9æ9æ¥æªæãåèå¸ã«ä¸é¸ããåèçå ã«ç大ãªè¢«å®³ããããããå°é¢¨15å·ãä¸é¸ç´å¾ã«ã¯çå ã»ã¼å ¨åã®ç´90ä¸æ¸ãåé»ããæ´é¢¨ã«ããå¤ãã®ä½å® ãæå£ãããåé»ãï¼é±éç¶ããå°åãå¤ããå°é¢¨ãå»ã£ã¦20æ¥ãçµã£ãç¾å¨ã§ã復æ§ãã¦ããªãå°åãããã ãããªè¢«ç½å°ã»åèã®ãªãã§ããç¹ã«è¢«å®³ã大ããã£ãçåé¨ã®é¤¨å±±å¸ã«æ®ããä½å®¶ã®ãããããããã彼女èªèº«ã¯å¹¸éã«ãã»ã¨ãã©è¢«å®³ã«éããã¨ã¯ãªãã£ãããã¾ã£ããæ³å®ãã¦ããªãã£ããã©ãã«ã®é£ç¶ã«ãç²¾ç¥çã«ããæ¸ã£ã¦ãã20æ¥éã ã£ãã¨ããã å±æ ¹ã丸ãã¨é£ã°ããã家 9æ9æ¥ï¼æï¼å°é¢¨15å·ã«ãã大åé»1æ¥ç® åå1æéããå°é¢¨15å·ãä¸é¸ããã¨æãããæå»ãåèç館山å¸ã¯ããã¤ã¦çµé¨ãããã¨ããªãã»ã©ã®æ´é¢¨é¨ã«è¦èããã¦ããã ç§ã¯ãé«é½¢ã®ä¸¡è¦ªï¼ç¶89æ³ãæ¯87æ³ï¼ã¨åå± ãã¦ãã館山å¸å ã®èªå® ã§ãä¸å®ãªå¤ãéããã¦ãããçªç¶ãããªããªã¨ããé³ãããã¨æ
ã§ã¯ãã©ãããéåããè³ãè²ã¦ãããã«å¹æçãªã®ããã¬ã¤ãã£æ°ãå§ããã®ã¯ãä¸å®æéã«ããã£ã¦å¿ææ°ãä¸ããã¿ã¤ãã®éåã ãç 究ã«ããã¨ãæ°ããä½åã®è©ä¾¡åºæºã®ãã¡ãã¨ãã«å¿èºæ©è½ãå¦æ¥æ績ã¨å¼·ãç¸é¢é¢ä¿ã示ãã¦ããã¨ããã å ·ä½çãªå¿èºæ©è½ã®é«ãæ¹ã¯ãé足ã§ã®ã¦ãªã¼ãã³ã°ãã©ã³ãã³ã°ãã¨ã¢ããã¯ã¹ãã¨ã¢ããã¤ã¯ã使ã£ãéåãªã©ãé±ã«2æ¥ã¯æ大å¿ææ°ï¼æ³¨ï¼ã®75.90ï¼ ã¾ã§ä¸ããéåãçãã«ãæ®ã4æ¥ã¯65.75ï¼ ã¾ã§ã®éåãããé·ãã«ãã¨ããã®ãè³ã®ããã«ã¯çæ³çã ã¨ãããå¿ææ°ã®ç®å®ã¨ãã¦ã¯ãã©ã³ãã³ã°ã§ãã¨ããã¨ãæ大å¿ææ°ã«å¯¾ãã¦80ï¼ ä»¥ä¸ã¨ããã®ã¯ããªããã¤ãå ¨åç¾èµ°ã70ï¼ ã¯ããæ¯ãä¸ããèµ°ãè¾¼ã¿ã¨ãã£ãå ·åã ãå¿æè¨ã使ã£ã¦æ¸¬ã£ã¦ã¿ãã®ãããã ããã ã¸ã§ã³ã»Jã»ã¬ã¤ã㣠ãã¼ãã¼ã大å¦å»å¦é¨åææãç²¾ç¥å»å¦ãå°éã¨ãã¦å¹ åºãæ´»èºãã¤ãªãã¤å·ãã¼ãã¼ã´ã£ã«ã®äºä¾ãç 究ããéå
