-
Gene Music using Protein Sequence of HTR5A "5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 5A, G PROTEIN-"
Shop HTR5A - https://www.redbubble.com/people/genemusic/works/46670372-htr5a?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of HTR5A '5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 5A, G PROTEIN-COUPLED'
published: 01 Mar 2016
-
The Serotonin Receptors (The Serotonergic Series #2)
This video provides a brief overview of the serotonin receptors.
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published: 27 Aug 2020
-
Serotonin receptor agonist | Wikipedia audio article
This is an audio version of the Wikipedia Article:
Serotonin receptor agonist
Listening is a more natural way of learning, when compared to reading. Written
language only began at around 3200 BC, but spoken language has existed long ago.
Learning by listening is a great way to:
- increases imagination and understanding
- improves your listening skills
- improves your own spoken accent
- learn while on the move
- reduce eye strain
Now learn the vast amount of general knowledge available on Wikipedia through
audio (audio article). You could even learn subconsciously by playing the audio
while you are sleeping! If you are planning to listen a lot, you could try using
a bone conduction headphone, or a standard speaker instead of an earphone.
You can find other Wikipedia...
published: 28 Oct 2018
-
Choosing a drug target (Drug discovery)
Correction at 01:58
Serotonin Receptor Types
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a neurotransmitter that plays a crucial role in various physiological processes, including mood regulation, sleep, appetite, and gastrointestinal function. Serotonin exerts its effects by binding to specific receptors located on the cell membranes of target cells. There are several types of serotonin receptors, which are classified into "seven main families": 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7. Each receptor family is further divided into subtypes:
1. 5-HT1 receptors:
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
2. 5-HT2 receptors:
5-HT2A
5-HT2B
5-HT2C
3. 5-HT3 receptors: This is the only serotonin receptor subtype that functions as an ion channel (ligand-gated ion ch...
published: 20 Jul 2023
-
#naratriptan | Uses, Dosage, Side Effects & Mechanism | Amerge
Naratriptan is a 5-HT1B/1D receptor agonist used to treat migraines.
In this video, let’s find found:
What is naratriptan?
What is naratriptan used for?
Contraindication
What are the side effects of taking naratriptan?
How does naratriptan work?
How to use naratriptan?
▶ Share this video with others: https://youtu.be/uhSaU3iaB3s
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#naratriptan #migraine #Amerge
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Tags: he-info, naratriptan, Amerge, naratriptan uses, naratriptan dosage, naratriptan side effects, naratriptan mechanism, naratriptan indication, naratriptan contraindications, naratriptan mechanism of action...
published: 28 Sep 2023
-
SB-699551 | Wikipedia audio article
This is an audio version of the Wikipedia Article:
SB-699551
Listening is a more natural way of learning, when compared to reading. Written
language only began at around 3200 BC, but spoken language has existed long ago.
Learning by listening is a great way to:
- increases imagination and understanding
- improves your listening skills
- improves your own spoken accent
- learn while on the move
- reduce eye strain
Now learn the vast amount of general knowledge available on Wikipedia through
audio (audio article). You could even learn subconsciously by playing the audio
while you are sleeping! If you are planning to listen a lot, you could try using
a bone conduction headphone, or a standard speaker instead of an earphone.
You can find other Wikipedia audio articles t...
published: 27 Oct 2018
-
#almotriptan | Uses, Dosage, Side Effects & Mechanism | Axert
Almotriptan is a 5-HT1B/1D receptor agonist used to treat migraines.
In this video, let’s find found:
What is almotriptan?
What is almotriptan used for?
Contraindication
What are the side effects of taking almotriptan?
How does almotriptan work?
How to use almotriptan?
▶ Share this video with others: https://youtu.be/NlMGJecepRY
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#almotriptan #migraine #Axert
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Tags: he-info, almotriptan, Axert, almotriptan uses, almotriptan dosage, almotriptan side effects, almotriptan mechanism, almotriptan indication, almotriptan contraindications, almotriptan mechanism of action, ...
published: 28 Sep 2023
-
#eletriptan | Uses, Dosage, Side Effects & Mechanism | Relpax
Eletriptan is a triptan used for the treatment of migraines.
In this video, let’s find found:
What is eletriptan?
What is eletriptan used for?
Contraindication
What are the side effects of taking eletriptan?
How does eletriptan work?
How to use eletriptan?
