Physiobiologic Bases and Behavior Neuroscience: Biology and Behavior
Physiobiologic Bases and Behavior Neuroscience: Biology and Behavior
Physiobiologic Bases and Behavior Neuroscience: Biology and Behavior
BASES AND
BEHAVIOR
NEUROSCIENCE:
BIOLOGY AND
BEHAVIOR
Allam, Jeremiah
Aquino, Kristiene Kyle
Balisi, Jasmin
Cagurangan, Alyssa Samantha
Lucas, Jelmar
Mateo, Ma. Melizzae
Ranjo, Rodamae
Brain
- is divided into:
Cerebrum
Cerebellum
Brain Stem
Limbic System
NEUROTRANSMITTERS
- Are chemical substances manufactured in neuron that aid in the transmission of
information throughout the body.
- Approximately 100 billion of brain cells form groups of neurons, or nerve cells that
are arranged in networks.
- These neurons communicate information with one another by sending
electrochemical messages from neuron to neuron, a process called
neurotransmission.
- These electrochemical messages pass from dendrites (projection from the cell
body), through the soma or cell body, down the axon (long extended strictures),
and across the synapses (gaps between cells) to the dendrites of the next neuron.
- In the nervous system, the electrochemical messages cross the synapses between
neural cells by way of special chemical messengers called neurotransmitters.
- They either excite or stimulate an action in the cells (excitatory) or inhibit or stop
an action (inhibitory).
- These neurotransmitters fit into specific receptor cells embedded in the membrane
of the dendrite, just like a certain key shape fits into a lock.
- After neurotransmitters are released into the synapse, and relay the message to
the receptor cells, they are either transported back from the synapse to the axon to
be stored for later use (reuptake) or metabolized and inactivated by enzymes,
primarily Monoamine Oxidase (MAO).
Dopamine
- is a neurotransmitter located primarily in the brain stem, and has been found to be
involved in the control of complex movements, motivation, cognition, and
regulation of emotional responses.
- Dopamine is generally excitatory and is synthesized from tyrosine, a dietary
amino acid.
- Dopamine us implicated in Schizophrenia and other psychoses as well in
movement disorders such as Parkinson’s disease.
- Antipsychotic medications work by blocking dopamine receptors and reducing
dopamine activity,
Histamine
- The role of histamine in mental illness is under investigation.
- It is involved un peripheral allergic responses, control of gastric secretions, cardiac
stimulation, and alertness.
- Some psychotropic drugs block histamine resulting in weight gain, sedation and
hypertension.
Acetylcholine
- is a neurotransmitter found in the brain, spinal cord, and peripheral nervous
system.
- It can be excitatory or inhibitory.
- It is synthesized from dietary choline found in red meat and vegetables, and has
been found to affect the sleep- wake cycle and to signal muscles to become
active.
- Alzheimer’s disease has decreased acetylcholine- secreting neurons, and people
with myasthenia gravis (a muscular disorder, causes muscle weakness.)
Glutamate
- Is an excitatory amino acid that at high level can have major neurotoxic effects.
- Glutamate has been implicated in the brain damage caused by stroke,
hypoglycemia, sustained hypoxia, or ischemia, and some degenerative diseases
such as Huntington’s or Alzheimer’s.
- Gamma- aminobutyric acid (GABA)
COGNITIVE FRAMEWORK
- Focuses on distorted or negative thought pattern that leads to maladaptive or
symptomatic feelings and behaviors.
PATTERNS OF BEHAVIOR
Group adaptation is a process by which the group maintains a balance so that it can
promote growth of individual and group members.
The word “Stress” was derived from Latin word “Stringere” which means “to draw tight”.
Change in the internal/ external environment causes stress and an organism has to adapt to
it to survive. The stimulus preceding or precipitating the changes are called stressors.
crisis is a disturbance caused by a stressful event or a perceived threat. The person usual
way of coping becomes ineffective in dealing with the threat, causing anxiety.
Disaster is defined by the WHO as “A severe disruption, ecological and psychological,
which greatly exceeds the coping capacity of the affected community. It can be natural and
man- made, psychological reaction may be either adaptive or maladaptive.
1. Genetic theories
2. Biochemical theories
3. Psychological theories
4. Behavioral and cognitive theories
5. Social Theories
Cause of mental illness can be chronologically divided into 3 groups:
I. Pre- disposing Factors: These occurs before the onset of the disease or before
psychopathology have appeared.
