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Imgatuzumab

From Wikipedia, the free encyclopedia
Imgatuzumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized (from rat)
TargetEGFR
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6434H9942N1718O2016S44
Molar mass145028.96 g·mol−1

Imgatuzumab (INN) is a humanized monoclonal antibody designed for the treatment of cancer. It is an anti-EGFR antibody[1] that acts as an immunomodulator.[2][3]

The drug was developed by Genentech/Roche.

References

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  1. ^ Kol A, Terwisscha van Scheltinga A, Pool M, Gerdes C, de Vries E, de Jong S (July 2017). "ADCC responses and blocking of EGFR-mediated signaling and cell growth by combining the anti-EGFR antibodies imgatuzumab and cetuximab in NSCLC cells". Oncotarget. 8 (28): 45432–45446. doi:10.18632/oncotarget.17139. PMC 5542198. PMID 28467975.
  2. ^ World Health Organization (2012). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 107" (PDF). WHO Drug Information. 26 (2).
  3. ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Imgatuzumab, American Medical Association.