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#eletriptan #migraines #Relpax
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Tags: he-info, eletriptan, Relpax, eletriptan uses, eletriptan dosage, eletriptan side effects, eletriptan mechanism, eletriptan indication, eletriptan contraindications, eletriptan mechanism of action, eletriptan pharmaco...
published: 27 Sep 2023
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I Stopped Fluvoxamine Cold-Turkey So You Don't Have To!! Vigorous Withdrawals
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🦍 Gorilla Mind (Mode, Nitric, Smooth, Energy, Turkesterone, etc.) 10% Discount Code: VIGOROUS
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published: 10 Jan 2023
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The Road - Offline Grid (Music IS Better with YOU, Dub Techno MiX)
Pharmacodynamics
Binding affinities of LSD for various receptors. The lower the dissociation constant (Ki), the more strongly LSD binds to that receptor (i.e. with higher affinity). The horizontal line represents an approximate value for human plasma concentrations of LSD, and hence, receptor affinities that are above the line are unlikely to be involved in LSD's effect. Data averaged from data from the Ki Database
Binding affinity for various serotonin receptors
Most serotonergic psychedelics are not significantly dopaminergic, and LSD is therefore atypical in this regard. The agonism of the D2 receptor by LSD may contribute to its psychoactive effects in humans.[28][90]
LSD binds to most serotonin receptor subtypes except for the 5-HT3 and 5-HT4 receptors. However, most of these recep...
published: 25 Mar 2023
1:32
Gene Music using Protein Sequence of HTR5A "5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 5A, G PROTEIN-"
Shop HTR5A - https://www.redbubble.com/people/genemusic/works/46670372-htr5a?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene...
Shop HTR5A - https://www.redbubble.com/people/genemusic/works/46670372-htr5a?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of HTR5A '5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 5A, G PROTEIN-COUPLED'
https://wn.com/Gene_Music_Using_Protein_Sequence_Of_Htr5A_5_Hydroxytryptamine_(Serotonin)_Receptor_5A,_G_Protein
Shop HTR5A - https://www.redbubble.com/people/genemusic/works/46670372-htr5a?asc=u
Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences)
Gene Music using Protein Sequence of HTR5A '5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 5A, G PROTEIN-COUPLED'
- published: 01 Mar 2016
- views: 35
40:54
The Serotonin Receptors (The Serotonergic Series #2)
This video provides a brief overview of the serotonin receptors.
JOIN OUR COMMUNITY:
Reddit ▶ https://www.reddit.com/r/TheLongLived/
FOR GENETIC ANALYSIS & CO...
This video provides a brief overview of the serotonin receptors.
JOIN OUR COMMUNITY:
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This video provides a brief overview of the serotonin receptors.
JOIN OUR COMMUNITY:
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- published: 27 Aug 2020
- views: 9088
10:22
Serotonin receptor agonist | Wikipedia audio article
This is an audio version of the Wikipedia Article:
Serotonin receptor agonist
Listening is a more natural way of learning, when compared to reading. Written...
This is an audio version of the Wikipedia Article:
Serotonin receptor agonist
Listening is a more natural way of learning, when compared to reading. Written
language only began at around 3200 BC, but spoken language has existed long ago.
Learning by listening is a great way to:
- increases imagination and understanding
- improves your listening skills
- improves your own spoken accent
- learn while on the move
- reduce eye strain
Now learn the vast amount of general knowledge available on Wikipedia through
audio (audio article). You could even learn subconsciously by playing the audio
while you are sleeping! If you are planning to listen a lot, you could try using
a bone conduction headphone, or a standard speaker instead of an earphone.
You can find other Wikipedia audio articles too at:
https://www.youtube.com/channel/UCuKfABj2eGyjH3ntPxp4YeQ
In case you don't find one that you were looking for, put a comment.
This video uses Google TTS en-US-Standard-D voice.
SUMMARY
=======
A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin (5-hydroxytryptamine; 5-HT), a neurotransmitter and hormone and the endogenous ligand of the serotonin receptors.
https://wn.com/Serotonin_Receptor_Agonist_|_Wikipedia_Audio_Article
This is an audio version of the Wikipedia Article:
Serotonin receptor agonist
Listening is a more natural way of learning, when compared to reading. Written
language only began at around 3200 BC, but spoken language has existed long ago.
Learning by listening is a great way to:
- increases imagination and understanding
- improves your listening skills
- improves your own spoken accent
- learn while on the move
- reduce eye strain
Now learn the vast amount of general knowledge available on Wikipedia through
audio (audio article). You could even learn subconsciously by playing the audio
while you are sleeping! If you are planning to listen a lot, you could try using
a bone conduction headphone, or a standard speaker instead of an earphone.
You can find other Wikipedia audio articles too at:
https://www.youtube.com/channel/UCuKfABj2eGyjH3ntPxp4YeQ
In case you don't find one that you were looking for, put a comment.
This video uses Google TTS en-US-Standard-D voice.
SUMMARY
=======
A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin (5-hydroxytryptamine; 5-HT), a neurotransmitter and hormone and the endogenous ligand of the serotonin receptors.
- published: 28 Oct 2018
- views: 46
6:15
Choosing a drug target (Drug discovery)
Correction at 01:58
Serotonin Receptor Types
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a neurotransmitter that plays a crucial role in variou...
