LIN28A

LIN28A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CQF, 2LI8
Dynodwyr
Cyfenwau	LIN28A, CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A, lin-28 homolog A, Lin28a, LIN28A (gene), Lin-28 homolog A
Dynodwyr allanol	OMIM: 611043 HomoloGene: 32592 GeneCards: LIN28A
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • zinc ion binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • RNA binding; • nucleic acid binding; • translation initiation factor binding; • mRNA binding; • G-quadruplex RNA binding; • miRNA binding; • sequence-specific mRNA binding; • polysome binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • nucleolus; • cnewyllyn cell; • Reticwlwm endoplasmig; • rough endoplasmic reticulum; • polysome; • P-body; • cytoplasmic stress granule; • ribonucleoprotein complex;
Prosesau biolegol	• GO:1905616 regulation of gene silencing by miRNA; • germ cell development; • miRNA catabolic process; • GO:0009373 regulation of transcription, DNA-templated; • RNA 3'-end processing; • somatic stem cell population maintenance; • negative regulation of glial cell differentiation; • positive regulation of translation; • stem cell differentiation; • positive regulation of cell proliferation involved in kidney development; • stem cell population maintenance; • pre-miRNA processing; • positive regulation of neuron differentiation; • GO:0061715 miRNA metabolic process; • gene silencing; • negative regulation of translation; • positive regulation of TOR signaling; • positive regulation of protein kinase B signaling; • cellular response to glucose stimulus; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • positive regulation of cytoplasmic translation;
	Sources:Amigo / QuickGO
Orthologau
	79727
	n/a
	ENSG00000131914
	n/a
	Q9H9Z2
	n/a
	NM_024674
	n/a
	NP_078950
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIN28A yw LIN28A a elwir hefyd yn Lin-28 homolog A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.11.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LIN28A.

CSDD1
LIN28
LIN-28
ZCCHC1
lin-28A

Llyfryddiaeth

"Lin28 induces resistance to anti-androgens via promotion of AR splice variant generation. ". Prostate. 2016. PMID 26714839.
"Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner. ". Tumour Biol. 2016. PMID 26687759.
"Lin28a enhances in vitro osteoblastic differentiation of human periosteum-derived cells. ". Cell Biochem Funct. 2017. PMID 29143345.
"Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. ". Stem Cell Res Ther. 2016. PMID 27230676.
"RNA-binding protein Lin28 in cancer and immunity.". Cancer Lett. 2016. PMID 26945970.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LIN28A - Cronfa NCBI

[1]

[2]