1) Genetic Factors
2) Biological Factors
3) Psychological Factors
II. Precipitating Factors: These are events that occur shortly before the onset of
disorders and appear to have induced it.
1) Physical Factors
2) Physiological Factors
3) Psychological Factors
4) Social factors
III. Perpetuating Factors: These are factors that prolong the course of a disorder after it
has been provoked. It is extremely vital to consider these factors while planning
treatment.
1. DISORDERS OF PERSONALITY
a) Over Activity (seen in mania, can be goal directed but goal keeps changing)
b) Decreased Activity (takes long time to start activity, once started it is done very
slowly)
c) Stereotypy (persistent, constant repetition of activities, that involve position,
movement or speech) (e.g: catalepsy, waxy- flexibility, mannerisms, verbigeration)
d) Repetitious Activities (activity is initiated, there is tendency to repeat)
e) Automatic Behavior (echolalia, echopraxia)
f) Negativism (manifested by opposition and resistance to what is suggested)
g) Compulsion (morbid and irresistible urges to perform purposeless acts repetitiously)
h) Violence (expression of aggressiveness in the form of murders, assaults, rape,
damaging self)
i) Suicide (means self- destruction, feel rejected and unloved, commonly seen
recovery depression, acute schizophrenia and delirium)
3. DISORDERS OF PERCEPTION
4. DISORDERS OF THINKING
5. DISTURBANCES OF AFFECT
6. DISTURBANCES OF ATTENTION
a) Disordered attention (conation, affect and associations, fatigue, toxic states and
organic lesion interfere and lowered attention)
b) Distractibility (inability to hold attention for sufficient length of time)
7. DISORDERS OF CONSCIOUSNESS
8. DISORDERS OF MEMORY
9. DÉJÀ VU
10. DEMENTIA
Patterns of Adaptation
Adaptation is the ability to adjust to new information and experiences. Learning is
essentially adapting to our constantly changing environment. Through adaptation,
we are able to adopt new behaviors that allow us to cope with change.
Twentieth century Swiss psychologist and genetic epistemologist Jean Piaget's
theory of cognitive development outlined four stages of learning. These stages
include sensorimotor (0 to 2 years old), preoperational (2 to 7 years old), concrete
operational (7 to 12 years old), and formal operational (12 years old and up)—
however, the age each stage starts can vary.2
According to Piaget's theory, adaptation is one of the important processes guiding
cognitive development. The adaptation process itself can take place in two ways:
assimilation and accommodation.
Meaning of conflict
Douglas and Holland define conflict as a painful emotional state which
results from a tension between opposed and contradictory wishes
Barney and Lehner defines conflict is a state of tension brought by the
presence in the individual of two or more opposing desires.
Types of conflict
o Approach-Approach conflict: This arises when an individual is faced with the
problem of making a choice between two or more positive goals almost equally
motivating and important. For example, a child may have to choose between
watching a movie in TV or going out to play games.
o Avoidance-Avoidance conflict: In this, an individual is forced to choose between two
negative courses of action. For example, a child who does not want to study and at
the same time does not want to displease the parents by failing in the examination
may experience such conflict.
o Approach-Avoidance conflict: In this, an individual is faced with a problem of choice
between approaching and avoiding tendencies at the same time.
Sources of Conflict
o The conflict arises from the home, school, occupational social and cultural
environment. The faulty upbringing at home, unhealthy relationships, over
protection is the sources of conflict from home environment. Unpleasant school or
college environment, role of teachers, faulty method of teaching, denial of
opportunities for self expression and classmates are some of the sources of conflict
in youngsters. Improper working environment, dissatisfaction with the working
conditions, unsatisfactory relationships and poor salary or wages is the sources of
conflict in occupational environment. The taboos, inhibitions and the negative
attitude towards sex are the causes of many sex conflicts in the minds of youth and
adults.
Conflict resolution
o Negotiation is an important part of conflict resolution
o First of all, accept each desire as it arrives without judgment or resistance
o Remove any barrier or resistance in choosing among conflicting desires
o Think the goals of life and which one of the desires will be helpful to achieve the
life’s goal
o Choose one desire and follow it with full enthusiasm
Meaning of Frustration
o Frustration means emotional tension resulting from the blocking of a desire or need
(Good, 1959)
o According to Barney and Lehner (1953), frustration refers to failure to satisfy a basic
need because of either condition in the individual or external obstacles.
