Unit Wise Important Questions
Medicinal Chemistry-III
Unit-I
1. What are beta-lactam antibiotics? Give some examples (2)
2. Draw the chemical structures of minocycline and doxycycline. (2)
3. Discuss in detail about cephalosporins with suitable examples. (10)
4. Explain the SAR of tetracycline. Discuss its MOA and uses. (10)
5. Explain in detail about aminoglycosides with examples. (7)
6. Explain the SAR of tetracycline. Discuss its mechanism of action and
uses. (7)
7. Describe the nomenclature of beta-lactam antibiotics. (2)
8. Give two examples of tetracycline antibiotics. (2)
9. Outline the classification of beta-lactam antibiotics with examples.
Explain the structure-activity relationship for penicillin. (10)
10. Write in brief about beta lactamase inhibitors with examples (2)
11. Write in brief about aminoglycosides antibiotics with their clinical uses.
(2)
12. What are tetracyclines? classify it with suitable examples. Write the
SAR and mechanism of action. (10)
13. Classify beta lactam antibiotics with structural examples. Discuss SAR
in detail. (7)
Unit-II
1. Write the mechanism of action of Chloramphenicol. (2)
2. Define Prodrugs with examples. (2)
3. Describe SAR of 4-amino quinolone. Explain MOA and synthesis of
Chloroquine. (10)
4. Describe the concept of Prodrug in drug development. (2)
5. Outline the synthesis of chloramphenicol. (2)
6. Illustrate in detail about types of prodrugs with their application. (7)
7. Define prodrug with examples. (2)
8. Enlist Macrolide antibiotics with combinatorial chemistry. (2)
9. Write the structure and structures and uses of chloramphenicol
examples. (2)
10. Give the SAR of 4-amino quinolines with structural examples. Describe
the synthesis of chloroquine and pamaquine. (10)
Unit-III
1. Enlist urinary tract anti-infective agents. (2)
2. Write the mode of action and uses of zidovudine. (2)
3. Write the mode of action of action and synthesis of isoniazid. (2)
4. Define and classify anti-tubercular agents. Explain in detail with a
suitable example. (7)
5. Describe the synthesis and uses of Acyclovir, Ciprofloxacin and
Dapsone. (7)
6. Enlist anti-tubercular antibiotics. (2)
7. Outline the synthesis of acyclovir. (2)
8. Outline the classification of anti-infective agents used in urinary tract
infections. Explain the structure-activity relationship for Quinolones
and the synthesis of Ciprofloxacin. (10)
9. Outline the synthesis and use of Isoniazid and Nitrofurantion. (7)
10. Classify antiviral agents with examples and explain their MOA. (7)
11. Define polyenes antibiotics with examples. (2)
12. Define and classify antitubercular agents. Write the synthesis and
SAR of Isoniazid. (7)
13. Discuss SAR for Quinolones antibiotics used in urinary tract
infection. Give synthesis of ciprofloxacin. (7)
14. Draw the structure of acyclovir and zidovudine with their mechanism
of action and clinical uses in detail. (7)
Unit IV
1. Define anthelmintic agents. Write the synthesis of Mebendazole. (2)
2. Discuss the chemistry, classification, and SAR of Sulfonamides with
suitable examples. (7)
3. Classify synthetic antifungal agents. Describe the mechanism of action,
synthesis, and uses of Miconazole. (7)
4. Describe the synthesis of Dapsone. (2)
5. Define antiprotozoal agents with examples. (2)
6. Describe the synthesis and uses of Diethylcarbamazine citrate and
Mebendazole. (7)
7. Illustrate the classification of sulfonamides with the synthesis of
sulfacetamide. (7)
8. Describe azoles as antifungal agents with suitable examples. (7)
9. Draw the structure of mebendazole and Diethylcarbamazine citrate. (2)
10. Enlist Anthelmintics drugs. (2)
11. Outline the synthesis of Dapsone. (2)
12. Classify Sulfonamides with structural examples. Give the SAR of
sulfonamides and synthesis of sulfacetamide. (10)
13. Classify antiprotozoal agents? Give synthesis, mechanism of action and
clinical applications of metronidazole. (7)
14. Classify synthetic antifungal agents with suitable examples. Synthesis
and clinical uses of Miconazole. (7)
Unit V
1. Describe the application of combinatorial Chemistry. (2)
2. Define QSAR. (2)
3. Explain substituent hydrophobicity constant about drug design. (7)
4. Define combinatorial chemistry and explain in detail about solid phase
5. synthesis. (7)
6. Illustrate combinatorial synthesis in drug discovery. (2)
7. Define Molecular Docking. (2)
8. Enlist and illustrate the physicochemical parameters used in QSAR. (10)
9. Illustrate solid phase and solution phase synthesis along with their
applications. (7)
10. Explain solid phase synthesis in combinatorial chemistry. (2)
11. Write down the physicochemical parameters of QSAR in detail. (7)
