- published: 31 Dec 2023
- views: 159
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remove the playlistSphingosine-1-phosphate
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Sphingosine-1-phosphate
Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is also referred to as a bioactive lipid mediator. It was discovered by Sarah Spiegel, then a professor of biochemistry and molecular biology at Georgetown University School of Medicine, in the mid-1990s. Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine.
Production
Sphingosine can be released from ceramides, a process catalyzed by the enzyme ceramidase. Phosphorylation of sphingosine is catalyzed by sphingosine kinase, an enzyme ubiquitously found in the cytosol and endoplasmatic reticulum of various types of cells. S1P can be dephosphorylated to sphingosine by sphingosine phosphatases and can be irreversibly degraded by an enzyme, Sphingosine phosphate lyase.
Function
S1P is a blood borne lipid mediator, in particular in association with lipoproteins such as high density lipoprotein (HDL). It is less abundant in tissue fluids. This is referred to as the S1P gradient, which seems to have biological significance in immune cell trafficking.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Sphingosine-1-phosphate
Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein-molecule that receives chemical-signals from outside a cell. When such chemical-signals bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, a receptor is a protein-molecule that recognises and responds to endogenous-chemical signals, e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Receptor-proteins are embedded in all cells' plasmatic-membranes; facing extracellular-(cell surface receptors), cytoplasmic (cytoplasmic-receptors), or in the nucleus (nuclear receptors). A molecule that binds to a receptor is called a ligand, and can be a peptide (short-protein) or another small molecule such as a neurotransmitter, hormone, pharmaceutical-drug, toxin, or parts of the outside of a virus or microbe. The endogenously designated-molecule for a particular receptor is referred to as its endogenous-ligand. E.g. the endogenous-ligand for the nicotinic-acetylcholine receptor is acetylcholine but the receptor can also be activated by nicotine and blocked by curare.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Receptor_(biochemistry)
Immune receptor
An immune receptor (or immunologic receptor) is a receptor, usually on a cell membrane, which binds to a substance (for example, a cytokine) and causes a response in the immune system.
Types
The main receptors in the immune system are pattern recognition receptors (PRRs), Toll-like receptors (TLRs), killer activated and killer inhibitor receptors (KARs and KIRs), complement receptors, Fc receptors, B cell receptors and T cell receptors.
See also
References
External links
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Immune_receptor
Beta-1 adrenergic receptor
The beta-1 adrenergic receptor (β1 adrenoreceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it. It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue.
Receptor
Actions
Actions of the β1 receptor include:
- Increase heart rate in sinoatrial node (SA node) (chronotropic effect)
- Increase atrial cardiac muscle contractility. (inotropic effect)
- Increases contractility and automaticity of ventricular cardiac muscle.
- Increases conduction and automaticity of atrioventricular node (AV node)
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Beta-1_adrenergic_receptor
Risk
Risk is the potential of gaining or losing something of value. Values (such as physical health, social status, emotional well-being or financial wealth) can be gained or lost when taking risk resulting from a given action or inaction, foreseen or unforeseen. Risk can also be defined as the intentional interaction with uncertainty. Uncertainty is a potential, unpredictable, and uncontrollable outcome; risk is a consequence of action taken in spite of uncertainty.
Risk perception is the subjective judgment people make about the severity and probability of a risk, and may vary person to person. Any human endeavor carries some risk, but some are much riskier than others.
Definitions
The Oxford English Dictionary cites the earliest use of the word in English (in the spelling of risque from its Arabic original "رزق" ) which mean working to gain income gain and profit (see Wikipedia Arabic meaning ) as of 1621, and the spelling as risk from 1655. It defines risk as:
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Risk
RISKS Digest
The RISKS Digest or Forum On Risks to the Public in Computers and Related Systems is an online periodical published since 1985 by the Committee on Computers and Public Policy of the Association for Computing Machinery. The editor is Peter G. Neumann.
It is a moderated forum concerned with the security and safety of computers, software, and technological systems. Security, and risk, here are taken broadly; RISKS is concerned not merely with so-called security holes in software, but with unintended consequences and hazards stemming from the design (or lack thereof) of automated systems. Other recurring subjects include cryptography and the effects of technically ill-considered public policies. RISKS also publishes announcements and Calls for Papers from various technical conferences, and technical book reviews (usually by Rob Slade, though occasionally by others).
Although RISKS is a forum of a computer science association, most contributions are readable and informative to anyone with an interest in the subject. It is heavily read by system administrators, and computer security managers, as well as computer scientists and engineers.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/RISKS_Digest
Podcasts:
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Sphingosine-1-Phosphate: Orchestrator of Cellular Dynamics | GlpBio
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that plays a crucial role in various cellular processes, including cell proliferation, migration, differentiation, and survival. It is synthesized from sphingosine, a long-chain amino alcohol, and is involved in the regulation of many physiological and pathological processes, including inflammation, immunity, angiogenesis, and cancer. S1P is produced by the phosphorylation of sphingosine by sphingosine kinase (SphK) enzymes, and it can be released from cells into the circulation, where it acts as a ligand for a family of G protein-coupled receptors known as S1P receptors. There are five known S1P receptors (S1P1-5), which are expressed on the surface of various cell types, including immune cells, endothelial cells, and smooth mus...
published: 31 Dec 2023 -
Sphingosine 1 Phosphate Receptor Modulator
0:11 MS Overview 0:55 Target Selection 1:38 Lead Discovery 2:56 Pre-clinical Trials 5:06 Clinical Trials 7:41 Registration 8:05 Summary Fong Shao Bing Ong, Ying Min Wu, Tommy Zhou, Richard Wang
published: 01 Sep 2018 -
Sphingosine 1-Phosphate Signaling: From the Receptor, Signaling Mechanisms to Novel Therapeutics.
NAVBO Education Committee Webinar Series. Presented by Dr. Timothy Hla on December 20, 2018: Sphingosine 1-Phosphate Signaling: From the Receptor, Signaling Mechanisms to Novel Therapeutics.
published: 05 Jul 2020 -
Optical control of Sphingosine-1-phosphate formation and function - Mar 22 2021
In this entry of our 2nd PhD student contest, Johannes Morstein of NYU, USA discusses the development of photoswitchable analogs of S1P (PhotoS1P) and its precursor sphingosine (PhotoSph)m and describes the evaluation of photoS1P as a tool for modulating S1P receptors in vitro and in vivo. He also discusses how, as photoS1P has prolonged metabolic stability and its formation is light-dependent, it has advantages as a novel tool to probe sphingolipid biology.
published: 25 Mar 2021 -
S1P receptor modulators in the treatment of MS
Bruce Cree, MD, PhD, MAS, University of California San Francisco, San Francisco, CA, speaks about sphingosine-1-phosphate (S1P) receptor modulators for treating multiple sclerosis (MS). The first approved oral MS therapy of such form was fingolimod, which is less effective than newer therapies and remains restricted by a challenging adverse event profile. At present, three improved modulators are approved: ozanimod and siponimod, S1P1/5 selective agents, and ponesimod, being solely S1P1 selective. Data has shown more favorable adverse event profiles and improved half-lives of these drugs, allowing for self-administration by patients at home, instead of requiring first dose observations. The drugs have also demonstrated higher efficacy, measured by the reduction in relapse rates and new les...
published: 29 Jun 2022 -
Sphingolipids || Chemical structure , biogenesis and function
This video talks about sphingolipids .They are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature
published: 03 Nov 2020 -
Advantages of ozanimod over previous sphingosine 1-phosphate modulators
Giancarlo Comi, MD, Vita-Salute San Raffaele University, Milan, Italy, describes the mechanism of action of ozanimod, a recently approved drug for the treatment of relapsing-remitting multiple sclerosis (MS), highlighting its benefits over fingolimod. Both ozanimod and fingolimod are sphingosine 1-phosphate (S1P) receptor modulators. However, whilst fingolimod targets four out of five S1P receptors, ozanimod targets only S1P1 and S1P5, thereby causing less adverse effects. Prof. Comi explains that through its action on S1P1, ozanimod prevents aggressive lymphocytes from entering the circulation and the brain, thus preventing brain damage. Due to its decreased toxicity, it is not necessary to monitor patients in the hospital during the first day of treatment. Finally, Prof. Comi comments on...
published: 04 Oct 2021 -
Sphingosine-1-phosphate signaling modulation for the treatment of acute myeloid leukemia (AML)
Stephanie Xie from the Princess Margaret Cancer Centre in Toronto, Canada presents on the role of sphingosine 1-phosphate (S1P) signaling in the interplay between normal hematopoiesis, AML and inflammation. She discusses how S1P activation of S1P receptor 3 (S1PR3) is a key process for myeloid lineage differentiation in human HSC that is dysregulated in AML - and functionally shows how modulating this pathway could be an effective and novel therapeutic approach for AML treatment.
published: 02 Nov 2020 -
Exit strategies: S1P signaling in inflammation - 12th July 2021
Susan Schwab from NYU College of Medicine, USA discusses how lymph and lymph node S1P are regulated during inflammation, and how alterations in S1P gradients can influence leukocytes during the immune response.
published: 16 May 2022 -
Benefits & Risks of S1P Receptor Modulators: Part 1
published: 16 Sep 2024
developed with YouTube
2:30
Sphingosine-1-Phosphate: Orchestrator of Cellular Dynamics | GlpBio
- Order: Reorder
- Duration: 2:30
- Uploaded Date: 31 Dec 2023
- views: 159
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that plays a crucial role in various cellular processes, including cell proliferation, migration, di...
