CD24

O CD24 (cluster de diferenciación, transdutor de sinais CD24 ou antíxeno estable á calor CD24 (HSA) é unha proteína da superficie de certas células, que nos humanos está codificado polo xene CD24 do cromosoma 6.^[1] O CD24 funciona como molécula de adhesión celular.

O CD24 é unha glicoproteína expresada na superficie da maioría dos linfocitos B e neuroblastos en diferenciación e granulocitos maduros. A proteína está ancorada por un enlace de glicosilfosfatidilinositol (GPI) á superficie celular.^[2] O xene está asignado ao cromosoma 6, pero un aliñamento desta secuencia xénica atopa localizacións xenómicas con semellanzas nas rexións cromosómicas 3p26, 15q21, 15q22, 20q11.2 e Yq11.1.^[3]

Esta proteína de adhesión celular foi identificada orixinalmente como antíxeno estable á calor do rato. Está implicado nas metástases e exprésase moito nas células dos neoplasmas.^[4] Variacións xenéticas do xene CD24 foron asociadas coa susceptibilidade á esclerose múltiple.^[5]

O CD24 modula as respostas de activación de células B. A sinalización podería estar desencadeada pola unión dun ligando de tipo lectina aos carbohidratos de CD24, e transducida pola liberación dun segundo mensaxeiro derivado da áncora GPI. Promove a proliferación dependente de antíxeno das células B, e impide a súa diferenciación terminal a células produtoras de anticorpos.^[6]

Notas

↑ Hough MR, Rosten PM, Sexton TL, Kay R, Humphries RK (1994). "Mapping of CD24 and homologous sequences to multiple chromosomal loci". Genomics 22 (1): 154–61. PMID 7959762. doi:10.1006/geno.1994.1356.
↑ OMIM CD24
↑ Entrez gene CD24. NCBI resources
↑ MeshName - CD24+Antigen
↑ Zhou Q, Rammohan K, Lin S, Robinson N, Li O, Liu X, Bai XF, Yin L, Scarberry B, Du P, You M, Guan K, Zheng P, Liu Y. CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15041-6. Epub 2003 Dec 1. PMID 14657362. [1]
↑ Suzuki T, Kiyokawa N, Taguchi T, Sekino T, Katagiri YU, Fujimoto J. CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system. J Immunol. 2001 May 1;166(9):5567-77. PMID 11313396. [2]

