Эчтәлеккә күчү

ITGA4

Wikipedia — ирекле энциклопедия проектыннан ([http://tt.wikipedia.org.ttcysuttlart1999.aylandirow.tmf.org.ru/wiki/ITGA4 latin yazuında])
ITGA4
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген Интегрин альфа-4[d][1]
Молекуляр функция связывание с белками плазмы[d][2][3][4][…], protein antigen binding[d][5], связывание с ионом металла[d][5], antigen binding[d][5], fibronectin binding[d][5], cell adhesion molecule binding[d][6][7][5], coreceptor activity[d][8], C-X3-C chemokine binding[d][8] һәм protein heterodimerization activity[d][9]
Күзәнәк компоненты экзосома[d][10][11][12], мембрана өлеше[d][5], мембрана[d][10][13], фокальные контакты[d][14], күзәнәк өслеге[d][5][7][15][…], integrin alpha4-beta7 complex[d][7][15], integrin complex[d][5], күзәнәк мембранасы[d][5][5][6], фокальные контакты[d][16], мембрана[d][5][17], Конус роста[d][5], soma[d][5], экзосома[d][5][18][19] һәм protein-containing complex[d][9]
Биологик процесс endodermal cell differentiation[d][20], B cell differentiation[d][21], positive regulation of T cell migration[d][5], extracellular matrix organization[d][5], heterotypic cell-cell adhesion[d][22], substrate adhesion-dependent cell spreading[d][7], cellular response to cytokine stimulus[d][5], cell-matrix adhesion involved in ameboidal cell migration[d][7], cell-matrix adhesion[d][7][15], leukocyte tethering or rolling[d][15], Диапедез[d][5], regulation of immune response[d][5], integrin-mediated signaling pathway[d][5], leukocyte migration[d][5], positive regulation of leukocyte tethering or rolling[d][5], positive regulation of leukocyte cell-cell adhesion[d][5], positive regulation of leukocyte migration[d][5], import into cell[d][5], leukocyte cell-cell adhesion[d][21], negative regulation of protein homodimerization activity[d][6], clathrin-dependent extracellular exosome endocytosis[d][5], агрегация клеток[d][5][5], receptor clustering[d][7], cell-cell adhesion mediated by integrin[d][23], heterotypic cell-cell adhesion[d][15][23], axonogenesis involved in innervation[d][5], cell-cell adhesion in response to extracellular stimulus[d][23], cellular response to amyloid-beta[d][23], positive regulation of vascular endothelial cell proliferation[d][24], neuron projection extension[d][5] һәм positive regulation of endothelial cell apoptotic process[d][24]
Изображение Gene Atlas

ITGA4 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[25][26]

