About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
Newly identified quality control mechanism of RNA Polymerase II transcription
Ana Tufegdžić Vidaković’s group, in the LMB’s PNAC Division, have worked with Scott Berry’s group, at the University of New South Wales, to identify the mechanism cells use to regulate gene expression via control of quality and quantity of Pol II molecules.
Discovery of a factor that accelerates protein deliveries to the endoplasmic reticulum
Huping Wang and Manu Hegde, in the LMB's Cell Biology Division, have found a factor that helps nascent secretory and membrane proteins quickly access the protein translocation machinery when they arrive at the endoplasmic reticulum.
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Latest News
- LMB wins Openness Award from Understanding Animal Research
UAR presented the Openness Award to the LMB, recognising multiple successful public engagement events sharing meaningful insights into the LMB’s work with animals. […]
- Marta Shahbazi joins EMBO Young Investigator Programme
Marta Shahbazi, Group Leader in the LMB’s Cell Biology Division, joins the global community of early-career researchers, with training, mentorship and networking opportunities from EMBO. […]
Latest Publications
- Modelling human brain development and disease with organoids.
Birtele, M., Lancaster, M., Quadrato, G.
Nat Rev Mol Cell Biol [Epub ahead of print]. (12th December 2024) - Circadian Control of Protein Synthesis.
James, NR., O'Neill, JS.
Bioessays : e202300158 [Epub ahead of print]. (12th December 2024) - Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus.
Ochner, H., Böhning, J., Wang, Z., Tarafder, AK., Caspy, I., Bharat, TAM.
PLoS Pathog 20(12): e1012773 [Epub ahead of print]. (12th December 2024) - A framework for neural organoids, assembloids and transplantation studies.
Pașca, SP., et al.
Nature [Epub ahead of print]. (9th December 2024) - A cryo-electron tomography study of ciliary rootlet organization.
van Hoorn, C., Carter, AP.
Elife 12. (6th December 2024) - A finger that gets in the way: When binding isn't just about the bound state.
Neuhaus, D., Stott, K.
Structure 32(12): 2182-2185. (5th December 2024) - CRL3 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription.
Cacioppo, R., et al.
Mol Cell [Epub ahead of print]. (5th December 2024)
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