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    Isosorbide Mononitrate: Adult: PO Regular Release (ISMO, Monoket) 20 MG B.I.D. 7 H Apart

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    Aubrey Unique Evangelista
    Isosorbide mononitrate is a long-acting vasodilator used to prevent angina. It comes in both regular and sustained release forms, with dosing twice daily for regular release and once daily for sustained release. Common side effects include headaches, dizziness, hypotension, and gastrointestinal issues. Nursing responsibilities include monitoring for signs of toxicity or hypotension, checking electrolytes periodically, and educating patients about proper administration and drug interactions.

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    Isosorbide Mononitrate: Adult: PO Regular Release (ISMO, Monoket) 20 MG B.I.D. 7 H Apart

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    Aubrey Unique Evangelista
    197 views2 pages
    Isosorbide mononitrate is a long-acting vasodilator used to prevent angina. It comes in both regular and sustained release forms, with dosing twice daily for regular release and once daily for sustained release. Common side effects include headaches, dizziness, hypotension, and gastrointestinal issues. Nursing responsibilities include monitoring for signs of toxicity or hypotension, checking electrolytes periodically, and educating patients about proper administration and drug interactions.

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    ISORBIDE MONONITRATE

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    Isosorbide mononitrate is a long-acting vasodilator used to prevent angina. It comes in both regular and sustained release forms, with dosing twice daily for regular release and once daily for sustained release. Common side effects include headaches, dizziness, hypotension, and gastrointestinal issues. Nursing responsibilities include monitoring for signs of toxicity or hypotension, checking electrolytes periodically, and educating patients about proper administration and drug interactions.

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    197 views2 pages

    Isosorbide Mononitrate: Adult: PO Regular Release (ISMO, Monoket) 20 MG B.I.D. 7 H Apart

    Uploaded by

    Aubrey Unique Evangelista
    Isosorbide mononitrate is a long-acting vasodilator used to prevent angina. It comes in both regular and sustained release forms, with dosing twice daily for regular release and once daily for sustained release. Common side effects include headaches, dizziness, hypotension, and gastrointestinal issues. Nursing responsibilities include monitoring for signs of toxicity or hypotension, checking electrolytes periodically, and educating patients about proper administration and drug interactions.

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    ISOSORBIDE MONONITRATE

    Generic Name ISOSORBIDE


    MONONITRATE

    Brand Name Ismo, Imdur,


    Monoket

    Classification CARDIOVASCULAR AGENT; NITRATE VASODILATOR


    General Action Isosorbide mononitrate is a long-acting metabolite of the coronary
    vasodilator isosorbide dinitrate. It decreases preload as measured by
    pulmonary capillary wedge pressure (PCWP), and left ventricular end
    volume and diastolic pressure (LVEDV), with a consequent reduction in
    myocardial oxygen consumption.
    Dose and Route Prevention of Angina
    Adult: PO Regular release (ISMO, Monoket) 20 mg b.i.d. 7 h apart;
    Sustained release (Imdur) 30–60 mg every morning, may increase up to
    120 mg once daily after several days if needed (max: dose 240 mg)

    Indications or Prevention of angina. Not indicated for acute attacks.


    Purposes
    Side effects CNS: Headache, agitation, anxiety, confusion, loss of coordination,
    hypoesthesia, hypokinesia, insomnia or somnolence, nervousness, migraine
    headache, paresthesia, vertigo, ptosis, tremor.
    CV: Aggravation of angina, abnormal heart sounds, murmurs, MI,
    transient hypotension, palpitations.
    Hematologic: Hypochromic anemia, purpura, thrombocytopenia,
    methemoglobinemia (high doses).
    GI: Nausea, vomiting, dry mouth, abdominal pain, constipation, diarrhea,
    dyspepsia, flatulence, tenesmus, gastric ulcer, hemorrhoids, gastritis,
    glossitis.
    Metabolic: Hyperuricemia, hypokalemia.
    GU: Renal calculus, UTI, atrophic vaginitis, dysuria, polyuria, urinary
    frequency, decreased libido, impotence.
    Respiratory: Bronchitis, pneumonia, upper respiratory tract infection,
    nasal congestion, bronchospasm, coughing, dyspnea, rales, rhinitis.
    Skin: Rash, pruritus, hot flashes, acne, abnormal texture.
    Special Senses: Diplopia, blurred vision, photophobia, conjunctivitis.
    Contraindications Hypersensitivity to nitrates; severe anemia; closed-angle glaucoma,
    postural hypotension, head trauma, cerebral hemorrhage (increases
    intracranial pressure). Safe use during pregnancy [(category C) and
    (category B) for sustained form] or lactation is not established.
    Nursing Assessment & Drug Effects
    Responsibilities
     Monitor cardiac status, frequency and severity of angina, and BP.
     Assess for and report possible S&S of toxicity, including orthostatic
    hypotension, syncope, dizziness, palpitations, light-headedness,
    severe headache, blurred vision, and difficulty breathing.
     Lab tests: Monitor serum electrolytes periodically.

    Patient & Family Education

     Do not crush or chew sustained release tablets. May break tablets in


    two and take with adequate fluid (4–8 oz).
     Do not withdraw drug abruptly; doing so may precipitate acute
    angina.
     Maintain correct dosing interval with twice daily dosing.
     Note: Geriatric patients are more susceptible to the possibility of
    developing postural hypotension.
     Avoid alcohol ingestion and aspirin unless specifically permitted by
    physician.
     Do not breast feed while taking this drug without consulting
    physician.

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