CD34

CD34
معین‌کننده‌ها
نام‌های دیگر	CD34, entrez:947, CD34 molecule
شناسه‌های بیرونی	OMIM: 142230 MGI: 88329 HomoloGene: 1343 GeneCards: CD34
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	194,643,587 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transcription factor binding; • sulfate binding; • carbohydrate binding;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • membrane; • پوسته یاخته; • integral component of plasma membrane; • extracellular region; • cell surface; • basal plasma membrane; • glomerular endothelium fenestra; • apical plasma membrane; • intercellular bridge; • perinuclear region of cytoplasm; • کافنده‌تن; • external side of plasma membrane; • cell periphery;
فرایند زیستی	• extracellular exosome assembly; • stem cell proliferation; • positive regulation of interleukin-10 production; • cell motility; • negative regulation of blood coagulation; • metanephric glomerular mesangial cell differentiation; • پیام‌رسانی پاراکراین; • hematopoietic stem cell proliferation; • positive regulation of granulocyte colony-stimulating factor production; • negative regulation of gene expression; • positive regulation of angiogenesis; • regulation of blood pressure; • vascular wound healing; • GO:1901313 positive regulation of gene expression; • glomerular filtration; • negative regulation of nitric oxide biosynthetic process; • چسبندگی سلولی; • endothelial cell proliferation; • mesangial cell-matrix adhesion; • tissue homeostasis; • positive regulation of vasculogenesis; • endothelium development; • regulation of immune response; • negative regulation of cellular response to heat; • positive regulation of transforming growth factor beta production; • glomerular endothelium development; • negative regulation of tumor necrosis factor production; • cell-matrix adhesion; • تکثیر سلولی; • positive regulation of odontogenesis; • negative regulation of cellular response to hypoxia; • leukocyte migration; • GO:0072468 ورارسانی پیام; • transdifferentiation; • negative regulation of neuron death; • cell-cell adhesion; • هماتوپوئز;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	947
	12490
	ENSG00000174059
	ENSMUSG00000016494
	P28906
	Q64314
	NM_001773 NM_001025109، NM_001773
	NM_133654 NM_001111059، NM_133654
	NP_001764 NP_001020280، NP_001764
	NP_598415 NP_001104529، NP_598415
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

مجموعه تمایزی ۳۴ (انگلیسی: 34 Cluster of Differentiation) که با نام‌های دیگری همچون «آنتی‌ژن سلولی پیش‌ساز سلول‌های خونساز CD34» و «آنتی‌ژن CD34» شناخته می‌شود و اصولاً به «CD34» مشهور است، یک پروتئین است که در انسان توسط ژن «CD34» کد می‌شود.^[۴]^[۵]^[۶]

این پروتئین را نخستین بار سیوین و تیندل و همکارانشان به‌طور مستقل^[۷]^[۸]^[۹]^[۱۰] در سطح سلول و به‌عنوان یک فاکتور چسبندگی سلول توصیف کردند. احتمالاً این سلول در اتصال یاخته بنیادی به ماتریکس خارج‌سلولیِ مغز استخوان یا مستقیماً به سلول‌های استرومال آن نقش داشته باشد.

علاوه بر سلول‌های سالم، این آنتی‌ژن بر سطح برخی سلول‌های سرطانی همچون سارکوم کاپوسی، لوسمی حاد مغز استخوان، مننژیوما، تومورهای استرومال دستگاه گوارش و شوانوما هم مشاهده می‌شود.

فقدان این پروتئین، سارکوم یوئینگ و میوفیبروسارکومای پستان را رد می‌کند.

از تزریق سلول‌های بنیادی خونساز CD34⁺ در درمان «ضایعات نخاعی»،^[۱۱] «سیروز کبدی»^[۱۲] و «بیماری‌های عروق محیطی»^[۱۳] مؤثر است.