Causes of Frustration
o External factors
Physical factors: Natural calamities, floods, droughts, earthquakes, fire and
accidents cause frustration in an individual.
Social and societal factors: Societal norms and values impose certain
obstacle in meeting the individual needs which leads to frustration
Economic and financial factors: Unemployment and lack of money causes
frustration in an individual.
o Internal factors
Physical abnormality or defects: Too small or too big a stature, very heavy or
thin body, an ugly face or dark complexion etc causes frustration.
Conflicting desires or aims: When a person has conflicting desires, he develops
frustration. For example, a nurse wants to work in abroad and does not want to
leave her family in home country causes frustration.
Individual’s morality and high ideals: An individual’s moral standards, code of
ethics and high ideals may become a source of frustration to him.
Level of aspirations: One may aspire very high in spite of one’s incapabilities or
human limitations which may lead to frustration
Lack of persistence and sincerity in efforts: Frustration may result in one’s own
weakness in putting continuous and persistent efforts with courage, enthusiasm
and will power.
Anxiety is a part of everyday life. It has always existed and belongs to no particular era or
culture. Anxiety involves one’s body, perceptions of self, and relationships with others,
making it a basic concept in the study of psychiatric nursing and human behavior.
Anxiety disorders are the most common psychiatric disorders in the United States,
affecting between 15% and 25% of the population. Those with an anxiety disorder have
significant impairment in quality of life and functioning.
Defining Characteristics
Anxiety is an emotion and a subjective individual experience. It is energy and
cannot be observed directly. A nurse infers that a patient is anxious based on
certain behaviors. The nurse needs to validate this inference with the patient
Anxiety is an emotion without a specific object. It is provoked by the
unknown and accompanies all new experiences, such as entering school,
starting a new job, or giving birth to a child. This characteristic of anxiety
differentiates it from fear
Fear has a specific source or object that the person can identify and describe.
Fear involves the cognitive appraisal of a threatening stimulus; anxiety is the
emotional response to that appraisal. Fear is caused by physical or
psychological exposure to a threatening situation. Fear produces anxiety.
Fear and anxiety are different, and this is reflected in our speech: We speak
of having a fear but of being anxious.
Anxiety is communicated interpersonally. If a nurse is talking with a patient
who is anxious, within a short time the nurse also will experience feelings of
anxiety. Similarly, if a nurse is anxious in a particular situation, this anxiety
will be communicated to the patient. The “contagious” nature of anxiety can
have positive and negative effects on the therapeutic relationship. The nurse
must carefully monitor these effects.
Anxiety is about self-preservation. It occurs as a result of a threat to a
person’s selfhood, self-esteem, or identity. It results from a threat to
something that is central to one’s personality and essential to one’s
existence and security. It may be connected with fear of punishment,
disapproval, withdrawal of love, disruption of a relationship, isolation, or loss
of body functioning. Culture is related to anxiety, because culture can
influence the values one considers most important (Gwynn et al, 2008;
Westermeyer et al, 2010).
Levels of Anxiety
Peplau (1963) identified four levels of anxiety and described their effects:
1. Mild anxiety occurs with the tension of day-to-day living. During this stage the
person is alert and the perceptual field is increased. The person sees, hears, and
grasps more than before. This kind of anxiety can motivate learning and produce
growth and creativity.
2. Moderate anxiety, in which the person focuses only on immediate concerns,
involves narrowing of the perceptual field. The person sees, hears, and grasps less.
The person blocks selected areas but can attend to more if directed to do so.
3. Severe anxiety is marked by a significant reduction in the perceptual field. The
person tends to focus on a specific detail and not think about anything else. All
behavior is aimed at relieving anxiety, and much direction is needed to focus on
another area.
4. Panic is associated with dread and terror, as the person experiencing panic is unable
to do things even with direction. Increased motor activity, decreased ability to
relate to others, distorted perceptions, and loss of rational thought are all
symptoms of panic. The panicked person is unable to communicate or function
effectively. This level of anxiety cannot persist indefinitely, because it is
incompatible with life. A prolonged period of panic would result in exhaustion and
death. But panic can be treated safely and effectively.
