Ciklazocin

Ciklazocin
(IUPAC) ime
	3-(cyclopropylmethyl)- 6,11-dimethyl- 1,2,3,4,5,6-hexahydro- 2,6-methano- 3-benzazocin- 8-ol; or; 2-cyclopropylmethyl- 2'-hydroxy- 5,9-dimethyl- 6,7-benzomorphan
Klinički podaci
Identifikatori
CAS broj	7346-09-0
ATC kod	nije dodeljen
PubChem	19143
ChemSpider	18063
KEGG	D03618
ChEMBL	CHEMBL279449
Hemijski podaci
Formula	C18H25NO
Mol. masa	271.40 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H25NO/c1-12-17-9-14-5-6-15(20)10-16(14)18(12,2)7-8-19(17)11-13-3-4-13/h5-6,10,12-13,17,20H,3-4,7-9,11H2,1-2H3 ; Key: YQYVFVRQLZMJKJ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	?
Način primene	Oralno

Ciklazocin je mešoviti opioidni agonist/antagonist. On je srodan sa dezocinom, pentazocinom i fenazocinom. Ova familija opioidnih lekova se naziva benzomorfanima ili benzazocinima.^[6]

Upotreba

Ispitivanja moguće upotrebe ciklazocina za lečenje bipolarnih pacijenta sa depresijom su pokazala da 8 od 10 pacijenata doživljava umereno poboljšanje.

Istraživanja tokom 1960-ih i 1970-ih za upotrebu ciklazocina za kontrolu bola, i kasnije kao deo lečenja narkotične zavisnosti su bila ozbiljno ometana disforičnim i halucinogenim svojstvima ovog leka.^[7]

Doziranje

Doze od 1–3 mg su korištene u testovima.

Povezano

Benzomorfan

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Sydney Archer, Stanley D Glick, Jean M Bidlack (1996). Cyclazocine revisited - Neurochemical Research. 21. pp. 1369-1373. DOI:10.1007/BF02532378.
↑ Alfred M. Freedman, MD, Max Fink, MD, Robert Sharoff, MD, and Arthur Zaks, MD. „Cyclazocine and Methadone in Narcotic Addiction”.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Sydney Archer, Stanley D Glick, Jean M Bidlack (1996). Cyclazocine revisited - Neurochemical Research. 21. pp. 1369-1373. DOI:10.1007/BF02532378.

[7] Alfred M. Freedman, MD, Max Fink, MD, Robert Sharoff, MD, and Arthur Zaks, MD. „Cyclazocine and Methadone in Narcotic Addiction”.

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