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that plays a crucial role in various cellular processes, including cell proliferation, migration, differentiation, and survival. It is synthesized from sphingosine, a long-chain amino alcohol, and is involved in the regulation of many physiological and pathological processes, including inflammation, immunity, angiogenesis, and cancer.
S1P is produced by the phosphorylation of sphingosine by sphingosine kinase (SphK) enzymes, and it can be released from cells into the circulation, where it acts as a ligand for a family of G protein-coupled receptors known as S1P receptors. There are five known S1P receptors (S1P1-5), which are expressed on the surface of various cell types, including immune cells, endothelial cells, and smooth muscle cells.
The binding of S1P to its receptors triggers a variety of intracellular signaling pathways, including the activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, the mitogen-activated protein kinase (MAPK) pathway, and the Rho GTPase pathway. These pathways regulate many cellular functions, including cell survival, proliferation, migration, and cytoskeletal rearrangement.
S1P has been implicated in a wide range of physiological and pathological processes. For example, it plays a critical role in the development and maintenance of the cardiovascular system, and S1P receptor agonists have been investigated as potential therapies for cardiovascular diseases such as atherosclerosis. S1P also plays a role in regulating the immune system, and S1P receptor modulators have been developed as potential therapies for autoimmune diseases such as multiple sclerosis.
In addition, S1P has been shown to play a role in cancer progression and metastasis. S1P signaling has been implicated in promoting tumor cell survival, proliferation, and migration, and S1P receptor antagonists have been investigated as potential therapies for cancer.
Overall, Sphingosine-1-phosphate is a bioactive lipid molecule that plays a critical role in regulating various cellular processes. Its involvement in many physiological and pathological processes makes it a subject of ongoing research in fields such as cardiovascular disease, immunology, and cancer biology.
For details please check:
https://www.glpbio.com/sphingosine-1-phosphate.html
https://wn.com/Sphingosine_1_Phosphate_Orchestrator_Of_Cellular_Dynamics_|_Glpbio
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that plays a crucial role in various cellular processes, including cell proliferation, migration, differentiation, and survival. It is synthesized from sphingosine, a long-chain amino alcohol, and is involved in the regulation of many physiological and pathological processes, including inflammation, immunity, angiogenesis, and cancer.
S1P is produced by the phosphorylation of sphingosine by sphingosine kinase (SphK) enzymes, and it can be released from cells into the circulation, where it acts as a ligand for a family of G protein-coupled receptors known as S1P receptors. There are five known S1P receptors (S1P1-5), which are expressed on the surface of various cell types, including immune cells, endothelial cells, and smooth muscle cells.
The binding of S1P to its receptors triggers a variety of intracellular signaling pathways, including the activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, the mitogen-activated protein kinase (MAPK) pathway, and the Rho GTPase pathway. These pathways regulate many cellular functions, including cell survival, proliferation, migration, and cytoskeletal rearrangement.
S1P has been implicated in a wide range of physiological and pathological processes. For example, it plays a critical role in the development and maintenance of the cardiovascular system, and S1P receptor agonists have been investigated as potential therapies for cardiovascular diseases such as atherosclerosis. S1P also plays a role in regulating the immune system, and S1P receptor modulators have been developed as potential therapies for autoimmune diseases such as multiple sclerosis.
In addition, S1P has been shown to play a role in cancer progression and metastasis. S1P signaling has been implicated in promoting tumor cell survival, proliferation, and migration, and S1P receptor antagonists have been investigated as potential therapies for cancer.
Overall, Sphingosine-1-phosphate is a bioactive lipid molecule that plays a critical role in regulating various cellular processes. Its involvement in many physiological and pathological processes makes it a subject of ongoing research in fields such as cardiovascular disease, immunology, and cancer biology.
For details please check:
https://www.glpbio.com/sphingosine-1-phosphate.html
8:51
Sphingosine 1 Phosphate Receptor Modulator
- Order: Reorder
- Duration: 8:51
- Uploaded Date: 01 Sep 2018
- views: 1748
0:11 MS Overview
0:55 Target Selection
1:38 Lead Discovery
2:56 Pre-clinical Trials
5:06 Clinical Trials
7:41 Registration
8:05 Summary
Fong Shao Bing O...
0:11 MS Overview
0:55 Target Selection
1:38 Lead Discovery
2:56 Pre-clinical Trials
5:06 Clinical Trials
7:41 Registration
8:05 Summary
Fong Shao Bing Ong, Ying Min Wu, Tommy Zhou, Richard Wang
https://wn.com/Sphingosine_1_Phosphate_Receptor_Modulator
0:11 MS Overview
0:55 Target Selection
1:38 Lead Discovery
2:56 Pre-clinical Trials
5:06 Clinical Trials
7:41 Registration
8:05 Summary
Fong Shao Bing Ong, Ying Min Wu, Tommy Zhou, Richard Wang
- published: 01 Sep 2018
- views: 1748
59:20
Sphingosine 1-Phosphate Signaling: From the Receptor, Signaling Mechanisms to Novel Therapeutics.
- Order: Reorder
- Duration: 59:20
- Uploaded Date: 05 Jul 2020
- views: 3107
NAVBO Education Committee Webinar Series.
Presented by Dr. Timothy Hla on December 20, 2018: Sphingosine 1-Phosphate Signaling: From the Receptor, Signaling M...
NAVBO Education Committee Webinar Series.
Presented by Dr. Timothy Hla on December 20, 2018: Sphingosine 1-Phosphate Signaling: From the Receptor, Signaling Mechanisms to Novel Therapeutics.
https://wn.com/Sphingosine_1_Phosphate_Signaling_From_The_Receptor,_Signaling_Mechanisms_To_Novel_Therapeutics.
NAVBO Education Committee Webinar Series.
Presented by Dr. Timothy Hla on December 20, 2018: Sphingosine 1-Phosphate Signaling: From the Receptor, Signaling Mechanisms to Novel Therapeutics.
- published: 05 Jul 2020
- views: 3107
13:10
Optical control of Sphingosine-1-phosphate formation and function - Mar 22 2021
- Order: Reorder
- Duration: 13:10
- Uploaded Date: 25 Mar 2021
- views: 781
In this entry of our 2nd PhD student contest, Johannes Morstein of NYU, USA discusses the development of photoswitchable analogs of S1P (PhotoS1P) and its precu...
In this entry of our 2nd PhD student contest, Johannes Morstein of NYU, USA discusses the development of photoswitchable analogs of S1P (PhotoS1P) and its precursor sphingosine (PhotoSph)m and describes the evaluation of photoS1P as a tool for modulating S1P receptors in vitro and in vivo. He also discusses how, as photoS1P has prolonged metabolic stability and its formation is light-dependent, it has advantages as a novel tool to probe sphingolipid biology.
https://wn.com/Optical_Control_Of_Sphingosine_1_Phosphate_Formation_And_Function_Mar_22_2021
In this entry of our 2nd PhD student contest, Johannes Morstein of NYU, USA discusses the development of photoswitchable analogs of S1P (PhotoS1P) and its precursor sphingosine (PhotoSph)m and describes the evaluation of photoS1P as a tool for modulating S1P receptors in vitro and in vivo. He also discusses how, as photoS1P has prolonged metabolic stability and its formation is light-dependent, it has advantages as a novel tool to probe sphingolipid biology.
