Schistosomiasis Consortium for Operational Research and Evaluation

The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was established in December 2008 to answer strategic questions about schistosomiasis control and elimination. SCORE was funded by the Bill & Melinda Gates Foundation through a grant to the University of Georgia Research Foundation (UGARF). SCORE activities were completed September 2020.

Schistosomiasis, also known as bilharzia, is caused by worms that live in the blood vessels, is found predominantly in tropical and sub-tropical climates, especially Africa, Asia, South America and the Middle East, and infects approximately 200 million people worldwide.  SCORE’s focus was on the two major disease-causing schistosomes in Africa, South America, and the Middle East –Schistosoma mansoni and S. haematobium.

SCORE’s goal was to find answers to help current and future schistosomiasis control program managers do the job better. This included learning what approaches to controlling and eliminating schistosomiasis work best and developing and evaluating new tools for program managers to use. Our vision was for our work to inform efforts to gain control of schistosomiasis in high-prevalence areas, sustain control and move towards elimination in areas of moderate prevalence, and ultimately eliminate schistosomiasis. SCORE did this work by funding investigators from around the world to conduct the needed research and evaluation activities.

The terms of the grant to UGARF precluded funding research on S. japonicum, vaccines, or drug discovery. The use of the funds for capacity development as such was also precluded, unless determined essential for conducting SCORE activities.

The SCORE Secretariat was located on the campus of the University of Georgia in Athens, Georgia, USA, within the Center for Tropical and Emerging Global Diseases (CTEGD), but the program involved investigators from around the globe. The SCORE Secretariat office closed on September 30, 2020, after all activities were completed.

A special issue about the SCORE program history, results, and messages for the future was published in the July 2020 issue of the American Journal of Tropical Medicine and Hygiene.

People

The Secretariat provided leadership and management for the SCORE programs

Daniel G. Colley, PhD: Director of SCORE

Carl H. Campbell, Jr: Associate Director for Management

Tammy Andros: Administrator

Jennifer Castleman: Data Coordinator

Sue Binder, MD: Senior Consultant

Charles H. King, MD: Senior Scientist for SCORE

Nupur Kittur: Research Professional

The Advisory Committee provided advice and input on all major SCORE activities

Joseph A. Cook, MD, MPH: Adjunct Epidemiology Professor, Gillings School for Global Public Health, University of North Carolina, Chapel Hill, NC

Paul Hagan, PhD: Vice-Principal and Pro Vice-Chancellor for Research, Robert Gordon University, Aberdeen, Scotland

Stephanie James, PhD: Director of Science, Foundation for the National Institutes of Health, Bethesda, MA

Eric Ottesen, MD: Director, Neglected Tropical Diseases Support Center, Task Force for Global Health, Atlanta, GA

Stephen McGarvey, PhD: Director, International Health Institute, Brown University, Providence, RI

Investigators

SCORE funded investigators with a range of experience and expertise. In addition to the funded researchers, many others participated in an ad hoc or ongoing basis in developing and providing input to SCORE’s efforts.

Projects

• Gaining control of schistosomiasis. These projects evaluated alternative approaches to mass drug administration (MDA) in communities with high prevalence rates of schistosomiasis. Studies related to subtle morbidity, snail infections and schistosome population genetics were layered onto interventions in some areas where gaining control projects had been implemented.
• Sustaining control of schistosomiasis.  These projects evaluated alternative approaches to MDA in areas of moderate prevalence.
• Elimination of schistosomiasis.  The original focus of this project was eliminating schistosomiasis in Zanzibar and providing data and insights into effective strategies for moving large areas from having a low prevalence of infection to eliminating schistosomiasis. In addition to demonstrating that infections in humans were reduced and/or eliminated, data were collected on snail infections and schistosome population genetics.
  • In July, 2013, SCORE received a supplemental award focused on the elimination of S. mansoni, to complement efforts already underway on S. haematobium on Zanzibar. These additional resources supported research on snail control, as well as studies comparing different approaches to eliminating schistosomiasis in large geographic areas with transmission characteristics associated with S. mansoni infection.
• Field evaluations of the point-of-care (POC) circulating cathodic antigen (CCA) urine assay for use as a screening tool for S. mansoni infection in humans.
• Research and evaluation on human diagnostic tests for schistosomiasis.
• Development of tools for studies of schistosome population genetics.
• Rapid Answers Project (RAP). The RAP projects provided critical information by analyzing and synthesizing existing data.
• To optimize the use of the SCORE data, especially the field studies on gaining and sustaining control of schistosomiasis and the studies that have been layered on them, SCORE worked with programmers and statisticians at UGA to integrate the data from the various study sites and conduct analyses of the combined data.

Rapid Answers Project

Through its RAP program, SCORE conducted systematic evaluations and meta-analysis of existing research evidence concerning several key operational issues relevant to schistosomiasis control and elimination. See below for more information on these RAPs, links to published articles, and links to 2-page brochures for disseminating the findings to a broad audience.

RAP 1 – What is the impact of double treatment (two doses close together) for S. mansoni and for S. haematobium?

In a paper published in PLoS NTD, King et al. showed that, although schedules for repeated treatment with praziquantel require greater inputs in terms of direct costs and community participation, cure rates and egg-reduction rates with double treatment were higher, particularly for S. mansoni infection. Based on decision-tree simulations, there are expected to be cost-effective incremental health benefits to this approach, with an estimated cost of $153 for S. mansoni and $211 for S. haematobium per additional lifetime QALY gained by using double treatment in school-based programs. RAP 1 is available as a 2-page brochure for download.

RAP 2 – How well do urine dipsticks perform for assessing prevalence of S. haematobium in low-prevalence areas?

King and Bertsch showed that heterogeneity between studies, even in stratified subgroups, has been very high. Nevertheless, dipsticks appear to be 58 – 75% sensitive relative to egg detection, with rates varying depending on underlying intensity of infection. Interestingly, post-treatment performance is not much different from pre-treatment values, perhaps because studies presenting such data have focused on high risk areas, where there were often many infected children still included in the post-control follow-up surveys. RAP 2 is available as a 2-page brochure for download.

RAP 3 – Do adults in areas with S. haematobium get reinfected after treatment, and, if so, at what rates?

Evaluation of adult reinfection with S. haematobium showed that adults do get reinfected and can contribute to transmission cycles. The quality and quantity of data on this topic did not support a formal review. However, we developed a “summary of the evidence”. RAP 3 is available as a 2-page brochure for download.

RAP 4 – How effective is niclosamide-based mollusciciding in reducing snail numbers and in reducing local Schistosoma infection risk?

