Izvorni kod stranice Faktor licenciranja DNK replikacije MCM2

{{PBB|geneid=4171}}
'''Faktor licenciranja DNK replikacije MCM2''' je [[protein]] koji je kod ljudi kodiran ''MCM2'' [[gen]]om.<ref name="pmid1710453">{{cite journal | author = Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V | title = Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle | journal = Biochem Biophys Res Commun | volume = 177 | issue = 1 | pages = 395–400 |date=Jul 1991 | pmid = 1710453 | pmc =  | doi =10.1016/0006-291X(91)91996-P  }}</ref><ref name="pmid8258304">{{cite journal | author = Mincheva A, Todorov I, Werner D, Fink TM, Lichter P | title = The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21 | journal = Cytogenet Cell Genet | volume = 65 | issue = 4 | pages = 276–7 |date=Jan 1994 | pmid = 8258304 | pmc =  | doi =10.1159/000133647  }}</ref>

Protein kodiran ovim genom je jedan od visoko konzerviranjih proteina održavanja mini-hromozoma (MCM) koji učestvuju u inicijaciji replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta [[Prereplikacioni kompleks|prereplikacionog kompleksa]] (pre-RC). On učestuje u formiranju replikacionih viljuški i regrutaciji drugih srodnih proteina replikacije DNK. Ovaj protein formira kompleks sa MCM4, 6, i 7, i pokazano je da reguliše helikaznu aktivnost kompleksa. Ovaj protein fosforilišu, i tim putem regulišu, proteinske kinaze CDC2 i CDC7.<ref name="entrez">{{cite web | title = Entrez Gene: MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4171| accessdate = }}</ref>

== Interakcije ==

MCM2 formira [[Protein-protein interakcija|interakcije]] sa [[Replikacioni protein A1|replikacionim proteinom A1]],<ref name=pmid12614612>{{cite journal |author = Kneissl Margot, Pütter Vera, Szalay Aladar A, Grummt Friedrich |date=Mar 2003 |title=Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells |journal=J. Mol. Biol. |volume=327 |issue=1 |pages=111–28 |publisher= |location = England| issn = 0022-2836| pmid = 12614612 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0022-2836(03)00079-2 }}</ref> [[AKAP8]],<ref name=pmid12740381>{{cite journal |authors=Eide Turid, Taskén Kristin A, Carlson Cathrine, Williams Gareth, Jahnsen Tore, Taskén Kjetil, Collas Philippe |date=Jul 2003 |title=Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication |journal=J. Biol. Chem. |volume=278 |issue=29 |pages=26750–6 |publisher= |location = United States| issn = 0021-9258| pmid = 12740381 |doi = 10.1074/jbc.M300765200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MCM5]],<ref name=pmid12614612/><ref name=pmid11248027>{{cite journal |authors=DaFonseca C J, Shu F, Zhang J J |date=Mar 2001 |title=Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=6 |pages=3034–9 |publisher= |location = United States| issn = 0027-8424| pmid = 11248027 |doi = 10.1073/pnas.061487598 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=30602 }}</ref> [[MCM6]],<ref name=pmid12614612/><ref name=pmid16189514>{{cite journal |authors = Rual Jean-François, Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |date=Oct 2005 |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12694531>{{cite journal |authors=Yabuta Norikazu, Kajimura Naoko, Mayanagi Kouta, Sato Michio, Gotow Takahito, Uchiyama Yasuo, Ishimi Yukio, Nojima Hiroshi |date=May 2003 |title=Mammalian Mcm2/4/6/7 complex forms a toroidal structure |journal=Genes Cells |volume=8 |issue=5 |pages=413–21 |publisher= |location = England| issn = 1356-9597| pmid = 12694531 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1046/j.1365-2443.2003.00645.x }}</ref><ref name=pmid10567526>{{cite journal |author = You Z, Komamura Y, Ishimi Y |date=Dec 1999 |title=Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity |journal=Mol. Cell. Biol. |volume=19 |issue=12 |pages=8003–15 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10567526 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_1999-12_19_12/page/8003| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=84885 }}</ref><ref name=pmid12207017>{{cite journal |author=You Zhiying, Ishimi Yukio, Masai Hisao, Hanaoka Fumio |date=Nov 2002 |title=Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex |journal=J. Biol. Chem. |volume=277 |issue=45 |pages=42471–9 |publisher= |location = United States| issn = 0021-9258| pmid = 12207017 |doi = 10.1074/jbc.M205769200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MCM7]],<ref name=pmid12614612/><ref name=pmid12694531/><ref name=pmid10567526/><ref name=pmid12207017/><ref name=pmid9099751>{{cite journal |author=Fujita M, Kiyono T, Hayashi Y, Ishibashi M |date=Apr 1997 |title=In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP |journal=J. Biol. Chem. |volume=272 |issue=16 |pages=10928–35 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9099751 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.16.10928 }}</ref> [[ORC1L]],<ref name=pmid12614612/> [[ORC2L]],<ref name=pmid12614612/> [[ORC4L]],<ref name=pmid12614612/> [[ORC5L]],<ref name=pmid12614612/> [[MCM4]],<ref name=pmid12614612/><ref name=pmid12694531/><ref name=pmid10567526/><ref name=pmid8798650>{{cite journal |author = Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H |date=Sep 1996 |title=Binding of human minichromosome maintenance proteins with histone H3 |journal=J. Biol. Chem. |volume=271 |issue=39 |pages=24115–22 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8798650 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.39.24115 }}</ref> [[MCM3]]<ref name=pmid12614612/> i [[proteinska kinaza srodna sa kinazom ciklusa ćelijske deobe 7]].<ref name=pmid12614612/>

== Reference ==
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== Literatura ==
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{{PBB_Further_reading 
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}}
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