OBGM 1213 Tam PDF
OBGM 1213 Tam PDF
OBGM 1213 Tam PDF
In this CASE 1 Early-stage pelvic organ prolapse active with her husband on roughly a weekly
Article
AC is a 64-year-old white woman with early basis.
Pessary indications stage III anterior and apical pelvic organ pro- On examination, the leading edge of her
and options lapse (POP). The prolapse is now affecting prolapse is the anterior vaginal wall, protrud-
her ability to do some of the things that she ing 1 cm beyond the introitus, and the cervix
page 43
enjoys, such as gardening and golfing. is at the hymenal ring. There is no significant
She has hypertension controlled with posterior wall prolapse.
Essential
medication and no other significant medical After she is counseled about all pos-
components of
issues except mild arthritic changes in her sible treatment approaches for her early-
successful fit hands and hips. She reports being sexually stage POP, the patient elects to try the vagi-
page 50 nal pessary. Now, it is your job to determine
the optimal pessary based on the extent of
Outcomes Dr. Tam is a graduated Fellow in the Division
her condition and to educate her about the
of Urogynecology and Minimally Invasive
page 59 Gynecologic Surgery, Department of Obstetrics potential side effects and best practices for
and Gynecology, Penn State Milton S. Hershey its ongoing use.
Medical Center. She is currently in private practice
T
at All for Women’s Healthcare in Chicago, Illinois.
Dr. Davies is Division Chief, Urogynecology and he vaginal pessary is an important
Minimally Invasive Gynecologic Surgery, Department component of a gynecologist’s ar-
of Obstetrics and Gynecology, at Penn State
mamentarium. It is a low-risk, cost-
Milton S. Hershey Medical Center, Penn State
College of Medicine, Hershey, Pennsylvania. effective, nonsurgical treatment option for
On the Web the management of POP and genuine stress
Dr. Tam reports that she has received a grant or
urinary incontinence (SUI).1,2 It is unfortu-
Dr. Tam demonstrates research support from Ethicon BioSurgery and is a
proper insertion speaker for Merck Pharmaceuticals. nate that training in North America typically
Dr. Davies reports that he is a consultant to Boston provides clinicians with only a cursory expe-
and removal Scientific and a speaker for Ethicon Endosurgical
techniques, at and Boston Scientific.
rience with pessary selection and care, mini-
obgmanagement.com mizing the device’s importance as a viable
FIGURE 1 FIGURE 2
A B
Ring pessary (A), and ring pessary with support (B)
FIGURE 3 FIGURE 4
A B
"
ÃÊ VÌ>}Ê
Ê >ÞÊ
LÌÊ Ì
iÊ iÌ>LÃÊ vÊ Ì
iÀÊ V«Õ`ðÊ
"
ÃÊ
beneath the bulge. The two bases rest on the
have been shown to significantly decrease plasma concentrations of lamotrig- posterior vagina against the lateral levator
ine, likely due to induction of lamotrigine glucuronidation. This may reduce sei-
zure control; therefore, dosage adjustments of lamotrigine may be necessary.
muscles.
Women on thyroid hormone replacement therapy may need increased doses
of thyroid hormone because serum concentration of thyroid-binding globulin Shaatz
increases with use of COCs.
7.3 Interference with Laboratory Tests This support pessary has a circular base sim-
The use of contraceptive steroids may influence the results of certain labora- ilar to the Gellhorn pessary but without the
tory tests, such as coagulation factors, lipids, glucose tolerance, and binding
proteins. rigid stem (Figure 4, page 44).
8 USE IN SPECIFIC POPULATIONS Insertion. Because it is stiff, insert this pes-
8.1 Pregnancy
There is little or no increased risk of birth defects in women who inadvertently sary vertically and then turn it to a horizontal
ÕÃiÊ
"
ÃÊ`ÕÀ}Êi>ÀÞÊ«Ài}>VÞ°Ê
«`i}VÊÃÌÕ`iÃÊ>`ÊiÌ>>>ÞÃiÃÊ position once it is inside the vagina.
have not found an increased risk of genital or non-genital birth defects (includ-
ing cardiac anomalies and limb-reduction defects) following exposure to low
dose COCs prior to conception or during early pregnancy. Lever
The administration of COCs to induce withdrawal bleeding should not be used
as a test for pregnancy. COCs should not be used during pregnancy to treat The Hodge, Smith, and Risser pessaries are
threatened or habitual abortion. collectively called the lever pessaries. They
8.3 Nursing Mothers
When possible, advise the nursing mother to use other forms of contracep- are used to manage uterine retroversion and
tion until she has weaned her child. COCs can reduce milk production in POP. They are rarely used.