RAP 4 examined the literature to determine and compare the efficacy of niclosamide application for intermediate host snail control in Schistosoma-endemic areas. We completed and published a scoping historical review of the perceived pros and cons of this approach, including a list of the technical inputs required to deliver snail control (see King and Bertsch). A second article, published December 2015 in PLOS Neglected Tropical Diseases, provides a quantitative meta-analysis of the reported impact of molluscicide-based snail control programs on Schistosoma incidence and prevalence among local human populations (see King, Sutherland, and Bertsch). RAP 4 is now available as a 2-page brochure for download.

RAP 5 – How best can treatment programs focused on school age children reach those who are not in school?

This published systematic review summarized the different approaches that MDA programs have taken to increase treatment participation by 5 – 18 year old children who are not in school. This group of children often have the greatest risk for infection and disease, yet often get missed by standard school-based treatment programs (see Burnim et al.). RAP 5 is now available as a 2-page brochure for download.

RAP 6 – On a quantitative basis, how does treatment-related reduction in Schistosoma infection intensity translate into reduction in infection-related morbidities?

This systematic review and meta-analysis examined the quantitative link between reported reductions in post-treatment Schistosoma infection intensity (egg reduction rate, ERR) and the changes seen in population prevalence of anemia, hepatosplenomegaly, growth retardation, and other clinical complications of schistosomiasis. The project’s objective was to document the impact of varied ERRs on prevalence of specific morbidities, in order to provide quantitative measures of the impact of anti-schistosomal treatments. This project was performed in collaboration with Universidade Federal de Minas Gerais, Brazil and has been published (see Andrade et al.). RAP 6 is now available as a 2-page brochure for download.

Publications

Pennance T, Neves MI, Webster BL, Gower CM, Knopp S, Khamis IS, Ame SM, Ali SM, Rabone M, Emery A, Allan F, Muhsin MA, Suleiman KR, Kabole F, Walker M, Rollinson D, Webster JP (2022) Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands. PLoS Negl Trop Dis. https://doi.org/10.1371/journal.pntd.0010419

Ouattara M, Bassa FK, Diakité NR, Hattendorf J, Coulibaly JT, Yao PK, Tian-Bi YT, Konan CK, Assaré RK, Koné N, Guindo-Coulibaly N, Utzinger J, N’Goran EK (2022) Effectiveness of Four Different Interventions Against Schistosoma haematobium in a Seasonal Transmission Setting of Côte d’Ivoire: A Cluster Randomized Trial. Clin Infect Dis. https://doi.org/10.1093/cid/ciab787

Grolimund CM, Bärenbold O, Hatz CF, Vennervald BJ, Mayombana C, Mshinda H, Utzinger J, Vounatsou P (2022) Infection intensity-dependent accuracy of reagent strip for the diagnosis of Schistosoma haematobium and estimation of treatment prevalence thresholds. PLoS Negl Trop Dis. https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010332

Ouattara M, Diakité NR, Yao PK, Saric J, Coulibaly JT, Assaré RK, Bassa FK, Koné N, Guindo-Coulibaly N, Hattendorf J, Utzinger J, N’Goran EK (2021) Effectiveness of school-based preventive chemotherapy strategies for sustaining the control of schistosomiasis in Cote d’Ivoire: Results of a 5-year cluster randomized trial. PLoS Negl Trop Dis. https://doi.org/10.1371/journal.pntd.0008845

Musuva RM, Odiere MR, Mwinzi PNM, Omondi IO, Rawago FO, Matendechero SH, Kittur N, Campbell CH, Jr., Colley DG (2021) Unprotected water sources and low latrine coverage are contributing factors to persistent hotspots for schistosomiasis in western Kenya. PloS One. https://doi.org/10.1371/journal.pone.0253115

Diakité NR, Ouattara M, Bassa FK, Coulibaly JT, Tian-Bi YT, Meité A, Hattendorf J, Utzinger J, N’Goran EK (2021) Baseline and Impact of First-Year Intervention on Schistosoma haematobium Infection in Seasonal Transmission Foci in the Northern and Central Parts of Côte d’Ivoire. Trop Med Infect Dis. https://doi.org/10.3390/tropicalmed6010007

Assaré RK, N’Tamon RN, Bellai LG, Koffi JA, Mathieu TI, Ouattara M, Hurlimann E, Coulibaly JT, Diabaté S, N’Goran EK, Utzinger J (2020) Characteristics of persistent hotspots of Schistosoma mansoni in western Côte d’Ivoire. Parasit Vectors 13: 337. https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-020-04188-x

Mwanga JR, Kinung’hi SM, Mosha J, Angelo T, Maganga J, Campbell C (2020) Village Response to Mass Drug Administration for Schistosomiasis in Mwanza Region, Northwestern Tanzania: Are We Missing Socioeconomic, Cultural, and Political Dimensions? Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0843

Phillips AE, Tohon Z, Dhanani N, Sofo B, Gnandou I, Sidikou B, Noma AG, Madougou B, Alto O, Sebangou H, Halilou KM, Andia R, Garba A, Fenwick, A, Hamidou AA  (2020) Evaluating the Impact of Biannual School-Based and Community-Wide Treatment on Urogenital Schistosomiasis in Niger. Parasit Vectors. https://doi.org/10.21203/rs.3.rs-39224/v1

Ramzy RMR, Rabiee A, Abd Elaziz KM, Campbell CH, Kittur N, Colley DG, Haggag AA (2020) Test, Treat, Track, Test, and Treat Active Surveillance toward Elimination of Schistosomiasis: A Feasibility Study. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.20-0156

Archer J, Barksby R, Pennance T, Rostron P, Bakar F, Knopp S, Allan F, Kabole F, Ali SM, Ame SM, Rollinson D, Webster BL (2020) Analytical and Clinical Assessment of a Portable, Isothermal Recombinase Polymerase Amplification (RPA) Assay for the Molecular Diagnosis of Urogenital Schistosomiasis. Molecules. https://www.mdpi.com/1420-3049/25/18/4175

Allan F, Ame SM, Tian-Bi YT, Hofkin BV, Webster BL, Diakité NR, N’Goran EK, Kabole F, Khamis IS, Gouvras AN, Emery AM, Pennance T, Rabone M, Kinung’hi S, Hamidou AA, Mkoji GM, McLaughlin JP, Kuris AM, Loker ES, Knopp S, Rollinson D (2020) Snail-Related Contributions from the Schistosomiasis Consortium for Operational Research and Evaluation Program Including Xenomonitoring, Focal Mollusciciding, Biological Control, and Modeling. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0831

Bergquist NR (2020) Schistosomiasis Consortium for Operational Research and Evaluation: Mission Accomplished. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0838

Binder S, Campbell CH, Andros T, Castleman J, Kittur N, King CH, Colley DG (2020) The Schistosomiasis Consortium for Operational Research and Evaluation 2008-2020: Approaches, Experiences, Lessons, and Recommendations. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0786

