The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4), and can form hetero- or homodimers. Bcl-2 proteins act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.
Interactions
BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into organelle membranes, primarily the outer mitochondrial membrane. Bax is believed to interact with, and induce the opening of the mitochondrial voltage-dependent anion channel, VDAC. Alternatively, growing evidence suggest that activated Bax and/or Bak form an oligomeric pore, MAC in the outer membrane. This results in the release of cytochrome c and other pro-apoptotic factors (such as SMAC/DIABLO) from the mitochondria, often referred to as mitochondrial outer membrane permeabilization, leading to activation of caspases. This defines BID as a direct activator of Bax, a role common to some of the pro-apoptotic Bcl-2 proteins containing only the BH3 domain.
The word death comes from Old English deað, which in turn comes from Proto-Germanic *dauthuz (reconstructed by etymological analysis). This comes from the Proto-Indo-European stem *dheu- meaning the "Process, act, condition of dying".
Associated terms
The concept and symptoms of death, and varying degrees of delicacy used in discussion in public forums, have generated numerous scientific, legal, and socially acceptable terms or euphemisms for death. When a person has died, it is also said they have passed away, passed on, expired, or are gone, among numerous other socially accepted, religiously specific, slang, and irreverent terms. Bereft of life, the dead person is then a corpse, cadaver, a body, a set of remains, and when all flesh has rotted away, a skeleton. The terms carrion and carcass can also be used, though these more often connote the remains of non-human animals. As a polite reference to a dead person, it has become common practice to use the participle form of "decease", as in the deceased; another noun form is decedent. The ashes left after a cremation are sometimes referred to by the neologismcremains, a portmanteau of "cremation" and "remains".
The discography of Death, a metal band, consists of seven studio albums and four live albums. Death was an American metal band founded in 1983. The band's founder, Chuck Schuldiner, is considered "a pioneering force in death metal and grindcore". The band ceased to exist after Schuldiner died of brain cancer in 2001, though it remains an enduring metal brand.
As of 2008, Death had sold over 2 million albums worldwide, with over 500,000 copies sold by December 2009 in the U.S. alone (excluding the numerous sales before the SoundScan era) making them the top-selling death metal band worldwide, and only topped in the U.S. by Cannibal Corpse.
Studio albums
Live albums
Compilation albums
Demo albums
Prior to the release of the band's debut album in 1987, Death released several demos and rehearsal tapes. Below is a list of the band's seven official demos according to its website.
Nostradamus is the sixteenth studio album by English heavy metal band Judas Priest, focusing on the 16th-century writer Nostradamus. It is a double album. The band's first concept album, it was originally intended to be released in late 2006 before being pushed back to a 2007 release, and was finally released in June 2008 on Epic Records. It is the band's final album to feature K. K. Downing, before his retirement.
The Nostradamus concept idea originated from manager Bill Curbishley and was pitched to the band while on tour in Estonia in 2005. Guitarist K. K. Downing revealed in a February 2007 interview with Brave Words & Bloody Knuckles that 18 tracks had been recorded with a total length of more than 90 minutes and that there was not much he would like to cut down. Musically, the album contains symphonic orchestrations, including the use of keyboards and choirs, which is unlike anything the band has previously attempted. In November 2007, the band began mixing the album.
Medical vocabulary: What does BH3 Interacting Domain Death Agonist Protein mean
What does BH3 Interacting Domain Death Agonist Protein mean in English?
published: 20 Jan 2016
Gene Music Using Protein Sequence of BID "BH3 INTERACTING DOMAIN DEATH AGONIST"
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Gene Music using Protein Sequence of BID 'BH3 INTERACTING DOMAIN DEATH AGONIST'
published: 25 Dec 2015
Apoptosis Regulation by Genes | Bcl-2 Family
In this video we have discussed the regulation of Apoptosis by genes.
The Apoptosis is regulated by various genes but Bcl family of genes are the primary regulators of the apoptosis.
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a form of programmed cell death that occurs in multicellular organisms.[2] Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global[vague] mRNA decay.
