ã¾ã£ã´ãããããã³ã¡ã³ããé ããã
ç§ã¯ãä¸ã¯140ã¡ãã£ã¨ã ã£ãã®ã§ãããä¸ã常ã«100ãè¶
ãã¦ãã¾ããã
æ¤æ»ã®ãã³ã«ãçè·å¸«ãããããä¸ã®è¡å§ãé«ãããã»ã»ã»ãã¨è¨ãããä»ã®äººã«ãä¸ããä¸ãé«ãã¨æãã¨è¨ããã¦ããã®ã§ãéé¢ããããã«ãªãã¾ããã
ããã£ã¦ããå»è
ã«ãã¾ãä¿¡é ¼ã¯ãã¦ããªãã®ã§ãããè¬ããããã®ã§éé¢ãã¦ãã¾ãã
è¡å§ãä¸ããè¬ã飲ã¿å§ãã¦åå¹´ã«ãªãã¾ãã
ä»ã¯ãä¸ã130åå¾ãä¸ã90åå¾ã§è½ã¡çãã¦ãã¾ãã
å¹´ã¯ããããã47æ³ã«ãªãã®ã§ãããçåãæã£ãã¾ã¾ãæ»ã¬ã¾ã§é£²ã¿ç¶ããã®ã¯ã©ããã¨æ©ãã§ããã¾ãã
ã§ããneruzohãã¾ã®ã話ã伺ããåã«è¡å§ãé«ãããã¨è¨ã£ã¦è¬ã飲ãã®ã§ã¯ãªããã¡ããã¨ããç
é¢ã¸è¡ã£ã¦å
çã¨ç¸è«ããã®ãã²ã¨ã¤ã®æ¹æ³ãã¨æãããã«ãªãã¾ããã
Â
仲ã®è¯ã妹ã ã£ãããã©ãè¨ããã
ã99%ãä½ããªãã¨æããããè¬(éå§è¬)ã¯æ¢ãã¦ãæ§åè¦ã§è¯ãã¨æãã
1%ã®ä½ããå±æ§ãããªããã¡ããã¨ããç é¢ã¸è¡ã£ã¦ãã¨ãããã¨ã«ãªãã¾ãã
Â
é«è¡å§ã®åºæºãæ(1990年代)ã¨ç¾å¨ã§å¤ãã£ã¦ãã¾ã£ã¦ããã®ã§ããªã³ã¯å ã示ããªãããã話ãããã¨ãã§ãã¾ããã
Â
ç§ãå¦ãã ç¥è(1990年代ã«å¦ãã ç¥è)ã§ãçããããã¾ãã
Â
é«è¡å§çã«ã¯ãæ¬æ æ§é«è¡å§çã¨äºæ¬¡æ§é«è¡å§çã¨ããã®ãããã¾ãã
æ¬æ æ§é«è¡å§çã«ã¤ã㦠| ã¡ãã£ã«ã«ãã¼ã
æ¬æ æ§é«è¡å§çã¨ã¯ãé«è¡å§çã®ãã¡ãè¡å§ãé«ããªãã¯ã£ããã¨ããåå ãç¹å®ã§ããªãå ´åã«è¨ºæããªããã¾ããã¯ã£ããããåå ãããé«è¡å§çã¯ãäºæ¬¡æ§é«è¡å§ã¨å¼ã°ããè å®è³ªæ§é«è¡å§ãè è¡ç®¡æ§é«è¡å§ãå åæ³æ§é«è¡å§ï¼åçºæ§ã¢ã«ãã¹ããã³çãã¯ãã·ã³ã°çå群ãè¤è²ç´°èè «ãªã©ï¼ãç¡ç æç¡å¼å¸çå群ãéºä¼æ§é«è¡å§ãè¬å¤èªçºæ§é«è¡å§ã¨ãã£ããã®ãæãããã¾ãã
æ¬æ æ§é«è¡å§çã¯ãé«è¡å§çæ£è ã®ãã¡85-90%ãå ããä¸è¬çã«ãé«è¡å§ãã¨ããå ´åã¯æ¬æ æ§é«è¡å§çãæããã¨ãå¤ãã§ãã
(å¼ç¨ã¯ããã¾ã§)
Â
æ¬æ æ§é«è¡å§ç
åè硬åãé²ãã§ãªãé«è¡å§ãä¸è¬çã«ã¯å¡©åã®æãéããåå ã¨è¨ããã¦ããããããã§ã¯ãªããç³è³ªã®æãéããåå ã¨ç§ã¯èãã¦ãããã¡ãªã¿ã«ç§ã¯90%ãæ¬æ æ§é«è¡å§çã ã¨å¦ãã è¨æ¶ãããã
æ¯ã¯80æ³ã®æç¹ã§140/80mmHgã ã£ãã
ç¾å¨ã®åºæºã§è¨ãã¨é«è¡å§ã ã£ãããæ¬æ æ§é«è¡å§çã ã£ãã¨æãã
Â
äºæ¬¡æ§é«è¡å§ç
â è å®è³ªæ§é«è¡å§ã5%ã¨å¦ãã è¨æ¶ããããè èãæªãã¦è¡å§ãä¸ãã£ããã®ã5%ã¨æ¬ã«æ¸ãã¦ãã£ãããç§ã¯è¨ºããã¨ããªãã
é«è¡å§ï¼è¡æ¶²æ¤æ»ã§è æ©è½ã«ç°å¸¸ããã(è¡æ¸ ã¯ã¬ã¢ããã³å¤ãé«ãã¨ã) and/or å°¿æ¤æ»ã§ç°å¸¸ããã(å°¿æ½è¡ï¼ã¨ãå°¿èç½ï¼ã¨ã)âè èå ç§ã¸ç´¹ä»ã