Binder S, Campbell CH, Castleman JD, Kittur N, Kinung’hi S, Olsen A, Magnussen P, Karanja DMS, Mwinzi PNM, Montgomery SP, Secor WE, Phillips AE, Dhanani N, Gazzinelli-Guimaraes PH, Clements M, N’Goran EK, Meité A, Utzinger J, Hamidou AA, Garba A, Fleming FM, Whalen CC, King CH, Colley DG (2020) Lessons Learned in Conducting Mass Drug Administration for Schistosomiasis Control and Measuring Coverage in an Operational Research Setting. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0789

Campbell CH, Binder S, King CH, Knopp S, Rollinson D, Person B, Webster B, Allan F, Utzinger J, Ame SM, Ali SM, Kabole F, N’Goran EK, Tediosi F, Salari P, Ouattara M, Diakité NR, Hattendorf J, Andros T, Kittur N, Colley DG (2020) SCORE Operational Research on Moving toward Interruption of Schistosomiasis Transmission. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0825

Colley DG, Fleming FM, Matendechero SH, Knopp S, Rollinson D, Utzinger J, Castleman JD, Kittur N, King CH, Campbell CH, Kabole FM, Kinung’hi S, Ramzy RMR, Binder S (2020) Contributions of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) to Schistosomiasis Control and Elimination: Key Findings and Messages for Future Goals, Thresholds, and Operational Research. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0787

Colley DG, Jacobson JA, Binder S (2020) Schistosomiasis Consortium for Operational Research and Evaluation (SCORE): Its Foundations, Development, and Evolution. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0785

Colley DG, King CH, Kittur N, Ramzy RMR, Secor WE, Fredericks-James M, Ortu G, Clements MN, Ruberanziza E, Umulisa I, Wittmann U, Campbell CH (2020) Evaluation, Validation, and Recognition of the Point-of-Care Circulating Cathodic Antigen, Urine-Based Assay for Mapping Schistosoma mansoni Infections. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0788

Corstjens P, de Dood CJ, Knopp S, Clements MN, Ortu G, Umulisa I, Ruberanziza E, Wittmann U, Kariuki T, LoVerde P, Secor WE, Atkins L, Kinung’hi S, Binder S, Campbell CH, Colley DG, van Dam GJ (2020) Circulating Anodic Antigen (CAA): A Highly Sensitive Diagnostic Biomarker to Detect Active Schistosoma Infections-Improvement and Use during SCORE. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0819

King CH, Bertsch D, Andrade GN, Burnim M, Ezeamama AE, Binder S, Colley DG (2020) The Schistosomiasis Consortium for Operational Research and Evaluation Rapid Answers Project: Systematic Reviews and Meta-Analysis to Provide Policy Recommendations Based on Available Evidence. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0806

King CH, Binder S, Shen Y, Whalen CC, Campbell CH, Wiegand RE, Olsen A, Secor WE, Montgomery SP, Musuva R, Mwinzi PNM, Magnussen P, Kinung’hi S, Andrade GN, Ezeamama AE, Colley DG (2020) SCORE Studies on the Impact of Drug Treatment on Morbidity due to Schistosoma mansoni and Schistosoma haematobium Infection. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0830

King CH, Kittur N, Binder S, Campbell CH, N’Goran EK, Meité A, Utzinger J, Olsen A, Magnussen P, Kinung’hi S, Fenwick A, Phillips AE, Gazzinelli-Guimaraes PH, Dhanani N, Ferro J, Karanja DMS, Mwinzi PNM, Montgomery SP, Wiegand RE, Secor WE, Hamidou AA, Garba A, Colley DG (2020) Impact of Different Mass Drug Administration Strategies for Gaining and Sustaining Control of Schistosoma mansoni and Schistosoma haematobium Infection in Africa. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0829

King CH, Kittur N, Wiegand RE, Shen Y, Ge Y, Whalen CC, Campbell CH, Hattendorf J, Binder S (2020) Challenges in Protocol Development and Interpretation of the Schistosomiasis Consortium for Operational Research and Evaluation Intervention Studies. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0805

King CH, Yoon N, Wang X, Lo NC, Alsallaq R, Ndeffo-Mbah M, Li E, Gurarie D (2020) Application of Schistosomiasis Consortium for Operational Research and Evaluation Study Findings to Refine Predictive Modeling of Schistosoma mansoni and Schistosoma haematobium Control in Sub-Saharan Africa. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0852

Kittur N, Campbell CH, Binder S, Shen Y, Wiegand R, Mwanga JR, Kinung’hi SM, Musuva RM, Odiere MR, Matendechero SH, Knopp S, Colley DG (2020) Discovering, Defining, and Summarizing Persistent Hotspots in SCORE Studies. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0815

Pennance T, Allan F, Emery A, Rabone M, Cable J, Garba AD, Hamidou AA, Webster JP, Rollinson D, Webster BL (2020) Interactions between Schistosoma haematobium group species and their Bulinus spp. intermediate hosts along the Niger River Valley. Parasites & Vectors 13: 268. https://doi.org/10.1186/s13071-020-04136-9

Ruberanziza E, Wittmann U, Mbituyumuremyi A, Mutabazi A, Campbell CH, Colley DG, Fleming FM, Ortu G, van Dam GJ, Umulisa I, Tallant J, Kabera M, Semakula M, Corstjens PLAM, Munyaneza T, Lancaster W, Mbonigaba JB, Clements MN (2020) Nationwide Remapping of Schistosoma mansoni Infection in Rwanda Using Circulating Cathodic Antigen Rapid Test: Taking Steps toward Elimination. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0866

Salari P, Fürst T, Knopp S, Utzinger J, Tediosi F (2020) Cost of interventions to control schistosomiasis: A systematic review of the literature. PLOS Negl Trop Dis. https://doi.org/10.1371/journal.pntd.0008098

Salari P, Fürst T, Knopp S, Rollinson D, Kabole F, Khamis MI, Omar MA, Bacon O, Ali SM, Utzinger J, Tediosi F (2020) Financial Costs of the Zanzibar Elimination of Schistosomiasis Transmission Project. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.20-0252

Webster JP, Neves MI, Webster BL, Pennance T, Rabone M, Gouvras AN, Allan F, Walker M, Rollinson D (2020) Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0827

Olsen A, Kinung’hi S, Kaatano G, Magnussen P (2020) Changes in Morbidity, Physical Fitness, and Perceived Quality of Life among Schoolchildren following Four Years of Different Mass Drug Administration Strategies against Schistosoma mansoni Infection in Mwanza Region, Northwestern Tanzania. Am J Trop Med Hyg 102: 100-105. https://doi.org/10.4269/ajtmh.19-0428

Keller D, Rothen J, Dangy JP, Saner C, Daubenberger C, Allan F, Ame SM, Ali SM, Kabole F, Hattendorf J, Rollinson D, Seyfarth R, Knopp S (2020) Performance of a real-time PCR approach for diagnosing Schistosoma haematobium infections of different intensity in urine samples from Zanzibar. Infect Dis Poverty. https://idpjournal.biomedcentral.com/articles/10.1186/s40249-020-00726-y

