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integrin subunit alpha 4 (Q4201951)

From Wikidata

mammalian protein found in Homo sapiens

269C wild type
integrin alpha-IV
CD49 antigen-like family member D
very late activation protein 4 receptor, alpha 4 subunit
alpha 4 subunit of VLA-4 receptor
antigen CD49D, alpha-4 subunit of VLA-4 receptor
VLA-4 subunit alpha
integrin alpha-4
ITGA4
Integrin alpha4

Language	Label	Description	Also known as
default for all languages	No label defined
English	integrin subunit alpha 4	mammalian protein found in Homo sapiens	269C wild type integrin alpha-IV CD49 antigen-like family member D very late activation protein 4 receptor, alpha 4 subunit alpha 4 subunit of VLA-4 receptor antigen CD49D, alpha-4 subunit of VLA-4 receptor VLA-4 subunit alpha integrin alpha-4 ITGA4 Integrin alpha4

Statements

1 reference

13 November 2019

UniProt protein ID

Integrin domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13612

integrin alpha chain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13612

Integrin alpha, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13612

Integrin alpha beta-propellor, protein family

1 reference

based on heuristic

inferred from protein domain or family

Integrin alpha-2, protein family

1 reference

based on heuristic

inferred from protein domain or family

FG-GAP repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

Integrin alpha chain, C-terminal cytoplasmic region, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

9 references

8 April 2019

Propolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

A family of beta 7 integrins on human mucosal lymphocytes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

protein antigen binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

antigen binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

fibronectin binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

cell adhesion molecule binding

determination method or standard

3 references

8 April 2019

JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

coreceptor activity

determination method or standard

1 reference

8 April 2019

Integrins αvβ3 and α4β1 Act as Coreceptors for Fractalkine, and the Integrin-Binding Defective Mutant of Fractalkine Is an Antagonist of CX3CR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

C-X3-C chemokine binding

determination method or standard

1 reference

8 April 2019

Integrins αvβ3 and α4β1 Act as Coreceptors for Fractalkine, and the Integrin-Binding Defective Mutant of Fractalkine Is an Antagonist of CX3CR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

protein heterodimerization activity

determination method or standard

1 reference

8 April 2019

Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

extracellular exosome

determination method or standard

3 references

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612

determination method or standard

17 October 2017

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612

determination method or standard

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

determination method or standard

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612

determination method or standard

determination method or standard

5 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

integrin alpha4-beta7 complex

determination method or standard

integrin complex

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

plasma membrane

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

determination method or standard

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

extracellular exosome

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

8 April 2019

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

protein-containing complex

determination method or standard

1 reference

8 April 2019

Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

biological process

endodermal cell differentiation

determination method or standard

1 reference

8 April 2019

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

B cell differentiation

determination method or standard

1 reference

8 April 2019

Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

positive regulation of T cell migration

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

extracellular matrix organization

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

heterotypic cell-cell adhesion

determination method or standard

1 reference

17 October 2017

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612

determination method or standard

substrate adhesion-dependent cell spreading

determination method or standard

1 reference

8 April 2019

Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

cellular response to cytokine stimulus

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

cell-matrix adhesion involved in ameboidal cell migration

determination method or standard

1 reference

8 April 2019

Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

cell-matrix adhesion

determination method or standard

leukocyte tethering or rolling

determination method or standard

1 reference

8 April 2019

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

regulation of immune response

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

integrin-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

leukocyte migration

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

positive regulation of leukocyte tethering or rolling

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

positive regulation of leukocyte cell-cell adhesion

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

positive regulation of leukocyte migration

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

import into cell

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

leukocyte cell-cell adhesion

determination method or standard

1 reference

8 April 2019

Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

negative regulation of protein homodimerization activity

determination method or standard

1 reference

8 April 2019

JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

clathrin-dependent extracellular exosome endocytosis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

receptor clustering

determination method or standard

1 reference

8 April 2019

Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

cell-cell adhesion mediated by integrin

determination method or standard

1 reference

8 April 2019

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

heterotypic cell-cell adhesion

determination method or standard

axonogenesis involved in innervation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

cell-cell adhesion in response to extracellular stimulus

determination method or standard

1 reference

8 April 2019

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

cellular response to amyloid-beta

determination method or standard

1 reference

8 April 2019

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

positive regulation of vascular endothelial cell proliferation

determination method or standard

1 reference

8 April 2019

MiR-30s Family Inhibit the Proliferation and Apoptosis in Human Coronary Artery Endothelial Cells Through Targeting the 3'UTR Region of ITGA4 and PLCG1.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

neuron projection extension

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

positive regulation of endothelial cell apoptotic process

determination method or standard

1 reference

8 April 2019

MiR-30s Family Inhibit the Proliferation and Apoptosis in Human Coronary Artery Endothelial Cells Through Targeting the 3'UTR Region of ITGA4 and PLCG1.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

determination method or standard

Gene Atlas image

PBB GE ITGA4 213416 at fs.png
732 × 530; 11 KB

0 references

Identifiers

MeSH descriptor ID

subject named as

Integrin alpha4

0 references

D12.776.543.750.705.408.100.450

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000380227

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380227

ENSP00000340149

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000340149

ENSP00000233573

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000233573

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(7 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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