ãã¯ããã«ï¼ç®çã è³ç±æ¥ç¥çµæ é¤å åï¼ä»¥ä¸BDNFï¼ã¯ï¼ã·ããã¹ã®å¯å¡æ§ã«é¢ä¸ãï¼è¨æ¶ãå¦ç¿ã®å½¢æã«ããã¦éè¦ãªå½¹å²ãæããåæ³ã¿ã³ãã¯è³ªã§ãããã¾ãï¼BDNFã¯ï¼Synaptophysinãªã©ã®ã·ããã¹é¢é£ã¿ã³ãã¯ã®ç£çãä¿é²ãï¼ç¥çµä¼éå¹çãæ¹åããã¨å ±åããã¦ãããæ人æã©ããã«å¯¾ããéåä»å ¥ã§ã¯ï¼è³å ã®æ§ã ãªé åãéª¨æ ¼çã§ã®BDNFã®çºç¾ãé«ãããã¨ãå ±åããã¦ããããããï¼èé½¢ã»ä¸å¹´é½¢ã©ããã対象ã¨ããé·æçãªéåä»å ¥ãç¥çµæ é¤å åã«ä¸ããå½±é¿ã¯ä¸æã§ãããããã§ï¼æ¬ç 究ã§ã¯ï¼èé½¢ã»ä¸å¹´é½¢ã®2群ã®ç°ãªãé±é½¢ã®ã©ããã«å¯¾ããé·æçãªéåä»å ¥ã«ããéåçæ³ã®å¹æã«ã¤ãã¦ï¼èé«ã«ãããBDNFï¼Synaptophysinã®çºç¾ã¸ã®å½±é¿ã解æãããã¨ãç®çã¨ãã¦è¡ã£ãã ãæ¹æ³ã Wistarç³»éæ§ã©ãã20å¹ï¼èé½¢ï¼ä¸å¹´é½¢å10å¹ï¼ã対象ã¨ãï¼å群ãèµ°è¡ç¾¤5å¹ï¼éèµ°è¡ç¾¤å5å¹ã¨ç¡ä½çº
ï¼ éåã»ãã¬ã¼ãã³ã°ã«ããéª¨æ ¼çè¥å¤§ã®ã¡ã«ããºã 主ã«ã©ããããã¦ã¹ã®çåãã¬ã¼ãã³ã°ã¢ãã«ï¼é»æ°åºæ¿ã«ããçå縮ããæè¡ã«ãã代åæ§è¥å¤§ï¼ãç¨ãã¦ããã¬ã¼ãã³ã°åºæ¿å¾ã®éºä¼åãã¿ã³ãã¯è³ªã®çºç¾ãªã©ã調ã¹ã¦ãã¾ãããã®ãããªç 究ã«ãããçåãã¬ã¼ãã³ã°ã®å¹æã®ã¡ã«ããºã ã解æããã¤ã¤ããã¾ãã ï¼è«æçªå·ï¼74: 77: 83; 90; 95ããªã©ï¼ â²ããã¼ã¸ãããã¸ ï¼ çéåãè³ã«åã¼ãå¹æï¼èªç¥çäºé²ãç®æã㦠éåãé«é½¢è ã®èªç¥çäºé²ã«å¹æçãªãã¨ããè¿å¹´ã®ç«å¦ç 究ããã¯ã£ããã¨ãã¦ãã¾ããããããããã®å¹æã®ã¡ã«ããºã ã¯ä¸æã§ããæã ã®ç 究室ã§ã¯ãã©ããéª¨æ ¼çãç´æ¥é»æ°åºæ¿ãã¦å縮ãèµ·ããããã¨ãã®ãè³ã®æµ·é¦¬ï¼çæè¨æ¶ä¸æ¢ï¼ã§ã®è³ç±æ¥ç¥çµæ é¤å åï¼BDNFï¼ã®çºç¾ãªã©ã調ã¹ã¦ãã¾ããBDNFã¯ãç¥çµç´°èã®å¢æ®ãä¿è·ã«éè¦ãªã¯ããããããã¨ãããéåã«ä¼´ã£ã¦çããåæ³ããããã«
æ°å¸¸èï¼ ãã¥ã¼ãã³ã¯éåã§å¢ãã ãã¼ãã¼ã´ã£ã«203å¦åºã®åãçµã¿ã¯ãéåãåä¾ãã¡ã®å¦æ¥æ績ã«ãã©ã¹ã®å½±é¿ãä¸ãããã¨ã証æãã¦ã¿ãããã§ã¯ãªããéåãããã¨é ãè¯ããªãã®ãã éåããè³ã®ç¥çµç´°èãè²ã¦ããããã ã¨ããã®ã¯ããè³ãéããã«ã¯éåãããªãï¼ãï¼NHKåºçï¼ã®èè ããã¼ãã¼ã大å¦å»å¦é¨ã®ã¸ã§ã³ã»Jã»ã¬ã¤ãã£å士ã ã ãéåããã¨ãè³ç±æ¥ç¥çµæ é¤å åï¼BDNFï¼ã¨ããç©è³ªãè³ã®ä¸ã§ãããã«åæ³ããã¾ãããã®BDNFããè³ã®ç¥çµç´°èï¼ãã¥ã¼ãã³ï¼ããè³ã«æ é¤ãéãè¡ç®¡ã®å½¢æãä¿ããã¨ãæããã«ãªãã¾ããã 以åã¯ãè³ã®ãã¥ã¼ãã³ã®æ°ã¯çã¾ããã¨ãã«æ±ºã¾ã£ã¦ããããã®å¾ã¯å é½¢ã¨ã¨ãã«æ¸ã£ã¦ããä¸æ¹ã§ãå¢ãããã¨ã¯ãªããã¨èãããã¦ãããã ãæè¿ã§ã¯ããã¾ãã¾ãªè¦å ã§å¾å¤©çã«å¢ãããã¨ãç§å¦çãªå¸¸èã¨ãªã£ã¦ããã ããã¥ã¼ãã³ã®æ°ãå¢ããããã«æãå¹æãæå¾ ã§ããã®ã¯ãéåã§ã
