In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In protein-ligand binding, the ligand is usually a signal-triggering molecule binding to a site on a target protein. The binding typically results in a change of conformation of the target protein. In DNA-ligand binding studies, the ligand can be a small molecule, ion, or protein which binds to the DNA double helix.
Ligand binding to a receptor (receptor protein) alters the chemical conformation (three-dimensional shape). The conformational state of a receptor protein determines the functional state. Ligands include substrates, inhibitors, activators, and neurotransmitters. The tendency or strength of binding is called affinity. Binding affinity is determined not only by host-guest interactions, but also by solvent effects that can play a dominant steric role in driving non-covalent binding in solution.
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The Johnny Alegre AFFINITY is a jazz group originating from the Philippines. It is led by self-taught Philippine guitarist-composer Johnny Alegre, together with bassist Colby de la Calzada, drummer Koko Bermejo, pianist Elhmir Saison and saxophonist Tots Tolentino. The ensemble first gathered in May 2002 at Manila’s Pink Noise Studios for Alegre’s composition, “Stones of Intramuros”, for inclusion in the jazz anthology CD, Adobo Jazz Vol. 1, and thereafter carried on as a working unit.
The band’s first public appearance in October of the same year for the Adobo Jazz album launch at the Monk’s Dream Jazz Bar heralded the AFFINITY’s reputation –as described by aficionados in the ensuing reviews— as “Manila’s Jazz Superband”, with a power trio at its core. For the remainder of the year, the group emerged in various guises and personnel variations, manned by a who’s who of luminaries from the Philippine jazz scene.
Season eight of Stargate SG-1, an American-Canadian military science fictiontelevision series, began airing on July 9, 2004 on the Sci Fi channel. The eighth season concluded on February 22, 2005, after 20 episodes on British Sky One, which overtook the Sci Fi Channel in mid-season. This was the first season of the show to have 20 episodes instead of 22, as well as the first to air concurrently with Stargate SG-1 spinoff series Stargate Atlantis (the first season thereof). The series was originally developed by Brad Wright and Jonathan Glassner, while Brad Wright and Robert C. Cooper served as executive producers. Season eight regular cast members include Richard Dean Anderson, Amanda Tapping, Christopher Judge, and Michael Shanks. The eighth season begins with the SG-1 team trying to revive Colonel Jack O'Neill (Richard Dean Anderson) after the events of the seventh season. At the end of the two-episode season opener, Colonel O'Neill is promoted to General and assumes command of Stargate Command (SGC), while Major Samantha Carter (Amanda Tapping) is promoted to Lieutenant Colonel and assumes command of SG-1. The season arc centers on the growing threat and seemingly final defeat of the Goa'uld and the Replicators, races who were introduced in the first and third season of the show, respectively.
Affinity Photo Tutorial For Beginners - Top 10 Things Beginners Want To Know
This is a COMPLETE Affinity Photo tutorial for beginners! If you are new to Affinity Photo, this is the perfect video for you. We cover the top 10 things beginners want to know how to do.
Enroll here for 100+ Affinity Photo tutorials! https://affinity.sale/Affinity_Photo
Download today's images: http://affinityrevolution.com/affinity-photo-top-10/
--------------------------------------------------------------------
In this tutorial, we cover the following topics:
0:28 - Opening Images
1:24 - Affinity Photo's Interface
4:48 - Cropping
6:46 - Removing Imperfections
11:47 - Adjustment Layers
17:12 - Masks
22:22 - Selections
26:13 - Changing the Background
29:10 - Adding Text
30:47 - Saving and Exporting
published: 02 Jun 2018
Why I Like Affinity Photo More than PhotoShop
Several months ago, I switched from using Adobe Creative Suite, and jumped over to Affinity Photo, Designer and Publisher. The learning curve was significant, but the rewards have been well worth the switch.
This time I'm talking about 10 things that I love about Affinity Photo that I struggled with in Adobe PhotoShop.
#affinityphoto #graphicdesign #designtutorial
=== === === ===
See my art:
http://www.daveconrey.com/
See more of my videos and subscribe:
https://youtube.com/user/daveconrey
TikTok:
https://www.tiktok.com/@davemakesthings
Instagram:
http://instagram.com/daveconrey
Twitter:
http://twitter.com/daveconrey
published: 17 Apr 2020
An overview of the Affinity suite with Ash Hewson
Ash Hewson – the Managing Director of Serif – kicks off Lockdown 2020: Affinity creative sessions by giving you a brief overview of the Affinity suite, with a particular focus on how the apps offer a substantial workflow improvement through sharing the same file format, as well as the revolutionary StudioLink feature in Affinity Publisher.