- published: 25 Mar 2021
- views: 781
5:43
S1P receptor modulators in the treatment of MS
- Order: Reorder
- Duration: 5:43
- Uploaded Date: 29 Jun 2022
- views: 494
Bruce Cree, MD, PhD, MAS, University of California San Francisco, San Francisco, CA, speaks about sphingosine-1-phosphate (S1P) receptor modulators for treating...
Bruce Cree, MD, PhD, MAS, University of California San Francisco, San Francisco, CA, speaks about sphingosine-1-phosphate (S1P) receptor modulators for treating multiple sclerosis (MS). The first approved oral MS therapy of such form was fingolimod, which is less effective than newer therapies and remains restricted by a challenging adverse event profile. At present, three improved modulators are approved: ozanimod and siponimod, S1P1/5 selective agents, and ponesimod, being solely S1P1 selective. Data has shown more favorable adverse event profiles and improved half-lives of these drugs, allowing for self-administration by patients at home, instead of requiring first dose observations. The drugs have also demonstrated higher efficacy, measured by the reduction in relapse rates and new lesion formation. Given the strong efficacy demonstrated in trials, Dr Cree says that he would use S1P receptor modulators as frontline medications. More research is needed on the various agents as there is a rebound effect apparent with fingolimod, unexpectedly not observed for ozanimod. This interview took place at the Consortium of Multiple Sclerosis Centers (CMSC) congress 2022 in Maryland.
https://wn.com/S1P_Receptor_Modulators_In_The_Treatment_Of_Ms
Bruce Cree, MD, PhD, MAS, University of California San Francisco, San Francisco, CA, speaks about sphingosine-1-phosphate (S1P) receptor modulators for treating multiple sclerosis (MS). The first approved oral MS therapy of such form was fingolimod, which is less effective than newer therapies and remains restricted by a challenging adverse event profile. At present, three improved modulators are approved: ozanimod and siponimod, S1P1/5 selective agents, and ponesimod, being solely S1P1 selective. Data has shown more favorable adverse event profiles and improved half-lives of these drugs, allowing for self-administration by patients at home, instead of requiring first dose observations. The drugs have also demonstrated higher efficacy, measured by the reduction in relapse rates and new lesion formation. Given the strong efficacy demonstrated in trials, Dr Cree says that he would use S1P receptor modulators as frontline medications. More research is needed on the various agents as there is a rebound effect apparent with fingolimod, unexpectedly not observed for ozanimod. This interview took place at the Consortium of Multiple Sclerosis Centers (CMSC) congress 2022 in Maryland.
- published: 29 Jun 2022
- views: 494
4:51
Sphingolipids || Chemical structure , biogenesis and function
- Order: Reorder
- Duration: 4:51
- Uploaded Date: 03 Nov 2020
- views: 66461
This video talks about sphingolipids .They are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphin...
This video talks about sphingolipids .They are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature
https://wn.com/Sphingolipids_||_Chemical_Structure_,_Biogenesis_And_Function
This video talks about sphingolipids .They are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature
- published: 03 Nov 2020
- views: 66461
4:06
Advantages of ozanimod over previous sphingosine 1-phosphate modulators
- Order: Reorder
- Duration: 4:06
- Uploaded Date: 04 Oct 2021
- views: 747
Giancarlo Comi, MD, Vita-Salute San Raffaele University, Milan, Italy, describes the mechanism of action of ozanimod, a recently approved drug for the treatment...
Giancarlo Comi, MD, Vita-Salute San Raffaele University, Milan, Italy, describes the mechanism of action of ozanimod, a recently approved drug for the treatment of relapsing-remitting multiple sclerosis (MS), highlighting its benefits over fingolimod. Both ozanimod and fingolimod are sphingosine 1-phosphate (S1P) receptor modulators. However, whilst fingolimod targets four out of five S1P receptors, ozanimod targets only S1P1 and S1P5, thereby causing less adverse effects. Prof. Comi explains that through its action on S1P1, ozanimod prevents aggressive lymphocytes from entering the circulation and the brain, thus preventing brain damage. Due to its decreased toxicity, it is not necessary to monitor patients in the hospital during the first day of treatment. Finally, Prof. Comi comments on other novel S1P receptor modulators, that could enable selection of the most appropriate drug for each patient. This interview took place during the XXV World Congress of Neurology.
https://wn.com/Advantages_Of_Ozanimod_Over_Previous_Sphingosine_1_Phosphate_Modulators
Giancarlo Comi, MD, Vita-Salute San Raffaele University, Milan, Italy, describes the mechanism of action of ozanimod, a recently approved drug for the treatment of relapsing-remitting multiple sclerosis (MS), highlighting its benefits over fingolimod. Both ozanimod and fingolimod are sphingosine 1-phosphate (S1P) receptor modulators. However, whilst fingolimod targets four out of five S1P receptors, ozanimod targets only S1P1 and S1P5, thereby causing less adverse effects. Prof. Comi explains that through its action on S1P1, ozanimod prevents aggressive lymphocytes from entering the circulation and the brain, thus preventing brain damage. Due to its decreased toxicity, it is not necessary to monitor patients in the hospital during the first day of treatment. Finally, Prof. Comi comments on other novel S1P receptor modulators, that could enable selection of the most appropriate drug for each patient. This interview took place during the XXV World Congress of Neurology.
- published: 04 Oct 2021
- views: 747
21:32
Sphingosine-1-phosphate signaling modulation for the treatment of acute myeloid leukemia (AML)
- Order: Reorder
- Duration: 21:32
- Uploaded Date: 02 Nov 2020
- views: 817
Stephanie Xie from the Princess Margaret Cancer Centre in Toronto, Canada presents on the role of sphingosine 1-phosphate (S1P) signaling in the interplay betwe...
Stephanie Xie from the Princess Margaret Cancer Centre in Toronto, Canada presents on the role of sphingosine 1-phosphate (S1P) signaling in the interplay between normal hematopoiesis, AML and inflammation. She discusses how S1P activation of S1P receptor 3 (S1PR3) is a key process for myeloid lineage differentiation in human HSC that is dysregulated in AML - and functionally shows how modulating this pathway could be an effective and novel therapeutic approach for AML treatment.
https://wn.com/Sphingosine_1_Phosphate_Signaling_Modulation_For_The_Treatment_Of_Acute_Myeloid_Leukemia_(Aml)
Stephanie Xie from the Princess Margaret Cancer Centre in Toronto, Canada presents on the role of sphingosine 1-phosphate (S1P) signaling in the interplay between normal hematopoiesis, AML and inflammation. She discusses how S1P activation of S1P receptor 3 (S1PR3) is a key process for myeloid lineage differentiation in human HSC that is dysregulated in AML - and functionally shows how modulating this pathway could be an effective and novel therapeutic approach for AML treatment.
- published: 02 Nov 2020
- views: 817
25:32
Exit strategies: S1P signaling in inflammation - 12th July 2021
- Order: Reorder
- Duration: 25:32
- Uploaded Date: 16 May 2022
- views: 582
Susan Schwab from NYU College of Medicine, USA discusses how lymph and lymph node S1P are regulated during inflammation, and how alterations in S1P gradients ca...
Susan Schwab from NYU College of Medicine, USA discusses how lymph and lymph node S1P are regulated during inflammation, and how alterations in S1P gradients can influence leukocytes during the immune response.
https://wn.com/Exit_Strategies_S1P_Signaling_In_Inflammation_12Th_July_2021
Susan Schwab from NYU College of Medicine, USA discusses how lymph and lymph node S1P are regulated during inflammation, and how alterations in S1P gradients can influence leukocytes during the immune response.
