III Sem - POC II - Question Bank-New

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NIRMALA COLLEGE OF PHARMACY

III SEMESTER B. PHARM

PHARMACEUTICAL ORGANIC CHEMISTRY – II

QUESTION BANK

UNIT 1 – Benzene and its derivatives


1. Discuss on the various analytical, synthetic & other evidences for the derivation of
structure of benzene?
2. Explain on the orbital picture & stability of benzene ring?
3. Briefly explain the resonance & aromaticity in benzene?
4. Write a note on Huckel’s rule?
5. Write the chemical reactions of benzene?
6. Write the mechanism of nitration in benzene?
7. Write the mechanism of sulphonation in benzene?
8. Write the mechanism of halogenation in benzene?
9. Write the mechanism & limitations of Friedel craft’s alkylation in benzene?
10. Write the mechanism of Friedel craft’s acylation in benzene?
11. Explain in detail the mechanism, reactivity & orientation of monosubstituted benzene
compounds towards electrophilic aromatic substitution?
12. Explain the reactivity & orientation of phenol on electrophilic aromatic substitution?
13. Explain the reactivity & orientation of aniline on electrophilic aromatic substitution?
14. Explain the reactivity & orientation of nitrobenzene on electrophilic aromatic
substitution?
15. Explain the reactivity & orientation of toluene on electrophilic aromatic substitution?
16. Write the chemical structure & uses of DDT, Saccharin, BHC and chloramine?

UNIT 2 – PHENOLS & AROMATIC AMINES


17. Write the method of preparation for phenol?
18. Write the reactions of phenol?
19. Discuss on the acidity of phenol & effect of substituents on acidity?
20. Write the qualitative tests for phenols?
21. Write the structure & uses of phenol, cresol, resorcinol & naphthol?
22. Write the method of preparation of aromatic amines?
23. Write the reactions of aromatic amines?
24. Explain the basicity of amines & effect of substituents on basicity?
25. Write a note on replacement & coupling reactions of aryl diazonium salts?
26. Write the preparation & synthetic applications of aryl diazonium salts?

UNIT 3 – FATS & OILS


27. Define fat or oil and discuss the nomenclature? Write the classification of lipids?
28. Write the reactions of fatty acids?
29. Explain the various chemical reactions of fats & oils?
30. Write a note on hydrolysis of fats?
31. Write a note on hydrogenation?
32. Write a note on saponification reaction (alkaline hydrolysis)?
33. Write a note on rancidity of oils?
34. Write a note on drying of oils?
35. Types of fatty acids?
36. Methods of extraction of fats & oils?
37. Discuss on various analytical constants used for the determination of purity of fat or
oil?
38. Write the principle & significance of acid value?
39. Write the principle & significance of saponification value?
40. Write the principle & significance of iodine value?
41. Write the principle & significance of ester value?
42. Write the principle & significance of acetyl value?
43. Write the principle & significance of RM value?

UNIT 4 – POLYNUCLEAR HYDROCARBONS


44. Classify polynuclear hydrocarbons & write the method of preparation of naphthalene?
45. Haworth synthesis?
46. Explain the aromaticity & reactivity of naphthalene?
47. Write the chemical properties of naphthalene?
48. Explain the orbital concept of naphthalene, anthracene & phenanthrene?
49. Compare the resonance & reactivity in naphthalene, anthracene & phenanthrene?
50. Write the method of preparation of anthracene?
51. Write the chemical properties of anthracene?
52. Write the method of preparation & reactions of phenanthrene?
53. Write the structure & uses of any 3 medicinal compounds containing naphthalene
nucleus?
54. Write the structure & uses of any 3 medicinal compounds containing anthracene
nucleus?
55. Write the structure & uses of any 3 medicinal compounds containing phenanthrene
nucleus?
56. Write the structure & uses of any 2 derivatives of diphenyl methane?
57. Write the structure & uses of any 2 derivatives of triphenyl methane?
58. Write the method of preparation & reactions of diphenyl methane?
59. Write the method of preparation & reactions of triphenyl methane?

UNIT 5 – CYCLOALKANES
60. Write the method of preparation of cycloalkanes?
61. Discuss the chemical reactions of cyclopropane and cyclobutane?
62. Explain the stability of cycloalkanes with Baeyer’s strain theory & its limitations?
63. Write a note on Coulson & moffit’s modification?
64. Explain the theory of strainless rings? (Sachse Mohr’s theory)

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