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HES5

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HES5
Identifiers
AliasesHES5, bHLHb38, hes family bHLH transcription factor 5
External IDsOMIM: 607348; MGI: 104876; HomoloGene: 7755; GeneCards: HES5; OMA:HES5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001010926

NM_010419
NM_001370755

RefSeq (protein)

NP_001010926

NP_034549
NP_001357684

Location (UCSC)Chr 1: 2.53 – 2.53 MbChr 4: 155.05 – 155.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.[5][6]

HES5 regulates the development of the early brain by maintaining stem cell neural progenitors in the ventricular zone.[7][8] HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.[9] Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.[10]

References

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  1. ^ a b c ENSG00000197921 GRCh38: Ensembl release 89: ENSG00000273529, ENSG00000197921Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048001Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takebayashi K, Akazawa C, Nakanishi S, Kageyama R (January 1995). "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element". The Journal of Biological Chemistry. 270 (3): 1342–1349. doi:10.1074/jbc.270.3.1342. PMID 7836401.
  6. ^ "Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)".
  7. ^ Ohtsuka T, Sakamoto M, Guillemot F, Kageyama R (August 2001). "Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain". The Journal of Biological Chemistry. 276 (32): 30467–30474. doi:10.1074/jbc.M102420200. PMID 11399758.
  8. ^ Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (November 2004). "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation". Development. 131 (22): 5539–5550. doi:10.1242/dev.01436. hdl:2433/144732. PMID 15496443.
  9. ^ Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X (2007). "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors". International Journal of Gynecological Cancer. 17 (6): 1293–1299. doi:10.1111/j.1525-1438.2007.00930.x. PMID 17388915. S2CID 25609083.
  10. ^ Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell and Tissue Research. 327 (3): 539–551. doi:10.1007/s00441-006-0307-0. PMID 17093926. S2CID 33749726.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.