Искәрмәләр

[үзгәртү | вики-текстны үзгәртү]
  1. ↑ 1,0 1,1 UniProt
  2. ↑ Y Takada Propolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrin // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1997. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.272.13.8447 — PMID:9079671
  3. ↑ Takada Y., Noda M. alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor // J. Cell Sci. — The Company of Biologists, 2004. — ISSN 0021-9533; 1477-9137 — doi:10.1242/JCS.01423 — PMID:15466886
  4. ↑ Ring C., Ginsberg M. H., Haling J. et al. Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2010. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.1012316108 — PMID:21173240
  5. ↑ 5,00 5,01 5,02 5,03 5,04 5,05 5,06 5,07 5,08 5,09 5,10 5,11 5,12 5,13 5,14 5,15 5,16 5,17 5,18 5,19 5,20 5,21 5,22 5,23 5,24 5,25 5,26 5,27 5,28 5,29 GOA
  6. ↑ 6,0 6,1 6,2 Breau M. A., Lutz P. G. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells // Blood — American Society of Hematology, Elsevier BV, 2003. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2002-11-3462 — PMID:12869515
  7. ↑ 7,0 7,1 7,2 7,3 7,4 7,5 7,6 Xu C. Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇ // J. Cell Sci. — The Company of Biologists, 2013. — ISSN 0021-9533; 1477-9137 — doi:10.1242/JCS.134528 — PMID:23986478
  8. ↑ 8,0 8,1 Takada Y. Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1, Integrins αvβ3 and α4β1 Act as Coreceptors for Fractalkine, and the Integrin-Binding Defective Mutant of Fractalkine Is an Antagonist of CX3CR1 // J. Immunol. — Baltimore: 2012. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.1200889 — PMID:23125415
  9. ↑ 9,0 9,1 Bernabeu C. Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation // Eur. J. Immunol. — Wiley-Blackwell, 1994. — ISSN 0014-2980; 1521-4141 — doi:10.1002/EJI.1830240107 — PMID:8020569
  10. ↑ 10,0 10,1 GOA
  11. ↑ Möbius W., Stoorvogel W. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2003. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M207550200 — PMID:12519789
  12. ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  13. ↑ Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom. — Wiley, 2010. — ISSN 1076-5174; 1096-9888 — doi:10.1002/JMS.1696 — PMID:19946888
  14. ↑ Waterman C. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol. — NPG, 2011. — ISSN 1465-7392; 1476-4679 — doi:10.1038/NCB2216 — PMID:21423176
  15. ↑ 15,0 15,1 15,2 15,3 15,4 Lalor P., Adams D. CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow // American Journal of Physiology: Gastrointestinal and Liver Physiology — American Physiological Society, 2008. — ISSN 0193-1857; 1522-1547 — doi:10.1152/AJPGI.00266.2007 — PMID:18308860
  16. ↑ Waterman C. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol. — NPG, 2011. — ISSN 1465-7392; 1476-4679 — doi:10.1038/NCB2216 — PMID:21423176
  17. ↑ Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom. — Wiley, 2010. — ISSN 1076-5174; 1096-9888 — doi:10.1002/JMS.1696 — PMID:19946888
  18. ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  19. ↑ Möbius W., Stoorvogel W. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2003. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M207550200 — PMID:12519789
  20. ↑ Brafman D. A., C Phung, N Kumar et al. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions // Cell Death & Differentiation — NPG, 2013. — ISSN 1350-9047; 1476-5403 — doi:10.1038/CDD.2012.138 — PMID:23154389
  21. ↑ 21,0 21,1 Ryan D. H., Nuccie B. L., Abboud C. N. et al. Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells // J. Clin. Invest. / R. S. Ahima — American Society for Clinical Investigation, 1991. — ISSN 0021-9738; 1558-8238 — doi:10.1172/JCI115403 — PMID:1715889
  22. ↑ Lalor P., Adams D. CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow // American Journal of Physiology: Gastrointestinal and Liver Physiology — American Physiological Society, 2008. — ISSN 0193-1857; 1522-1547 — doi:10.1152/AJPGI.00266.2007 — PMID:18308860
  23. ↑ 23,0 23,1 23,2 23,3 R Giri, Y Shen, M Stins et al. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. // American Journal of Physiology: Cell Physiology — 2000. — ISSN 0363-6143; 1522-1563 — doi:10.1152/AJPCELL.2000.279.6.C1772 — PMID:11078691
  24. ↑ 24,0 24,1 Ma F., Li T., Zhang H. et al. MiR-30s Family Inhibit the Proliferation and Apoptosis in Human Coronary Artery Endothelial Cells Through Targeting the 3'UTR Region of ITGA4 and PLCG1. // Journal of Cardiovascular Pharmacology — Lippincott Williams & Wilkins, 2016. — ISSN 0160-2446; 1533-4023 — doi:10.1097/FJC.0000000000000419 — PMID:27464494
  25. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  26. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

[үзгәртү | вики-текстны үзгәртү]
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


Миоглобин молекуласы
 Бу — аксым турында мәкалә төпчеге.
Сез мәкаләне үзгәртеп һәм мәгълүмат өстәп, Википедия проектына ярдәм итә аласыз.
Чыганак — https://tt.wikipedia.org/w/index.php?title=ITGA4&oldid=4129970