NOP2 10 6827 s001

Supplementary file 1

STROBE Statement—Checklist of items that should be included in reports of cross-sectional studies

Item Page
No Recommendation No.
Title and abstract 1 (a) Indicate the study’s design with a commonly used term in the title or 1
the abstract
(b) Provide in the abstract an informative and balanced summary of what 1-2
was done and what was found
Introduction
Background/rationale 2 Explain the scientific background and rationale for the investigation being 3-4
reported
Objectives 3 State specific objectives, including any prespecified hypotheses 4
Methods
Study design 4 Present key elements of study design early in the paper 4
Setting 5 Describe the setting, locations, and relevant dates, including periods of 5
recruitment, exposure, follow-up, and data collection
Participants 6 (a) Give the eligibility criteria, and the sources and methods of selection 4
of participants
Variables 7 Clearly define all outcomes, exposures, predictors, potential confounders, 5
and effect modifiers. Give diagnostic criteria, if applicable
Data sources/ 8* For each variable of interest, give sources of data and details of methods 5
measurement of assessment (measurement). Describe comparability of assessment
methods if there is more than one group
Bias 9 Describe any efforts to address potential sources of bias NA
Study size 10 Explain how the study size was arrived at 4
Quantitative variables 11 Explain how quantitative variables were handled in the analyses. If 6
applicable, describe which groupings were chosen and why
Statistical methods 12 (a) Describe all statistical methods, including those used to control for 6
confounding
(b) Describe any methods used to examine subgroups and interactions NA
(c) Explain how missing data were addressed NA
(d) If applicable, describe analytical methods taking account of sampling NA
strategy
(e) Describe any sensitivity analyses NA
Results
Participants 13* (a) Report numbers of individuals at each stage of study—eg numbers 6
potentially eligible, examined for eligibility, confirmed eligible, included
in the study, completing follow-up, and analysed
(b) Give reasons for non-participation at each stage NA
(c) Consider use of a flow diagram NA
Descriptive data 14* (a) Give characteristics of study participants (eg demographic, clinical, 6
social) and information on exposures and potential confounders
(b) Indicate number of participants with missing data for each variable of NA
interest
Outcome data 15* Report numbers of outcome events or summary measures 6
Main results 16 (a) Give unadjusted estimates and, if applicable, confounder-adjusted 6-7
estimates and their precision (eg, 95% confidence interval). Make clear
1
which confounders were adjusted for and why they were included
(b) Report category boundaries when continuous variables were NA
categorized
(c) If relevant, consider translating estimates of relative risk into absolute 7
risk for a meaningful time period
Other analyses 17 Report other analyses done—eg analyses of subgroups and interactions, NA
and sensitivity analyses
Discussion
Key results 18 Summarise key results with reference to study objectives 7-8
Limitations 19 Discuss limitations of the study, taking into account sources of potential 9
bias or imprecision. Discuss both direction and magnitude of any potential
bias
Interpretation 20 Give a cautious overall interpretation of results considering objectives, 9
limitations, multiplicity of analyses, results from similar studies, and other
relevant evidence
Generalisability 21 Discuss the generalisability (external validity) of the study results 8
Other information
Funding 22 Give the source of funding and the role of the funders for the present study 9
and, if applicable, for the original study on which the present article is
based

*Give information separately for exposed and unexposed groups.
Note: An Explanation and Elaboration article discusses each checklist item and gives methodological background and
published examples of transparent reporting. The STROBE checklist is best used in conjunction with this article (freely
available on the Web sites of PLoS Medicine at http://www.plosmedicine.org/, Annals of Internal Medicine at
http://www.annals.org/, and Epidemiology at http://www.epidem.com/). Information on the STROBE Initiative is
available at www.strobe-statement.org.

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Supplementary file 1

STROBE Statement—Checklist of items that should be included in reports of cross-sectional studies

*Give information separately for exposed and unexposed groups.

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