- published: 16 May 2022
- views: 582
0:38
Benefits & Risks of S1P Receptor Modulators: Part 1
- Order: Reorder
- Duration: 0:38
- Uploaded Date: 16 Sep 2024
- views: 90
- published: 16 Sep 2024
- views: 90
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Endocrinology | Receptor Pathways
Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! Join us for our lecture on receptor pathways. During this lecture Professor Zach Murphy will be describing both peptide and steroid hormones. We will also be discussing G protein coupled receptors and inhibition. We hope you enjoy this lecture and be sure to support us below! @27:05 - There is an error. I said phosphodiesterase break down phospholipase C. Phospholipase is a phosphodiesterase. Thanks! Table of Contents: (Thanks to Community Member Khaled!) 00:00 - Intro music 00:20 - Types of hormones. 00:47 - Peptide hormones. 02:32 - Second Messenger Systems 03:10 - Steroid hormones 05:15 - G Stimulatory pathway 14:00 - GQ pathway 21:20 - Oxytocin & muscle contraction 22:28 - Steroid Hormones Pathway 25:44 - G Inhibitory P...
published: 11 May 2017 -
Receptors: Types & Functions
Find notes here: https://www.nonstopneuron.com/post/receptors-types-and-functions Explore our entire animation video library at: https://www.nonstopneuron.com/ Video Summary: Receptors receive signals from cells exterior. They have a ligand-binding domain to recognize specific ligand and an effector domain to produce the downstream effect. Receptors for hydrophilic signal molecules are located on the cell membrane and receptors for hydrophobic molecules are located inside the cell. Various types of receptors are ligand-gated ion channels that regulate the opening or closing of the channel. G protein-coupled receptors act through G proteins and ultimately regulate the function of a wide range of enzymes and ion channels. Catalytic receptors mostly activate or inactivate a protein by phosph...
published: 30 Jun 2021 -
Common cell signaling pathway
What are common cell signaling pathways? To make a multicellular organism, cells must be able to communicate with one another, and to do it cells often send out tiny chemical signals that act on the receptors on other cells. Signals can be classified according to the distance between the signaling cell and the target cell. Find our full video library only on Osmosis: http://osms.it/more. Join millions of current and future clinicians who learn by Osmosis, along with hundreds of universities around the world who partner with Osmosis from Elseiver to make medical and health education more engaging and efficient. We have unparalleled tools and materials to prepare you for success in school, on your board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. If y...
published: 14 Oct 2020 -
Insulin Signaling Cascade and Downstream Effects - Biochemistry Lesson
Learn the insulin signaling transduction cascade/pathway in this biochemistry powerpoint-style lecture! Hey guys! Here is a new video where I teach the insulin signaling pathway in a new powerpoint style lecture format. Please let me know if you guys like this format of learning, and I will make more videos using this teaching method! I hope you all find it informative and please like and subscribe if you found the video helpful! All feedback is appreciated :) JJ *Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1 ****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and are intended for educational/teaching purposes only.**** -----------------------------------------------...
published: 11 Jan 2017 -
Receptors: Signal Transduction and Phosphorylation Cascade
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out! Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem Biology Tutorials: http://bit.ly/ProfDaveBio Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1 Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2 Mathematics Tutorials: http://bit.ly/ProfDaveMaths EMAIL► [email protected] PATREON► http://patreon.com/ProfessorDaveExplains Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience! Amazon: https://amzn.to/...
published: 06 Sep 2016 -
Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join My goal is to reduce educational disparities by making education FREE. These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.) For educational purposes only; NOT medical or other advice. Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised. Opinions are entirely my own.
published: 12 May 2021 -
Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon activation of a G protein-coupled receptor. Inositol triphosphate and DAG are cleavage products of phosphatidyl inositol 4,5 bisphosphate (PIP2), which is cleaved by phospholipase C. Increasing levels of IP3 lead to augmented cytosolic calcium levels that further lead to activation of downstream cellular targets. Hey everyone. In this lesson you will be introduced to the IP3 and calcium signaling pathway. We will also discuss the purpose of the pathway, enzymes involved in the pathway, and how the pathway is regulated. I hope you find this video helpful. If you do, please like and subscribe for more videos like this one....
published: 26 Jun 2018 -
Receptor Tyrosine Kinases (Newer Version)
published: 29 Sep 2017 -
MICROBIOLOGY BOOKS#MBBS
published: 01 Dec 2024 -
An Intro to Receptors | Types, Structure & Location | Part 1
#receptors #AnIntrotoReceptors #Receptors #GProteinCoupledReceptors #GPCRs #7PassReceptors An Intro to Receptors | Types, Structure & Location | Part 1 Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 800+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $45 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/ --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 8...
published: 21 Nov 2021
developed with YouTube
28:04
Endocrinology | Receptor Pathways
- Order: Reorder
- Duration: 28:04
- Uploaded Date: 11 May 2017
- views: 1383459
Official Ninja Nerd Website: https://ninjanerd.org
Ninja Nerds!
Join us for our lecture on receptor pathways. During this lecture Professor Zach Murphy will be...
Official Ninja Nerd Website: https://ninjanerd.org
Ninja Nerds!
Join us for our lecture on receptor pathways. During this lecture Professor Zach Murphy will be describing both peptide and steroid hormones. We will also be discussing G protein coupled receptors and inhibition. We hope you enjoy this lecture and be sure to support us below!
@27:05 - There is an error. I said phosphodiesterase break down phospholipase C. Phospholipase is a phosphodiesterase. Thanks!
Table of Contents: (Thanks to Community Member Khaled!)
00:00 - Intro music
00:20 - Types of hormones.
00:47 - Peptide hormones.
02:32 - Second Messenger Systems
03:10 - Steroid hormones
05:15 - G Stimulatory pathway
14:00 - GQ pathway
21:20 - Oxytocin & muscle contraction
22:28 - Steroid Hormones Pathway
25:44 - G Inhibitory Pathway & PDE
27:35 - Outro
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#ninjanerd #ReceptorPathways #Endocrinology
https://wn.com/Endocrinology_|_Receptor_Pathways
Official Ninja Nerd Website: https://ninjanerd.org
Ninja Nerds!
Join us for our lecture on receptor pathways. During this lecture Professor Zach Murphy will be describing both peptide and steroid hormones. We will also be discussing G protein coupled receptors and inhibition. We hope you enjoy this lecture and be sure to support us below!
@27:05 - There is an error. I said phosphodiesterase break down phospholipase C. Phospholipase is a phosphodiesterase. Thanks!
Table of Contents: (Thanks to Community Member Khaled!)
00:00 - Intro music
00:20 - Types of hormones.
00:47 - Peptide hormones.
02:32 - Second Messenger Systems
03:10 - Steroid hormones
05:15 - G Stimulatory pathway
14:00 - GQ pathway
21:20 - Oxytocin & muscle contraction
22:28 - Steroid Hormones Pathway
25:44 - G Inhibitory Pathway & PDE
27:35 - Outro
Join this channel to get access to perks:
https://www.youtube.com/channel/UC6QYFutt9cluQ3uSM963_KQ/join
APPAREL |
We are switching merchandise suppliers.
DONATE
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@NinjaNerdSci
DISCORD | https://discord.gg/3srTG4dngW
#ninjanerd #ReceptorPathways #Endocrinology
- published: 11 May 2017
- views: 1383459
7:14
Receptors: Types & Functions
- Order: Reorder
- Duration: 7:14
- Uploaded Date: 30 Jun 2021
- views: 163931
Find notes here: https://www.nonstopneuron.com/post/receptors-types-and-functions
Explore our entire animation video library at: https://www.nonstopneuron.com/
...
Find notes here: https://www.nonstopneuron.com/post/receptors-types-and-functions
Explore our entire animation video library at: https://www.nonstopneuron.com/
Video Summary:
Receptors receive signals from cells exterior. They have a ligand-binding domain to recognize specific ligand and an effector domain to produce the downstream effect. Receptors for hydrophilic signal molecules are located on the cell membrane and receptors for hydrophobic molecules are located inside the cell. Various types of receptors are ligand-gated ion channels that regulate the opening or closing of the channel. G protein-coupled receptors act through G proteins and ultimately regulate the function of a wide range of enzymes and ion channels. Catalytic receptors mostly activate or inactivate a protein by phosphorylating or dephosphorylating them and Nuclear receptors serve as transcription factors.
