Scribd Logo
Upload

Welcome to Scribd!

    • 56 views

    Turuan As. karboksilatKOL A #2

    Uploaded by

    Mahendra Aditya
    This document discusses various derivatives of carboxylic acids including chlorides, anhydrides, esters, amides, nitriles, and their properties and reactions. It provides examples of substitution and hydrolysis reactions of carboxylic acid derivatives. Hydrolysis of derivatives results in the formation of the original carboxylic acid. Carboxylic acid chlorides can be used to synthesize other derivatives like anhydrides, esters, and amides through nucleophilic substitution reactions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Turuan As. karboksilatKOL A #2

    Uploaded by

    Mahendra Aditya
    56 views24 pages
    This document discusses various derivatives of carboxylic acids including chlorides, anhydrides, esters, amides, nitriles, and their properties and reactions. It provides examples of substitution and hydrolysis reactions of carboxylic acid derivatives. Hydrolysis of derivatives results in the formation of the original carboxylic acid. Carboxylic acid chlorides can be used to synthesize other derivatives like anhydrides, esters, and amides through nucleophilic substitution reactions.

    Original Title

    turuan as. karboksilatKOL A #2

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document discusses various derivatives of carboxylic acids including chlorides, anhydrides, esters, amides, nitriles, and their properties and reactions. It provides examples of substitution and hydrolysis reactions of carboxylic acid derivatives. Hydrolysis of derivatives results in the formation of the original carboxylic acid. Carboxylic acid chlorides can be used to synthesize other derivatives like anhydrides, esters, and amides through nucleophilic substitution reactions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    56 views24 pages

    Turuan As. karboksilatKOL A #2

    Uploaded by

    Mahendra Aditya
    This document discusses various derivatives of carboxylic acids including chlorides, anhydrides, esters, amides, nitriles, and their properties and reactions. It provides examples of substitution and hydrolysis reactions of carboxylic acid derivatives. Hydrolysis of derivatives results in the formation of the original carboxylic acid. Carboxylic acid chlorides can be used to synthesize other derivatives like anhydrides, esters, and amides through nucleophilic substitution reactions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    You are on page 1of 24

    Turunan Asam Karboksilat

    Klorida asam
    Asam anhidrida
    Ester
    Amida
    Nitril

    Substitusi Nukleofilik
    Sifat Fisik Senyawa Turunan
    Asam Karboksilat
    Reaktivitas Turunan Asam
    Karboksilat
    Reaksi Konversi Gugus Fungsu Turunan Asam Karboksilat
    Substitusi Nukleofilik
    Tatanama IUPAC
    (menggunakan template asam karboksilat)
    O O O

    Cl O
    drop "ic acid" add "yl chloride" drop "acid" add "anhydride"
    pentanoyl chloride pentanoic anhydride
    O O

    OCH3 NH2
    "alkyl" _ drop "ic acid" add "ate" drop "oic acid" add "amide"
    methyl pentanoate pentanamide
    CN
    drop "ic acid" add "e_nitrile"
    pentanenitrile
    Klorida Asam
    OCH3 O
    CCl Cl

    o-methoxybenzoyl chloride (E) 2-octenoyl chloride

    O
    CH3O CH2CCl

    (p-methoxyphenyl)acetyl chloride
    Asam Anhidrida
    O O
    O O C C
    O CH3
    O
    butanoic anhydride acetic benzoic anhydride
    butyric anhydride

    O
    OH O O O
    HO
    O
    succinnic acid succinnic anhydride
    Ester
    O
    COCH2CH2CH3 O

    O
    propyl benzoate (Z) cyclopentyl 2-butenoate
    O O
    COCH2CH(CH3)2 CH2COCH2CH3

    isobutyl cyclohexanecarboxylate ethyl phenylacetate


    Amida
    O
    CNH2

    CH3 H2N O
    meta methylbenzamide 2-ethyl-3-methylpentanamide
    -ethyl--methylvaleramide
    O
    CN(CH3)2 O

    HCN
    H
    N-benzylformamide
    N,N-dimethylcyclopentanecarboxamide
    Lacton (ester siklik) O
    O
    O
    HO OH + H2O

    -hydroxyvaleric acid -valerolactone

    O
    O
    O
    OH + H2O

    OH
    -hydroxyenanthic acid -enantholactone
    Asam γ-Hidroksibutirat

    HO CO 2H HO CO2 Na

    -hydroxybutyric acid sodium 4-hydroxybutanoate


    or sodium -hydroxybutyrate
    H 3O
    + (GHB)

    CNS depressant
    O as of 2000, Schedule I
    controlled substance
    O + H2O
    If mixed with ROH, the depressant
    effects are enhanced
    -butyrolactone
    Semua turunan asam karboksilat
    dapat dihidrolisis menghasilkan asam
    karboksilat O O

    (CH3)2CHO OCH(CH3)2
    diisopropyl pimelate
    Hydrolysis
    +
    H3O or
    in base
    O O

    HO OH
    + 2 (CH3)2CHOH
    Tuliskan tiga produk dari hidrolisis
    senyawa berikut?
    O
    C N(CH2CH3)2
    +
    O H3O

    O products are carboxylic acid(s)


    + conjugate acid of the LGs
    Two hydrolyzable groups
    Produk Hidrolisis
    O
    C N(CH2CH3)2 CO2H
    + OH
    O H3O

    + HN(CH2CH3)2
    O
    HO
    +
    O
    Hidrolisis of klorida asam
    Pembuatan klorida asam
    O O
    COH CCl
    SOCl2
    + SO2
    in N
    + HCl
    O O

    SOCl2, pyridine CCl


    OH
    + HCl
    + SO2
    O
    S
    Cl Cl O
    O S
    O Cl
    C OH
    C O
    Cl

    O O
    O
    S S
    S Cl O Cl
    O Cl
    O Cl
    C OH C
    C OH pyr: O
    Cl
    Substitusi Nukleofilik
    O O
    O
    + Nu LG + LG
    LG Nu
    Nu
    O
    LG = Cl , OCCH3 , OCH3 , NH2
    best worst
    Pembuatan asam anhidrida menggunakan klorida
    asam dilakukan tanpa menggunakan katalis
    O
    HO
    Cl
    O
    addition
    O O H

    O
    Cl
    elimination Cl
    O O H

    deprotonation O O + HCl

    O
    Sintesis ester dari klorida
    asam
    Sintesis amida dari klorida
    asam
    Amida dari anhidrida

    You might also like