Ash will be available on Live Chat on YouTube for this session’s premiere on Friday, 1 May 2020 at 4pm BST. The image of the drone, drone jet brush and the luminance brush pack used in this session are available to download for free at https://affin.co/LD2020Ash if you want to follow along.
** Lockdown 2020: Affinity creative sessions **
Stay tuned to the official Affinity YouTube channel as every day in May at 4pm BST we will be premiering inspira...
published: 01 May 2020
Can You Ditch Adobe for Affinity
Update: I have a new course on Affinity Publisher: https://skl.sh/2L91Y07
Update: Affinity Publisher is now available for purchase and is ready for professional work.
Check out my courses on design: https://www.skillshare.com/r/user/benn
Is it time to ditch the Adobe Creative Cloud subscription for the single purchase Affinity apps?
The answer really depends on what you need to do. In this video I examine it from the perspective of only needing to use Illustrator, Photoshop, and InDesign. Can you replace them with Affinity Designer, Affinity Photo, and Affinity Publisher?
This is a COMPLETE Affinity Photo tutorial for beginners! If you are new to Affinity Photo, this is the perfect video for you. We cover the top 10 things beginn...
This is a COMPLETE Affinity Photo tutorial for beginners! If you are new to Affinity Photo, this is the perfect video for you. We cover the top 10 things beginners want to know how to do.
Enroll here for 100+ Affinity Photo tutorials! https://affinity.sale/Affinity_Photo
Download today's images: http://affinityrevolution.com/affinity-photo-top-10/
--------------------------------------------------------------------
In this tutorial, we cover the following topics:
0:28 - Opening Images
1:24 - Affinity Photo's Interface
4:48 - Cropping
6:46 - Removing Imperfections
11:47 - Adjustment Layers
17:12 - Masks
22:22 - Selections
26:13 - Changing the Background
29:10 - Adding Text
30:47 - Saving and Exporting
This is a COMPLETE Affinity Photo tutorial for beginners! If you are new to Affinity Photo, this is the perfect video for you. We cover the top 10 things beginners want to know how to do.
Enroll here for 100+ Affinity Photo tutorials! https://affinity.sale/Affinity_Photo
Download today's images: http://affinityrevolution.com/affinity-photo-top-10/
--------------------------------------------------------------------
In this tutorial, we cover the following topics:
0:28 - Opening Images
1:24 - Affinity Photo's Interface
4:48 - Cropping
6:46 - Removing Imperfections
11:47 - Adjustment Layers
17:12 - Masks
22:22 - Selections
26:13 - Changing the Background
29:10 - Adding Text
30:47 - Saving and Exporting
Several months ago, I switched from using Adobe Creative Suite, and jumped over to Affinity Photo, Designer and Publisher. The learning curve was significant, b...
Several months ago, I switched from using Adobe Creative Suite, and jumped over to Affinity Photo, Designer and Publisher. The learning curve was significant, but the rewards have been well worth the switch.
This time I'm talking about 10 things that I love about Affinity Photo that I struggled with in Adobe PhotoShop.
#affinityphoto #graphicdesign #designtutorial
=== === === ===
See my art:
http://www.daveconrey.com/
See more of my videos and subscribe:
https://youtube.com/user/daveconrey
TikTok:
https://www.tiktok.com/@davemakesthings
Instagram:
http://instagram.com/daveconrey
Twitter:
http://twitter.com/daveconrey
Several months ago, I switched from using Adobe Creative Suite, and jumped over to Affinity Photo, Designer and Publisher. The learning curve was significant, but the rewards have been well worth the switch.
This time I'm talking about 10 things that I love about Affinity Photo that I struggled with in Adobe PhotoShop.
#affinityphoto #graphicdesign #designtutorial
=== === === ===
See my art:
http://www.daveconrey.com/
See more of my videos and subscribe:
https://youtube.com/user/daveconrey
TikTok:
https://www.tiktok.com/@davemakesthings
Instagram:
http://instagram.com/daveconrey
Twitter:
http://twitter.com/daveconrey
Ash Hewson – the Managing Director of Serif – kicks off Lockdown 2020: Affinity creative sessions by giving you a brief overview of the Affinity suite, with a p...
Ash Hewson – the Managing Director of Serif – kicks off Lockdown 2020: Affinity creative sessions by giving you a brief overview of the Affinity suite, with a particular focus on how the apps offer a substantial workflow improvement through sharing the same file format, as well as the revolutionary StudioLink feature in Affinity Publisher.