The initiation of apoptosis is tightly regulated by activation mechanisms, because once apoptosis has begun, it inevitably leads to the death of the cell. The two best-understood activation mechanisms are the intrinsic pathway (also called the mi...
published: 25 Feb 2019
Bcl-2 domains (with sound)
There are 2 kinds of Bcl-2 family proteins, pro-apoptotic and anti-apoptotic. In addition, there are several BH3 (Bcl Homology 3) only proteins which regulate the activity of the Bcl-2 family proteins. Bcl-2 domains are alpha-heical, with a central helix surrounded by 7 amphipathic helices. Bcl-homology 1-3 regions are in proximity, and makes a cavity. To this cavity, Bcl-2 C terminal transmembrane helix and BH3 regions of BH3 only proteins bind. When pro-apoptotic Bax binds to a BH3 peptide, its Bcl-2 domain is re-organized to form a domain-swapped dimer.
published: 17 Feb 2013
"What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade
( http://www.abnova.com ) - BAD (Bcl-2 antagonist of cell death) belongs to the pro-apoptotic BH3-only subfamily of Bcl- 2 proteins. Physiological activity of BAD is highly controlled by phosphorylation. To further analyze the regulation of BAD function, the authors (Polzien L, Baljuls A, Albrecht M, Hekman M, Rapp UR) investigated the role of recently identified phosphorylation sites on BAD-mediated apoptosis. More videos at Abnova http://www.abnova.com
published: 28 Mar 2011
5 5 Lecture 4 Regulation of mammalian Bid 15 20
published: 25 Jan 2014
A Question of Life or Death - Differentiating Healthy and Apoptotic CellsAL
For more information, visit http://www.bio-rad.com/HuCAL-Apoptosis
The “A question of Life or Death” webinar provides an overview of the different modes of apoptosis and what antibody applications and assays to use to differentiate between healthy and apoptotic cells. Special focus is placed on explaining the different stages of apoptosis and what experimental read-outs to use to determine if a cell has passed “the point of no return”.
https://www.bio-rad-antibodies.com/custom-monoclonal-antibody-generation.html?WT.mc_id=sm-abd-ww-abdserotec-vyt-20160824-fZ6S96JbXfs
We Are Bio-Rad.
Our mission: To provide useful, high-quality products and services that advance scientific discovery and improve healthcare. At Bio-Rad, we are united behind this effort. These two objectives are the driving...
published: 01 Sep 2016
BH3
Testing hyperlink on BH3 Hasheet downloaded from BH3 website
published: 09 Jun 2014
Apoptosis "Programmed Cell Death"
Apoptosis "Programmed Cell Death"
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Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of BID 'BH3 INTERACTING DOMAIN DEATH AGONIST'
Shop BID - https://www.redbubble.com/people/genemusic/works/45423571-bid?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of BID 'BH3 INTERACTING DOMAIN DEATH AGONIST'
In this video we have discussed the regulation of Apoptosis by genes.
The Apoptosis is regulated by various genes but Bcl family of genes are the primary regul...
In this video we have discussed the regulation of Apoptosis by genes.
The Apoptosis is regulated by various genes but Bcl family of genes are the primary regulators of the apoptosis.
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a form of programmed cell death that occurs in multicellular organisms.[2] Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global[vague] mRNA decay.
The initiation of apoptosis is tightly regulated by activation mechanisms, because once apoptosis has begun, it inevitably leads to the death of the cell. The two best-understood activation mechanisms are the intrinsic pathway (also called the mitochondrial pathway) and the extrinsic pathway.
In this video we have discussed the regulation of Apoptosis by genes.
The Apoptosis is regulated by various genes but Bcl family of genes are the primary regulators of the apoptosis.
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a form of programmed cell death that occurs in multicellular organisms.[2] Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global[vague] mRNA decay.
The initiation of apoptosis is tightly regulated by activation mechanisms, because once apoptosis has begun, it inevitably leads to the death of the cell. The two best-understood activation mechanisms are the intrinsic pathway (also called the mitochondrial pathway) and the extrinsic pathway.
There are 2 kinds of Bcl-2 family proteins, pro-apoptotic and anti-apoptotic. In addition, there are several BH3 (Bcl Homology 3) only proteins which regulate t...
There are 2 kinds of Bcl-2 family proteins, pro-apoptotic and anti-apoptotic. In addition, there are several BH3 (Bcl Homology 3) only proteins which regulate the activity of the Bcl-2 family proteins. Bcl-2 domains are alpha-heical, with a central helix surrounded by 7 amphipathic helices. Bcl-homology 1-3 regions are in proximity, and makes a cavity. To this cavity, Bcl-2 C terminal transmembrane helix and BH3 regions of BH3 only proteins bind. When pro-apoptotic Bax binds to a BH3 peptide, its Bcl-2 domain is re-organized to form a domain-swapped dimer.