Gaspard J, Usey MM, Fredericks-James M, Sanchez MJ, Atkins L, Campbell CH, Corstjens P, van Dam GJ, Colley DG, Secor WE (2020) Survey of Schistosomiasis in Saint Lucia: Evidence for Interruption of Transmission. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0904

Walker JW, Kittur N, Binder S, Castleman JD, Drake JM, Campbell CH, King CH, Colley DG (2019) Environmental Predictors of Schistosomiasis Persistent Hotspots following Mass Treatment with Praziquantel. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0658

Tian-Bi YT, Webster B, Konan CK, Allan F, Diakité NR, Ouattara M, Salia D, Kone A, Kakou AK, Rabone M, Coulibaly JT, Knopp S, Meité A, Utzinger J, N’Goran EK, Rollinson D (2019) Molecular characterization and distribution of Schistosoma cercariae collected from naturally infected bulinid snails in northern and central Cote d’Ivoire. Parasit Vectors 12: 117. https://doi.org/10.1186/s13071-019-3381-3

Sousa MS, van Dam GJ, Pinheiro MCC, de Dood CJ, Peralta JM, Peralta RHS, Daher EF, Corstjens P, Bezerra FSM (2019) Performance of an Ultra-Sensitive Assay Targeting the Circulating Anodic Antigen (CAA) for Detection of Schistosoma mansoni Infection in a Low Endemic Area in Brazil. Front Immunol 10: 682. https://doi.org/10.3389/fimmu.2019.00682

Shen Y, Wiegand RE, Olsen A, King CH, Kittur N, Binder S, Zhang F, Whalen CC, Secor WE, Montgomery SP, Mwinzi PNM, Magnussen P, Kinung’hi S, Campbell CH, Colley DG (2019) Five-Year Impact of Different Multi-Year Mass Drug Administration Strategies on Childhood Schistosoma mansoni-Associated Morbidity: A Combined Analysis from the Schistosomiasis Consortium for Operational Research and Evaluation Cohort Studies in the Lake Victoria Regions of Kenya and Tanzania. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0273

Shen Y, Sung MH, King CH, Binder S, Kittur N, Whalen CC, Colley DG (2019) Modeling approaches to predicting persistent hotspots in SCORE studies for gaining control of schistosomiasis mansoni in Kenya and Tanzania. J Infect Dis. https://doi.org/10.1093/infdis/jiz529

Secor WE, Wiegand RE, Montgomery SP, Karanja DMS, Odiere MR (2019) Comparison of School-Based and Community-Wide Mass Drug Administration for Schistosomiasis Control in an Area of Western Kenya with High Initial Schistosoma mansoni Infection Prevalence: A Cluster Randomized Trial. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.19-0626

Rostron P, Pennance T, Bakar F, Rollinson D, Knopp S, Allan F, Kabole F, Ali SM, Ame SM, Webster BL (2019) Development of a recombinase polymerase amplification (RPA) fluorescence assay for the detection of Schistosoma haematobium. Parasit Vectors 12: 514. https://doi.org/10.1186/s13071-019-3755-6

Rabone M, Wiethase JH, Allan F, Gouvras AN, Pennance T, Hamidou AA, Webster BL, Labbo R, Emery AM, Garba AD, Rollinson D (2019) Freshwater snails of biomedical importance in the Niger River Valley: evidence of temporal and spatial patterns in abundance, distribution and infection with Schistosoma spp. Parasit Vectors 12: 498. https://doi.org/10.1186/s13071-019-3745-8

Platt RN, McDew-White M, Le Clec’h W, Chevalier FD, Allan F, Emery AM, Garba A, Hamidou AA, Ame SM, Webster JP, Rollinson D, Webster BL, Anderson TJC (2019) Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites. Mol Biol Evol. https://doi.org/10.1093/molbev/msz154

Mutuku MW, Laidemitt MR, Beechler BR, Mwangi IN, Otiato FO, Agola EL, Ochanda H, Kamel B, Mkoji GM, Steinauer ML, Loker ES (2019) A Search for Snail-Related Answers to Explain Differences in Response of Schistosoma mansoni to Praziquantel Treatment among Responding and Persistent Hotspot Villages along the Kenyan Shore of Lake Victoria. Am J Trop Med Hyg 101: 65-77. https://doi.org/10.4269/ajtmh.19-0089

Li EY, Gurarie D, Lo NC, Zhu X, King CH (2019) Improving public health control of schistosomiasis with a modified WHO strategy: a model-based comparison study. Lancet Glob Health 7: e1414-e1422. https://doi.org/10.1016/S2214-109X(19)30346-8

Knopp S, Person B, Ame SM, Ali SM, Hattendorf J, Juma S, Muhsin J, Khamis IS, Mohammed KA, Utzinger J, Hollenberg E, Kabole F, Rollinson D (2019) Evaluation of integrated interventions layered on mass drug administration for urogenital schistosomiasis elimination: a cluster-randomised trial. Lancet Glob Health 7: e1118-e1129. https://doi.org/10.1016/S2214-109X(19)30189-5

Knopp S, Ame SM, Person B, Hattendorf J, Rabone M, Juma S, Muhsin J, Khamis IS, Hollenberg E, Mohammed KA, Kabole F, Ali SM, Rollinson D (2019) A 5-Year intervention study on elimination of urogenital schistosomiasis in Zanzibar: Parasitological results of annual cross-sectional surveys. PLOS Neglected Tropical Diseases 13: e0007268. https://doi.org/10.1371/journal.pntd.0007268

Kittur N, King CH, Campbell CH, Kinung’hi S, Mwinzi PNM, Karanja DMS, N’Goran EK, Phillips AE, Gazzinelli-Guimaraes PH, Olsen A, Magnussen P, Secor WE, Montgomery SP, Utzinger J, Walker JW, Binder S, Colley DG (2019) Persistent Hot spots in Schistosomiasis Consortium for Operational Research and Evaluation Studies for Gaining and Sustaining Control of Schistosomiasis after Four Years of Mass Drug Administration of Praziquantel. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.19-0193

Jia TW, Wang W, Sun LP, Lv S, Yang K, Zhang NM, Huang XB, Liu JB, Liu HC, Liu RH, Gawish FA, Habib MR, El-Emam MA, King CH, Zhou XN (2019) Molluscicidal effectiveness of Luo-Wei, a novel plant-derived molluscicide, against Oncomelania hupensis, Biomphalaria alexandrina and Bulinus truncatus. Infect Dis Poverty 8: 27. https://doi.org/10.1186/s40249-019-0535-7