Correction at 01:58
Serotonin Receptor Types
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a neurotransmitter that plays a crucial role in various physiological processes, including mood regulation, sleep, appetite, and gastrointestinal function. Serotonin exerts its effects by binding to specific receptors located on the cell membranes of target cells. There are several types of serotonin receptors, which are classified into "seven main families": 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7. Each receptor family is further divided into subtypes:
1. 5-HT1 receptors:
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
2. 5-HT2 receptors:
5-HT2A
5-HT2B
5-HT2C
3. 5-HT3 receptors: This is the only serotonin receptor subtype that functions as an ion channel (ligand-gated ion channel). It plays a role in nausea, vomiting, and anxiety.
5-HT3
4. 5-HT4 receptors: These receptors are found in the gastrointestinal tract, where they mediate various functions, including smooth muscle contraction and neurotransmitter release.
5-HT4
5. 5-HT5 receptors:
5-HT5A
5-HT5B
6. 5-HT6 receptors: These receptors are primarily expressed in the central nervous system and are involved in learning, memory, and cognition.
5-HT6
7. 5-HT7 receptors: These receptors are widely distributed in the central nervous system and are involved in mood regulation and other cognitive functions.
5-HT7
Each serotonin receptor subtype is associated with distinct signaling pathways and physiological responses, making them important targets for various medications used to treat conditions like depression, anxiety, migraine, and gastrointestinal disorders. ✔
Drug Discovery, Design & Development
https://youtube.com/playlist?list=PLVKf14jysESBwf4RGPMXQm2VcyrM5CZkU
Drugs in Pregnancy
https://youtube.com/playlist?list=PLVKf14jysESDb9Roy369OAtqflNmqhnze
Drug Interaction
https://youtube.com/playlist?list=PLVKf14jysESCLoX2rB1D9Xc2AUrjghzEN
Electron microscopy
https://www.youtube.com/playlist?list=PLVKf14jysESD7lHs3jhftCtRLP24G-tAc
Antiviral Drugs
https://youtube.com/playlist?list=PLVKf14jysESAgpD0C5zN-DwtShKzxl4ix
Clinical Toxicology
https://youtube.com/playlist?list=PLVKf14jysESCVxerXo1UtcIDntcyHRiZ0
Adrenergic Drugs
https://youtube.com/playlist?list=PLVKf14jysESDmlfJMIFrfrXA68oGsOjC9
Antidiabetic Drugs
https://youtube.com/playlist?list=PLVKf14jysESDcPkjBISW3m6Ktraxs_Hzo
Cardiovascular System playlist:
https://youtube.com/playlist?list=PLVKf14jysESAxFO_hCrDBMKuxyKQzP5rQ
Human Physiology Playlist:
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Cardiovascular playlist:
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Spectroscopy playlist:
https://youtube.com/playlist?list=PLVKf14jysESAiEpJ2QzzLvBiLp7g-uO1e
Stereochemistry playlist:
https://youtube.com/playlist?list=PLVKf14jysESDeX3IHNJ9emjJM6ElxxfAK
Qualitative Chemistry playlist:
https://youtube.com/playlist?list=PLVKf14jysESArT8d-UFZvuGSLIZSuIQI4
Organic Chemistry playlist:
https://youtube.com/playlist?list=PLVKf14jysESADgaCvb8vPOpARfF3j9QiH
Quantitative Chemistry:
https://youtube.com/playlist?list=PLVKf14jysESAsM_uN2E3z9wWrVe8oNBFK
Newtonian Mechanics Playlist:
https://youtube.com/playlist?list=PLVKf14jysESC-h8IX9pawabpED57JEnmY
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https://wn.com/Choosing_A_Drug_Target_(Drug_Discovery)
Correction at 01:58
Serotonin Receptor Types
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a neurotransmitter that plays a crucial role in various physiological processes, including mood regulation, sleep, appetite, and gastrointestinal function. Serotonin exerts its effects by binding to specific receptors located on the cell membranes of target cells. There are several types of serotonin receptors, which are classified into "seven main families": 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7. Each receptor family is further divided into subtypes:
1. 5-HT1 receptors:
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
2. 5-HT2 receptors:
5-HT2A
5-HT2B
5-HT2C
3. 5-HT3 receptors: This is the only serotonin receptor subtype that functions as an ion channel (ligand-gated ion channel). It plays a role in nausea, vomiting, and anxiety.
5-HT3
4. 5-HT4 receptors: These receptors are found in the gastrointestinal tract, where they mediate various functions, including smooth muscle contraction and neurotransmitter release.
5-HT4
5. 5-HT5 receptors:
5-HT5A
5-HT5B
6. 5-HT6 receptors: These receptors are primarily expressed in the central nervous system and are involved in learning, memory, and cognition.
