С Википедије, слободне енциклопедије
Topiramat Prodajno ime Topamax, Topamax Sprinkle Drugs.com Monografija Način primene Oralno Poluvreme eliminacije 19 - 23 h
CAS broj 97240-79-4 Y ATC kod N03AX11 (WHO PubChem CID 5284627 DrugBank DB00273 Y ChemSpider 4447672 Y KEGG C07502 Y ChEMBL CHEMBL220492 Y Formula C 12 H 21 N O 8 S Molarna masa 339,362
[H][C@@]12CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@@]3([H])[C@]1([H])OC(C)(C)O2
InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
Y Key:KJADKKWYZYXHBB-XBWDGYHZSA-N
Y
Topiramat je organsko jedinjenje , koje sadrži 12 atoma ugljenika i ima molekulsku masu od 339,362 Da .[ 1] [ 2] [ 3]
^ Blum D, Meador K, Biton V, Fakhoury T, Shneker B, Chung S, Mills K, Hammer A, Isojarvi J: Cognitive effects of lamotrigine compared with topiramate in patients with epilepsy. Blum, D.; Meador, K.; Biton, V.; Fakhoury, T.; Shneker, B.; Chung, S.; Mills, K.; Hammer, A.; Isojärvi, J. (2006 Aug 8). „Cognitive effects of lamotrigine compared with topiramate in patients with epilepsy”. Neurology . 67 (3): 400—6. PMID 16894098 . doi :10.1212/01.wnl.0000232737.72555.06 .
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs” . Nucleic Acids Research . 39 (Database issue): D1035—41. PMC 3013709 PMID 21059682 . doi :10.1093/nar/gkq1126 . ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets” . Nucleic Acids Research . 36 (Database issue): D901—6. PMC 2238889 PMID 18048412 . doi :10.1093/nar/gkm958 . ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods” . J. Phys. Chem. A . 102 : 3762—3772. doi :10.1021/jp980230o . ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences . 41 (6): 1488—1493. PMID 11749573 . doi :10.1021/ci000392t . ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry . 43 (20): 3714—3717. PMID 11020286 . doi :10.1021/jm000942e .
Molimo Vas, obratite pažnju na važno upozorenje oblasti medicine (zdravlja) .
. PMID 21059682. doi:10.1093/nar/gkq1126.