Ash will be available on Live Chat on YouTube for this session’s premiere on Friday, 1 May 2020 at 4pm BST. The image of the drone, drone jet brush and the luminance brush pack used in this session are available to download for free at https://affin.co/LD2020Ash if you want to follow along.
** Lockdown 2020: Affinity creative sessions **
Stay tuned to the official Affinity YouTube channel as every day in May at 4pm BST we will be premiering inspirational creative sessions for Lockdown 2020. The sessions will be led by top creatives who use Affinity or one of our in-house product experts and give you the chance to follow along as incredible artists, illustrators, designers and photographers work on a project using the apps.
We will be announcing each daily session on our social channels, so make sure you're following us on Instagram (https://www.instagram.com/affinitybyserif/), Twitter (https://twitter.com/affinitybyserif) and Facebook (https://www.facebook.com/affinitybyserif/) to learn about each daily session.
You can find out more about the Affinity suite, including getting access to free trials, over on https://affinity.serif.com/.
Artist credits:
Artwork shown by Rubens Scarelli, Peter Greenwood, Romain Trystram, Jonathan Ball (pokedstudio), Ben the Illustrator and Sylvain Pfister (Secteur 19)
Ash Hewson – the Managing Director of Serif – kicks off Lockdown 2020: Affinity creative sessions by giving you a brief overview of the Affinity suite, with a particular focus on how the apps offer a substantial workflow improvement through sharing the same file format, as well as the revolutionary StudioLink feature in Affinity Publisher.
Ash will be available on Live Chat on YouTube for this session’s premiere on Friday, 1 May 2020 at 4pm BST. The image of the drone, drone jet brush and the luminance brush pack used in this session are available to download for free at https://affin.co/LD2020Ash if you want to follow along.
** Lockdown 2020: Affinity creative sessions **
Stay tuned to the official Affinity YouTube channel as every day in May at 4pm BST we will be premiering inspirational creative sessions for Lockdown 2020. The sessions will be led by top creatives who use Affinity or one of our in-house product experts and give you the chance to follow along as incredible artists, illustrators, designers and photographers work on a project using the apps.
We will be announcing each daily session on our social channels, so make sure you're following us on Instagram (https://www.instagram.com/affinitybyserif/), Twitter (https://twitter.com/affinitybyserif) and Facebook (https://www.facebook.com/affinitybyserif/) to learn about each daily session.
You can find out more about the Affinity suite, including getting access to free trials, over on https://affinity.serif.com/.
Artist credits:
Artwork shown by Rubens Scarelli, Peter Greenwood, Romain Trystram, Jonathan Ball (pokedstudio), Ben the Illustrator and Sylvain Pfister (Secteur 19)
Update: I have a new course on Affinity Publisher: https://skl.sh/2L91Y07
Update: Affinity Publisher is now available for purchase and is ready for professional...
Update: I have a new course on Affinity Publisher: https://skl.sh/2L91Y07
Update: Affinity Publisher is now available for purchase and is ready for professional work.
Check out my courses on design: https://www.skillshare.com/r/user/benn
Is it time to ditch the Adobe Creative Cloud subscription for the single purchase Affinity apps?
The answer really depends on what you need to do. In this video I examine it from the perspective of only needing to use Illustrator, Photoshop, and InDesign. Can you replace them with Affinity Designer, Affinity Photo, and Affinity Publisher?
Update: I have a new course on Affinity Publisher: https://skl.sh/2L91Y07
Update: Affinity Publisher is now available for purchase and is ready for professional work.
Check out my courses on design: https://www.skillshare.com/r/user/benn
Is it time to ditch the Adobe Creative Cloud subscription for the single purchase Affinity apps?
The answer really depends on what you need to do. In this video I examine it from the perspective of only needing to use Illustrator, Photoshop, and InDesign. Can you replace them with Affinity Designer, Affinity Photo, and Affinity Publisher?
This is a COMPLETE Affinity Photo tutorial for beginners! If you are new to Affinity Photo, this is the perfect video for you. We cover the top 10 things beginners want to know how to do.
Enroll here for 100+ Affinity Photo tutorials! https://affinity.sale/Affinity_Photo
Download today's images: http://affinityrevolution.com/affinity-photo-top-10/
--------------------------------------------------------------------
In this tutorial, we cover the following topics:
0:28 - Opening Images
1:24 - Affinity Photo's Interface
4:48 - Cropping
6:46 - Removing Imperfections
11:47 - Adjustment Layers
17:12 - Masks
22:22 - Selections
26:13 - Changing the Background
29:10 - Adding Text
30:47 - Saving and Exporting
Several months ago, I switched from using Adobe Creative Suite, and jumped over to Affinity Photo, Designer and Publisher. The learning curve was significant, but the rewards have been well worth the switch.