breastfeeding mothers. This is less likely to occur once breastfeeding is well
established; however, it can occur at any time in some women. Small amounts
The Hodge pessary is beneficial to pa-
of oral contraceptive steroids and/or metabolites are present in breast milk. tients with a narrow vaginal introitus, mild
8.4 Pediatric Use
Safety and efficacy of Quartette have been established in women of reproduc-
cystocele, and cervical insufficiency. The an-
ÌÛiÊ >}i°Ê
vwV>VÞÊ ÃÊ iÝ«iVÌi`Ê ÌÊ LiÊ Ì
iÊ Ã>iÊ vÀÊ «ÃÌ«ÕLiÀÌ>Ê >`iÃViÌÃÊ terior portion of a Hodge pessary is rectangu-
under the age of 18 as for users 18 years and older. Use of Quartette before lar (Figure 5A ).
menarche is not indicated.
8.5 Geriatric Use The Smith pessary is useful for patients
Quartette has not been studied in women who have reached menopause and with well-defined pubic notches because the
is not indicated in this population.
8.6 Hepatic Impairment anterior portion is rounded (Figure 5B ).
ÊÃÌÕ`iÃÊ
>ÛiÊLiiÊV`ÕVÌi`ÊÌÊiÛ>Õ>ÌiÊÌ
iÊivviVÌÊvÊ
i«>ÌVÊ«>ÀiÌÊÊ For patients with a very shallow pubic
the disposition of Quartette. However, steroid hormones may be poorly metabo-
lized in patients with hepatic impairment. Acute or chronic disturbances of liver notch, the Risser pessary is useful. The Riss-
function may necessitate the discontinuation of COC use until markers of liver er’s anterior portion is rectangular with in-
function return to normal and COC causation has been excluded. [See Contra-
indications (4) and Warnings and Precautions (5.2)] dentation but wider than the Hodge pessary
8.7 Renal Impairment (Figure 5C) .
ÊÃÌÕ`iÃÊ
>ÛiÊLiiÊV`ÕVÌi`ÊÌÊiÛ>Õ>ÌiÊÌ
iÊivviVÌÊvÊÀi>Ê«>ÀiÌÊÊ
the disposition of Quartette. Insertion. Fold the pessary and insert it into
10 OVERDOSAGE the vagina with the index finger on the poste-
There have been no reports of serious ill effects from overdose of oral contra-
ceptives, including ingestion by children. Overdosage may cause withdrawal rior curved bar until the pessary rests behind
bleeding in females and nausea. the cervix and the anterior horizontal bar
rests behind the symphysis pubis.
Manufactured by:
Teva Women’s Health, Inc.
-ÕLÃ`>ÀÞÊvÊ/
6Ê*,
1/
-Ê1-]ÊV° Space-occupying pessaries
-iiÀÃÛi]Ê*Ê£nÈä The second pessary category is the space-
Quartette™ is a trademark of Teva Women’s Health, Inc. filling pessary. These pessaries are used
©2013 Teva Women’s Health, Inc.
/
ÃÊ LÀivÊ ÃÕ>ÀÞÊ ÃÊ L>Ãi`Ê Ê +Õ>ÀÌiÌÌiÒÊ vÕÊ *ÀiÃVÀL}Ê vÀ>Ì] primarily to support severe POP, especially
Iss. 3/2013. posthysterectomy vaginal vault prolapse.
QUA-40103 They have larger bases to support the vaginal
apex or cervix; therefore, they are more diffi-
cult to insert and remove. When this pessary
type is in place, sexual intercourse is not pos-
sible. Examples include the Gellhorn, donut,
cube, and inflatable pessaries.
A B C
Hodge pessary (A), Smith pessary (B), and Risser pessary (C)
base with a stem (Figure 6 ). The broad base the tip of the stem is just inside the vaginal
supports the vaginal apex while the stem introitus (Figure 7). Many medical illustra-
keeps the circular base from rotating and tions inaccurately depict the Gellhorn pes-
prevents pessary expulsion. The stem comes sary in a final placement that appears too
in long or short lengths. The concave base high in the pelvis. This figure, which has
provides vaginal suction and keeps the pes- the patient in a standing position, shows
sary in place. The holes in the stem and base how low in the pelvis this space-filling
provide vaginal drainage. The Gellhorn pes- pessary can sit in a patient with advanced
sary is useful for women with more advanced prolapse. The space-filling
prolapse and less perineal support. Remove this pessary by gently pulling pessaries support
Insertion. Folding one side of the base to the the stem while inserting the opposite hand advanced-stage
stem, insert the Gellhorn pessary vertically beneath an edge of the pessary base to break prolapse, with some,
inside the vagina. To facilitate insertion, the vaginal suction (see Vaginal pessaries:
such as the donut
separate the labia with the nondominant An instructional video, on page 43).
