A conformational epitope is a sequence of sub-units (usually amino acids) composing an antigen that come in direct contact with a receptor of the immune system.
An antigen is any substance that the immune system can recognize as foreign. Antigens are usually proteins that are too large to bind as a whole to any receptor so only specific segments, that form the antigen, bind with a specific receptor. Such segments are called epitopes. Likewise, it is only paratope of the receptor that comes in contact with the epitope.
Proteins are composed of repeating nitrogen-containing subunits called amino acids that in nature do not exist as straight chains called primary structure, but as folded whorls with complex loops. The latter is known as the tertiary structure of a protein. So, whenever a receptor interacts with an undigested antigen, the surface amino acids that come in contact may not be continuous with each other if the protein is unwound. Such discontinuous amino acids that come together in three-dimensional conformation and interact with the receptor's paratope are called conformational epitopes. In contrast, if the antigen is digested, small segments called peptides are formed, which bind with major histocompatibility complex molecules, and then later with T cell receptors through amino acids that are continuous in a line. These are known as linear epitopes.
Compared to ELISA kits coated with L1 protein and antibody detection kits coated with VLP L1, VLPs have conformational and type-specific epitopes similar to the actual viral structure ... About Creative Diagnostics ... MediaContact. CompanyName ... Email ... State.
Due to these challenges, there is a growing interest in exploring new detection strategies ... A key highlight is their ability to target conformational epitopes, offering higher precision in allergen detection, especially in complex food matrices ... Prof.
With a much smaller size compared to traditional antibodies, combined with structural diversity, Knobs can bind to conformational, linear or discontinuous epitopes in "undruggable" areas of validated targets.
With a much smaller size compared to traditional antibodies, combined with structural diversity, Knobs can bind to conformational, linear or discontinuous epitopes in "undruggable" areas of validated targets.
With a much smaller size compared to traditional antibodies, combined with structural diversity, Knobs can bind to conformational, linear or discontinuous epitopes in "undruggable" areas of validated targets.
With a much smaller size compared to traditional antibodies, combined with structural diversity, Picobodies can bind to conformational, linear or discontinuous epitopes in "undruggable" areas of validated targets.
In turn, this affects the conformation of the antigen and may provide functional epitopes to the immune system of immunized individuals ... of pH of the solution on chemical and conformational stability.
... monoclonal antibodies incorporate a stronger ability to detect subtle antigenic alterations and small targets comprising epitope variants, post-translational modifications, and conformational changes.
REDWOOD CITY, Calif. & BOSTON--(BUSINESS WIRE)--Adicet Bio, Inc. (Nasdaq... Additionally, Adicet’s novel mode of targeting PSMA demonstrated selective binding to conformational epitopes and superior function compared to clinically relevant benchmarks.
... monoclonal antibodies incorporate a stronger ability to detect subtle antigenic alterations and small targets comprising epitope variants, post-translational modifications, and conformational changes.
... monoclonal antibodies incorporate a stronger ability to detect subtle antigenic alterations and small targets comprising epitope variants, post-translational modifications, and conformational changes.
... monoclonal antibodies incorporate a stronger ability to detect subtle antigenic alterations and small targets comprising epitope variants, post-translational modifications, and conformational changes.
Rational design of a vaccine for Alzheimer’s disease using a computationally-derived conformational epitope to selectively target toxic amyloid-beta oligomers.
The Daily Independent - Ridgecrest
06 Apr 2024
The Daily Independent - Ridgecrest
06 Apr 2024