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. 2019 Dec 4;20(1):585.
doi: 10.1186/s12891-019-2958-5.

Association between dietary selenium intake and the prevalence of osteoporosis: a cross-sectional study

Yuqing Wang  1 , Dongxing Xie  1 , Jiatian Li  1 , Huizhong Long  1 , Jing Wu  2 , Ziying Wu  1 , Hongyi He  1 , Haochen Wang  1 , Tuo Yang  3   4   5   6 , Yilun Wang  7
Affiliations

Association between dietary selenium intake and the prevalence of osteoporosis: a cross-sectional study

Yuqing Wang et al. BMC Musculoskelet Disord. .

Abstract

Objective: To examine the correlation between dietary selenium (Se) intake and the prevalence of osteoporosis (OP) in the general middle-aged and older population in China.

Methods: Data for analyses were collected from a population based cross-sectional study performed at the Xiangya Hospital Health Management Centre. Dietary Se intake was evaluated using a validated semi-quantitative food frequency questionnaire. OP was diagnosed on the basis of bone mineral density scans using a compact radiographic absorptiometry system. The correlation between dietary Se intake and the prevalence of OP was primarily examined by multivariable logistic regression.

Results: This cross-sectional study included a total of 6267 subjects (mean age: 52.2 ± 7.4 years; 42% women), and the prevalence of OP among the included subjects was 9.6% (2.3% in men and 19.7% in women). Compared with the lowest quartile, the energy intake, age, gender and body mass index (BMI)-adjusted odds ratios of OP were 0.72 (95% confidence interval [CI] 0.55-0.94), 0.72 (95% CI 0.51-1.01) and 0.47 (95% CI 0.31-0.73) for the second, third and fourth quartiles of dietary Se intake, respectively (P for trend = 0.001). The results remained consistent in male and female subjects. Adjustment for additional potential confounders (i.e., smoking status, drinking status, physical activity level, nutritional supplements, diabetes, hypertension, fibre intake, and calcium intake) did not cause substantial changes to the results.

Conclusions: In the middle-aged and older humans, participants with lower levels of dietary Se intake have a higher prevalence of OP in a dose-response manner.

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Conflict of interest statement

The authors declare that they have no competing interest.

Figures

Fig. 1
Fig. 1
Dose-response relationship between dietary selenium intake and the odds ratio for osteoporosis in the total population (n = 6267). OP osteoporosis, CI confidence interval, OR odds ratio
See this image and copyright information in PMC

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