A. Physiological
o Cardiovascular
Palpitations
Racing heart
Increasedblood pressure
Faintness∗
Actual fainting∗
Decreased blood pressure∗
Decreased pulse rate∗
o Respiratory
Rapid breathing
Shortness of breath
Pressure on chest
Shallow breathing
Lump in throat
Choking sensation
Gasping
o Gastrointestinal
Loss of appetite
Revulsion toward food
Abdominal discomfort
Abdominal pain
Nausea
Heartburn
Diarrhea
o Neuromuscular
Increased reflexes
Startle reaction
Eyelid twitching
Insomnia
Tremors
Rigidity
Fidgeting
Pacing
Strained face
Generalized weakness
Wobbly legs
Clumsy movement
o Urinary Tract
Pressure to urinate∗
Frequent urination∗
o Skin
Flushed face
Localized sweating (e.g., palms)
Itching
Hot and cold spells
Pale face
Generalized sweating
o Behavioral
Restlessness
Physical tension
Tremors
Startle reaction
Hypervigilance
Rapid speech
Lack of coordination
Accident proneness
Interpersonal withdrawal
Inhibition
Flight
Avoidance
Hyperventilation
o Cognitive
Impaired attention
Poor concentration
Forgetfulness
Errors in judgment
Preoccupation
Blocking of thoughts
Decreased perceptual field
Reduced creativity
Diminished productivity
Confusion
Self-consciousness
Loss of objectivity
Fear of losing control
Frightening visual images
Fear of injury or death
Flashbacks
Nightmares
o Affective
Edginess
Impatience
Uneasiness
Tension
Nervousness
Fear
Fright
Frustration
Helplessness
Alarm
Terror
Jitteriness
Jumpiness
Numbing
Guilt
Shame
Frustration
Helplessness
PREDISPOSING FACTORS
A. Biological
The majority of studies point to a dysfunction in multiple systems rather than
implicating one particular neurotransmitter in the development of an anxiety
disorder. These systems include the following:
GABA system. The regulation of anxiety is related to the activity of the
neurotransmitter gamma-aminobutyric acid (GABA), which controls the activity, or
firing rates, of neurons in the parts of the brain responsible for producing anxiety.
GABA is the most common inhibitory neurotransmitter in the brain.
Norepinephrine system. The norepinephrine (NE) system is thought to mediate the
fight-or-flight response. The part of the brain that manufactures NE is the locus
ceruleus. It is connected by neurotransmitter pathways to other structures of the
brain associated with anxiety, such as the amygdala, the hippocampus, and the
cerebral cortex.
Medications that decrease the activity of the locus ceruleus (antidepressants such
as the tricyclics) effectively treat some anxiety disorders. This suggests that anxiety
may be caused in part by an inappropriate activation of the NE system in the locus
ceruleus and an imbalance between NE and other neurotransmitter systems.
Serotonin system. A dysregulation of serotonin (5-HT) neurotransmission may play
a role in the etiology of anxiety, because patients experiencing these disorders may
have hypersensitive 5-HT receptors.
Drugs that regulate serotonin, such as the selective serotonin reuptake inhibitors
(SSRIs), have been shown to be particularly effective in treating several of the
anxiety disorders, suggesting a major role for 5-HT and its balance with other
neurotransmitter systems in the etiology of anxiety disorders.
B. Familial
Anxiety disorders run in families. The heritability of panic disorder is estimated to be
about 40%. Individuals with a family history of psychiatric illness are three times
more likely to develop PTSD after a traumatic event.
Despite strong evidence for genetic vulnerability, no single or specific gene has
been clearly identified for anxiety disorders. This is due, in part, to the critical role
that the environment plays in interacting with genetic vulnerability in mental
disorders.
It is also important to understand that anxiety disorders can overlap, as can anxiety
disorders and depression. People with one anxiety disorder are more likely to
develop another or to experience a major depression within their lifetime.
C. Psychological
Learning theorists believe that people who have been exposed in early life to
intense fears are more likely to be anxious in later life, so parental influences are
important. Children who see their parents respond with anxiety to every minor
stress soon develop a similar pattern. In contrast, if parents are completely
unmoved by potentially stressful situations, children feel alone and lack emotional
support from their families. The appropriate emotional response of parents gives
children security and helps them learn constructive coping methods.
D. Behavioral
Anxiety can be a product of frustration caused by anything that interferes with
attaining a desired goal. An example of an external frustration might be the loss of a
job. Many goals may thus be blocked, such as financial security, pride in work, and
perception of self as family provider. An internal frustration is seen when young
college graduates set unrealistically high career goals and are frustrated by entry-
level job offers. Their view of self is threatened by their unrealistic goals and they
are likely to experience feelings of failure, insignificance, and mounting anxiety.