🎞 More videos on General Physiology:
• Milieu Interieur vs Milieu Exterieur: Milieu Interieur vs Milieu Exterieur: https://youtu.be/S5YEVctChV8
• Homeostasis & Negative feedback loop: https://youtu.be/MaMpqslvyOA
• Biological Membrane and Fluid Mosaic Model: https://youtu.be/lD_f1Gy2fsc
• Phospholipids in Water: https://youtu.be/6znxvYowmxQ
• Cell Nucleus: https://youtu.be/wcKEcu2Z3pw
• Endoplasmic Reticulum: https://youtu.be/NRiJhzYE4Ko
• Golgi Apparatus: https://youtu.be/ZfL--3KNEy8
• Interesting facts about Protein Synthesis and SecretionL https://youtu.be/4as57LAHotE
• Mitochondria: https://youtu.be/WkMOIO7HhZY
• Interesting facts about Protein Synthesis and SecretionL https://youtu.be/4as57LAHotE
• Why ATPs are called Energy Currency of the Cell: https://youtu.be/bjwmxqpyV3g
• How Physiological Parameters are Controlled?: https://youtu.be/DEBajDp8QlA
• Cell to Cell Communication: https://youtu.be/i3bY-JCYs4A
• Primary vs Secondary Active Transport: https://youtu.be/N-iBdwtQn4Q
● Follow me at:
• Facebook: https://www.facebook.com/NonstopNeuron
• Instagram: https://www.instagram.com/NonstopNeuron/
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.
https://wn.com/Receptors_Types_Functions
Find notes here: https://www.nonstopneuron.com/post/receptors-types-and-functions
Explore our entire animation video library at: https://www.nonstopneuron.com/
Video Summary:
Receptors receive signals from cells exterior. They have a ligand-binding domain to recognize specific ligand and an effector domain to produce the downstream effect. Receptors for hydrophilic signal molecules are located on the cell membrane and receptors for hydrophobic molecules are located inside the cell. Various types of receptors are ligand-gated ion channels that regulate the opening or closing of the channel. G protein-coupled receptors act through G proteins and ultimately regulate the function of a wide range of enzymes and ion channels. Catalytic receptors mostly activate or inactivate a protein by phosphorylating or dephosphorylating them and Nuclear receptors serve as transcription factors.
🎞 More videos on General Physiology:
• Milieu Interieur vs Milieu Exterieur: Milieu Interieur vs Milieu Exterieur: https://youtu.be/S5YEVctChV8
• Homeostasis & Negative feedback loop: https://youtu.be/MaMpqslvyOA
• Biological Membrane and Fluid Mosaic Model: https://youtu.be/lD_f1Gy2fsc
• Phospholipids in Water: https://youtu.be/6znxvYowmxQ
• Cell Nucleus: https://youtu.be/wcKEcu2Z3pw
• Endoplasmic Reticulum: https://youtu.be/NRiJhzYE4Ko
• Golgi Apparatus: https://youtu.be/ZfL--3KNEy8
• Interesting facts about Protein Synthesis and SecretionL https://youtu.be/4as57LAHotE
• Mitochondria: https://youtu.be/WkMOIO7HhZY
• Interesting facts about Protein Synthesis and SecretionL https://youtu.be/4as57LAHotE
• Why ATPs are called Energy Currency of the Cell: https://youtu.be/bjwmxqpyV3g
• How Physiological Parameters are Controlled?: https://youtu.be/DEBajDp8QlA
• Cell to Cell Communication: https://youtu.be/i3bY-JCYs4A
• Primary vs Secondary Active Transport: https://youtu.be/N-iBdwtQn4Q
● Follow me at:
• Facebook: https://www.facebook.com/NonstopNeuron
• Instagram: https://www.instagram.com/NonstopNeuron/
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.
- published: 30 Jun 2021
- views: 163931
9:41
Common cell signaling pathway
- Order: Reorder
- Duration: 9:41
- Uploaded Date: 14 Oct 2020
- views: 562934
What are common cell signaling pathways? To make a multicellular organism, cells must be able to communicate with one another, and to do it cells often send out...
What are common cell signaling pathways? To make a multicellular organism, cells must be able to communicate with one another, and to do it cells often send out tiny chemical signals that act on the receptors on other cells. Signals can be classified according to the distance between the signaling cell and the target cell. Find our full video library only on Osmosis: http://osms.it/more.
Join millions of current and future clinicians who learn by Osmosis, along with hundreds of universities around the world who partner with Osmosis from Elseiver to make medical and health education more engaging and efficient. We have unparalleled tools and materials to prepare you for success in school, on your board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. If you're interested in exploring an institutional partnership, visit osmosis.org/educators to request a personalized demo.
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Our Vision: Everyone who cares for someone will learn by Osmosis.
Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: http://osms.it/mission
Medical disclaimer: Osmosis from Elsevier does not provide medical advice. Osmosis from Elsevier and the content available on the Osmosis from Elsevier properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed healthcare provider. Always seek the advice of a physician or other qualified healthcare professional with any questions you have regarding a medical condition.
© 2024 Elsevier. All rights reserved.
https://wn.com/Common_Cell_Signaling_Pathway
What are common cell signaling pathways? To make a multicellular organism, cells must be able to communicate with one another, and to do it cells often send out tiny chemical signals that act on the receptors on other cells. Signals can be classified according to the distance between the signaling cell and the target cell. Find our full video library only on Osmosis: http://osms.it/more.
Join millions of current and future clinicians who learn by Osmosis, along with hundreds of universities around the world who partner with Osmosis from Elseiver to make medical and health education more engaging and efficient. We have unparalleled tools and materials to prepare you for success in school, on your board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. If you're interested in exploring an institutional partnership, visit osmosis.org/educators to request a personalized demo.
Follow us on social:
Facebook: http://osms.it/facebook
Twitter: http://osms.it/twitter
Instagram for med: http://osms.it/instagram
Instagram for nursing: https://osms.it/ignursing
TikTok: https://osms.it/tiktok
Linkedin: https://osms.it/linkedin
Our Vision: Everyone who cares for someone will learn by Osmosis.
Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: http://osms.it/mission
Medical disclaimer: Osmosis from Elsevier does not provide medical advice. Osmosis from Elsevier and the content available on the Osmosis from Elsevier properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed healthcare provider. Always seek the advice of a physician or other qualified healthcare professional with any questions you have regarding a medical condition.
© 2024 Elsevier. All rights reserved.
- published: 14 Oct 2020
- views: 562934
10:07
Insulin Signaling Cascade and Downstream Effects - Biochemistry Lesson
- Order: Reorder
- Duration: 10:07
- Uploaded Date: 11 Jan 2017
- views: 184654
Learn the insulin signaling transduction cascade/pathway in this biochemistry powerpoint-style lecture!
Hey guys! Here is a new video where I teach the insulin...
Learn the insulin signaling transduction cascade/pathway in this biochemistry powerpoint-style lecture!
Hey guys! Here is a new video where I teach the insulin signaling pathway in a new powerpoint style lecture format. Please let me know if you guys like this format of learning, and I will make more videos using this teaching method! I hope you all find it informative and please like and subscribe if you found the video helpful! All feedback is appreciated :) JJ
*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1
****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and are intended for educational/teaching purposes only.****
-------------------------------------------------------------------------------------------------------------
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Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Medical Terminology - Anatomical Terms:
https://www.youtube.com/watch?v=KkXiE3NEJxw
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ
https://wn.com/Insulin_Signaling_Cascade_And_Downstream_Effects_Biochemistry_Lesson
Learn the insulin signaling transduction cascade/pathway in this biochemistry powerpoint-style lecture!
Hey guys! Here is a new video where I teach the insulin signaling pathway in a new powerpoint style lecture format. Please let me know if you guys like this format of learning, and I will make more videos using this teaching method! I hope you all find it informative and please like and subscribe if you found the video helpful! All feedback is appreciated :) JJ
*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1
****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and are intended for educational/teaching purposes only.****
-------------------------------------------------------------------------------------------------------------
Try Audible and Get A Free Audiobook
https://www.amazon.com/dp/B00NB86OYE/?_encoding=UTF8&ref_=sv_adbl_subnav_ref1_1
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Please help support this channel and future lessons by becoming a patron (and get cool stuff) ➜ https://www.patreon.com/jjmedicine
Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
Check out the best tool to help grow your YouTube channel (it’s helped me!)
https://www.tubebuddy.com/jjmedicine
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Medical Terminology - Anatomical Terms:
https://www.youtube.com/watch?v=KkXiE3NEJxw
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ
- published: 11 Jan 2017
- views: 184654
6:26
Receptors: Signal Transduction and Phosphorylation Cascade
- Order: Reorder
- Duration: 6:26
- Uploaded Date: 06 Sep 2016
- views: 452542
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it,...
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMaths
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
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Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
https://wn.com/Receptors_Signal_Transduction_And_Phosphorylation_Cascade
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMaths
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
- published: 06 Sep 2016
- views: 452542
17:26
Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)
- Order: Reorder
- Duration: 17:26
- Uploaded Date: 12 May 2021
- views: 488769
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FRE...
