Desmin is a protein that in humans is encoded by the DESgene. Desmin is a muscle-specific, type IIIintermediate filament that integrates the sarcolemma, Z disk and nuclear membrane in sarcomeres and regulates sarcomere architecture.
Structure
Desmin is a 53.5 kD protein composed of 470 amino acids. There are three major domains to the desmin protein: a conserved alpha helix rod, a variable non alpha helix head, and a carboxy-terminal tail. Desmin, as all intermediate filaments, shows no polarity when assembled. The rod domain consists of 308 amino acids with parallel alpha helical coiled coil dimers and three linkers to disrupt it. The rod domain connects to the head domain. The head domain 84 amino acids with many arginine, serine, and aromatic residues is important in filament assembly and dimer-dimer interactions. The tail domain is responsible for the integration of filaments and interaction with proteins and organelles. Desmin is only expressed in vertebrates, however homologous proteins are found in many organisms. Desmin is a subunit of intermediate filaments in cardiac muscle, skeletal muscle and smooth muscle tissue. In cardiac muscle, desmin is present in Z-discs and intercalated discs. Desmin has been shown to interact with desmoplakin and αB-crystallin.
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published: 09 Jul 2022
Desmond Dennis - Desmond Has a Big Head [Offical Music Video]
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'Desmond Has a Big Head' from episode 4 of the Desmond Dennis Show!
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published: 18 Sep 2022
Brayton the Bully (Episode 1 Part 6)
Brayton's class gets a new student!
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published: 19 Feb 2021
Brayton the Bully (Episode 1 Part 10)
Desmond builds up enough courage to fight Brayton!
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published: 25 Feb 2021
My Grandpop’s Lawn
published: 27 Aug 2021
Desmin degradation and dilatation in hiPSC-derived engineered heart tissues
In this episode, Peter van der Meer and Mathilde Vermeer explain the pathological role of KLHL24 methionine start codon mutations in the development of dilated cardiomyopathy using hiPSC-derived dynamically loaded engineered heart tissues.
published: 03 Sep 2021
The Life of Brayton & Aython (Marathon)
A marathon of Life of Braython and Aython!
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All of the episodes of "The School Trouble Maker"!
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The first episode of Desmond Dennis's brand new YouTube show featuring all his characters!
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The first episode of Desmond Dennis's brand new YouTube show featuring all his characters!
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The first episode of Desmond Dennis's brand new YouTube show featuring all his characters!
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'Desmond Has a Big Head' from episode 4 of the Desmond Dennis Show!
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'Desmond Has a Big Head' from episode 4 of the Desmond Dennis Show!
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Brayton's class gets a new student!
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Brayton's class gets a new student!
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In this episode, Peter van der Meer and Mathilde Vermeer explain the pathological role of KLHL24 methionine start codon mutations in the development of dilated ...
In this episode, Peter van der Meer and Mathilde Vermeer explain the pathological role of KLHL24 methionine start codon mutations in the development of dilated cardiomyopathy using hiPSC-derived dynamically loaded engineered heart tissues.
In this episode, Peter van der Meer and Mathilde Vermeer explain the pathological role of KLHL24 methionine start codon mutations in the development of dilated cardiomyopathy using hiPSC-derived dynamically loaded engineered heart tissues.
A marathon of Life of Braython and Aython!
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A marathon of Life of Braython and Aython!
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A marathon of Life of Braython and Aython!
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All of the episodes of "The School Trouble Maker"!
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Copyright: Desmond Dennis Productions LLC
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Copyright: Desmond Dennis Productions LLC
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In this episode, Peter van der Meer and Mathilde Vermeer explain the pathological role of KLHL24 methionine start codon mutations in the development of dilated cardiomyopathy using hiPSC-derived dynamically loaded engineered heart tissues.
A marathon of Life of Braython and Aython!
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All of the episodes of "The School Trouble Maker"!
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Copyright: Desmond Dennis Productions LLC
Desmin is a protein that in humans is encoded by the DESgene. Desmin is a muscle-specific, type IIIintermediate filament that integrates the sarcolemma, Z disk and nuclear membrane in sarcomeres and regulates sarcomere architecture.
Structure
Desmin is a 53.5 kD protein composed of 470 amino acids. There are three major domains to the desmin protein: a conserved alpha helix rod, a variable non alpha helix head, and a carboxy-terminal tail. Desmin, as all intermediate filaments, shows no polarity when assembled. The rod domain consists of 308 amino acids with parallel alpha helical coiled coil dimers and three linkers to disrupt it. The rod domain connects to the head domain. The head domain 84 amino acids with many arginine, serine, and aromatic residues is important in filament assembly and dimer-dimer interactions. The tail domain is responsible for the integration of filaments and interaction with proteins and organelles. Desmin is only expressed in vertebrates, however homologous proteins are found in many organisms. Desmin is a subunit of intermediate filaments in cardiac muscle, skeletal muscle and smooth muscle tissue. In cardiac muscle, desmin is present in Z-discs and intercalated discs. Desmin has been shown to interact with desmoplakin and αB-crystallin.
A dramedy about a couple in crisis when their newly acquired rescue dog goes missing, “Hangdog” immediately establishes that unemployed Walt (Desmin Borges, “Only Murders in the ...