Haggag AA, Rabiee A, Abd Elaziz KM, Campbell CH, Colley DG, Ramzy RMR (2019) Thirty-Day Daily Comparisons of Kato-Katz and CCA Assays of 45 Egyptian Children in Areas with Very Low Prevalence of Schistosoma mansoni. Am J Trop Med Hyg 100: 578-583. https://doi.org/10.4269/ajtmh.18-0829

Haggag AA, Casacuberta Partal M, Rabiee A, Abd Elaziz KM, Campbell CH, Colley DG, Ramzy RMR (2019) Multiple Praziquantel Treatments of Schistosoma mansoni Egg-Negative, CCA-Positive Schoolchildren in a Very Low Endemic Setting in Egypt Do Not Consistently Alter CCA Results. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.18-0961

Clark NJ, Umulisa I, Ruberanziza E, Owada K, Colley DG, Ortu G, Campbell CH, Jr., Ruzindana E, Lancaster W, Mbonigaba JB, Mbituyumuremyi A, Fenwick A, Soares Magalhaes RJ, Turate I (2019) Mapping Schistosoma mansoni endemicity in Rwanda: a critical assessment of geographical disparities arising from circulating cathodic antigen versus Kato-Katz diagnostics. PLoS Negl Trop Dis 13: e0007723. https://doi.org/10.1371/journal.pntd.0007723

Toor J, Alsallaq R, Truscott JE, Turner HC, Werkman M, Gurarie D, King CH, Anderson RM (2018) Are We on Our Way to Achieving the 2020 Goals for Schistosomiasis Morbidity Control Using Current World Health Organization Guidelines? Clin Infect Dis 66: S245-S252. https://doi.org/10.1093/cid/ciy001

Tian-Bi YT, Ouattara M, Knopp S, Coulibaly JT, Hurlimann E, Webster B, Allan F, Rollinson D, Meité A, Diakité NR, Konan CK, N’Goran EK, Utzinger J (2018) Interrupting seasonal transmission of Schistosoma haematobium and control of soil-transmitted helminthiasis in northern and central Cote d’Ivoire: a SCORE study protocol. BMC Public Health 18: 186. https://doi.org/10.1186/s12889-018-5044-2

Sircar AD, Mwinzi PNM, Onkanga IO, Wiegand RE, Montgomery SP, Secor WE (2018) Schistosoma mansoni Mass Drug Administration Regimens and Their Effect on Morbidity among Schoolchildren over a 5-Year Period-Kenya, 2010-2015. Am J Trop Med Hyg 99: 362-369. https://doi.org/10.4269/ajtmh.18-0067

Secor WE, Colley DG (2018) When Should the Emphasis on Schistosomiasis Control Move to Elimination? Trop Med Infect Dis 3. https://doi.org/10.3390/tropicalmed3030085

Phillips AE, Gazzinelli-Guimaraes PH, Aurelio HO, Dhanani N, Ferro J, Nala R, Deol A, Fenwick A (2018) Urogenital schistosomiasis in Cabo Delgado, northern Mozambique: baseline findings from the SCORE study. Parasit Vectors 11: 30. https://doi.org/10.1186/s13071-017-2592-8

Pennance T, Ame SM, Amour AK, Suleiman KR, Allan F, Rollinson D, Webster BL (2018) Occurrence of Schistosoma bovis on Pemba Island, Zanzibar: implications for urogenital schistosomiasis transmission monitoring. Parasitology 145: 1727-1731. https://doi.org/10.1017/S0031182018001154

Palmeirim MS, Ouattara M, Essé C, Koffi VA, Assaré RK, Hurlimann E, Coulibaly JT, Diakité NR, Dongo K, Bonfoh B, Utzinger J, N’Goran EK, Raso G (2018) Are schoolchildren less infected if they have good knowledge about parasitic worms? A case study from rural Côte d’Ivoire. BMC Public Health 18: 951. https://doi.org/10.1186/s12889-018-5776-z

Olsen A, Kinung’hi S, Magnussen P (2018) Comparison of the Impact of Different Mass Drug Administration Strategies on Infection with Schistosoma mansoni in Mwanza Region, Tanzania—A Cluster-Randomized Controlled Trial. The American Journal of Tropical Medicine and Hygiene 99: 1573-1579. https://doi.org/10.4269/ajtmh.18-0671

Mohamed I, Kinung’hi S, Mwinzi PNM, Onkanga IO, Andiego K, Muchiri G, Odiere MR, Vennervald BJ, Olsen A (2018) Diet and hygiene practices influence morbidity in schoolchildren living in Schistosomiasis endemic areas along Lake Victoria in Kenya and Tanzania-A cross-sectional study. PLoS Negl Trop Dis 12: e0006373. https://doi.org/10.1371/journal.pntd.0006373

Lo NC, Gurarie D, Yoon N, Coulibaly JT, Bendavid E, Andrews JR, King CH (2018) Impact and cost-effectiveness of snail control to achieve disease control targets for schistosomiasis. Proc Natl Acad Sci U S A 115: E584-E591. https://doi.org/10.1073/pnas.1708729114

Le Clec’h W, Chevalier FD, McDew-White M, Allan F, Webster BL, Gouvras AN, Kinunghi S, Tchuem Tchuente LA, Garba A, Mohammed KA, Ame SM, Webster JP, Rollinson D, Emery AM, Anderson TJC (2018) Whole genome amplification and exome sequencing of archived schistosome miracidia. Parasitology 145: 1739-1747. https://doi.org/10.1017/S0031182018000811

King CH (2018) Helminthiasis Epidemiology and Control: Scoring Successes and Meeting the Remaining Challenges. Advances in Parasitology. London, UK: Academic Press, Elsevier Ltd. pp. 11-30. https://doi.org/10.1016/bs.apar.2018.08.001

King CH (2018) Mapping Out the under-Recognized Burden of Human Infertility Linked to Schistosoma haematobium Infection. Am J Trop Med Hyg 98: 937-938. https://doi.org/10.4269/ajtmh.17-1016

Ivy JA, King CH, Cook JA, Colley DG (2018) Historical perspective: Revisiting the St. Lucia Project, a multi-year comparison trial of schistosomiasis control strategies. PLoS Negl Trop Dis 12: e0006223. https://doi.org/10.1371/journal.pntd.0006223

Gurarie D, Lo NC, Ndeffo-Mbah ML, Durham DP, King CH (2018) The human-snail transmission environment shapes long term schistosomiasis control outcomes: Implications for improving the accuracy of predictive modeling. PLoS Negl Trop Dis 12: e0006514. https://doi.org/10.1371/journal.pntd.0006514

Gazzinelli-Guimaraes PH, Dhanani N, King CH, Campbell CH, Aurelio HO, Ferro J, Nala R, Fenwick A, Phillips AE (2018) Accuracy of the WHO praziquantel dose pole for large-scale community treatment of urogenital schistosomiasis in northern Mozambique: Is it time for an update? PLoS Negl Trop Dis 12: e0006957. https://doi.org/10.1371/journal.pntd.0006957