5-HT6
7. 5-HT7 receptors: These receptors are widely distributed in the central nervous system and are involved in mood regulation and other cognitive functions.
5-HT7
Each serotonin receptor subtype is associated with distinct signaling pathways and physiological responses, making them important targets for various medications used to treat conditions like depression, anxiety, migraine, and gastrointestinal disorders. ✔
Drug Discovery, Design & Development
https://youtube.com/playlist?list=PLVKf14jysESBwf4RGPMXQm2VcyrM5CZkU
Drugs in Pregnancy
https://youtube.com/playlist?list=PLVKf14jysESDb9Roy369OAtqflNmqhnze
Drug Interaction
https://youtube.com/playlist?list=PLVKf14jysESCLoX2rB1D9Xc2AUrjghzEN
Electron microscopy
https://www.youtube.com/playlist?list=PLVKf14jysESD7lHs3jhftCtRLP24G-tAc
Antiviral Drugs
https://youtube.com/playlist?list=PLVKf14jysESAgpD0C5zN-DwtShKzxl4ix
Clinical Toxicology
https://youtube.com/playlist?list=PLVKf14jysESCVxerXo1UtcIDntcyHRiZ0
Adrenergic Drugs
https://youtube.com/playlist?list=PLVKf14jysESDmlfJMIFrfrXA68oGsOjC9
Antidiabetic Drugs
https://youtube.com/playlist?list=PLVKf14jysESDcPkjBISW3m6Ktraxs_Hzo
Cardiovascular System playlist:
https://youtube.com/playlist?list=PLVKf14jysESAxFO_hCrDBMKuxyKQzP5rQ
Human Physiology Playlist:
https://youtube.com/playlist?list=PLVKf14jysESCfPGoWe64w4fE920IVgrDH
LIKE👍, SUBSCRIBE👆 & SHARE👋 with Your Friends.
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Cardiovascular playlist:
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Spectroscopy playlist:
https://youtube.com/playlist?list=PLVKf14jysESAiEpJ2QzzLvBiLp7g-uO1e
Stereochemistry playlist:
https://youtube.com/playlist?list=PLVKf14jysESDeX3IHNJ9emjJM6ElxxfAK
Qualitative Chemistry playlist:
https://youtube.com/playlist?list=PLVKf14jysESArT8d-UFZvuGSLIZSuIQI4
Organic Chemistry playlist:
https://youtube.com/playlist?list=PLVKf14jysESADgaCvb8vPOpARfF3j9QiH
Quantitative Chemistry:
https://youtube.com/playlist?list=PLVKf14jysESAsM_uN2E3z9wWrVe8oNBFK
Newtonian Mechanics Playlist:
https://youtube.com/playlist?list=PLVKf14jysESC-h8IX9pawabpED57JEnmY
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- published: 20 Jul 2023
- views: 25
4:26
#naratriptan | Uses, Dosage, Side Effects & Mechanism | Amerge
Naratriptan is a 5-HT1B/1D receptor agonist used to treat migraines.
In this video, let’s find found:
What is naratriptan?
What is naratriptan used for?
Contra...
Naratriptan is a 5-HT1B/1D receptor agonist used to treat migraines.
In this video, let’s find found:
What is naratriptan?
What is naratriptan used for?
Contraindication
What are the side effects of taking naratriptan?
How does naratriptan work?
How to use naratriptan?
▶ Share this video with others: https://youtu.be/uhSaU3iaB3s
▶ Subscribe to learn more about @HeInFo123
#naratriptan #migraine #Amerge
_____________________________________________________
Do not forget to like, share and subscribe #He-info
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Tags: he-info, naratriptan, Amerge, naratriptan uses, naratriptan dosage, naratriptan side effects, naratriptan mechanism, naratriptan indication, naratriptan contraindications, naratriptan mechanism of action, naratriptan pharmacology, naratriptan migraine, naratriptan timli, naratriptan migräne, anti migraine drugs, migraine medication, best migraine medication, back head migraine, naratriptan 2.5 mg, naratriptan hcl, naratriptan drug class, Serotonin 5-HT-Receptor Agonists; Antimigraine Agents
https://wn.com/Naratriptan_|_Uses,_Dosage,_Side_Effects_Mechanism_|_Amerge
Naratriptan is a 5-HT1B/1D receptor agonist used to treat migraines.
In this video, let’s find found:
What is naratriptan?
What is naratriptan used for?
Contraindication
What are the side effects of taking naratriptan?
How does naratriptan work?
How to use naratriptan?
