LEP

LEP
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1AX8
Dynodwyr
Cyfenwau	LEP, LEPD, OB, OBS, leptin
Dynodwyr allanol	OMIM: 164160 HomoloGene: 193 GeneCards: LEP
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• hormone activity; • peptide hormone receptor binding; • signaling receptor binding;
Cydrannau o'r gell	• cytoplasm; • extracellular region; • extracellular space;
Prosesau biolegol	• regulation of protein phosphorylation; • response to dietary excess; • cellular response to retinoic acid; • positive regulation of developmental growth; • negative regulation of glucagon secretion; • placenta development; • cardiac muscle hypertrophy; • regulation of angiogenesis; • prostaglandin secretion; • regulation of intestinal cholesterol absorption; • T cell differentiation; • positive regulation of reactive oxygen species metabolic process; • central nervous system neuron development; • Rhythm circadaidd; • positive regulation of ion transport; • angiogenesis; • glucose metabolic process; • positive regulation of peroxisome proliferator activated receptor signaling pathway; • positive regulation of hepatic stellate cell activation; • regulation of endothelial cell proliferation; • intestinal absorption; • response to ethanol; • negative regulation of autophagy; • positive regulation of p38MAPK cascade; • positive regulation of protein kinase B signaling; • negative regulation of metabolic process; • negative regulation of vasoconstriction; • glucose homeostasis; • regulation of insulin secretion; • regulation of steroid biosynthetic process; • insulin secretion; • regulation of natural killer cell activation; • regulation of fat cell differentiation; • response to vitamin E; • response to nutrient levels; • bone mineralization involved in bone maturation; • positive regulation of T cell proliferation; • positive regulation of protein import into nucleus; • regulation of brown fat cell differentiation; • fatty acid beta-oxidation; • regulation of metabolic process; • hormone metabolic process; • positive regulation of MAPK cascade; • positive regulation of TOR signaling; • cellular response to L-ascorbic acid; • ovulation from ovarian follicle; • activation of protein kinase C activity; • atgynhyrchu rhywiol; • negative regulation of cartilage development; • response to nutrient; • negative regulation of glutamine transport; • leptin-mediated signaling pathway; • bile acid metabolic process; • female pregnancy; • negative regulation of apoptotic process; • cholesterol metabolic process; • positive regulation of follicle-stimulating hormone secretion; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of appetite; • regulation of protein localization to nucleus; • regulation of blood pressure; • negative regulation of glucose import; • leukocyte tethering or rolling; • negative regulation of lipid storage; • adipose tissue development; • GO:1903106 positive regulation of insulin receptor signaling pathway; • bone growth; • positive regulation of receptor signaling pathway via JAK-STAT; • glycerol biosynthetic process; • positive regulation of luteinizing hormone secretion; • fatty acid catabolic process; • regulation of gluconeogenesis; • response to estradiol; • GO:0007243 intracellular signal transduction; • adult feeding behavior; • response to hypoxia; • regulation of natural killer cell proliferation; • eating behavior; • GO:0032737 positive regulation of cytokine production; • regulation of cytokine production involved in inflammatory response; • regulation of nitric-oxide synthase activity; • response to activity; • cellular response to leptin stimulus; • regulation of cell cycle; • regulation of natural killer cell mediated cytotoxicity; • positive regulation of fat cell apoptotic process; • positive regulation of cell population proliferation; • regulation of lipoprotein lipid oxidation; • positive regulation of phosphatidylinositol 3-kinase signaling; • GO:0072468 signal transduction; • regulation of bone remodeling; • lipid metabolism; • negative regulation of appetite by leptin-mediated signaling pathway; • interleukin-12 production; • positive regulation of tumor necrosis factor production; • interleukin-6 production; • response to insulin; • tyrosine phosphorylation of STAT protein; • ffagocytosis; • energy reserve metabolic process; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • determination of adult lifespan; • regulation of lipid biosynthetic process; • positive regulation of cold-induced thermogenesis; • aorta development; • GO:0048552 regulation of catalytic activity; • elastin metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	3952
	n/a
	ENSG00000174697
	n/a
	P41159
	n/a
	NM_000230
	n/a
	NP_000221
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LEP yw LEP a elwir hefyd yn Leptin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q32.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LEP.

OB
OBS
LEPD

Llyfryddiaeth

"Leptin and autoimmune disease. ". Nihon Rinsho Meneki Gakkai Kaishi. 2017. PMID 28747601.
"Physical fitness and plasma leptin in women with recent gestational diabetes. ". PLoS One. 2017. PMID 28609470.
"Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity. ". PLoS One. 2017. PMID 28542631.
"High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. ". Carcinogenesis. 2017. PMID 28426873.
"Associations of LEP, CRH, ICAM-1, and LINE-1 methylation, measured in saliva, with waist circumference, body mass index, and percent body fat in mid-childhood.". Clin Epigenetics. 2017. PMID 28360946.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LEP - Cronfa NCBI

[1]

[2]