab leads to incredible advances in cancer and dementia treatment....
published: 06 Apr 2022
Play in Full Screen
2:32
Nanoparticle-based drug delivery in the fight against cancer
This animation describes the latest research developments in nanoparticle-based cancer the...
published: 30 Aug 2017
Play in Full Screen
16:22
Nanoscience and drug delivery -- small particles for big problems | Taylor Mabe | TEDxGreensboro
Getting sufficient therapeutic drugs to the precise disease cell would reduce the amount o...
published: 01 Jul 2015
Play in Full Screen
37:45
Robert S. Langer (MIT) Part 1: Advances in Controlled Drug Release Technology: An Overview
http://www.ibiology.org/ibioseminars/robert-langer-part-1.html Talk Overview: The tradi...
published: 17 Feb 2015
Play in Full Screen
1:49
Smart Drug Delivery System
New "smart" material could automatically deliver your medication inside your body without ...
published: 22 Apr 2014
Play in Full Screen
1:53
Ultrasound drug delivery
Using ultrasound waves, researchers have found a way to enable rapid delivery of drugs to ...
published: 21 Oct 2015
Play in Full Screen
2:21
Nanoparticles for Drug Delivery
Animation showing how nanoparticles can be used to delivery drugs
published: 26 Apr 2016
Play in Full Screen
1:38
Nanomedicines for oral drug delivery
Our laboratory is active in patient-centred, pharmaceutical research. Specific interests c...
published: 20 May 2019
Play in Full Screen
30:37
Innovations and Breakthroughs in Epinephrine Delivery: Optimizing Outcomes With Early Interventio...
Learn about innovative methods for epinephrine administration and improve patient outcomes...
published: 06 Dec 2024
Play in Full Screen
1:27
Forms of Drug delivery
What are examples of drug delivery? By understanding the different forms of drug delivery ...
published: 30 Nov 2023
Play in Full Screen

Drug delivery

Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. It may involve scientific site-targeting within the body, or it might involve facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of drug presence. Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.

Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Drug release is from: diffusion, degradation, swelling, and affinity-based mechanisms. Most common routes of administration include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection or a nanoneedle array. For example, many immunizations are based on the delivery of protein drugs and are often done by injection.

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