▶ Share this video with others: https://youtu.be/uhSaU3iaB3s
▶ Subscribe to learn more about @HeInFo123
#naratriptan #migraine #Amerge
_____________________________________________________
Do not forget to like, share and subscribe #He-info
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Tags: he-info, naratriptan, Amerge, naratriptan uses, naratriptan dosage, naratriptan side effects, naratriptan mechanism, naratriptan indication, naratriptan contraindications, naratriptan mechanism of action, naratriptan pharmacology, naratriptan migraine, naratriptan timli, naratriptan migräne, anti migraine drugs, migraine medication, best migraine medication, back head migraine, naratriptan 2.5 mg, naratriptan hcl, naratriptan drug class, Serotonin 5-HT-Receptor Agonists; Antimigraine Agents
- published: 28 Sep 2023
- views: 34
1:00
SB-699551 | Wikipedia audio article
This is an audio version of the Wikipedia Article:
SB-699551
Listening is a more natural way of learning, when compared to reading. Written
language only b...
This is an audio version of the Wikipedia Article:
SB-699551
Listening is a more natural way of learning, when compared to reading. Written
language only began at around 3200 BC, but spoken language has existed long ago.
Learning by listening is a great way to:
- increases imagination and understanding
- improves your listening skills
- improves your own spoken accent
- learn while on the move
- reduce eye strain
Now learn the vast amount of general knowledge available on Wikipedia through
audio (audio article). You could even learn subconsciously by playing the audio
while you are sleeping! If you are planning to listen a lot, you could try using
a bone conduction headphone, or a standard speaker instead of an earphone.
You can find other Wikipedia audio articles too at:
https://www.youtube.com/channel/UCuKfABj2eGyjH3ntPxp4YeQ
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SUMMARY
=======
SB-699551 is a drug which was the first compound developed to act as a selective antagonist for the serotonin receptor 5-HT5A, with selectivity of around 100x over other serotonin receptor subtypes. The function of the 5-HT5A receptor remains poorly defined, but SB-699551 was found to modulate serotonin release from neurons, suggesting it acts as a presynaptic inhibitory autoreceptor similar to the 5-HT1B and 5-HT1D receptors. Multiple therapeutic roles have been suggested for 5-HT5A ligands due to the presence of this receptor in several areas of the brain, but research is still at an early stage, with one possible application being the currently difficult to treat negative symptoms of schizophrenia.
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SB-699551
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In case you don't find one that you were looking for, put a comment.
This video uses Google TTS en-US-Standard-D voice.
SUMMARY
=======
SB-699551 is a drug which was the first compound developed to act as a selective antagonist for the serotonin receptor 5-HT5A, with selectivity of around 100x over other serotonin receptor subtypes. The function of the 5-HT5A receptor remains poorly defined, but SB-699551 was found to modulate serotonin release from neurons, suggesting it acts as a presynaptic inhibitory autoreceptor similar to the 5-HT1B and 5-HT1D receptors. Multiple therapeutic roles have been suggested for 5-HT5A ligands due to the presence of this receptor in several areas of the brain, but research is still at an early stage, with one possible application being the currently difficult to treat negative symptoms of schizophrenia.
- published: 27 Oct 2018
- views: 5
4:26
#almotriptan | Uses, Dosage, Side Effects & Mechanism | Axert
Almotriptan is a 5-HT1B/1D receptor agonist used to treat migraines.
In this video, let’s find found:
What is almotriptan?
What is almotriptan used for?
Contra...
Almotriptan is a 5-HT1B/1D receptor agonist used to treat migraines.
In this video, let’s find found:
What is almotriptan?
What is almotriptan used for?
Contraindication
What are the side effects of taking almotriptan?
How does almotriptan work?
How to use almotriptan?
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#almotriptan #migraine #Axert
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https://wn.com/Almotriptan_|_Uses,_Dosage,_Side_Effects_Mechanism_|_Axert
Almotriptan is a 5-HT1B/1D receptor agonist used to treat migraines.
In this video, let’s find found:
What is almotriptan?
What is almotriptan used for?
Contraindication
What are the side effects of taking almotriptan?
How does almotriptan work?
How to use almotriptan?
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- published: 28 Sep 2023
- views: 20
4:30
#eletriptan | Uses, Dosage, Side Effects & Mechanism | Relpax
Eletriptan is a triptan used for the treatment of migraines.
In this video, let’s find found:
What is eletriptan?
What is eletriptan used for?
Contraindication...
Eletriptan is a triptan used for the treatment of migraines.
In this video, let’s find found:
What is eletriptan?
What is eletriptan used for?
Contraindication
What are the side effects of taking eletriptan?
How does eletriptan work?
How to use eletriptan?
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#eletriptan #migraines #Relpax
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https://wn.com/Eletriptan_|_Uses,_Dosage,_Side_Effects_Mechanism_|_Relpax
Eletriptan is a triptan used for the treatment of migraines.
In this video, let’s find found:
What is eletriptan?
What is eletriptan used for?