There are 2 kinds of Bcl-2 family proteins, pro-apoptotic and anti-apoptotic. In addition, there are several BH3 (Bcl Homology 3) only proteins which regulate the activity of the Bcl-2 family proteins. Bcl-2 domains are alpha-heical, with a central helix surrounded by 7 amphipathic helices. Bcl-homology 1-3 regions are in proximity, and makes a cavity. To this cavity, Bcl-2 C terminal transmembrane helix and BH3 regions of BH3 only proteins bind. When pro-apoptotic Bax binds to a BH3 peptide, its Bcl-2 domain is re-organized to form a domain-swapped dimer.
This 3D medical animation explains the functioning of the extrinsic and intrinsic apoptotic pathways. We start off by taking a look at the important role apopto...
( http://www.abnova.com ) - BAD (Bcl-2 antagonist of cell death) belongs to the pro-apoptotic BH3-only subfamily of Bcl- 2 proteins. Physiological activity of B...
( http://www.abnova.com ) - BAD (Bcl-2 antagonist of cell death) belongs to the pro-apoptotic BH3-only subfamily of Bcl- 2 proteins. Physiological activity of BAD is highly controlled by phosphorylation. To further analyze the regulation of BAD function, the authors (Polzien L, Baljuls A, Albrecht M, Hekman M, Rapp UR) investigated the role of recently identified phosphorylation sites on BAD-mediated apoptosis. More videos at Abnova http://www.abnova.com
( http://www.abnova.com ) - BAD (Bcl-2 antagonist of cell death) belongs to the pro-apoptotic BH3-only subfamily of Bcl- 2 proteins. Physiological activity of BAD is highly controlled by phosphorylation. To further analyze the regulation of BAD function, the authors (Polzien L, Baljuls A, Albrecht M, Hekman M, Rapp UR) investigated the role of recently identified phosphorylation sites on BAD-mediated apoptosis. More videos at Abnova http://www.abnova.com
For more information, visit http://www.bio-rad.com/HuCAL-Apoptosis
The “A question of Life or Death” webinar provides an overview of the different modes of apo...
For more information, visit http://www.bio-rad.com/HuCAL-Apoptosis
The “A question of Life or Death” webinar provides an overview of the different modes of apoptosis and what antibody applications and assays to use to differentiate between healthy and apoptotic cells. Special focus is placed on explaining the different stages of apoptosis and what experimental read-outs to use to determine if a cell has passed “the point of no return”.
https://www.bio-rad-antibodies.com/custom-monoclonal-antibody-generation.html?WT.mc_id=sm-abd-ww-abdserotec-vyt-20160824-fZ6S96JbXfs
We Are Bio-Rad.
Our mission: To provide useful, high-quality products and services that advance scientific discovery and improve healthcare. At Bio-Rad, we are united behind this effort. These two objectives are the driving force behind every decision we make, from developing innovative ideas to building global solutions that help solve our customers' greatest challenges.
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For more information, visit http://www.bio-rad.com/HuCAL-Apoptosis
The “A question of Life or Death” webinar provides an overview of the different modes of apoptosis and what antibody applications and assays to use to differentiate between healthy and apoptotic cells. Special focus is placed on explaining the different stages of apoptosis and what experimental read-outs to use to determine if a cell has passed “the point of no return”.
https://www.bio-rad-antibodies.com/custom-monoclonal-antibody-generation.html?WT.mc_id=sm-abd-ww-abdserotec-vyt-20160824-fZ6S96JbXfs
We Are Bio-Rad.
Our mission: To provide useful, high-quality products and services that advance scientific discovery and improve healthcare. At Bio-Rad, we are united behind this effort. These two objectives are the driving force behind every decision we make, from developing innovative ideas to building global solutions that help solve our customers' greatest challenges.
Connect with Bio-Rad Antibodies Online:
Website: https://www.bio-rad-antibodies.com/
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Apoptosis "Programmed Cell Death"
Find more about microbiology in our page "#MicroRamziology"
https://www.facebook.com/MicroRamziology
Dr. Ahmed Ramzy official...
Apoptosis "Programmed Cell Death"
Find more about microbiology in our page "#MicroRamziology"
https://www.facebook.com/MicroRamziology
Dr. Ahmed Ramzy official page:
https://www.facebook.com/Dr.Ahmed.Ramzy79
#Fel3adal Show "في العضل":
https://www.youtube.com/channel/UCFOrnwL_Mf20XfKe9cHN1Iw/featured
#Fel3adal Show "في العضل" facebook page:
https://www.facebook.com/fel3adal
ِ
Apoptosis "Programmed Cell Death"
Find more about microbiology in our page "#MicroRamziology"
https://www.facebook.com/MicroRamziology
Dr. Ahmed Ramzy official page:
https://www.facebook.com/Dr.Ahmed.Ramzy79
#Fel3adal Show "في العضل":
https://www.youtube.com/channel/UCFOrnwL_Mf20XfKe9cHN1Iw/featured
#Fel3adal Show "في العضل" facebook page:
https://www.facebook.com/fel3adal
ِ
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Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of BID 'BH3 INTERACTING DOMAIN DEATH AGONIST'
In this video we have discussed the regulation of Apoptosis by genes.
