Calcium/calmodulin dependent protein kinase II delta (Q21100382)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

titin binding

1 reference

8 April 2019

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

protein homodimerization activity

1 reference

8 April 2019

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

protein binding

5 references

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

Network analysis of UBE3A/E6AP-associated proteins provides connections to several distinct cellular processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

sodium channel inhibitor activity

1 reference

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

calmodulin-dependent protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

31 October 2017

31 October 2017

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

31 October 2017

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

1 January 2018

1 January 2018

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

transmembrane transporter binding

calmodulin binding

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

31 October 2017

calmodulin-dependent protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

8 April 2019

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

calmodulin binding

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

endocytic vesicle membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

sarcoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

sarcoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

sarcolemma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

neuron projection

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

nucleus

1 reference

8 April 2019

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

calcium channel complex

1 reference

31 October 2017

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

regulation of heart contraction

biological process

1 reference

8 April 2019

Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

interferon-gamma-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of membrane depolarization

1 reference

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

positive regulation of cardiac muscle hypertrophy

1 reference

8 April 2019

Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

3 references

8 April 2019

8 April 2019

Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

cellular response to calcium ion

1 reference

8 April 2019

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of cardiac muscle cell action potential involved in regulation of contraction

1 reference

8 April 2019

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of histone deacetylase activity

1 reference

8 April 2019

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of cellular localization

1 reference

8 April 2019

Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

negative regulation of sodium ion transmembrane transport

1 reference

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

regulation of the force of heart contraction

1 reference

8 April 2019

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of ryanodine-sensitive calcium-release channel activity

negative regulation of sodium ion transmembrane transporter activity

1 reference

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

1 reference

1 January 2018

protein complex oligomerization

1 reference

8 April 2019

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of cell growth

NAS

1 reference

8 April 2019

Identification of novel human tumor cell-specific CaMK-II variants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of cellular response to heat

NAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

1 reference

8 April 2019

regulation of cell communication by electrical coupling involved in cardiac conduction

1 reference

8 April 2019

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of heart rate by cardiac conduction

1 reference

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

1 reference

31 October 2017

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13557&geneProductId=UniProtKB:Q13557

1 reference

31 October 2017

regulation of cell communication by electrical coupling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

positive regulation of cardiac muscle cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

peptidyl-serine phosphorylation

2 references

8 April 2019

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

peptidyl-threonine phosphorylation

2 references

8 April 2019

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

endoplasmic reticulum calcium ion homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

protein autophosphorylation

1 reference

8 April 2019

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

relaxation of cardiac muscle

1 reference

8 April 2019

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

cardiac muscle cell contraction

1 reference

8 April 2019

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of cardiac muscle cell action potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of relaxation of cardiac muscle

1 reference

8 April 2019

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13557

Identifiers

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13 November 2019

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9 August 2016

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9 August 2016