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
https://wn.com/Signal_Transduction_Pathways_(G_Protein,_Receptor_Tyrosine_Kinase,_Cgmp)
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
- published: 12 May 2021
- views: 488769
5:42
Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System
- Order: Reorder
- Duration: 5:42
- Uploaded Date: 26 Jun 2018
- views: 174052
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregul...
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon activation of a G protein-coupled receptor. Inositol triphosphate and DAG are cleavage products of phosphatidyl inositol 4,5 bisphosphate (PIP2), which is cleaved by phospholipase C. Increasing levels of IP3 lead to augmented cytosolic calcium levels that further lead to activation of downstream cellular targets.
Hey everyone. In this lesson you will be introduced to the IP3 and calcium signaling pathway. We will also discuss the purpose of the pathway, enzymes involved in the pathway, and how the pathway is regulated.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
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Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Medical Terminology - Anatomical Terms:
https://www.youtube.com/watch?v=KkXiE3NEJxw
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
----------------------------------------------------------------------------------------------------
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe! JJ
----------------------------------------------------------------------------------------------------
DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
https://wn.com/Inositol_Triphosphate_(Ip3)_And_Calcium_Signaling_Pathway_|_Second_Messenger_System
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon activation of a G protein-coupled receptor. Inositol triphosphate and DAG are cleavage products of phosphatidyl inositol 4,5 bisphosphate (PIP2), which is cleaved by phospholipase C. Increasing levels of IP3 lead to augmented cytosolic calcium levels that further lead to activation of downstream cellular targets.
Hey everyone. In this lesson you will be introduced to the IP3 and calcium signaling pathway. We will also discuss the purpose of the pathway, enzymes involved in the pathway, and how the pathway is regulated.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Microphone I use to record these lessons
https://www.amazon.com/dp/B00N1YPXW2/?tag=aiponsite-20&linkCode=ic5&ascsubtag=amzn1.idea.1K2H9Z4RF77DB&creativeASIN=B00N1YPXW2&ref=exp_jjmedicine_dp_vv_d
Stethoscope I use in my clinical work
https://www.amazon.com/dp/B01M0I4KOZ/?tag=aiponsite-20&linkCode=ic5&ascsubtag=amzn1.idea.1K2H9Z4RF77DB&creativeASIN=B01M0I4KOZ&ref=exp_jjmedicine_dp_vv_d
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Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Medical Terminology - Anatomical Terms:
https://www.youtube.com/watch?v=KkXiE3NEJxw
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
----------------------------------------------------------------------------------------------------
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe! JJ
----------------------------------------------------------------------------------------------------
DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
- published: 26 Jun 2018
- views: 174052
4:39
Receptor Tyrosine Kinases (Newer Version)
- Order: Reorder
- Duration: 4:39
- Uploaded Date: 29 Sep 2017
- views: 322025
- published: 29 Sep 2017
- views: 322025
0:17
MICROBIOLOGY BOOKS#MBBS
- Order: Reorder
- Duration: 0:17
- Uploaded Date: 01 Dec 2024
- views: 3
- published: 01 Dec 2024
- views: 3
54:38
An Intro to Receptors | Types, Structure & Location | Part 1
- Order: Reorder
- Duration: 54:38
- Uploaded Date: 21 Nov 2021
- views: 189851
#receptors #AnIntrotoReceptors #Receptors #GProteinCoupledReceptors #GPCRs #7PassReceptors
An Intro to Receptors | Types, Structure & Location | Part 1
Like t...
#receptors #AnIntrotoReceptors #Receptors #GProteinCoupledReceptors #GPCRs #7PassReceptors
An Intro to Receptors | Types, Structure & Location | Part 1
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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
In this video Dr. Najeeb discusses the following points.
00:00 - 01:40 What are we going to discuss in this lecture?
01:41 - 02:48 Sensory receptors and receptors of physiology, biochemistry and pharmacology.
02:48 - 12:20 What is a receptor?
12:51 - 15:16 Where are the receptors located?
15:17 - 37:42 transmembrane receptors and their types with examples.
21:04 - 30:13 G-Protein receptors – a transmembrane type of receptor.
26:27 - 30:06 Trimeric G proteins and monomeric G-proteins.
37:43 - 44:46 Intracellular receptors (cytosolic and nuclear receptors) with examples.
44:47 - 49:40 Extracellular receptors and their examples.
45:35 - 48:12 Antithrombin III as an extracellular drug receptor. Heparin and it’s mechanism of action.
49:41 - 53:28. Review/Summary of this lecture.
53:30 - 54:37 What we are going to discuss in the upcoming lecture?
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https://wn.com/An_Intro_To_Receptors_|_Types,_Structure_Location_|_Part_1
#receptors #AnIntrotoReceptors #Receptors #GProteinCoupledReceptors #GPCRs #7PassReceptors
An Intro to Receptors | Types, Structure & Location | Part 1
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Membership Features for premium website members.
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2. Basic Medical Sciences & Clinical Medicine.
3. Mobile-friendly interface with android and iOS apps.
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5. Download option for offline video playback.
6. Fanatic customer support and that's 24/7.
7. Fast video playback option to learn faster.
8. Trusted by over 2M+ students in 190 countries.
---------------------------------------------------------------------------------------------------------------------------
▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
In this video Dr. Najeeb discusses the following points.
00:00 - 01:40 What are we going to discuss in this lecture?
01:41 - 02:48 Sensory receptors and receptors of physiology, biochemistry and pharmacology.
02:48 - 12:20 What is a receptor?
12:51 - 15:16 Where are the receptors located?
15:17 - 37:42 transmembrane receptors and their types with examples.
21:04 - 30:13 G-Protein receptors – a transmembrane type of receptor.
26:27 - 30:06 Trimeric G proteins and monomeric G-proteins.
37:43 - 44:46 Intracellular receptors (cytosolic and nuclear receptors) with examples.
44:47 - 49:40 Extracellular receptors and their examples.
45:35 - 48:12 Antithrombin III as an extracellular drug receptor. Heparin and it’s mechanism of action.
49:41 - 53:28. Review/Summary of this lecture.
53:30 - 54:37 What we are going to discuss in the upcoming lecture?
---------------------------------------------------------------------------------------------------------------------------
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Sign up now on our website at https://members.drnajeeblectures.com/
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- published: 21 Nov 2021
- views: 189851
2:30
Sphingosine-1-Phosphate: Orchestrator of Cellular Dynamics | GlpBio
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that plays a crucial role in v...
published: 31 Dec 2023
Sphingosine-1-Phosphate: Orchestrator of Cellular Dynamics | GlpBio
Sphingosine-1-Phosphate: Orchestrator of Cellular Dynamics | GlpBio
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- published: 31 Dec 2023
- views: 159
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that plays a crucial role in various cellular processes, including cell proliferation, migration, differentiation, and survival. It is synthesized from sphingosine, a long-chain amino alcohol, and is involved in the regulation of many physiological and pathological processes, including inflammation, immunity, angiogenesis, and cancer.
S1P is produced by the phosphorylation of sphingosine by sphingosine kinase (SphK) enzymes, and it can be released from cells into the circulation, where it acts as a ligand for a family of G protein-coupled receptors known as S1P receptors. There are five known S1P receptors (S1P1-5), which are expressed on the surface of various cell types, including immune cells, endothelial cells, and smooth muscle cells.
The binding of S1P to its receptors triggers a variety of intracellular signaling pathways, including the activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, the mitogen-activated protein kinase (MAPK) pathway, and the Rho GTPase pathway. These pathways regulate many cellular functions, including cell survival, proliferation, migration, and cytoskeletal rearrangement.
S1P has been implicated in a wide range of physiological and pathological processes. For example, it plays a critical role in the development and maintenance of the cardiovascular system, and S1P receptor agonists have been investigated as potential therapies for cardiovascular diseases such as atherosclerosis. S1P also plays a role in regulating the immune system, and S1P receptor modulators have been developed as potential therapies for autoimmune diseases such as multiple sclerosis.
In addition, S1P has been shown to play a role in cancer progression and metastasis. S1P signaling has been implicated in promoting tumor cell survival, proliferation, and migration, and S1P receptor antagonists have been investigated as potential therapies for cancer.