The Apoptosis is regulated by various genes but Bcl family of genes are the primary regulators of the apoptosis.
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a form of programmed cell death that occurs in multicellular organisms.[2] Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global[vague] mRNA decay.
The initiation of apoptosis is tightly regulated by activation mechanisms, because once apoptosis has begun, it inevitably leads to the death of the cell. The two best-understood activation mechanisms are the intrinsic pathway (also called the mitochondrial pathway) and the extrinsic pathway.
There are 2 kinds of Bcl-2 family proteins, pro-apoptotic and anti-apoptotic. In addition, there are several BH3 (Bcl Homology 3) only proteins which regulate the activity of the Bcl-2 family proteins. Bcl-2 domains are alpha-heical, with a central helix surrounded by 7 amphipathic helices. Bcl-homology 1-3 regions are in proximity, and makes a cavity. To this cavity, Bcl-2 C terminal transmembrane helix and BH3 regions of BH3 only proteins bind. When pro-apoptotic Bax binds to a BH3 peptide, its Bcl-2 domain is re-organized to form a domain-swapped dimer.
( http://www.abnova.com ) - BAD (Bcl-2 antagonist of cell death) belongs to the pro-apoptotic BH3-only subfamily of Bcl- 2 proteins. Physiological activity of BAD is highly controlled by phosphorylation. To further analyze the regulation of BAD function, the authors (Polzien L, Baljuls A, Albrecht M, Hekman M, Rapp UR) investigated the role of recently identified phosphorylation sites on BAD-mediated apoptosis. More videos at Abnova http://www.abnova.com
For more information, visit http://www.bio-rad.com/HuCAL-Apoptosis
The “A question of Life or Death” webinar provides an overview of the different modes of apoptosis and what antibody applications and assays to use to differentiate between healthy and apoptotic cells. Special focus is placed on explaining the different stages of apoptosis and what experimental read-outs to use to determine if a cell has passed “the point of no return”.
https://www.bio-rad-antibodies.com/custom-monoclonal-antibody-generation.html?WT.mc_id=sm-abd-ww-abdserotec-vyt-20160824-fZ6S96JbXfs
We Are Bio-Rad.
Our mission: To provide useful, high-quality products and services that advance scientific discovery and improve healthcare. At Bio-Rad, we are united behind this effort. These two objectives are the driving force behind every decision we make, from developing innovative ideas to building global solutions that help solve our customers' greatest challenges.
Connect with Bio-Rad Antibodies Online:
Website: https://www.bio-rad-antibodies.com/
LinkedIn: https://www.linkedin.com/showcase/bio-rad-antibodies/
Facebook: https://www.facebook.com/BioRadAntibodies/
Twitter: https://twitter.com/BioRadAbs
Pinterest: https://www.pinterest.com/BioRadAbs/
Instagram: @BioRadLabs
Snapchat: @BioRadLabs
Apoptosis "Programmed Cell Death"
Find more about microbiology in our page "#MicroRamziology"
https://www.facebook.com/MicroRamziology
Dr. Ahmed Ramzy official page:
https://www.facebook.com/Dr.Ahmed.Ramzy79
#Fel3adal Show "في العضل":
https://www.youtube.com/channel/UCFOrnwL_Mf20XfKe9cHN1Iw/featured
#Fel3adal Show "في العضل" facebook page:
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The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4), and can form hetero- or homodimers. Bcl-2 proteins act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.
Interactions
BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into organelle membranes, primarily the outer mitochondrial membrane. Bax is believed to interact with, and induce the opening of the mitochondrial voltage-dependent anion channel, VDAC. Alternatively, growing evidence suggest that activated Bax and/or Bak form an oligomeric pore, MAC in the outer membrane. This results in the release of cytochrome c and other pro-apoptotic factors (such as SMAC/DIABLO) from the mitochondria, often referred to as mitochondrial outer membrane permeabilization, leading to activation of caspases. This defines BID as a direct activator of Bax, a role common to some of the pro-apoptotic Bcl-2 proteins containing only the BH3 domain.