Inhibitor ribonukleotidne reduktaze
(Preusmjereno sa stranice Inhibitori ribonukleotid reduktaze)
Inhibitori ribonukleotidne reduktaze su familija antikancerni lekovi koji ometaju rast ćelija tumora blokiranjem formiranja dezoksiribonukleotida (gradivnih blokova DNK).
- Primeri
- moteksafin gadolinijum.[1]
- hidroksiureja[2]
- fludarabin, kladribin, gemcitabin, tezacitabin, i triapin[3]
- galijum maltolat, galijum nitrat[4]
- ↑ Zahedi Avval F, Berndt C, Pramanik A, Holmgren A (January 2009). „Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd)”. Biochem. Biophys. Res. Commun. 379 (3): 775–9. DOI:10.1016/j.bbrc.2008.12.128. PMID 19121624.
- ↑ Mayhew CN, Phillips JD, Cibull ML, Elford HL, Gallicchio VS (September 2002). „Short-term treatment with novel ribonucleotide reductase inhibitors Trimidox and Didox reverses late-stage murine retrovirus-induced lymphoproliferative disease with less bone marrow toxicity than hydroxyurea”. Antivir. Chem. Chemother. 13 (5): 305–14. PMID 12630679.
- ↑ Tsimberidou AM, Alvarado Y, Giles FJ (August 2002). „Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies”. Expert Rev Anticancer Ther 2 (4): 437–48. DOI:10.1586/14737140.2.4.437. PMID 12647987.
- ↑ Bernstein LR (1998). „Mechanisms of therapeutic activity for gallium”. Pharmacol. Rev. 50 (4): 665–682. PMID 9860806. Arhivirano iz originala na datum 2007-02-26. Pristupljeno 2014-07-08.
- Ribonucleotide reductase inhibitor entry in the public domain NCI Dictionary of Cancer Terms