Overall, Sphingosine-1-phosphate is a bioactive lipid molecule that plays a critical role in regulating various cellular processes. Its involvement in many physiological and pathological processes makes it a subject of ongoing research in fields such as cardiovascular disease, immunology, and cancer biology.
For details please check:
https://www.glpbio.com/sphingosine-1-phosphate.html
8:51
Sphingosine 1 Phosphate Receptor Modulator
0:11 MS Overview
0:55 Target Selection
1:38 Lead Discovery
2:56 Pre-clinical Trials
5:...
published: 01 Sep 2018
Sphingosine 1 Phosphate Receptor Modulator
Sphingosine 1 Phosphate Receptor Modulator
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- published: 01 Sep 2018
- views: 1748
0:11 MS Overview
0:55 Target Selection
1:38 Lead Discovery
2:56 Pre-clinical Trials
5:06 Clinical Trials
7:41 Registration
8:05 Summary
Fong Shao Bing Ong, Ying Min Wu, Tommy Zhou, Richard Wang
59:20
Sphingosine 1-Phosphate Signaling: From the Receptor, Signaling Mechanisms to Novel Therapeutics.
NAVBO Education Committee Webinar Series.
Presented by Dr. Timothy Hla on December 20, 20...
published: 05 Jul 2020
Sphingosine 1-Phosphate Signaling: From the Receptor, Signaling Mechanisms to Novel Therapeutics.
Sphingosine 1-Phosphate Signaling: From the Receptor, Signaling Mechanisms to Novel Therapeutics.
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- published: 05 Jul 2020
- views: 3107
NAVBO Education Committee Webinar Series.
Presented by Dr. Timothy Hla on December 20, 2018: Sphingosine 1-Phosphate Signaling: From the Receptor, Signaling Mechanisms to Novel Therapeutics.
13:10
Optical control of Sphingosine-1-phosphate formation and function - Mar 22 2021
In this entry of our 2nd PhD student contest, Johannes Morstein of NYU, USA discusses the ...
published: 25 Mar 2021
Optical control of Sphingosine-1-phosphate formation and function - Mar 22 2021
Optical control of Sphingosine-1-phosphate formation and function - Mar 22 2021
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- published: 25 Mar 2021
- views: 781
In this entry of our 2nd PhD student contest, Johannes Morstein of NYU, USA discusses the development of photoswitchable analogs of S1P (PhotoS1P) and its precursor sphingosine (PhotoSph)m and describes the evaluation of photoS1P as a tool for modulating S1P receptors in vitro and in vivo. He also discusses how, as photoS1P has prolonged metabolic stability and its formation is light-dependent, it has advantages as a novel tool to probe sphingolipid biology.
5:43
S1P receptor modulators in the treatment of MS
Bruce Cree, MD, PhD, MAS, University of California San Francisco, San Francisco, CA, speak...
published: 29 Jun 2022
S1P receptor modulators in the treatment of MS
S1P receptor modulators in the treatment of MS
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- published: 29 Jun 2022
- views: 494
Bruce Cree, MD, PhD, MAS, University of California San Francisco, San Francisco, CA, speaks about sphingosine-1-phosphate (S1P) receptor modulators for treating multiple sclerosis (MS). The first approved oral MS therapy of such form was fingolimod, which is less effective than newer therapies and remains restricted by a challenging adverse event profile. At present, three improved modulators are approved: ozanimod and siponimod, S1P1/5 selective agents, and ponesimod, being solely S1P1 selective. Data has shown more favorable adverse event profiles and improved half-lives of these drugs, allowing for self-administration by patients at home, instead of requiring first dose observations. The drugs have also demonstrated higher efficacy, measured by the reduction in relapse rates and new lesion formation. Given the strong efficacy demonstrated in trials, Dr Cree says that he would use S1P receptor modulators as frontline medications. More research is needed on the various agents as there is a rebound effect apparent with fingolimod, unexpectedly not observed for ozanimod. This interview took place at the Consortium of Multiple Sclerosis Centers (CMSC) congress 2022 in Maryland.
4:51
Sphingolipids || Chemical structure , biogenesis and function
This video talks about sphingolipids .They are a class of lipids containing a backbone of ...
published: 03 Nov 2020
Sphingolipids || Chemical structure , biogenesis and function
Sphingolipids || Chemical structure , biogenesis and function
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- published: 03 Nov 2020
- views: 66461
This video talks about sphingolipids .They are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature
4:06
Advantages of ozanimod over previous sphingosine 1-phosphate modulators
Giancarlo Comi, MD, Vita-Salute San Raffaele University, Milan, Italy, describes the mecha...
published: 04 Oct 2021
Advantages of ozanimod over previous sphingosine 1-phosphate modulators
Advantages of ozanimod over previous sphingosine 1-phosphate modulators
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- published: 04 Oct 2021
- views: 747
Giancarlo Comi, MD, Vita-Salute San Raffaele University, Milan, Italy, describes the mechanism of action of ozanimod, a recently approved drug for the treatment of relapsing-remitting multiple sclerosis (MS), highlighting its benefits over fingolimod. Both ozanimod and fingolimod are sphingosine 1-phosphate (S1P) receptor modulators. However, whilst fingolimod targets four out of five S1P receptors, ozanimod targets only S1P1 and S1P5, thereby causing less adverse effects. Prof. Comi explains that through its action on S1P1, ozanimod prevents aggressive lymphocytes from entering the circulation and the brain, thus preventing brain damage. Due to its decreased toxicity, it is not necessary to monitor patients in the hospital during the first day of treatment. Finally, Prof. Comi comments on other novel S1P receptor modulators, that could enable selection of the most appropriate drug for each patient. This interview took place during the XXV World Congress of Neurology.
21:32
Sphingosine-1-phosphate signaling modulation for the treatment of acute myeloid leukemia (AML)
Stephanie Xie from the Princess Margaret Cancer Centre in Toronto, Canada presents on the ...
published: 02 Nov 2020
Sphingosine-1-phosphate signaling modulation for the treatment of acute myeloid leukemia (AML)
Sphingosine-1-phosphate signaling modulation for the treatment of acute myeloid leukemia (AML)
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- published: 02 Nov 2020
- views: 817
Stephanie Xie from the Princess Margaret Cancer Centre in Toronto, Canada presents on the role of sphingosine 1-phosphate (S1P) signaling in the interplay between normal hematopoiesis, AML and inflammation. She discusses how S1P activation of S1P receptor 3 (S1PR3) is a key process for myeloid lineage differentiation in human HSC that is dysregulated in AML - and functionally shows how modulating this pathway could be an effective and novel therapeutic approach for AML treatment.
25:32
Exit strategies: S1P signaling in inflammation - 12th July 2021
Susan Schwab from NYU College of Medicine, USA discusses how lymph and lymph node S1P are ...
published: 16 May 2022
Exit strategies: S1P signaling in inflammation - 12th July 2021
Exit strategies: S1P signaling in inflammation - 12th July 2021
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- published: 16 May 2022
- views: 582
Susan Schwab from NYU College of Medicine, USA discusses how lymph and lymph node S1P are regulated during inflammation, and how alterations in S1P gradients can influence leukocytes during the immune response.
0:38
Benefits & Risks of S1P Receptor Modulators: Part 1
published: 16 Sep 2024
Benefits & Risks of S1P Receptor Modulators: Part 1
Benefits & Risks of S1P Receptor Modulators: Part 1
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- published: 16 Sep 2024
- views: 90
Sphingosine-1-phosphate
Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is also referred to as a bioactive lipid mediator. It was discovered by Sarah Spiegel, then a professor of biochemistry and molecular biology at Georgetown University School of Medicine, in the mid-1990s. Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine.
Production
Sphingosine can be released from ceramides, a process catalyzed by the enzyme ceramidase. Phosphorylation of sphingosine is catalyzed by sphingosine kinase, an enzyme ubiquitously found in the cytosol and endoplasmatic reticulum of various types of cells. S1P can be dephosphorylated to sphingosine by sphingosine phosphatases and can be irreversibly degraded by an enzyme, Sphingosine phosphate lyase.
Function
S1P is a blood borne lipid mediator, in particular in association with lipoproteins such as high density lipoprotein (HDL). It is less abundant in tissue fluids. This is referred to as the S1P gradient, which seems to have biological significance in immune cell trafficking.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Sphingosine-1-phosphate
28:04
Endocrinology | Receptor Pathways
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Join us for our lecture o...
published: 11 May 2017
Endocrinology | Receptor Pathways
Endocrinology | Receptor Pathways
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- published: 11 May 2017
- views: 1383459
Official Ninja Nerd Website: https://ninjanerd.org
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Join us for our lecture on receptor pathways. During this lecture Professor Zach Murphy will be describing both peptide and steroid hormones. We will also be discussing G protein coupled receptors and inhibition. We hope you enjoy this lecture and be sure to support us below!
