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Drug Study (Tapazole)

Tapazole (methimazole) is an anti-thyroid drug used to treat hyperthyroidism. It works by inhibiting thyroid hormone synthesis. Common side effects include nausea, vomiting, headache and dizziness. Nurses should monitor patients for potential adverse effects on liver function, blood counts, and signs of hypothyroidism or allergic reaction. Patients should take the drug as prescribed and report any severe or concerning symptoms to their doctor.

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Izza Deloria
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746 views3 pages

Drug Study (Tapazole)

Tapazole (methimazole) is an anti-thyroid drug used to treat hyperthyroidism. It works by inhibiting thyroid hormone synthesis. Common side effects include nausea, vomiting, headache and dizziness. Nurses should monitor patients for potential adverse effects on liver function, blood counts, and signs of hypothyroidism or allergic reaction. Patients should take the drug as prescribed and report any severe or concerning symptoms to their doctor.

Uploaded by

Izza Deloria
Copyright
© © All Rights Reserved
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Download as DOCX, PDF, TXT or read online on Scribd
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DRUG STUDY

NAME OF DRUG Brand Name: Tapazole


Generic Name: methimazole

Dose: 5 mg/tab QD
Route: PO
CLASSIFICATION OF DRUG Pharmacologic classification:
thyroid hormone antagonist
Therapeutic classification:
anti-thyroid drug
Pregnancy risk category D
MECHANISM OF ACTION It prevents thyroid hormone synthesis by
inhibiting the thyroid peroxidase-catalyzed
reactions & blocking iodine organification.
INDICATIONS It is a treatment for hyperthyroidism and
used when thyroidectomy is not advisable.
CONTRAINDICATIONS Contraindicated in patients hypersensitive
to drug and in breast-feeding women.
Used cautiously in pregnant women.
SIDE EFFECTS  nausea
 vomiting (may be dose-related)
 upset stomach
 headache
 dizziness or drowsiness
 rash
 itching
ADVERSE EFFECTS  CNS: vertigo, paresthesia, neuritis,
neuropathies, CNS stimulation,
depression, fever
 GI: diarrhea, salivary gland
enlargement, loss of taste,
epigastric distress.
 GU: nephritis
 Hematologic: agranulocytosis,
leukopenia, thrombocytopenia,
aplastic anemia
 Hepatic: jaundice, hepatic
dysfunction, hepatitis
 Metabolic: hypothyroidism
 Musculoskeletal: arthralgia,
myalgia.
 Skin: urticaria, pruritus, erythema
nodosum, exfoliative dermatitis,
lupus-like syndrome
 Other: lymphadenopathy
NURSING RESPONSIBILITIES  Monitor CBC of the patient
 Monitor patient’s vital signs
 Monitor liver function test values,
especially if hepatic dysfunction is
suspected
 Periodically monitor thyroid function
tests to monitor progress
 Advise the patient to take drug after
meals
 Advise patient not to store drug in
bathroom since heat and humidity
causes it to deteriorate
 Educate the patient to not take
extra medicine to make up the
missed dose.
 Tell the patient to that while using
the drug, do not start, stop, or
change the dosage of any other
medicines without the doctor's
approval
 Tell patient to promptly report fever,
sore throat, malaise, unusual
bleeding, yellowing of eyes,
nausea, or vomiting
 Inform the patient to avoid driving or
engaging in potentially hazardous
activities because it may cause
dizziness and drowsiness

SOURCES:
https://www.drugs.com/mtm/methimazole.html
http://tmedweb.tulane.edu/pharmwiki/doku.php/methimazole
https://www.glowm.com/resources/glowm/cd/pages/drugs/m030.html

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