French MD, Evans D, Fleming FM, Secor WE, Biritwum NK, Brooker SJ, Bustinduy A, Gouvras A, Kabatereine N, King CH, Rebollo Polo M, Reinhard-Rupp J, Rollinson D, Tchuem Tchuente LA, Utzinger J, Waltz J, Zhang Y (2018) Schistosomiasis in Africa: Improving strategies for long-term and sustainable morbidity control. PLoS Negl Trop Dis 12: e0006484. https://doi.org/10.1371/journal.pntd.0006484

Ezeamama AE, Bustinduy AL, Nkwata AK, Martinez L, Pabalan N, Boivin MJ, King CH (2018) Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. PLoS Negl Trop Dis 12: e0005524. https://doi.org/10.1371/journal.pntd.0005524

Diakité NR, N’Zi KG, Ouattara M, Coulibaly JT, Saric J, Yao PK, Hattendorf J, Utzinger J, N’Goran EK (2018) Association of riverine prawns and intermediate host snails and correlation with human schistosomiasis in two river systems in south-eastern Côte d’Ivoire. Parasitology 145: 1792-1800. https://doi.org/10.1017/S003118201800135X

de Dood CJ, Hoekstra PT, Mngara J, Kalluvya SE, van Dam GJ, Downs JA, Corstjens P (2018) Refining Diagnosis of Schistosoma haematobium Infections: Antigen and Antibody Detection in Urine. Front Immunol 9: 2635. https://doi.org/10.3389/fimmu.2018.02635

Colley DG, Loker ES (2018) New Tools for Old Questions: How Strictly Human Are “Human Schistosomes”-And Does It Matter? J Infect Dis 218: 344-346. https://doi.org/10.1093/infdis/jiy030

Clements MN, Corstjens P, Binder S, Campbell CH, Jr., de Dood CJ, Fenwick A, Harrison W, Kayugi D, King CH, Kornelis D, Ndayishimiye O, Ortu G, Lamine MS, Zivieri A, Colley DG, van Dam GJ (2018) Latent class analysis to evaluate performance of point-of-care CCA for low-intensity Schistosoma mansoni infections in Burundi. Parasit Vectors 11: 111. https://doi.org/10.1186/s13071-018-2700-4

Bärenbold O, Garba A, Colley DG, Fleming FM, Haggag AA, Ramzy RMR, Assaré RK, Tukahebwa EM, Mbonigaba JB, Bucumi V, Kebede B, Yibi MS, Meité A, Coulibaly JT, N’Goran EK, Tchuem Tchuenté LA, Mwinzi P, Utzinger J, Vounatsou P (2018) Translating preventive chemotherapy prevalence thresholds for Schistosoma mansoni from the Kato-Katz technique into the point-of-care circulating cathodic antigen diagnostic test. PLoS Negl Trop Dis 12: e0006941. https://doi.org/10.1371/journal.pntd.0006941

Assaré RK, Tra MBI, Ouattara M, Hurlimann E, Coulibaly JT, N’Goran EK, Utzinger J (2018) Sensitivity of the Point-of-Care Circulating Cathodic Antigen Urine Cassette Test for Diagnosis of Schistosoma mansoni in Low-Endemicity Settings in Cote d’Ivoire. Am J Trop Med Hyg 99: 1567-1572. https://doi.org/10.4269/ajtmh.18-0550

Wiegand RE, Mwinzi PNM, Montgomery SP, Chan YL, Andiego K, Omedo M, Muchiri G, Ogutu MO, Rawago F, Odiere MR, Karanja DMS, Secor WE (2017) A Persistent Hotspot of Schistosoma mansoni Infection in a Five-Year Randomized Trial of Praziquantel Preventative Chemotherapy Strategies. J Infect Dis 216: 1425-1433.  https://doi.org/10.1093/infdis/jix496

Webster JP, Borlase A, Rudge JW (2017) Who acquires infection from whom and how? Disentangling multi-host and multi-mode transmission dynamics in the ‘elimination’ era. Philos Trans R Soc Lond B Biol Sci 372. https://doi.org/10.1098/rstb.2016.0091

Shen Y, King CH, Binder S, Zhang F, Whalen CC, Evan Secor W, Montgomery SP, Mwinzi PNM, Olsen A, Magnussen P, Kinung’hi S, Phillips AE, Nalá R, Ferro J, Aurelio HO, Fleming F, Garba A, Hamidou A, Fenwick A, Campbell CH, Jr., Colley DG (2017) Protocol and baseline data for a multi-year cohort study of the effects of different mass drug treatment approaches on functional morbidities from schistosomiasis in four African countries. BMC Infect Dis 17: 652. https://doi.org/10.1186/s12879-017-2738-5

Phillips AE, Gazzinelli-Guimaraes PH, Aurelio HO, Ferro J, Nala R, Clements M, King CH, Fenwick A, Fleming FM, Dhanani N (2017) Assessing the benefits of five years of different approaches to treatment of urogenital schistosomiasis: A SCORE project in Northern Mozambique. PLoS Negl Trop Dis 11: e0006061. https://doi.org/10.1371/journal.pntd.0006061

Ortu G, Ndayishimiye O, Clements M, Kayugi D, Campbell CH, Jr., Lamine MS, Zivieri A, Magalhaes RS, Binder S, King CH, Fenwick A, Colley DG, Jourdan PM (2017) Countrywide Reassessment of Schistosoma mansoni Infection in Burundi Using a Urine-Circulating Cathodic Antigen Rapid Test: Informing the National Control Program. Am J Trop Med Hyg 96: 664-673. https://doi.org/10.4269/ajtmh.16-0671

Musuva R, Shen Y, Wei X, Binder S, Ivy JA, Secor WE, Montgomery SP, King CH, Mwinzi PNM (2017) Change in children’s school behavior after mass administration of praziquantel for Schistosoma mansoni infection in endemic areas of western Kenya: A pilot study using the Behavioral Assessment System for Children (BASC-2). PLoS One 12: e0181975. https://doi.org/10.1371/journal.pone.0181975

Lo NC, Addiss DG, Hotez PJ, King CH, Stothard JR, Evans DS, Colley DG, Lin W, Coulibaly JT, Bustinduy AL, Raso G, Bendavid E, Bogoch, II, Fenwick A, Savioli L, Molyneux D, Utzinger J, Andrews JR (2017) A call to strengthen the global strategy against schistosomiasis and soil-transmitted helminthiasis: the time is now. Lancet Infect Dis 17: e64-e69. https://doi.org/10.1016/S1473-3099(16)30535-7

Kittur N, Binder S, Campbell CH, King CH, Kinung’hi S, Olsen A, Magnussen P, Colley DG (2017) Defining Persistent Hotspots: Areas That Fail to Decrease Meaningfully in Prevalence after Multiple Years of Mass Drug Administration with Praziquantel for Control of Schistosomiasis. Am J Trop Med Hyg 97: 1810-1817. https://doi.org/10.4269/ajtmh.17-0368