@27:05 - There is an error. I said phosphodiesterase break down phospholipase C. Phospholipase is a phosphodiesterase. Thanks!
Table of Contents: (Thanks to Community Member Khaled!)
00:00 - Intro music
00:20 - Types of hormones.
00:47 - Peptide hormones.
02:32 - Second Messenger Systems
03:10 - Steroid hormones
05:15 - G Stimulatory pathway
14:00 - GQ pathway
21:20 - Oxytocin & muscle contraction
22:28 - Steroid Hormones Pathway
25:44 - G Inhibitory Pathway & PDE
27:35 - Outro
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7:14
Receptors: Types & Functions
Find notes here: https://www.nonstopneuron.com/post/receptors-types-and-functions
Explore ...
published: 30 Jun 2021
Receptors: Types & Functions
Receptors: Types & Functions
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- published: 30 Jun 2021
- views: 163931
Find notes here: https://www.nonstopneuron.com/post/receptors-types-and-functions
Explore our entire animation video library at: https://www.nonstopneuron.com/
Video Summary:
Receptors receive signals from cells exterior. They have a ligand-binding domain to recognize specific ligand and an effector domain to produce the downstream effect. Receptors for hydrophilic signal molecules are located on the cell membrane and receptors for hydrophobic molecules are located inside the cell. Various types of receptors are ligand-gated ion channels that regulate the opening or closing of the channel. G protein-coupled receptors act through G proteins and ultimately regulate the function of a wide range of enzymes and ion channels. Catalytic receptors mostly activate or inactivate a protein by phosphorylating or dephosphorylating them and Nuclear receptors serve as transcription factors.
🎞 More videos on General Physiology:
• Milieu Interieur vs Milieu Exterieur: Milieu Interieur vs Milieu Exterieur: https://youtu.be/S5YEVctChV8
• Homeostasis & Negative feedback loop: https://youtu.be/MaMpqslvyOA
• Biological Membrane and Fluid Mosaic Model: https://youtu.be/lD_f1Gy2fsc
• Phospholipids in Water: https://youtu.be/6znxvYowmxQ
• Cell Nucleus: https://youtu.be/wcKEcu2Z3pw
• Endoplasmic Reticulum: https://youtu.be/NRiJhzYE4Ko
• Golgi Apparatus: https://youtu.be/ZfL--3KNEy8
• Interesting facts about Protein Synthesis and SecretionL https://youtu.be/4as57LAHotE
• Mitochondria: https://youtu.be/WkMOIO7HhZY
• Interesting facts about Protein Synthesis and SecretionL https://youtu.be/4as57LAHotE
• Why ATPs are called Energy Currency of the Cell: https://youtu.be/bjwmxqpyV3g
• How Physiological Parameters are Controlled?: https://youtu.be/DEBajDp8QlA
• Cell to Cell Communication: https://youtu.be/i3bY-JCYs4A
• Primary vs Secondary Active Transport: https://youtu.be/N-iBdwtQn4Q
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DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.
9:41
Common cell signaling pathway
What are common cell signaling pathways? To make a multicellular organism, cells must be a...
published: 14 Oct 2020
Common cell signaling pathway
Common cell signaling pathway
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- published: 14 Oct 2020
- views: 562934
What are common cell signaling pathways? To make a multicellular organism, cells must be able to communicate with one another, and to do it cells often send out tiny chemical signals that act on the receptors on other cells. Signals can be classified according to the distance between the signaling cell and the target cell. Find our full video library only on Osmosis: http://osms.it/more.
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10:07
Insulin Signaling Cascade and Downstream Effects - Biochemistry Lesson
Learn the insulin signaling transduction cascade/pathway in this biochemistry powerpoint-s...
published: 11 Jan 2017
Insulin Signaling Cascade and Downstream Effects - Biochemistry Lesson
Insulin Signaling Cascade and Downstream Effects - Biochemistry Lesson
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- published: 11 Jan 2017
- views: 184654
Learn the insulin signaling transduction cascade/pathway in this biochemistry powerpoint-style lecture!
Hey guys! Here is a new video where I teach the insulin signaling pathway in a new powerpoint style lecture format. Please let me know if you guys like this format of learning, and I will make more videos using this teaching method! I hope you all find it informative and please like and subscribe if you found the video helpful! All feedback is appreciated :) JJ
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****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and are intended for educational/teaching purposes only.****
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Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Medical Terminology - Anatomical Terms:
https://www.youtube.com/watch?v=KkXiE3NEJxw
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ
6:26
Receptors: Signal Transduction and Phosphorylation Cascade
Did you know that cells can talk to one another? One cell can send a molecule over to anot...
published: 06 Sep 2016
Receptors: Signal Transduction and Phosphorylation Cascade
Receptors: Signal Transduction and Phosphorylation Cascade
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- published: 06 Sep 2016
- views: 452542
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
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17:26
Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join ...
published: 12 May 2021
Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)
Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)
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- published: 12 May 2021
- views: 488769
SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
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Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
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5:42
Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and...
published: 26 Jun 2018
Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System
Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System
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- published: 26 Jun 2018
- views: 174052
Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon activation of a G protein-coupled receptor. Inositol triphosphate and DAG are cleavage products of phosphatidyl inositol 4,5 bisphosphate (PIP2), which is cleaved by phospholipase C. Increasing levels of IP3 lead to augmented cytosolic calcium levels that further lead to activation of downstream cellular targets.
Hey everyone. In this lesson you will be introduced to the IP3 and calcium signaling pathway. We will also discuss the purpose of the pathway, enzymes involved in the pathway, and how the pathway is regulated.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
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Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Medical Terminology - Anatomical Terms:
https://www.youtube.com/watch?v=KkXiE3NEJxw
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
----------------------------------------------------------------------------------------------------
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe! JJ
----------------------------------------------------------------------------------------------------
DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
4:39
Receptor Tyrosine Kinases (Newer Version)
published: 29 Sep 2017
Receptor Tyrosine Kinases (Newer Version)
Receptor Tyrosine Kinases (Newer Version)
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- published: 29 Sep 2017
- views: 322025
54:38
An Intro to Receptors | Types, Structure & Location | Part 1
#receptors #AnIntrotoReceptors #Receptors #GProteinCoupledReceptors #GPCRs #7PassReceptors...
published: 21 Nov 2021
An Intro to Receptors | Types, Structure & Location | Part 1
An Intro to Receptors | Types, Structure & Location | Part 1
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- published: 21 Nov 2021
- views: 189851
#receptors #AnIntrotoReceptors #Receptors #GProteinCoupledReceptors #GPCRs #7PassReceptors
An Intro to Receptors | Types, Structure & Location | Part 1
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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
In this video Dr. Najeeb discusses the following points.
00:00 - 01:40 What are we going to discuss in this lecture?
01:41 - 02:48 Sensory receptors and receptors of physiology, biochemistry and pharmacology.
02:48 - 12:20 What is a receptor?
12:51 - 15:16 Where are the receptors located?
15:17 - 37:42 transmembrane receptors and their types with examples.
21:04 - 30:13 G-Protein receptors – a transmembrane type of receptor.
26:27 - 30:06 Trimeric G proteins and monomeric G-proteins.
37:43 - 44:46 Intracellular receptors (cytosolic and nuclear receptors) with examples.
44:47 - 49:40 Extracellular receptors and their examples.
45:35 - 48:12 Antithrombin III as an extracellular drug receptor. Heparin and it’s mechanism of action.
49:41 - 53:28. Review/Summary of this lecture.
53:30 - 54:37 What we are going to discuss in the upcoming lecture?
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Endocrinology | Receptor Pathways...
Receptors: Types & Functions...
Common cell signaling pathway...
Insulin Signaling Cascade and Downstream Effects -...
Receptors: Signal Transduction and Phosphorylation...
Signal Transduction Pathways (G-Protein, Receptor ...
Inositol Triphosphate (IP3) and Calcium Signaling ...
Receptor Tyrosine Kinases (Newer Version)...
MICROBIOLOGY BOOKS#MBBS...