and cube designs,
FIGURE 6 FIGURE 7
more difficult to
Photos: Courtesy of ©CooperSurgical, except where noted.
remove
Accurate selection and placement of a pessary requires Insert the pessary into the vagina using the dominant
appropriate examination and fitting, beginning with deter- hand. Using the nondominant hand, separate the introitus
mination of the patient’s stage of prolapse and introitus. and depress the perineal body. Apply a small amount of
Key steps include: lubricant to the leading edge of the pessary.
• Examine the patient with an empty bladder in the After insertion, ask the patient to strain and cough,
lithotomy position ambulate in the office, and void. Reexamine the patient
• Perform bimanual pelvic and speculum examination to ensure that the pessary is still in the correct position
using a Sims speculum (or bivalve speculum broken in and that placement has not shifted. Perform the cough
half) with the patient in a supine position leak test with the patient in a standing position and the
• Administer the Pelvic Organ Prolapse Quantification pessary in place. Re-examine the patient while she is in a
(POP-Q) exam standing position. Use the largest pessary that is com-
• Perform digital examination fortable for her. Advise her to bring the pessary back to
• Assess vaginal atrophy, vaginal introitus, and vaginal the office if it gets expelled.
width and length This is a trial-and-error process; advise the patient
• Evaluate pelvic floor muscle strength (Kegel squeeze). of this. It may require a trial of several styles and sizes to
Next, gauge the correct pessary size by approximat- find the right pessary fit. Once you find the correct size,
ing the number of fingerbreadths accommodated across document the final pessary size.
the vaginal width.
Another method of estimating pessary size is to
insert two fingers inside the vagina and estimate the Follow-up
distance between the posterior fornix and the posterior
Schedule a follow-up appointment 1 to 2 weeks after in-
pubic symphysis (see Vaginal pessaries: An instructional
sertion. Ask the patient whether she has experienced any
video, on page 43). An easy reference is to start with a
discomfort, malodorous discharge, or vaginal bleeding.
size 3 or 4 ring pessary if the vaginal introitus is 1 to 2 fin-
Also inquire about any changes in urinary habits or bowel
gerbreadths in width and the prolapse is stage II to III. If
movements and related complaints.
the vagina accommodates 3 to 4 fingerbreadths, or there
Remove the pessary and clean it with mild soap and
is stage IV prolapse, use a Gellhorn pessary.
water. Examine the vagina for pressure points, abrasions,
Here are the different types of pessaries and the
ulcerations, and erosions.
most common sizes available. (Pessary sizes change in
Teach the patient how to remove, clean, and reinsert
quarter-inch increments.)
the pessary, and advise her to perform these tasks on a
Ring: Size 3 to 5 or 2.5 to 3 inches weekly basis.
Gehrung: Size 3 to 5 or 2.5 to 3 inches Schedule a follow-up visit in 1 to 2 months, and
another visit 6 to 12 months after that.
Lever: 2 to 4 inches
If the patient cannot or will not remove her pessary,
Gellhorn: 2.5 to 3 inches ask her to return in less time, usually 1 to 2 months, to
Cube: 2 to 4 inches observe her progress, with subsequent visits every 3 to
4 months for pessary cleaning and assessment, again
Donut: 2.5 to 3 inches
depending on the condition of her progress.
Inflatable: Sizes are medium or large
FIGURE 8 FIGURE 9
A B
Donut pessary Cube pessary (A) with drainage holes (B)
(Figure 10 ). Some models also include a usually adequate to eliminate them. Tempo-
deflation key. The inflatable pessary comes rary discontinuation of pessary use may be
in small, medium, large, and extra-large siz- warranted until symptoms subside. If these
es. This pessary type must be removed and maneuvers do not resolve the issue, then the
cleaned daily.
FIGURE 10
Insertion. Place the deflated pessary into the
Photos: Courtesy of Bioteque America.
space-occupying changes in their urinary function. Many She frequently voids small amounts of urine
women with anterior or apical prolapse but never feels complete relief. She defe-
pessary is 3 to 4
will have altered urine streams with slow or cates normally.
months
Her medical history is significant for
FIGURE 12
coronary artery disease with prior myocar-
Ring pessary with knob Since the failure rate for pessary usage
increases with advancing prolapse stage, a
cont inued on page 59
References
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