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BIRC2

С Википедије, слободне енциклопедије
Bakulovirni protein 2, koji sadrži IAP ponavljanje
PDB prikaz baziran na 1qbh​.
Dostupne strukture
1QBH​, 2L9M​, 3D9T​, 3D9U​, 3M1D​, 3MUP​, 3OZ1​, 3T6P​, 3UW4
Identifikatori
Simboli BIRC2; API1; HIAP2; Hiap-2; MIHB; RNF48; c-IAP1; cIAP1
Vanjski ID OMIM601712 MGI1197009 HomoloGene900 GeneCards: BIRC2 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 329 11797
Ensembl ENSG00000110330 ENSMUSG00000057367
UniProt Q13490 Q62210
RefSeq (mRNA) NM_001166.4 NM_007465.2
RefSeq (protein) NP_001157.1 NP_031491.2
Lokacija (UCSC) Chr 11:
102.22 - 102.25 Mb
Chr 9:
7.82 - 7.84 Mb
PubMed pretraga [1] [2]

Bakuloviralni protein 2 koji sadrži IAP ponavljanje (cIAP1) je protein koji je kod ljudi kodiran BIRC2 genom.[1][2]

cIAP1 je član familije inhibitora apoptoze, koja inhibira apoptozu putem ometanja dejstva kaspaza.

BIRC2 formira interakcije sa HtrA serinskom peptidazom 2,[3][4] Diablo homologom,[3][5] TRAF1,[6][7][8] TRAF2,[6][7][8][9][10][11] HSP90B1,[12] RIPK1,[13] Kaspaza-9,[14] TNFSF14,[15] GSPT1,[3] RIPK2[16][17] i Ubikvitin C.[12][13][18]

  1. ^ Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (1996). „Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes”. Nature. 379 (6563): 349—53. PMID 8552191. doi:10.1038/379349a0. 
  2. ^ Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (1996). „The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins”. Cell. 83 (7): 1243—52. PMID 8548810. doi:10.1016/0092-8674(95)90149-3. 
  3. ^ а б в Hegde, Ramesh; Srinivasula Srinivasa M; Datta Pinaki; Madesh Muniswamy (2003). Wassell Richard, Zhang ZhiJia, Cheong NaEun, Nejmeh Julie, Fernandes-Alnemri Teresa, Hoshino Shin-ichi, Alnemri Emad S. „The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein”. J. Biol. Chem. United States. 278 (40): 38699—706. ISSN 0021-9258. PMID 12865429. doi:10.1074/jbc.M303179200. 
  4. ^ Verhagen, Anne M; Silke John; Ekert Paul G (2002). Pakusch Miha, Kaufmann Hitto, Connolly Lisa M, Day Catherine L, Tikoo Anjali, Burke Richard, Wrobel Carolyn, Moritz Robert L, Simpson Richard J, Vaux David L. „HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins”. J. Biol. Chem. United States. 277 (1): 445—54. ISSN 0021-9258. PMID 11604410. doi:10.1074/jbc.M109891200. 
  5. ^ Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL (2000). „Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins”. Cell. United States. 102 (1): 43—53. ISSN 0092-8674. PMID 10929712. doi:10.1016/S0092-8674(00)00009-X. 
  6. ^ а б Roy, N; Deveraux Q L; Takahashi R; Salvesen G S; Reed J C (1997). „The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases”. EMBO J. ENGLAND. 16 (23): 6914—25. ISSN 0261-4189. PMC 1170295Слободан приступ. PMID 9384571. doi:10.1093/emboj/16.23.6914. 
  7. ^ а б Shu, H B; Takeuchi M; Goeddel D V (1996). „The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex”. Proc. Natl. Acad. Sci. U.S.A. United States. 93 (24): 13973—8. ISSN 0027-8424. PMC 19479Слободан приступ. PMID 8943045. doi:10.1073/pnas.93.24.13973. 
  8. ^ а б Li, Xiaoming; Yang Yili; Ashwell Jonathan D (2002). „TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2”. Nature. England. 416 (6878): 345—7. ISSN 0028-0836. PMID 11907583. doi:10.1038/416345a. 
  9. ^ Rual, Jean-François; Venkatesan Kavitha; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. England. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209. 
  10. ^ Uren, A G; Pakusch M; et al. (1996). „Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors”. Proc. Natl. Acad. Sci. U.S.A. United States. 93 (10): 4974—8. ISSN 0027-8424. PMC 39390Слободан приступ. PMID 8643514. doi:10.1073/pnas.93.10.4974. 
  11. ^ Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (2000). „Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein”. J. Biol. Chem. United States. 275 (15): 11114—20. ISSN 0021-9258. PMID 10753917. doi:10.1074/jbc.275.15.11114. 
  12. ^ а б Didelot C, Lanneau D, Brunet M, Bouchot A, Cartier J, Jacquel A, Ducoroy P, Cathelin S, Decologne N, Chiosis G, Dubrez-Daloz L, Solary E, Garrido C (2008). „Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation”. Cell Death Differ. England. 15 (5): 859—66. ISSN 1350-9047. PMID 18239673. doi:10.1038/cdd.2008.5. 
  13. ^ а б Bertrand, Mathieu J M; Milutinovic Snezana; et al. (2008). „cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination”. Mol. Cell. United States. 30 (6): 689—700. PMID 18570872. doi:10.1016/j.molcel.2008.05.014. 
  14. ^ Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC (1998). „IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases”. EMBO J. ENGLAND. 17 (8): 2215—23. ISSN 0261-4189. PMC 1170566Слободан приступ. PMID 9545235. doi:10.1093/emboj/17.8.2215. 
  15. ^ Kuai, June; Nickbarg Elliott; et al. (2003). „Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis”. J. Biol. Chem. United States. 278 (16): 14363—9. ISSN 0021-9258. PMID 12571250. doi:10.1074/jbc.M208672200. 
  16. ^ McCarthy JV, Ni J, Dixit VM (1998). „RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase”. J. Biol. Chem. United States. 273 (27): 16968—75. ISSN 0021-9258. PMID 9642260. doi:10.1074/jbc.273.27.16968. 
  17. ^ Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (1998). „Identification of CARDIAK, a RIP-like kinase that associates with caspase-1”. Curr. Biol. ENGLAND. 8 (15): 885—8. ISSN 0960-9822. PMID 9705938. doi:10.1016/S0960-9822(07)00352-1. 
  18. ^ Sekine, Keiko; Takubo Kohei; et al. (2008). „Small molecules destabilize cIAP1 by activating auto-ubiquitylation”. J. Biol. Chem. United States. 283 (14): 8961—8. ISSN 0021-9258. PMID 18230607. doi:10.1074/jbc.M709525200.