This time I'm talking about 10 things that I love about Affinity Photo that I struggled with in Adobe PhotoShop.
#affinityphoto #graphicdesign #designtutorial
=== === === ===
See my art:
http://www.daveconrey.com/
See more of my videos and subscribe:
https://youtube.com/user/daveconrey
TikTok:
https://www.tiktok.com/@davemakesthings
Instagram:
http://instagram.com/daveconrey
Twitter:
http://twitter.com/daveconrey
Ash Hewson – the Managing Director of Serif – kicks off Lockdown 2020: Affinity creative sessions by giving you a brief overview of the Affinity suite, with a particular focus on how the apps offer a substantial workflow improvement through sharing the same file format, as well as the revolutionary StudioLink feature in Affinity Publisher.
Ash will be available on Live Chat on YouTube for this session’s premiere on Friday, 1 May 2020 at 4pm BST. The image of the drone, drone jet brush and the luminance brush pack used in this session are available to download for free at https://affin.co/LD2020Ash if you want to follow along.
** Lockdown 2020: Affinity creative sessions **
Stay tuned to the official Affinity YouTube channel as every day in May at 4pm BST we will be premiering inspirational creative sessions for Lockdown 2020. The sessions will be led by top creatives who use Affinity or one of our in-house product experts and give you the chance to follow along as incredible artists, illustrators, designers and photographers work on a project using the apps.
We will be announcing each daily session on our social channels, so make sure you're following us on Instagram (https://www.instagram.com/affinitybyserif/), Twitter (https://twitter.com/affinitybyserif) and Facebook (https://www.facebook.com/affinitybyserif/) to learn about each daily session.
You can find out more about the Affinity suite, including getting access to free trials, over on https://affinity.serif.com/.
Artist credits:
Artwork shown by Rubens Scarelli, Peter Greenwood, Romain Trystram, Jonathan Ball (pokedstudio), Ben the Illustrator and Sylvain Pfister (Secteur 19)
Update: I have a new course on Affinity Publisher: https://skl.sh/2L91Y07
Update: Affinity Publisher is now available for purchase and is ready for professional work.
Check out my courses on design: https://www.skillshare.com/r/user/benn
Is it time to ditch the Adobe Creative Cloud subscription for the single purchase Affinity apps?
The answer really depends on what you need to do. In this video I examine it from the perspective of only needing to use Illustrator, Photoshop, and InDesign. Can you replace them with Affinity Designer, Affinity Photo, and Affinity Publisher?
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In protein-ligand binding, the ligand is usually a signal-triggering molecule binding to a site on a target protein. The binding typically results in a change of conformation of the target protein. In DNA-ligand binding studies, the ligand can be a small molecule, ion, or protein which binds to the DNA double helix.
Ligand binding to a receptor (receptor protein) alters the chemical conformation (three-dimensional shape). The conformational state of a receptor protein determines the functional state. Ligands include substrates, inhibitors, activators, and neurotransmitters. The tendency or strength of binding is called affinity. Binding affinity is determined not only by host-guest interactions, but also by solvent effects that can play a dominant steric role in driving non-covalent binding in solution.
Key Highlights... Non-Sulfonamide Compounds ... These multitarget compounds, with their broader affinity, show fewer issues related to high-affinity binding and efficacy loss, suggesting a more stable pharmacological profile and better long-term outcomes.
Through molecular docking simulations and deep learning algorithms, AI can predict candidate compounds' binding affinity and pharmacological properties, prioritizing those with the highest likelihood of success for further experimental validation.
It has attracted scientific interest due to its unique pharmacological properties, exhibiting moderate to weak affinity for various neurotransmitter receptors and increasing the transcription of ...
Germany's government has now announced limited legalization for adults ... (Also read ... Is cannabis a gateway drug?. Claim ... Unproven ... "Cannabis naturally stimulates the reward center in the brain and could pharmacologically promote drug affinity," she said.
In summary, AEF0117 is the first drug candidate in the new pharmacological class of CB1-SSi, which exhibits high specificity, signaling selectivity, and affinity for the CB1 receptor at a distinct ...
... and size-based separation steps, an affinity chromatography process, and two methods of loading exosomes with a wide range of pharmacological agents including oligonucleotides and small molecules.