Véxase tamén

Bibliografía

Li D, Zheng L, Jin L; et al. (2009). "CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection.". Hepatology 50 (3): 735–42. PMID 19610054. doi:10.1002/hep.23047.
Piotrowski P, Lianeri M, Wudarski M; et al. (2010). "CD24 Ala57Val gene polymorphism and the risk of systemic lupus erythematosus.". Tissue antigens 75 (6): HASH(0x2aadb3dd8b00). PMID 20230526. doi:10.1111/j.1399-0039.2010.01447.x.
Honeth G, Bendahl PO, RingnÃ©r M; et al. (2008). "The CD44+/CD24- phenotype is enriched in basal-like breast tumors". Breast Cancer Res. 10 (3): R53. PMC 2481503. PMID 18559090. doi:10.1186/bcr2108.
Nagy B, Szendroi A, Romics I (2009). "Overexpression of CD24, c-myc and phospholipase 2A in prostate cancer tissue samples obtained by needle biopsy". Pathol. Oncol. Res. 15 (2): 279–83. PMID 18752058. doi:10.1007/s12253-008-9077-1.
Kim KH, Choi JS, Kim JM; et al. (2009). "Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium". Histol. Histopathol. 24 (3): 309–16. PMID 19130400.
Buess M, Rajski M, Vogel-Durrer BM; et al. (2009). "Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer". Neoplasia 11 (10): 987–1002. PMC 2745665. PMID 19794958.
Pruszak J, Ludwig W, Blak A; et al. (2009). "CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells". Stem Cells 27 (12): 2928–40. PMID 19725119. doi:10.1002/stem.211.
Liu Y, Chen GY, Zheng P (2009). "CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns". Trends Immunol. 30 (12): 557–61. PMC 2788100. PMID 19786366. doi:10.1016/j.it.2009.09.006.
Vesuna F, Lisok A, Kimble B, Raman V (2009). "Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression". Neoplasia 11 (12): 1318–28. PMC 2794513. PMID 20019840.
Sagiv E, Arber N (2008). "The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy". Expert review of gastroenterology & hepatology 2 (1): 125–33. PMID 19072375. doi:10.1586/17474124.2.1.125.
Bauerschmitz GJ, Ranki T, Kangasniemi L; et al. (2008). "Tissue-specific promoters active in CD44+CD24-/low breast cancer cells". Cancer Res. 68 (14): 5533–9. PMID 18632604. doi:10.1158/0008-5472.CAN-07-5288.
Carl JW, Liu JQ, Joshi PS; et al. (2008). "Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway". J. Immunol. 181 (1): 320–8. PMID 18566397.
Baumhoer D, Riener MO, Zlobec I; et al. (2009). "Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater". Mod. Pathol. 22 (2): 306–13. PMID 19043399. doi:10.1038/modpathol.2008.192.
Wang W, Wang X, Peng L; et al. (2010). "CD24-dependent MAPK pathway activation is required for colorectal cancer cell proliferation". Cancer Sci. 101 (1): 112–9. PMID 19860845. doi:10.1111/j.1349-7006.2009.01370.x.
Sano A, Kato H, Sakurai S; et al. (2009). "CD24 expression is a novel prognostic factor in esophageal squamous cell carcinoma". Ann. Surg. Oncol. 16 (2): 506–14. PMID 19050962. doi:10.1245/s10434-008-0252-0.
Yang XR, Xu Y, Yu B; et al. (2009). "CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery". Clin. Cancer Res. 15 (17): 5518–27. PMID 19706825. doi:10.1158/1078-0432.CCR-09-0151.
Lee JH, Kim SH, Lee ES, Kim YS (2009). "CD24 overexpression in cancer development and progression: a meta-analysis". Oncol. Rep. 22 (5): 1149–56. PMID 19787233.
Gekara NO, Weiss S (2004). "Lipid rafts clustering and signalling by listeriolysin O". Biochem. Soc. Trans. 32 (Pt 5): 712–4. PMID 15493995. doi:10.1042/BST0320712.
Athanassiadou P, Grapsa D, Gonidi M; et al. (2009). "CD24 expression has a prognostic impact in breast carcinoma". Pathol. Res. Pract. 205 (8): 524–33. PMID 19243896. doi:10.1016/j.prp.2009.01.008.
Ronaghi M, Vallian S, Etemadifar M (2009). "CD24 gene polymorphism is associated with the disease progression and susceptibility to multiple sclerosis in the Iranian population". Psychiatry Res 170 (2–3): 271–2. PMID 19896210. doi:10.1016/j.psychres.2009.01.002.

Ligazóns externas

[pmid7959762-1] Hough MR, Rosten PM, Sexton TL, Kay R, Humphries RK (1994). "Mapping of CD24 and homologous sequences to multiple chromosomal loci". Genomics 22 (1): 154–61. PMID 7959762. doi:10.1006/geno.1994.1356.

[2] OMIM CD24

[3] Entrez gene CD24. NCBI resources

[4] MeshName - CD24+Antigen

[5] Zhou Q, Rammohan K, Lin S, Robinson N, Li O, Liu X, Bai XF, Yin L, Scarberry B, Du P, You M, Guan K, Zheng P, Liu Y. CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15041-6. Epub 2003 Dec 1. PMID 14657362. [1]

[6] Suzuki T, Kiyokawa N, Taguchi T, Sekino T, Katagiri YU, Fujimoto J. CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system. J Immunol. 2001 May 1;166(9):5567-77. PMID 11313396. [2]

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