جستارهای وابسته

مجموعه تمایزی

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CD34 CD34 molecule".
↑ Simmons DL, Satterthwaite AB, Tenen DG, Seed B (Jan 1992). "Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells". Journal of Immunology. 148 (1): 267–71. PMID 1370171.
↑ Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG (Apr 1992). "Structure of the gene encoding CD34, a human hematopoietic stem cell antigen". Genomics. 12 (4): 788–94. doi:10.1016/0888-7543(92)90310-O. PMID 1374051.
↑ Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH (1984). "Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells". Journal of Immunology. 133 (1): 157–65. PMID 6586833.
↑ Tindle RW. Nichols R. Chan L. Campana D. Birnie GD. (1985). "A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B, non-T lymphoblasts in acute leukaemia and CGL blast crises, and react with immature cells in normal bone marrow". Leukaemia Research. 9: 1–9. doi:10.1016/0145-2126(85)90016-5.
↑ Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. (1987). "BI-3C5 (CD34) defines multipotential and lineage restricted progenitor cells and their leukaemic counterparts ". In 'Leucocyte typing 111: White cell differentiation antigens. Oxford University Press, 654-655.
↑ Loken M. Shah V. Civin CI.. (1987). "Characterization of myeloid antigens on human bone marrow using multicolour immunofluorescence". In: McMichael, Leucocyte Typing III:White cell differentiation antigens.Oxford University Press 630-635.
↑ Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, Thamaraikannan P, Abraham S (2010). "Autologous Multiple Injections of in Vitro Expanded Autologous Bone Marrow Stem Cells For Cervical Level Spinal Cord Injury - A Case Report". Journal of Stem Cells and Regenerative Medicine.
↑ Terai S, Ishikawa T, Omori K, Aoyama K, Marumoto Y, Urata Y, Yokoyama Y, Uchida K, Yamasaki T, Fujii Y, Okita K, Sakaida I (Oct 2006). "Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy". Stem Cells. 24 (10): 2292–8. doi:10.1634/stemcells.2005-0542. PMID 16778155.
↑ Subrammaniyan R, Amalorpavanathan J, Shankar R, Rajkumar M, Baskar S, Manjunath SR, Senthilkumar R, Murugan P, Srinivasan VR, Abraham S (Sep 2011). "Application of autologous bone marrow mononuclear cells in six patients with advanced chronic critical limb ischemia as a result of diabetes: our experience". Cytotherapy. 13 (8): 993–9. doi:10.3109/14653249.2011.579961. PMID 21671823.

مشارکت‌کنندگان ویکی‌پدیا. «CD34». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۵ دسامبر ۲۰۱۷.

بیشتر بخوانید

Bellini A, Mattoli S (Sep 2007). "The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses". Laboratory Investigation. 87 (9): 858–70. doi:10.1038/labinvest.3700654. PMID 17607298.
Simmons DL, Satterthwaite AB, Tenen DG, Seed B (Jan 1992). "Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells". Journal of Immunology. 148 (1): 267–71. PMID 1370171.
Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG (Apr 1992). "Structure of the gene encoding CD34, a human hematopoietic stem cell antigen". Genomics. 12 (4): 788–94. doi:10.1016/0888-7543(92)90310-O. PMID 1374051.
Fina L, Molgaard HV, Robertson D, Bradley NJ, Monaghan P, Delia D, Sutherland DR, Baker MA, Greaves MF (Jun 1990). "Expression of the CD34 gene in vascular endothelial cells". Blood. 75 (12): 2417–26. PMID 1693532.
Fackler MJ, Civin CI, Sutherland DR, Baker MA, May WS (Jul 1990). "Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells". The Journal of Biological Chemistry. 265 (19): 11056–61. PMID 1694174.^{^{[پیوند مرده]}}
Sutherland DR, Watt SM, Dowden G, Karhi K, Baker MA, Greaves MF, Smart JE (Dec 1988). "Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34". Leukemia. 2 (12): 793–803. PMID 2462139.
Nakamura Y, Komano H, Nakauchi H (Feb 1993). "Two alternative forms of cDNA encoding CD34". Experimental Hematology. 21 (2): 236–42. PMID 7678811. INIST:4784611.
Huyhn A, Dommergues M, Izac B, Croisille L, Katz A, Vainchenker W, Coulombel L (Dec 1995). "Characterization of hematopoietic progenitors from human yolk sacs and embryos". Blood. 86 (12): 4474–85. PMID 8541536.^{^{[پیوند مرده]}}
Tavian M, Coulombel L, Luton D, Clemente HS, Dieterlen-Lièvre F, Péault B (Jan 1996). "Aorta-associated CD34+ hematopoietic cells in the early human embryo". Blood. 87 (1): 67–72. PMID 8547678.^{^{[پیوند مرده]}}
Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (Sep 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Uchida N, Yang Z, Combs J, Pourquié O, Nguyen M, Ramanathan R, Fu J, Welply A, Chen S, Weddell G, Sharma AK, Leiby KR, Karagogeos D, Hill B, Humeau L, Stallcup WB, Hoffman R, Tsukamoto AS, Gearing DP, Péault B (Apr 1997). "The characterization, molecular cloning, and expression of a novel hematopoietic cell antigen from CD34+ human bone marrow cells". Blood. 89 (8): 2706–16. PMID 9108388.^{^{[پیوند مرده]}}
Ruiz ME, Cicala C, Arthos J, Kinter A, Catanzaro AT, Adelsberger J, Holmes KL, Cohen OJ, Fauci AS (Oct 1998). "Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV". Journal of Immunology. 161 (8): 4169–76. PMID 9780190.
Kees UR, Ford J (Feb 1999). "Synergistic action of stem-cell factor and interleukin-7 in a human immature T-cell line". Immunology. 96 (2): 202–6. doi:10.1046/j.1365-2567.1999.00674.x. PMC 2326741. PMID 10233696.
Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S (May 1999). "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin". The Journal of Cell Biology. 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC 2133194. PMID 10330415.
Lataillade JJ, Clay D, Dupuy C, Rigal S, Jasmin C, Bourin P, Le Bousse-Kerdilès MC (Feb 2000). "Chemokine SDF-1 enhances circulating CD34(+) cell proliferation in synergy with cytokines: possible role in progenitor survival". Blood. 95 (3): 756–68. PMID 10648383.^{^{[پیوند مرده]}}
Felschow DM, McVeigh ML, Hoehn GT, Civin CI, Fackler MJ (Jun 2001). "The adapter protein CrkL associates with CD34". Blood. 97 (12): 3768–75. doi:10.1182/blood.V97.12.3768. PMID 11389015.
Dobo I, Robillard N, Pineau D, Geneviève F, Piard N, Rapp MJ, Boasson M, Zandecki M, Hermouet S (Nov 2001). "Use of pathology-specific peripheral blood CD34 thresholds to predict leukapheresis CD34 content with optimal accuracy: a bicentric analysis of 299 leukaphereses". Annals of Hematology. 80 (11): 639–46. doi:10.1007/s002770100365. PMID 11757722.
Hogan CJ, Shpall EJ, Keller G (Jan 2002). "Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice". Proceedings of the National Academy of Sciences of the United States of America. 99 (1): 413–8. Bibcode:2002PNAS...99..413H. doi:10.1073/pnas.012336799. JSTOR 3057551. PMC 117574. PMID 11782553. INIST:13429907.
Krauter J, Hartl M, Hambach L, Kohlenberg A, Gunsilius E, Ganser A, Heil G (Dec 2001). "Receptor-mediated endocytosis of CD34 on hematopoietic cells after stimulation with the monoclonal antibody anti-HPCA-1". Journal of Hematotherapy & Stem Cell Research. 10 (6): 863–71. doi:10.1089/152581601317210953. PMID 11798512.
Okuno Y, Iwasaki H, Huettner CS, Radomska HS, Gonzalez DA, Tenen DG, Akashi K (Apr 2002). "Differential regulation of the human and murine CD34 genes in hematopoietic stem cells". Proceedings of the National Academy of Sciences of the United States of America. 99 (9): 6246–51. Bibcode:2002PNAS...99.6246O. doi:10.1073/pnas.092027799. JSTOR 3058657. PMC 122934. PMID 11983914.
Hotfilder M, Röttgers S, Rosemann A, Jürgens H, Harbott J, Vormoor J (Jul 2002). "Immature CD34+CD19- progenitor/stem cells in TEL/AML1-positive acute lymphoblastic leukemia are genetically and functionally normal". Blood. 100 (2): 640–6. doi:10.1182/blood.V100.2.640. PMID 12091359.

