SRY (sex determining region Y)-box 8 (Q21990153)

High mobility group box domain superfamily

1 reference

High mobility group box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Sox developmental protein N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

sequence-specific DNA binding

1 reference

14 February 2019

Cloning and characterisation of the Sry-related transcription factor gene Sox8.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

protein heterodimerization activity

1 reference

14 February 2019

Deciphering the Sox-Oct partner code by quantitative cooperativity measurements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

RNA polymerase II core promoter sequence-specific DNA binding

1 reference

14 February 2019

Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

DNA-binding transcription factor activity

SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

Cloning and characterisation of the Sry-related transcription factor gene Sox8.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

3 references

14 February 2019

14 February 2019

Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

transcription factor binding

1 reference

14 February 2019

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

protein binding

1 reference

14 February 2019

SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

cell component

cytoplasm

nucleus

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

Sox8 is a critical regulator of adult Sertoli cell function and male fertility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

retina development in camera-type eye

biological process

1 reference

14 February 2019

The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

metanephric nephron tubule formation

1 reference

14 February 2019

SOX9 controls epithelial branching by activating RET effector genes during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

negative regulation of apoptotic process

1 reference

14 February 2019

Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

positive regulation of branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

SOX9 controls epithelial branching by activating RET effector genes during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04886&geneProductId=UniProtKB:Q04886

1 reference

27 March 2018

signal transduction

1 reference

14 February 2019

SOX9 controls epithelial branching by activating RET effector genes during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

osteoblast differentiation

1 reference

14 February 2019

The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

negative regulation of photoreceptor cell differentiation

1 reference

14 February 2019

The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

skeletal muscle cell differentiation

1 reference

14 February 2019

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

enteric nervous system development

1 reference

27 March 2018

Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04886&geneProductId=UniProtKB:Q04886

negative regulation of myoblast differentiation

1 reference

14 February 2019

Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

astrocyte fate commitment

1 reference

14 February 2019

The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

positive regulation of gene expression

1 reference

14 February 2019

Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

peripheral nervous system development

1 reference

27 March 2018

Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04886&geneProductId=UniProtKB:Q04886

retinal rod cell differentiation

1 reference

14 February 2019

The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

fat cell differentiation

1 reference

14 February 2019

Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

positive regulation of transcription, DNA-templated

SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

neural crest cell migration

1 reference

14 February 2019

Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

positive regulation of kidney development

1 reference

14 February 2019

SOX9 controls epithelial branching by activating RET effector genes during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

in utero embryonic development

1 reference

14 February 2019

Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

regulation of hormone levels

1 reference

14 February 2019

Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

positive regulation of gliogenesis

1 reference

14 February 2019

Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

1 reference

14 February 2019

oligodendrocyte differentiation

1 reference

27 March 2018

SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04886&geneProductId=UniProtKB:Q04886

cell fate commitment

1 reference

14 February 2019

Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

ureter morphogenesis

1 reference

14 February 2019

SOX9 controls epithelial branching by activating RET effector genes during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

morphogenesis of a branching epithelium

1 reference

14 February 2019

SOX9 controls epithelial branching by activating RET effector genes during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

male gonad development

negative regulation of transcription, DNA-templated

positive regulation of osteoblast proliferation

1 reference

14 February 2019

The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

renal vesicle induction

1 reference

14 February 2019

SOX9 controls epithelial branching by activating RET effector genes during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

cell maturation

2 references

Sertoli cell development

IEP

spermatogenesis

positive regulation of transcription by RNA polymerase II

6 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04886&geneProductId=UniProtKB:Q04886

Ensembl genome database project

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04886&geneProductId=UniProtKB:Q04886

27 March 2018

The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04886&geneProductId=UniProtKB:Q04886

27 March 2018

Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04886&geneProductId=UniProtKB:Q04886

27 March 2018

Cloning and characterisation of the Sry-related transcription factor gene Sox8.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04886&geneProductId=UniProtKB:Q04886

27 March 2018

SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04886&geneProductId=UniProtKB:Q04886

morphogenesis of an epithelium

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

central nervous system development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

peripheral nervous system development

positive regulation of transcription by RNA polymerase II

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

Cloning and characterisation of the Sry-related transcription factor gene Sox8.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04886

enteric nervous system development

oligodendrocyte differentiation

Sox developmental protein N-terminal

has part(s)

1 reference

High mobility group box domain

1 reference