King CH (2017) The evolving schistosomiasis agenda 2007-2017-Why we are moving beyond morbidity control toward elimination of transmission. PLoS Negl Trop Dis 11: e0005517. https://doi.org/10.1371/journal.pntd.0005517

Karanja DMS, Awino EK, Wiegand RE, Okoth E, Abudho BO, Mwinzi PNM, Montgomery SP, Secor WE (2017) Cluster randomized trial comparing school-based mass drug administration schedules in areas of western Kenya with moderate initial prevalence of Schistosoma mansoni infections. PLoS Negl Trop Dis 11: e0006033. https://doi.org/10.1371/journal.pntd.0006033

Gurarie D, King CH, Yoon N, Wang X, Alsallaq R (2017) Seasonal dynamics of snail populations in coastal Kenya: Model calibration and snail control. Advances in Water Resources 108: 397-405. https://doi.org/10.1016/j.advwatres.2016.11.008

Gouvras AN, Allan F, Kinung’hi S, Rabone M, Emery A, Angelo T, Pennance T, Webster B, Nagai H, Rollinson D (2017) Longitudinal survey on the distribution of Biomphalaria sudanica and B. choanomophala in Mwanza region, on the shores of Lake Victoria, Tanzania: implications for schistosomiasis transmission and control. Parasit Vectors 10: 316. https://doi.org/10.1186/s13071-017-2252-z

Corstjens P, Hoekstra PT, de Dood CJ, van Dam GJ (2017) Utilizing the ultrasensitive Schistosoma up-converting phosphor lateral flow circulating anodic antigen (UCP-LF CAA) assay for sample pooling-strategies. Infect Dis Poverty 6: 155. https://doi.org/10.1186/s40249-017-0368-1

Colley DG, Andros TS, Campbell CH, Jr. (2017) Schistosomiasis is more prevalent than previously thought: what does it mean for public health goals, policies, strategies, guidelines and intervention programs? Infect Dis Poverty 6: 63. https://doi.org/10.1186/s40249-017-0275-5

Andrade G, Bertsch DJ, Gazzinelli A, King CH (2017) Decline in infection-related morbidities following drug-mediated reductions in the intensity of Schistosoma infection: A systematic review and meta-analysis. PLoS Negl Trop Dis 11: e0005372. https://doi.org/10.1371/journal.pntd.0005372

Burnim M, Ivy JA, King CH (2017) Systematic review of community-based, school-based, and combined delivery modes for reaching school-aged children in mass drug administration programs for schistosomiasis. PLoS Negl Trop Dis 11: e0006043. https://doi.org/10.1371/journal.pntd.0006043

Webster JP, Gower CM, Knowles SC, Molyneux DH, Fenton A (2016) One health – an ecological and evolutionary framework for tackling Neglected Zoonotic Diseases. Evol Appl 9: 313-333. https://doi.org/10.1111/eva.12341

Walker M, Mabud TS, Olliaro PL, Coulibaly JT, King CH, Raso G, Scherrer AU, Stothard JR, Sousa-Figueiredo JC, Stete K, Utzinger J, Basáñez MG (2016) New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel. Parasit Vectors 9: 41. https://doi.org/10.1186/s13071-016-1312-0

Person B, Knopp S, Ali SM, A’Kadir F M, Khamis AN, Ali JN, Lymo JH, Mohammed KA, Rollinson D (2016) Community Co-Designed Schistosomiasis Control Interventions for School-Aged Children in Zanzibar. J Biosoc Sci 48 Suppl 1: S56-73. https://doi.org/10.1017/S0021932016000067

Person B, Ali SM, A’Kadir FM, Ali JN, Mohammed UA, Mohammed KA, Rollinson D, Knopp S (2016) Community Knowledge, Perceptions, and Practices Associated with Urogenital Schistosomiasis among School-Aged Children in Zanzibar, United Republic of Tanzania. PLoS Negl Trop Dis 10: e0004814. https://doi.org/10.1371/journal.pntd.0004814

Pennance T, Person B, Muhsin MA, Khamis AN, Muhsin J, Khamis IS, Mohammed KA, Kabole F, Rollinson D, Knopp S (2016) Urogenital schistosomiasis transmission on Unguja Island, Zanzibar: characterisation of persistent hot-spots. Parasit Vectors 9: 646. https://doi.org/10.1186/s13071-016-1847-0

Onkanga IO, Mwinzi PN, Muchiri G, Andiego K, Omedo M, Karanja DM, Wiegand RE, Secor WE, Montgomery SP (2016) Impact of two rounds of praziquantel mass drug administration on Schistosoma mansoni infection prevalence and intensity: a comparison between community wide treatment and school based treatment in western Kenya. Int J Parasitol 46: 439-445. https://doi.org/10.1016/j.ijpara.2016.01.006

Mo AX, Colley DG (2016) Workshop report: Schistosomiasis vaccine clinical development and product characteristics. Vaccine 34: 995-1001. https://doi.org/10.1016/j.vaccine.2015.12.032

Léger E, Garba A, Hamidou AA, Webster BL, Pennance T, Rollinson D, Webster JP (2016) Introgressed Animal Schistosomes Schistosoma curassoni and S. bovis Naturally Infecting Humans. Emerg Infect Dis 22: 2212-2214. https://dx.doi.org/10.3201/eid2212.160644

Knopp S, Person B, Ame SM, Ali SM, Muhsin J, Juma S, Khamis IS, Rabone M, Blair L, Fenwick A, Mohammed KA, Rollinson D (2016) Praziquantel coverage in schools and communities targeted for the elimination of urogenital schistosomiasis in Zanzibar: a cross-sectional survey. Parasit Vectors 9: 5. https://doi.org/10.1186/s13071-015-1244-0

Kittur N, Castleman JD, Campbell CH, Jr., King CH, Colley DG (2016) Comparison of Schistosoma mansoni Prevalence and Intensity of Infection, as Determined by the Circulating Cathodic Antigen Urine Assay or by the Kato-Katz Fecal Assay: A Systematic Review. Am J Trop Med Hyg 94: 605-610. https://doi.org/10.4269/ajtmh.15-0725

Kinung’hi S, Magnussen P, Kaatano G, Olsen A (2016) Infection with Schistosoma mansoni has an Effect on Quality of Life, but not on Physical Fitness in Schoolchildren in Mwanza Region, North-Western Tanzania: A Cross-Sectional Study. PLoS Negl Trop Dis 10: e0005257. https://doi.org/10.1371/journal.pntd.0005257

King CH (2016) Defining the Necessary Next Steps for Effective Control of Helminthic Infections. Clin Infect Dis 62: 208-209. https://doi.org/10.1093/cid/civ833