پیوند به بیرون

Antigens, CD34 در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم CD34 انسانی و صفحهٔ جزئیات ژنی CD34 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Entrez Gene: CD34 CD34 molecule".

[pmid1370171-5] Simmons DL, Satterthwaite AB, Tenen DG, Seed B (Jan 1992). "Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells". Journal of Immunology. 148 (1): 267–71. PMID 1370171.

[pmid1374051-6] Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG (Apr 1992). "Structure of the gene encoding CD34, a human hematopoietic stem cell antigen". Genomics. 12 (4): 788–94. doi:10.1016/0888-7543(92)90310-O. PMID 1374051.

[7] Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH (1984). "Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells". Journal of Immunology. 133 (1): 157–65. PMID 6586833.

[8] Tindle RW. Nichols R. Chan L. Campana D. Birnie GD. (1985). "A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B, non-T lymphoblasts in acute leukaemia and CGL blast crises, and react with immature cells in normal bone marrow". Leukaemia Research. 9: 1–9. doi:10.1016/0145-2126(85)90016-5.

[9] Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. (1987). "BI-3C5 (CD34) defines multipotential and lineage restricted progenitor cells and their leukaemic counterparts ". In 'Leucocyte typing 111: White cell differentiation antigens. Oxford University Press, 654-655.

[10] Loken M. Shah V. Civin CI.. (1987). "Characterization of myeloid antigens on human bone marrow using multicolour immunofluorescence". In: McMichael, Leucocyte Typing III:White cell differentiation antigens.Oxford University Press 630-635.

[Srivastava_2010-11] Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, Thamaraikannan P, Abraham S (2010). "Autologous Multiple Injections of in Vitro Expanded Autologous Bone Marrow Stem Cells For Cervical Level Spinal Cord Injury - A Case Report". Journal of Stem Cells and Regenerative Medicine.

[Terai_2006-12] Terai S, Ishikawa T, Omori K, Aoyama K, Marumoto Y, Urata Y, Yokoyama Y, Uchida K, Yamasaki T, Fujii Y, Okita K, Sakaida I (Oct 2006). "Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy". Stem Cells. 24 (10): 2292–8. doi:10.1634/stemcells.2005-0542. PMID 16778155.

[pmid21671823-13] Subrammaniyan R, Amalorpavanathan J, Shankar R, Rajkumar M, Baskar S, Manjunath SR, Senthilkumar R, Murugan P, Srinivasan VR, Abraham S (Sep 2011). "Application of autologous bone marrow mononuclear cells in six patients with advanced chronic critical limb ischemia as a result of diabetes: our experience". Cytotherapy. 13 (8): 993–9. doi:10.3109/14653249.2011.579961. PMID 21671823.

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