ã³ã¯ã©ã³å ±åè¨ç»ã¯å½éçãªéå¶å©ç 究çµç¹ã§ãã¡ã¿åæ(試é¨ã®æ°ã¯å¤ããåã ã®è¦æ¨¡ãå°ãããåç¬ã§ã¯çããåºããªãã¨ãã«æå¹)ãå«ãå»çæ å ±ãä½ç³»çã«ã¾ã¨ãã¦çºä¿¡ãã¦ãã¾ããhttp://www.thecochranelibrary.com/view/0/index.html æ¥æ¬èªã§é¨åçã«èªãããµã¤ãâhttp://minds.jcqhc.or.jp/n/ 使ãæ¹âhttp://plaza.umin.ac.jp/~literis/cgi-bin/fswiki/wiki.cgi?page=TheCochraneLibrary âhttp://www.wiley.co.jp/ æ¥æ¬èªãµã¤ã(Minds)ã§è³åä¸é¢é£ã®ãªãããªã«ã¤ãã¦èª¿ã¹ã¦ã¿ã¾ããã è¨æ¶é害ã注æé害ãåå´ç¡è¦ã失è¡ãæ©æã®ADæ£è ã¾ãã¯è¡ç®¡æ§ç´åæ£è ã«å¯¾ããèªç¥ãã¬ã¼ãã³ã°ãèªç¥é害ã«å¯¾ããä½æ¥çæ³ãªã©é«æ¬¡è³æ©è½é害ã«ã¤ã
ï¼ï¼éåã«ããBDNFå¹æï¼èªç¥çã»ã¢ã«ããã¤ãã¼ï¼ æ©ããã¨ã¯äººéã«ã¨ã£ã¦æè¯ã®è¬ã§ãã ããã¯ã©ãã¹ æ¦è¦ ç¥çµç´°èå復ã®éµãæ¡ãBDNF 以åã¯ãè³ç¥çµç´°èã¯ä¸åº¦æ»ãã§ãã¾ãã¨ãäºåº¦ã¨å¾©æ´»ããªãã¨ãããã¨ãå®èª¬ã ã£ãããä»ã§ã¯å°ãªãã¨ã海馬ãèå¤å´åé åç®è³ªãªã©ããç¹å®ã®é åã§ã¯ãç¥çµç´°èãåã³å復ããã¨ããã¦ããã è³ç¥çµç´°èãæé·ãããå åã«ã¯BDNFã¨NGFãç¥ããã¦ããããç¹ã«BDNFããé常ã«éè¦ãªéµãæ¡ã£ã¦ãããBDNFãããã«å¤ãå¢ããã¦ãããããçæè¨æ¶ãå¸ã海馬細èãå復ããããããã²ãã¦ã¯è³æ©è½ã®ä½ä¸ãé²ãããã«éè¦ã«ãªã£ã¦ããã éåã®ãã£ã¨ãéè¦ãªèªç¥æ©è½å¹æã¯BDNFã®å¢å¼· éåã®èªç¥æ©è½æ¹åã¸ã®ä½ç¨ã¯å¤å²ã«ãããã®ã ããéåã®ãã£ã¨ã大ããªå©çã¯BDNFãå¢å ãããã¨ã«ããã¨å¤ãã®ç 究è ã®éã§èãããã¦ããã ã§ããã°ãåç´ã«BDNFãæä¸ããã°ããããã
ãªãªã¼ã¹ãé害æ å ±ãªã©ã®ãµã¼ãã¹ã®ãç¥ãã
ææ°ã®äººæ°ã¨ã³ããªã¼ã®é ä¿¡
å¦çãå®è¡ä¸ã§ã
j次ã®ããã¯ãã¼ã¯
kåã®ããã¯ãã¼ã¯
lãã¨ã§èªã
eã³ã¡ã³ãä¸è¦§ãéã
oãã¼ã¸ãéã
{{#tags}}- {{label}}
{{/tags}}