Coping Mechanisms
As anxiety increases to the severe and panic levels, the behaviors displayed by a
person become more intense and potentially injurious, and quality of life decreases.
People seek to avoid anxiety and the circumstances that produce it
The nurse needs to be familiar with the coping mechanisms people use when
experiencing the various levels of anxiety. For mild anxiety, caused by the tensions
of day-to-day living, several coping mechanisms commonly used include crying,
sleeping, eating, yawning, laughing, cursing, physical exercise, and daydreaming.
Oral behavior, such as smoking and drinking, is another way of coping with mild
anxiety
When dealing with other people, the individual copes with low levels of anxiety
through superficiality, lack of eye contact, use of clichés, and limited self-disclosure.
People also can protect themselves from anxiety by assuming comfortable roles
and limiting close relationships to those with values similar to their own
Moderate, severe, and panic levels of anxiety pose greater threats to the ego. They
require more energy to cope with the threat. These coping mechanisms can be
categorized as problem or task focused and as emotion or ego focused.
FUNDAMENTAL CONCEPTS
MENTAL HEALTH
- Is a state of emotional, psychological, and social wellness evidenced by:
Satisfying interpersonal relationships
Effective behavior and coping
Positive self-concept
Emotional stability
Self-awareness
Mental Illness
- A mental disorder or condition manifested by disorganization and impairment of
functions that arises from various causes such as psychological, neurobiological and
genetic factors.
The Neuroses – Usually the patient retains insight and orientation; they experience
deep distress and may commit suicide as depression
The Psychoses – (the patient is disorientated, deluded, and lacking in insight) e.g.,
Schizophrenia, puerperal psychosis
- The Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text
Revision (DSM-IV-TR).
- Diagnostic criteria are listed for each of the psychiatric disorders.
- A multiaxial system- people are evaluated from multiple aspects or points of
function.
Axis I - Clinical disorders and other conditions that may be a focus of clinical attention
Axis II - Personality disorders and mental retardation
Axis III - General medical conditions
Axis IV - Psychosocial and environmental problems
Axis V - The measurement of an individual’s psychological, social, and occupational
functioning on the GAF Scale
It is increasingly recognised that mental illness is a chronic and relapsing condition and
that treatment may, in consequence be for months, years or even for life. Previously
many patients spent weary years in long-stay care-the mental asylums. They became
institutionalised. There was no effective therapy and they were simply looked after in a
simple routine, the worst of their symptoms often “burned out’ but by that time they
had lost all contact with family, friends,work etc. Now many more patients can be cared
for in the community after discharge from hospital. They may never need hospital
admission or attend day hospital as part of therapy. Community care is expensive in the
professional time and effort to look after patients in a social setting rather than an
institution. There are more demands upon friends, family and social services but the
results are much better. Long term medication, supervised therapy and intense
rehabilitation all play their part.
Psychiatric Nursing
- Psychiatric nursing or mental health nursing is the specialty of nursing that cares for
people of all ages with mental illness or mental distress.
- An interpersonal process that promotes and maintains behavior that contributes to
integrated functioning
Nursing Approach/Model
Components:
1. Nurse-Client Interactive Relationship
- mutuality, collaboration, and problem-solving; tools: communication and nurse-
client relationship
2. Environmental Management
- provide therapeutic environment by serving as advocates and role models, by
offering social support and by engaging clients in collaborative problem-solving of
here-and-now problems of daily living
3. Nursing Process
Personality
Each human being is unique
We all have different personalities
My personality reflects genetic inheritance and environment
Personality will be reflected in behaviour and predilection to a particular mental
state.
E.g., Introvert/Extrovert Practical men and Visionaries Idle and industrious Thinkers
and Doers
It is possible to do a Personality inventory and classify human beings quite
accurately into their predominant personality type and to predict their preferred
mode of behaviour in a particular set of circumstances
Magical thinking – primitive thought process thoughts alone can change events.
Autistic thinking – regressive thought process-subjective interpretations not validated
with objective reality
5. Disturbances in memory
Confabulation – filling of memory gaps
Amnesia – memory loss (inability to recall past events)
o Retrograde-distant past
o Anterograde – immediate past
o Anomia – lack of memory of items
SUMMARY