Contraindication
What are the side effects of taking eletriptan?
How does eletriptan work?
How to use eletriptan?
▶ Share this video with others: https://youtu.be/P9bNajncAk8
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#eletriptan #migraines #Relpax
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Tags: he-info, eletriptan, Relpax, eletriptan uses, eletriptan dosage, eletriptan side effects, eletriptan mechanism, eletriptan indication, eletriptan contraindications, eletriptan mechanism of action, eletriptan pharmacology, eletriptan hydrobromide, migraine, headache, Migraine Headache, eletriptan hydrobromide 40 mg, eletriptan 40 mg, eletriptan review, is eletriptan a narcotic, eletriptan and pregnancy
- published: 27 Sep 2023
- views: 473
29:22
I Stopped Fluvoxamine Cold-Turkey So You Don't Have To!! Vigorous Withdrawals
Website: https://vigoroussteve.com/
Consultations: https://vigoroussteve.com/consultations/
Advice By Email: https://vigoroussteve.com/personalized-advice-by-em...
Website: https://vigoroussteve.com/
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TIMESTAMPS:
00:00 - Intro Teaser
00:24 - I Stopped Fluvoxamine Cold-Turkey So You Don't Have To!!
01:57 - Why Did Steve Go On Fluvoxamine In The First Place?
05:56 - Fluvoxamine's Effect On Fertility
08:44 - PEDs And Their Effect On Fertility
09:52 - Fluvoxamine Withdrawal Effects
13:53 - SERT Occupancy & 5-HTx Receptor Downregulation
16:22 - Online SSRI Withdrawal Support Groups
17:21 - Steve's Worst Withdrawal Symptoms
19:35 - SSRI Withdrawal Vs. Post-Cycle Therapy
24:13 - Steve Almost Had A Fluvoxamine-Relapse
25:33 - SSRI Withdrawal Vs. Proper Life Trauma
27:12 - How To Deal With Your Own Withdrawal Period
28:19 - Closing Thoughts
#VigorousSteve #Fluvoxamine #Withdrawal
https://wn.com/I_Stopped_Fluvoxamine_Cold_Turkey_So_You_Don't_Have_To_Vigorous_Withdrawals
Website: https://vigoroussteve.com/
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🏥 Essential Health Monitoring Devices:
RENPHO Digital Bluetooth Body Weight Scale: https://amzn.to/37p5O2E
OMRON 7 Series Wireless Wrist Blood Pressure Monitor: https://amzn.to/3udI3n7
KETO-MOJO GK+ Bluetooth Glucose & Ketone Testing Kit: https://amzn.to/3NLsJG5
KETO-MOJO GK+ 60x Blood Glucose + 60x Blood Ketone Testing Strips Combo Pack: https://amzn.to/3LK3ylf
KETOSCAN Mini Breath Ketone Meter: https://amzn.to/36QOB29
BRAUN ThermoScan 7 Digital Ear Thermometer: https://amzn.to/3KfvWeP
EMAY Digital Sleep Oxygen Monitor: https://amzn.to/45RG4FN
FITBIT Charge 5 Advanced Fitness, Stress, Sleep & Health Tracker: https://amzn.to/3LDU2Qy
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BNB Chain (BNB on BSC Network): 0x924ACdc205551160cf4906de1D3085868aB582a9
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Binance USD (BUSD on BSC Network): 0x924ACdc205551160cf4906de1D3085868aB582a9
TIMESTAMPS:
00:00 - Intro Teaser
00:24 - I Stopped Fluvoxamine Cold-Turkey So You Don't Have To!!
01:57 - Why Did Steve Go On Fluvoxamine In The First Place?
05:56 - Fluvoxamine's Effect On Fertility
08:44 - PEDs And Their Effect On Fertility
09:52 - Fluvoxamine Withdrawal Effects
13:53 - SERT Occupancy & 5-HTx Receptor Downregulation
16:22 - Online SSRI Withdrawal Support Groups
17:21 - Steve's Worst Withdrawal Symptoms
19:35 - SSRI Withdrawal Vs. Post-Cycle Therapy
24:13 - Steve Almost Had A Fluvoxamine-Relapse
25:33 - SSRI Withdrawal Vs. Proper Life Trauma
27:12 - How To Deal With Your Own Withdrawal Period
28:19 - Closing Thoughts
#VigorousSteve #Fluvoxamine #Withdrawal
- published: 10 Jan 2023
- views: 8823
1:01:40
The Road - Offline Grid (Music IS Better with YOU, Dub Techno MiX)
Pharmacodynamics
Binding affinities of LSD for various receptors. The lower the dissociation constant (Ki), the more strongly LSD binds to that receptor (i.e. ...
