ZNF350

ZNF350
Identifiers
Aliases	ZNF350, ZBRK1, ZFQR, zinc finger protein 350
External IDs	OMIM: 605422; HomoloGene: 130723; GeneCards: ZNF350; OMA:ZNF350 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,986,856 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; monocyte; ; amniotic fluid; ; prostate; ; gonad; ; bone marrow; ; sperm; ; germinal epithelium; ; rectum; ; granulocyte;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; DNA binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	nuclear matrix; transcription repressor complex; intracellular anatomical structure; nucleus; nucleoplasm; nuclear body;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	59348
	n/a
	ENSG00000256683
	n/a
	Q9GZX5
	n/a
	NM_021632
	n/a
	NP_067645
	n/a
	Wikidata
View/Edit Human

Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.^[3]^[4]^[5]

Interactions

ZNF350 has been shown to interact with BRCA1.^[3]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000256683 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH (Oct 2000). "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1". Molecular Cell. 6 (4): 757–68. doi:10.1016/S1097-2765(00)00075-7. PMID 11090615.
^ Ran Q, Wadhwa R, Bischof O, Venable S, Smith JR, Pereira-Smith OM (Feb 2001). "Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells". Experimental Cell Research. 263 (1): 156–62. doi:10.1006/excr.2000.5068. PMID 11161714.
^ "Entrez Gene: ZNF350 zinc finger protein 350".

Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Rutter JL, Smith AM, Dávila MR, Sigurdson AJ, Giusti RM, Pineda MA, Doody MM, Tucker MA, Greene MH, Zhang J, Struewing JP (Aug 2003). "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals". Human Mutation. 22 (2): 121–8. doi:10.1002/humu.10238. PMID 12872252. S2CID 36167584.
Yun J, Lee WH (Oct 2003). "Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage". Molecular and Cellular Biology. 23 (20): 7305–14. doi:10.1128/MCB.23.20.7305-7314.2003. PMC 230312. PMID 14517299.
Tan W, Zheng L, Lee WH, Boyer TG (Feb 2004). "Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression". The Journal of Biological Chemistry. 279 (8): 6576–87. doi:10.1074/jbc.M312270200. PMID 14660588.
Surpili MJ, Delben TM, Kobarg J (Dec 2003). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
Li H, Seth A (Mar 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.
Tan W, Kim S, Boyer TG (Dec 2004). "Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1". The Journal of Biological Chemistry. 279 (53): 55153–60. doi:10.1074/jbc.M410926200. PMID 15496401.
Liao G, Huang J, Fixman ED, Hayward SD (Jan 2005). "The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor". Journal of Virology. 79 (1): 245–56. doi:10.1128/JVI.79.1.245-256.2005. PMC 538732. PMID 15596820.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Bulliard Y, Wiznerowicz M, Barde I, Trono D (Nov 2006). "KRAB can repress lentivirus proviral transcription independently of integration site". The Journal of Biological Chemistry. 281 (47): 35742–6. doi:10.1074/jbc.M602843200. PMID 16997916.
Desjardins S, Belleau P, Labrie Y, Ouellette G, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Durocher F (Jan 2008). "Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families". International Journal of Cancer. 122 (1): 108–16. doi:10.1002/ijc.23058. PMID 17764113. S2CID 27596530.

External links

ZNF350+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000256683 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11090615-3] Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH (Oct 2000). "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1". Molecular Cell. 6 (4): 757–68. doi:10.1016/S1097-2765(00)00075-7. PMID 11090615.

[pmid11161714-4] Ran Q, Wadhwa R, Bischof O, Venable S, Smith JR, Pereira-Smith OM (Feb 2001). "Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells". Experimental Cell Research. 263 (1): 156–62. doi:10.1006/excr.2000.5068. PMID 11161714.

[entrez-5] "Entrez Gene: ZNF350 zinc finger protein 350".

[1]

[2]

[3]

[4]

[5]

ZNF350

Interactions

See also

References

Further reading

External links