â¡è è¡ç®¡æ§é«è¡å§çã1%ã¨å¦ãã è¨æ¶ããããè èã¸è¡ãè¡ç®¡(è åè)ã®å è ãçããªã£ã¦(è åèãççªãã¦)ãè¡å§ãé«ããªã£ããã®ã
è ¹é¨ã¨ã³ã¼æ¤æ»ã§è åèãççªãã¦ããã®ãè¦ã¤ãããè¦ã¤ãã£ãããè åèãçããªã£ã¦ããã®ãé å½±æ¤æ»ã§ç¢ºèªããã®ã ããã¨æãã
ä¸äººããããã人ã診ããã¨ãããã
è¡æ¸ ã¯ã¬ã¢ããã³å¤ãé«ãã£ããâ循ç°å¨å ç§ã®å çã«å¼ãç¶ãã ã
Â
â¢åçºæ§ã¢ã«ãã¹ããã³ç
å¯è ç®è³ªããã¢ã«ãã¹ããã³ã¨ãããã«ã¢ã³ãããããåºã¦ãããããã§é«è¡å§ã«ãªããâ診ããã¨ããªãã§ãã
åçºæ§ã¢ã«ãã¹ããã³çï½ä¸è¬ã®çæ§ã¸ï½æ¥æ¬å åæ³å¦ä¼
éç度ã®é«ãçä¾ã§ã¯ãä½K(ã«ãªã¦ã )è¡çãåãã¾ããä½Kè¡çã®åºç¾ã¯å¿ çºã§ã¯ãªãã5å²æªæºã¨è¨ããã¦ãã¾ãããå¡©åè² è·ãå©å°¿è¬ä½¿ç¨ã«èªçºããã¦ä½Kçä¾ãåãããã¨ããããã¾ãé«è¡å§ã¨æ¯ã¹ã¦ãããã®ç æ°ã«ç¹ç°æ§ã®é«ãçç¶ãªã®ã§ãé常ã«éè¦ãªçç¶ã§ãã
(å¼ç¨ã¯ããã¾ã§)
é«è¡å§ï¼ä½ã«ãªã¦ã è¡ç(è¡æ¶²æ¤æ»ã§ã«ãªã¦ã ãä½ã)âåçºæ§ã¢ã«ãã¹ããã³çãçãã
Â
â£ã¯ãã·ã³ã°çå群
å¯è ç®è³ªããã³ã«ãã¾ã¼ã«ã¨ãããã«ã¢ã³ãããããåºã¦ãããããã§é«è¡å§ã«ãªãã
æºææ§é¡è²ã¨ãã£ã¦é¡ãçã丸ã«ãªããâã¾ã£ã´ãããã¯éãã¨æãã¾ãã
ã¯ãã·ã³ã°çå群 æºææ§é¡è² - æ¤ç´¢ ç»å
Â
â¤è¤è²ç´°èè «
å¯è é«è³ªããã«ãã³ã©ãã³(ã¢ãã¬ããªã³ããã«ã¢ãã¬ããªã³ãªã©)ãããããåºã¦ãããã¢ãã¬ããªã³ããã«ã¢ãã¬ããªã³ããã«ã¢ã³ã®ä¸ç¨®ãå¸å°ããã
è¤è²ç´°èè «ï¼ãã£ãããããã¼ããã ï¼ | å¸å°ããã»ã³ã¿ã¼
Â
ç§ã1990年代ã«åå¼·ããã®ã¯ããä½ã§ãã
Â
ï¼ï¼ï¼
Â
ã¾ã£ã´ãããã¯ã³ããã¯ã¯ãã³ã2åæ¥ç¨®ãã¦ããã¨èãã¦ãã¾ãã
Â
ã³ããã¯ã¯ãã³ã¯(è質ããç²åã¨ããããã±ã¼ã¸ã¨ããã«å ã¾ããmRNAã¯)ãèèãè¾èãåµå·£ãå¯è ã«ããèç©ããã¾ã(4ã¤ç®ã®å¯è ããã¤ã³ã)ã
Â
ä¸å ¨ãæãã®ã§ããã°ããã¡ãã¨èª¿ã¹ã¦ããããã¨ããå§ãè´ãã¾ãã
Â
ï¼ï¼ï¼
Â
ããã£ã¦ããå»è ã«ãã¾ãä¿¡é ¼ã¯ãã¦ããªã
Â
ããã®å»é¢ã§è¡æ¶²æ¤æ»ãåãã¦ããã®ã§ããã°ãè¡æ¸ ã¯ã¬ã¢ããã³å¤ã¯èª¿ã¹ã¦ããã¨æãã¾ããã«ãªã¦ã ã調ã¹ã¦ããã¨æãã¾ãã
ãã¨ãå ç§ã®å çãªããCushingçå群ã§æºææ§é¡è²(ã ã¼ã³ãã§ã¤ã¹)ãåãããã¨ã¯ç¥ã£ã¦ããã¨æãã¾ãã
Â
ãç§ã¯äºæ¬¡æ§é«è¡å§çã§ã¯ãªãã®ã§ãããã¨ä¸»æ²»å»ã®å ç(å»é¢ã®å ç)ã«è¨ãã
大ç é¢ã¸ç´¹ä»ç¶(診çæ å ±æä¾æ¸)ãæ¸ãã¦ãããã
ãããæã£ã¦ã大ç é¢ãå診ããã
大ããªç é¢ã§è¨ºã¦ãããããã¨ããã®ã§ããã°ããã®æé ãè¸ãã¨è¯ãã¨æãã¾ãã