Pharmacodynamics
Binding affinities of LSD for various receptors. The lower the dissociation constant (Ki), the more strongly LSD binds to that receptor (i.e. with higher affinity). The horizontal line represents an approximate value for human plasma concentrations of LSD, and hence, receptor affinities that are above the line are unlikely to be involved in LSD's effect. Data averaged from data from the Ki Database
Binding affinity for various serotonin receptors
Most serotonergic psychedelics are not significantly dopaminergic, and LSD is therefore atypical in this regard. The agonism of the D2 receptor by LSD may contribute to its psychoactive effects in humans.[28][90]
LSD binds to most serotonin receptor subtypes except for the 5-HT3 and 5-HT4 receptors. However, most of these receptors are affected at too low affinity to be sufficiently activated by the brain concentration of approximately 10–20 nM.[86] In humans, recreational doses of LSD can affect 5-HT1A (Ki=1.1nM), 5-HT2A (Ki=2.9nM), 5-HT2B (Ki=4.9nM), 5-HT2C (Ki=23nM), 5-HT5A (Ki=9nM [in cloned rat tissues]), and 5-HT6 receptors (Ki=2.3nM).[91][92] Although not present in humans, 5-HT5B receptors found in rodents also have a high affinity for LSD.[93] The psychedelic effects of LSD are attributed to cross-activation of 5-HT2A receptor heteromers.[94] Many but not all 5-HT2A agonists are psychedelics and 5-HT2A antagonists block the psychedelic activity of LSD. LSD exhibits functional selectivity at the 5-HT2A and 5HT2C receptors in that it activates the signal transduction enzyme phospholipase A2 instead of activating the enzyme phospholipase C as the endogenous ligand serotonin does.[95]
Exactly how LSD produces its effects is unknown, but it is thought that it works by increasing glutamate release in the cerebral cortex[86] and therefore excitation in this area, specifically in layers IV and V.[96] LSD, like many other drugs of recreational use, has been shown to activate DARPP-32-related pathways.[97] The drug enhances dopamine D2 receptor protomer recognition and signaling of D2–5-HT2A receptor complexes,[27] which may contribute to its psychotropic effects.[27] LSD has been shown to have low affinity for H1 receptors, displaying antihistamine effects.[98][99][100]
LSD is a biased agonist that induces a conformation in serotonin receptors that preferentially recruits β-arrestin over activating G proteins.[101][102] LSD also has an exceptionally long residence time when bound to serotonin receptors lasting hours, consistent with the long lasting effects of LSD despite its relatively rapid clearance.[101][102] A crystal structure of 5-HT2B bound to LSD reveals an extracellular loop that forms a lid over the diethylamide end of the binding cavity which explains the slow rate of LSD unbinding from serotonin receptors.[103][104][105] The related lysergamide lysergic acid amide (LSA) that lacks the diethylamide moiety is far less hallucinogenic in comparison.[105]
Pharmacokinetics
The effects of LSD normally last between 6 and 12 hours depending on dosage, tolerance, and age.[106] The Sandoz prospectus for "Delysid" warned: "intermittent disturbances of affect may occasionally persist for several days."[107] Aghajanian and Bing (1964) found LSD had an elimination half-life of only 175 minutes (about 3 hours).[91] However, using more accurate techniques, Papac and Foltz (1990) reported that 1 µg/kg oral LSD given to a single male volunteer had an apparent plasma half-life of 5.1 hours, with a peak plasma concentration of 5 ng/mL at 3 hours post-dose.[108]
The pharmacokinetics of LSD were not properly determined until 2015, which is not surprising for a drug with the kind of low-μg potency that LSD possesses.[9][6] In a sample of 16 healthy subjects, a single mid-range 200 μg oral dose of LSD was found to produce mean maximal concentrations of 4.5 ng/mL at a median of 1.5 hours (range 0.5–4 hours) post-administration.[9][6] Concentrations of LSD decreased following first-order kinetics with a half-life of 3.6±0.9 hours and a terminal half-life of 8.9±5.9 hours.[9][6]
The effects of the dose of LSD given lasted for up to 12 hours and were closely correlated with the concentrations of LSD present in circulation over time, with no acute tolerance observed.[9][6] Only 1% of the drug was eliminated in urine unchanged, whereas 13% was eliminated as the major metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD) within 24 hours.[9][6] O-H-LSD is formed by cytochrome P450 enzymes, although the specific enzymes involved are unknown, and it does not appear to be known whether O-H-LSD is pharmacologically active or not.[9][6] The oral bioavailability of LSD was crudely estimated as approximately 71% using previous data on intravenous administration of LSD.[9][6] The sample was equally divided between male and female subjects and there were no significant sex differences observed in the pharmacokinetics of LSD.[9][6]
Chemistry
https://wn.com/The_Road_Offline_Grid_(Music_Is_Better_With_You,_Dub_Techno_Mix)