Gurarie D, King CH, Yoon N, Li E (2016) Refined stratified-worm-burden models that incorporate specific biological features of human and snail hosts provide better estimates of Schistosoma diagnosis, transmission, and control. Parasit Vectors 9: 428.  https://doi.org/10.1186/s13071-016-1681-4

Ezeamama AE, He CL, Shen Y, Yin XP, Binder SC, Campbell CH, Jr., Rathbun S, Whalen CC, N’Goran EK, Utzinger J, Olsen A, Magnussen P, Kinung’hi S, Fenwick A, Phillips A, Ferro J, Karanja DM, Mwinzi PN, Montgomery S, Secor WE, Hamidou A, Garba A, King CH, Colley DG (2016) Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries. BMC Infect Dis 16: 229. https://doi.org/10.1186/s12879-016-1575-2

Celone M, Person B, Ali SM, Lyimo JH, Mohammed UA, Khamis AN, Mohammed YS, Mohammed KA, Rollinson D, Knopp S (2016) Increasing the reach: Involving local Muslim religious teachers in a behavioral intervention to eliminate urogenital schistosomiasis in Zanzibar. Acta Trop 163: 142-148. https://doi.org/10.1016/j.actatropica.2016.08.004

Casacuberta M, Kinunghi S, Vennervald BJ, Olsen A (2016) Evaluation and optimization of the Circulating Cathodic Antigen (POC-CCA) cassette test for detecting Schistosoma mansoni infection by using image analysis in school children in Mwanza Region, Tanzania. Parasite Epidemiology and Control 1: 105-115. https://doi.org/10.1016/j.parepi.2016.04.002

Assaré RK, Tian-Bi YN, Yao PK, N’Guessan NA, Ouattara M, Yapi A, Coulibaly JT, Meité A, Hürlimann E, Knopp S, Utzinger J, N’Goran EK (2016) Sustaining Control of Schistosomiasis Mansoni in Western Côte d’Ivoire: Results from a SCORE Study, One Year after Initial Praziquantel Administration. PLoS Negl Trop Dis 10: e0004329. https://doi.org/10.1371/journal.pntd.0004329

Assaré RK, Hürlimann E, Ouattara M, N’Guessan NA, Tian-Bi YN, Yapi A, Yao PK, Coulibaly JT, Knopp S, N’Goran EK, Utzinger J (2016) Sustaining the Control of Schistosoma mansoni in Western Côte d’Ivoire: Baseline Findings Before the Implementation of a Randomized Trial. Am J Trop Med Hyg 94: 352-360. https://doi.org/10.4269/ajtmh.15-0530

Worrell CM, Bartoces M, Karanja DM, Ochola EA, Matete DO, Mwinzi PN, Montgomery SP, Secor WE (2015) Cost Analysis of Tests for the Detection of Schistosoma mansoni Infection in Children in Western Kenya. Am J Trop Med Hyg 92: 1233-1239. https://doi.org/10.4269/ajtmh.14-0644

Webster BL, Rabone M, Pennance T, Emery AM, Allan F, Gouvras A, Knopp S, Garba A, Hamidou AA, Mohammed KA, Ame SM, Rollinson D, Webster JP (2015) Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of Schistosoma haematobium. Parasit Vectors 8: 432. https://doi.org/10.1186/s13071-015-1044-6

van Dam GJ, Xu J, Bergquist R, de Dood CJ, Utzinger J, Qin ZQ, Guan W, Feng T, Yu XL, Zhou J, Zheng M, Zhou XN, Corstjens PL (2015) An ultra-sensitive assay targeting the circulating anodic antigen for the diagnosis of Schistosoma japonicum in a low-endemic area, People’s Republic of China. Acta Trop 141: 190-197. https://doi.org/10.1016/j.actatropica.2014.08.004

van Dam GJ, Odermatt P, Acosta L, Bergquist R, de Dood CJ, Kornelis D, Muth S, Utzinger J, Corstjens PL (2015) Evaluation of banked urine samples for the detection of circulating anodic and cathodic antigens in Schistosoma mekongi and S. japonicum infections: a proof-of-concept study. Acta Trop 141: 198-203. https://doi.org/10.1016/j.actatropica.2014.09.003

Olsen A, Kinung’hi S, Magnussen P (2015) Schistosoma mansoni infection along the coast of Lake Victoria in Mwanza region, Tanzania. Am J Trop Med Hyg 92: 1240-1244. https://doi.org/10.4269/ajtmh.14-0676

Olliaro PL, Vaillant M, Diawara A, Coulibaly JT, Garba A, Keiser J, King CH, Knopp S, Landouré A, N’Goran EK, Raso G, Scherrer AU, Sousa-Figueiredo JC, Stete K, Zhou XN, Utzinger J (2015) Toward Measuring Schistosoma Response to Praziquantel Treatment with Appropriate Descriptors of Egg Excretion. PLoS Negl Trop Dis 9: e0003821. https://doi.org/10.1371/journal.pntd.0003821

Mwinzi PN, Kittur N, Ochola E, Cooper PJ, Campbell CH, Jr., King CH, Colley DG (2015) Additional Evaluation of the Point-of-Contact Circulating Cathodic Antigen Assay for Schistosoma mansoni Infection. Front Public Health 3: 48. https://doi.org/10.3389/fpubh.2015.00048

Knopp S, Corstjens PL, Koukounari A, Cercamondi CI, Ame SM, Ali SM, de Dood CJ, Mohammed KA, Utzinger J, Rollinson D, van Dam GJ (2015) Sensitivity and Specificity of a Urine Circulating Anodic Antigen Test for the Diagnosis of Schistosoma haematobium in Low Endemic Settings. PLoS Negl Trop Dis 9: e0003752. https://doi.org/10.1371/journal.pntd.0003752

King CH, Sutherland LJ, Bertsch D (2015) Systematic Review and Meta-analysis of the Impact of Chemical-Based Mollusciciding for Control of Schistosoma mansoni and S. haematobium Transmission. PLoS Negl Trop Dis 9: e0004290. https://doi.org/10.1371/journal.pntd.0004290

King CH, Bertsch D (2015) Historical perspective: snail control to prevent schistosomiasis. PLoS Negl Trop Dis 9: e0003657. https://doi.org/10.1371/journal.pntd.0003657

King CH (2015) Health metrics for helminth infections. Acta Trop 141: 150-160. https://doi.org/10.1016/j.actatropica.2013.12.001

Gurarie D, Yoon N, Li E, Ndeffo-Mbah M, Durham D, Phillips A, Aurelio H, Ferro J, Galvani A, King C (2015) Modelling control of Schistosoma haematobium infection: predictions of the long-term impact of mass drug administration in Africa. Parasit Vectors 8: 529. https://doi.org/10.1186/s13071-015-1144-3

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