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    Hydralazine

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    Marwin Odita
    Hydralazine is a vasodilator indicated to treat essential hypertension alone or in combination with other medications. It works by interfering with calcium transport in vascular smooth muscle, relaxing arteriolar smooth muscle and lowering blood pressure. Common side effects include increased heart rate. Nurses should consider these effects and monitor for changes in blood pressure when administering hydralazine intravenously or intramuscularly.

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    Hydralazine

    Uploaded by

    Marwin Odita
    14 views3 pages
    Hydralazine is a vasodilator indicated to treat essential hypertension alone or in combination with other medications. It works by interfering with calcium transport in vascular smooth muscle, relaxing arteriolar smooth muscle and lowering blood pressure. Common side effects include increased heart rate. Nurses should consider these effects and monitor for changes in blood pressure when administering hydralazine intravenously or intramuscularly.

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    Hydralazine is a vasodilator indicated to treat essential hypertension alone or in combination with other medications. It works by interfering with calcium transport in vascular smooth muscle, relaxing arteriolar smooth muscle and lowering blood pressure. Common side effects include increased heart rate. Nurses should consider these effects and monitor for changes in blood pressure when administering hydralazine intravenously or intramuscularly.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    14 views3 pages

    Hydralazine

    Uploaded by

    Marwin Odita
    Hydralazine is a vasodilator indicated to treat essential hypertension alone or in combination with other medications. It works by interfering with calcium transport in vascular smooth muscle, relaxing arteriolar smooth muscle and lowering blood pressure. Common side effects include increased heart rate. Nurses should consider these effects and monitor for changes in blood pressure when administering hydralazine intravenously or intramuscularly.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
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    DRUG STUDY

    Name of Drug: Hydralazine

    Drug Dosage/Route Classification Mechanisms of Action Indication Contraindication Adverse Effects Nursing Considerations

    Generic Name: - 5-10 mg IV/IM Vasodilator Hydralazine may interfere with Hydralazine is indicated alone or
    Hydralazine initially, THEN calcium transport in vascular smooth adjunct to standard therapy to treat
    5-10 mg q20- muscle by an unknown mechanism essential hypertension. A
    Brand Name: 30min PRN to relax arteriolar smooth muscle combination product with isosorbide
    and lower blood pressure. The dinitrate is indicated as an adjunct
    - 0.5-10 mg/hr IV interference with calcium transport therapy in the treatment of heart
    infusion may be by preventing influx of failure.
    calcium into cells, preventing
    calcium release from intracellular
    compartments, directly acting on
    actin and myosin, or a combination
    of these actions. This decrease in
    vascular resistance leads to
    increased heart rate, stroke volume,
    and cardiac output.

    Hydralazine also competes with


    protocollagen prolyl hydroxylase
    (CPH) for free iron. This competition
    inhibits CPH mediated hydroxylation
    of HIF-1α, preventing the
    degradation of HIF-1α. Induction of
    HIF-1α and VEGF promote
    proliferation of endothelial cells and
    angiogenesis.

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