Pharmacodynamics
Binding affinities of LSD for various receptors. The lower the dissociation constant (Ki), the more strongly LSD binds to that receptor (i.e. with higher affinity). The horizontal line represents an approximate value for human plasma concentrations of LSD, and hence, receptor affinities that are above the line are unlikely to be involved in LSD's effect. Data averaged from data from the Ki Database
Binding affinity for various serotonin receptors
Most serotonergic psychedelics are not significantly dopaminergic, and LSD is therefore atypical in this regard. The agonism of the D2 receptor by LSD may contribute to its psychoactive effects in humans.[28][90]
LSD binds to most serotonin receptor subtypes except for the 5-HT3 and 5-HT4 receptors. However, most of these receptors are affected at too low affinity to be sufficiently activated by the brain concentration of approximately 10–20 nM.[86] In humans, recreational doses of LSD can affect 5-HT1A (Ki=1.1nM), 5-HT2A (Ki=2.9nM), 5-HT2B (Ki=4.9nM), 5-HT2C (Ki=23nM), 5-HT5A (Ki=9nM [in cloned rat tissues]), and 5-HT6 receptors (Ki=2.3nM).[91][92] Although not present in humans, 5-HT5B receptors found in rodents also have a high affinity for LSD.[93] The psychedelic effects of LSD are attributed to cross-activation of 5-HT2A receptor heteromers.[94] Many but not all 5-HT2A agonists are psychedelics and 5-HT2A antagonists block the psychedelic activity of LSD. LSD exhibits functional selectivity at the 5-HT2A and 5HT2C receptors in that it activates the signal transduction enzyme phospholipase A2 instead of activating the enzyme phospholipase C as the endogenous ligand serotonin does.[95]
Exactly how LSD produces its effects is unknown, but it is thought that it works by increasing glutamate release in the cerebral cortex[86] and therefore excitation in this area, specifically in layers IV and V.[96] LSD, like many other drugs of recreational use, has been shown to activate DARPP-32-related pathways.[97] The drug enhances dopamine D2 receptor protomer recognition and signaling of D2–5-HT2A receptor complexes,[27] which may contribute to its psychotropic effects.[27] LSD has been shown to have low affinity for H1 receptors, displaying antihistamine effects.[98][99][100]
LSD is a biased agonist that induces a conformation in serotonin receptors that preferentially recruits β-arrestin over activating G proteins.[101][102] LSD also has an exceptionally long residence time when bound to serotonin receptors lasting hours, consistent with the long lasting effects of LSD despite its relatively rapid clearance.[101][102] A crystal structure of 5-HT2B bound to LSD reveals an extracellular loop that forms a lid over the diethylamide end of the binding cavity which explains the slow rate of LSD unbinding from serotonin receptors.[103][104][105] The related lysergamide lysergic acid amide (LSA) that lacks the diethylamide moiety is far less hallucinogenic in comparison.[105]
Pharmacokinetics
The effects of LSD normally last between 6 and 12 hours depending on dosage, tolerance, and age.[106] The Sandoz prospectus for "Delysid" warned: "intermittent disturbances of affect may occasionally persist for several days."[107] Aghajanian and Bing (1964) found LSD had an elimination half-life of only 175 minutes (about 3 hours).[91] However, using more accurate techniques, Papac and Foltz (1990) reported that 1 µg/kg oral LSD given to a single male volunteer had an apparent plasma half-life of 5.1 hours, with a peak plasma concentration of 5 ng/mL at 3 hours post-dose.[108]
The pharmacokinetics of LSD were not properly determined until 2015, which is not surprising for a drug with the kind of low-μg potency that LSD possesses.[9][6] In a sample of 16 healthy subjects, a single mid-range 200 μg oral dose of LSD was found to produce mean maximal concentrations of 4.5 ng/mL at a median of 1.5 hours (range 0.5–4 hours) post-administration.[9][6] Concentrations of LSD decreased following first-order kinetics with a half-life of 3.6±0.9 hours and a terminal half-life of 8.9±5.9 hours.[9][6]
The effects of the dose of LSD given lasted for up to 12 hours and were closely correlated with the concentrations of LSD present in circulation over time, with no acute tolerance observed.[9][6] Only 1% of the drug was eliminated in urine unchanged, whereas 13% was eliminated as the major metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD) within 24 hours.[9][6] O-H-LSD is formed by cytochrome P450 enzymes, although the specific enzymes involved are unknown, and it does not appear to be known whether O-H-LSD is pharmacologically active or not.[9][6] The oral bioavailability of LSD was crudely estimated as approximately 71% using previous data on intravenous administration of LSD.[9][6] The sample was equally divided between male and female subjects and there were no significant sex differences observed in the pharmacokinetics of LSD.[9][6]
Chemistry
- published: 25 Mar 2023
- views: 42